Xiaodong Wang

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi Acute ethanol pretreatment increases FAS-mediated liver injury in mice: role of oxidative stress and CYP2E1-dependent and -independent pathways
    Xiaodong Wang
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Free Radic Biol Med 42:971-84. 2007
  2. ncbi Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy
    Defeng Wu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 53:1346-57. 2012
  3. ncbi Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase
    Xiaodong Wang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 47:518-28. 2009
  4. ncbi Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2-/- but not in c-Jun N-terminal kinase 1-/- mice
    Xiaodong Wang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 54:1753-66. 2011
  5. ncbi Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 49:1406-16. 2010
  6. ncbi Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice
    Xiaodong Wang
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
    Hepatology 42:400-10. 2005
  7. ncbi S-adenosyl-L-methionine attenuates hepatotoxicity induced by agonistic Jo2 Fas antibody following CYP2E1 induction in mice
    Xiaodong Wang
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Pharmacol Exp Ther 317:44-52. 2006
  8. ncbi S-adenosyl-L-methionine decreases the elevated hepatotoxicity induced by Fas agonistic antibody plus acute ethanol pretreatment in mice
    Xiaodong Wang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L Levy Place, 1468 Madison Avenue, New York, NY 10029, USA
    Arch Biochem Biophys 477:1-11. 2008
  9. ncbi Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 47:1483-94. 2008
  10. ncbi Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver
    Lili Yang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Free Radic Biol Med 53:1170-80. 2012

Collaborators

Detail Information

Publications20

  1. ncbi Acute ethanol pretreatment increases FAS-mediated liver injury in mice: role of oxidative stress and CYP2E1-dependent and -independent pathways
    Xiaodong Wang
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Free Radic Biol Med 42:971-84. 2007
    ..The enhanced hepatotoxicity involves increased oxidative and nitrosative stress, and appears to be mediated by CYP2E1-dependent and also CYP2E1-independent mechanisms...
  2. ncbi Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy
    Defeng Wu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 53:1346-57. 2012
    ..Inhibition of autophagy promotes binge ethanol induced hepatotoxicity, steatosis and oxidant stress via CYP2E1...
  3. ncbi Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase
    Xiaodong Wang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 47:518-28. 2009
    ..These results show that chronic ethanol feeding enhances Fas-induced liver injury by a mechanism associated with induction of CYP2E1, elevated serum TNF-alpha levels, and activation of MAPK...
  4. ncbi Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2-/- but not in c-Jun N-terminal kinase 1-/- mice
    Xiaodong Wang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 54:1753-66. 2011
    ..These findings raise the question as to the potential mechanisms of JNK1 activation related to alcoholic liver injury...
  5. ncbi Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 49:1406-16. 2010
    ....
  6. ncbi Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice
    Xiaodong Wang
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
    Hepatology 42:400-10. 2005
    ..In conclusion, enhanced hepatotoxicity of Fas was found in mice with elevated levels of CYP2E1. We speculate that overexpression of CYP2E1 might synergize and increase the susceptibility to Fas induced-liver injury...
  7. ncbi S-adenosyl-L-methionine attenuates hepatotoxicity induced by agonistic Jo2 Fas antibody following CYP2E1 induction in mice
    Xiaodong Wang
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Pharmacol Exp Ther 317:44-52. 2006
    ..These results indicate that SAM can have an important hepatoprotective role as an effective reagent against Fas plus CYP2E1-induced hepatotoxicity by lowering oxidative and nitrosative stress...
  8. ncbi S-adenosyl-L-methionine decreases the elevated hepatotoxicity induced by Fas agonistic antibody plus acute ethanol pretreatment in mice
    Xiaodong Wang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L Levy Place, 1468 Madison Avenue, New York, NY 10029, USA
    Arch Biochem Biophys 477:1-11. 2008
    ....
  9. ncbi Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 47:1483-94. 2008
    ....
  10. ncbi Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver
    Lili Yang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Free Radic Biol Med 53:1170-80. 2012
    ..The results show that acute alcohol elevation of CYP2E1, oxidative stress, and activation of JNK interact to lower autophagy and increase lipogenic SREBP resulting in fatty liver...
  11. ncbi Depletion of cytosolic or mitochondrial thioredoxin increases CYP2E1-induced oxidative stress via an ASK-1-JNK1 pathway in HepG2 cells
    Lili Yang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 51:185-96. 2011
    ..In conclusion, knockdown of TRX-1 or TRX-2 sensitizes cells to CYP2E1-induced oxidant stress partially via ASK-1 and JNK1 signaling pathways. Both TRX-1 and TRX-2 are important for defense against CYP2E1-induced oxidative stress...
  12. ncbi CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophagy in HepG2 E47 cells
    Defeng Wu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochem Biophys Res Commun 402:116-22. 2010
    ..We hypothesize that CYP2E1-induced oxidative stress promotes the accumulation of lipid droplets by ethanol and this may be responsible for the suppression of autophagy in the liver...
  13. ncbi Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signaling
    Raquel Urtasun
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 55:594-608. 2012
    ..CONCLUSION: OPN emerges as a key cytokine within the ECM protein network driving the increase in Collagen-I protein contributing to scarring and liver fibrosis...
  14. ncbi CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases
    Arthur I Cederbaum
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, P O Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Int J Hepatol 2012:582790. 2012
    ..We hypothesize that similar interactions occur as a result of ethanol induction of CYP2E1 and TNFα...
  15. ncbi Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole
    Yongke Lu
    Dept. of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, Box 1603, One Gustave L. Levy Place, New York, NY 10029, USA
    Am J Physiol Gastrointest Liver Physiol 289:G308-19. 2005
    ..The enhanced liver necrosis appears to involve an increase in oxidative and nitrosative stress generated by the combination of LPS plus elevated CYP2E1 levels...
  16. ncbi Cytokines in alcoholic liver disease
    Leon An
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arch Toxicol 86:1337-48. 2012
    ..Interactions between pro- and anti-inflammatory cytokines such as TNFα and adiponectin and other cytokines are likely to play important roles in the development and progression of alcoholic liver disease...
  17. ncbi [The study on the anti-oxidation effect of root of Mallotus apelta in the rat model of liver fibrosis]
    Jinjun Zhao
    First Military Medical University, Gunagzhou 510515
    Zhong Yao Cai 25:185-7. 2002
    ..To investigate the effect of root of Mallotus apelta in treatment of liver fibrosis and the effect of anti-oxidation in the rat model of liver fibrosis...
  18. ncbi [Protective effects of tanshinone IIA on injured primary cultured rat hepatocytes induced by CCl4]
    Yongzhong Liu
    Center Hospital of Xi'an, Xi'an 710003
    Zhong Yao Cai 26:415-7. 2003
    ....
  19. ncbi Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2
    Xiaodong Wang
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Amherst, NY 14260 1200, USA
    Drug Metab Dispos 35:268-74. 2007
    ..Bcrp1 inhibition by chrysin is likely one potential mechanism for the observed chrysin-nitrofurantoin pharmacokinetic interactions in rats...
  20. ncbi Generation and characterization of Smac/DIABLO-deficient mice
    Hitoshi Okada
    Amgen Institute and Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada M5G 2C1
    Mol Cell Biol 22:3509-17. 2002
    ..There were also no detectable differences in Fas-mediated apoptosis in the liver in vivo. Our data strongly suggest the existence of a redundant molecule or molecules capable of compensating for a loss of Smac function...