Huachen Wei

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi Isoflavone genistein: photoprotection and clinical implications in dermatology
    Huachen Wei
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Nutr 133:3811S-3819S. 2003
  2. ncbi Photoprotective effect of isoflavone genistein on ultraviolet B-induced pyrimidine dimer formation and PCNA expression in human reconstituted skin and its implications in dermatology and prevention of cutaneous carcinogenesis
    Julian O Moore
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY, USA
    Carcinogenesis 27:1627-35. 2006
  3. ncbi Protective effects of lycopene against ultraviolet B-induced photodamage
    Zsuzsanna Fazekas
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nutr Cancer 47:181-7. 2003
  4. ncbi p53 gene mutations in SKH-1 mouse tumors differentially induced by UVB and combined subcarcinogenic benzo[a]pyrene and UVA
    Yongyin Wang
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY, USA
    Photochem Photobiol 84:444-9. 2008
  5. ncbi Benzo[a]pyrene and its metabolites combined with ultraviolet A synergistically induce 8-hydroxy-2'-deoxyguanosine via reactive oxygen species
    Dayuan Gao
    Department of Dermatology, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1047, New York, NY 10029, USA
    Free Radic Biol Med 39:1177-83. 2005
  6. ncbi Effects of ultraviolet B exposure on the expression of proliferating cell nuclear antigen in murine skin
    Julian O Moore
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Photochem Photobiol 80:587-95. 2004
  7. ncbi Inhibition of ultraviolet light-induced oxidative events in the skin and internal organs of hairless mice by isoflavone genistein
    Huachen Wei
    Department of Dermatology, Box 1047, Mount Sinai School of Medicine, One Gustave Levy Place, 1425 Madison Avenue, New York, NY 10029, USA
    Cancer Lett 185:21-9. 2002
  8. ncbi The combination of benzo[a]pyrene and ultraviolet A causes an in vivo time-related accumulation of DNA damage in mouse skin
    Rao Saladi
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Photochem Photobiol 77:413-9. 2003
  9. ncbi Combined subcarcinogenic benzo[a]pyrene and UVA synergistically caused high tumor incidence and mutations in H-ras gene, but not p53, in SKH-1 hairless mouse skin
    Yongyin Wang
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Cancer 116:193-9. 2005
  10. ncbi Effects of the isoflavone 4',5,7-trihydroxyisoflavone (genistein) on psoralen plus ultraviolet A radiation (PUVA)-induced photodamage
    Eileen Q Shyong
    Department of Dermatology, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Carcinogenesis 23:317-21. 2002

Research Grants

  1. GENISTEIN IN INVESTIGATIVE AND CLINICAL DERMATOLOGY
    Huachen Wei; Fiscal Year: 2005
  2. Prevention of Skin Cancer by Scutellaria Baicalensis
    Huachen Wei; Fiscal Year: 2004
  3. SYNERGISTIC CARCINOGENICTY OF UVA AND BENZO(A)PYRENE
    Huachen Wei; Fiscal Year: 2003

Collaborators

  • Yan Wang
  • William G Stebbins
  • Fei Ye
  • Elizabeth C A Smith
  • David Y Zhang
  • M Lebwohl
  • Yan Wu
  • R N Saladi
  • Dayuan Gao
  • Julian O Moore
  • Yuhun Lu
  • Eileen Q Shyong
  • Xing Hua Gao
  • Dana Kazlow Stern
  • Zsuzsanna Fazekas
  • Robert G Phelps
  • Fiza Singh
  • Li Zhang
  • Hong Duo Chen
  • Hong-Duo Chen
  • Xing-Hua Gao
  • Wangui Muigai
  • Phyllis Spuls
  • Marsha Gordon
  • Erin Moshier
  • Stephanie Diamantis
  • Xueyan Zhou
  • Robert Phelps
  • Denise Guevara
  • Yunjing Luo
  • Mei Rui
  • Billie Goldwyn
  • Sapna R Palep
  • Amy Goldstein
  • Alison Lazinsky
  • Lisa M Austin

Detail Information

Publications17

  1. ncbi Isoflavone genistein: photoprotection and clinical implications in dermatology
    Huachen Wei
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Nutr 133:3811S-3819S. 2003
    ..In this article, we review the biological activities of genistein, as well as published and unpublished research from our laboratory. In addition, we discuss the potential application of genistein to clinical dermatology...
  2. ncbi Photoprotective effect of isoflavone genistein on ultraviolet B-induced pyrimidine dimer formation and PCNA expression in human reconstituted skin and its implications in dermatology and prevention of cutaneous carcinogenesis
    Julian O Moore
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY, USA
    Carcinogenesis 27:1627-35. 2006
    ..The implications of our findings serve as compelling validation to our conclusions that genistein may serve as a potent chemopreventive agent against photocarcinogenesis...
  3. ncbi Protective effects of lycopene against ultraviolet B-induced photodamage
    Zsuzsanna Fazekas
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nutr Cancer 47:181-7. 2003
    ....
  4. ncbi p53 gene mutations in SKH-1 mouse tumors differentially induced by UVB and combined subcarcinogenic benzo[a]pyrene and UVA
    Yongyin Wang
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY, USA
    Photochem Photobiol 84:444-9. 2008
    ..We show that individually subcarcinogenic levels of BaP and UVA synergistically induce a novel p53-mutation fingerprint. This fingerprint could serve as a prognostic indicator for the development of BaP-UVA-induced skin tumors...
  5. ncbi Benzo[a]pyrene and its metabolites combined with ultraviolet A synergistically induce 8-hydroxy-2'-deoxyguanosine via reactive oxygen species
    Dayuan Gao
    Department of Dermatology, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1047, New York, NY 10029, USA
    Free Radic Biol Med 39:1177-83. 2005
    ..Additionally, singlet oxygen was found to play a major role in 8-OHdG induction by BPDE and UVA. These results suggest that BaP metabolites such as BPDE synergize with UVA radiation to produce ROS, which in turn induce DNA damage...
  6. ncbi Effects of ultraviolet B exposure on the expression of proliferating cell nuclear antigen in murine skin
    Julian O Moore
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Photochem Photobiol 80:587-95. 2004
    ..Specific immunoreactivity patterns and the observable atypia in keratinocytes are relevant in elucidating malignant potentiation...
  7. ncbi Inhibition of ultraviolet light-induced oxidative events in the skin and internal organs of hairless mice by isoflavone genistein
    Huachen Wei
    Department of Dermatology, Box 1047, Mount Sinai School of Medicine, One Gustave Levy Place, 1425 Madison Avenue, New York, NY 10029, USA
    Cancer Lett 185:21-9. 2002
    ..Thus, the antioxidative properties of genistein may explain for the mechanisms of anti-photocarcinogenic action of genistein...
  8. ncbi The combination of benzo[a]pyrene and ultraviolet A causes an in vivo time-related accumulation of DNA damage in mouse skin
    Rao Saladi
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Photochem Photobiol 77:413-9. 2003
    ..80). These results indicate that genetic damage caused by exposures to BaP plus UVA accumulates with time and increases the potential for inductive events leading to carcinogenesis and tumor formation...
  9. ncbi Combined subcarcinogenic benzo[a]pyrene and UVA synergistically caused high tumor incidence and mutations in H-ras gene, but not p53, in SKH-1 hairless mouse skin
    Yongyin Wang
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Cancer 116:193-9. 2005
    ..G-->A mutations induced by BaP or BaP-UVA at position 38 of codon 13 have not been reported previously. C-->T transitions were detected in p53 hot spots of exon 8 in 2 of 19 BaP-UVA-induced tumors but were not found in nontumor skin...
  10. ncbi Effects of the isoflavone 4',5,7-trihydroxyisoflavone (genistein) on psoralen plus ultraviolet A radiation (PUVA)-induced photodamage
    Eileen Q Shyong
    Department of Dermatology, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Carcinogenesis 23:317-21. 2002
    ..005). These results indicate that genistein protects the skin from PUVA-induced photodamage...
  11. ncbi Use of Ber-EP4 protein in recurrent metastatic basal cell carcinoma: a case report and review of the literature
    Rao N Saladi
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Dermatol 43:600-3. 2004
    ..The tumor cells were bcl-2 negative and positive for Ber-EP4. The negative expression of bcl-2 correlates with the aggressive nature of this tumor and Ber-EP4 confirmed the diagnosis of BCC...
  12. ncbi Shikonin modulates cell proliferation by inhibiting epidermal growth factor receptor signaling in human epidermoid carcinoma cells
    Fiza Singh
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cancer Lett 200:115-21. 2003
    ..Overall, shikonin treatment was associated with increased intracellular levels of phosphorylated apoptosis-related proteins, and decreased levels of proteins associated with proliferation in human epidermoid carcinoma cells...
  13. ncbi Synergistic enhancement of H2O2 production in human epidermoid carcinoma cells by Benzo[a]pyrene and ultraviolet A radiation
    Eileen Q Shyong
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Toxicol Appl Pharmacol 188:104-9. 2003
    ....
  14. ncbi Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis
    David Y Zhang
    Department of Pathology, Mount Sinai School of Medicine, New York University, New York, New York 10029, USA
    Cancer Res 63:4037-43. 2003
    ..Differences in biological effects of Scutellaria baicalensis compared with baicalein suggest the synergistic effects among components in Scutellaria baicalensis...
  15. ncbi Water content and other aspects of brittle versus normal fingernails
    Dana Kazlow Stern
    Mount Sinai Hospital, Mount Sinai School of Medicine, New York, New York, USA
    J Am Acad Dermatol 57:31-6. 2007
    ..Previous authors have claimed that dehydration of the nail plate causes brittle nails. Some experts claim that normal nails contain 18% water, and brittle nails contain less than 16%...
  16. ncbi Protective effects of cyclooxygenase-2 inhibitors on narrow-band ultraviolet B-irradiated epidermal Ia+ Langerhans cells and Thy-1+ dendritic epidermal T cells in mice
    Yan Wu
    Department of Dermatology, No 1 Hospital of China Medical University, Shenyang, China
    Photochem Photobiol 84:484-8. 2008
    ..In conclusion, COX-2 inhibitors protected against chronic NB-UVB-induced density and morphologic changes in epidermal Ia+ LCs and Thy-1+ DETCs in mice...
  17. ncbi Efficacy and safety of innovative cosmeceuticals
    Xing Hua Gao
    Department of Dermatology, No 1 Hospital of China Medical University, Shenyang, China
    Clin Dermatol 26:367-74. 2008
    ..This article reviews some of the ingredients that are currently in use or might be potential candidates in cosmeceuticals of different categories...

Research Grants17

  1. GENISTEIN IN INVESTIGATIVE AND CLINICAL DERMATOLOGY
    Huachen Wei; Fiscal Year: 2005
    ..Successful completion of the proposed studies will contribute to development of this soybean isoflavone as a preventive and/or therapeutic agent against human skin cancer and photodamage. ..
  2. Prevention of Skin Cancer by Scutellaria Baicalensis
    Huachen Wei; Fiscal Year: 2004
    ..abstract_text> ..
  3. SYNERGISTIC CARCINOGENICTY OF UVA AND BENZO(A)PYRENE
    Huachen Wei; Fiscal Year: 2003
    ..abstract_text> ..