J Uribarri

..Although this study is promising, the short duration and use of only urinary markers as a surrogate outcome weaken the conclusions...

..Although elevated AGE levels in patients with renal failure have been attributed to impaired renal clearance and increased endogenous AGE formation, recent data suggest an important role for diet as a source of AGEs...

..The recent development of low phosphorus-containing food products represents a very useful addition for CKD patients...

..The current study was designed to test the acute effects of dietary advanced glycation end products (AGEs) on endothelial function of diabetic and nondiabetic subjects...

..Low serum sodium is uncommon in peritoneal dialysis (PD), which is surprising in view of the important role of normal kidney function to regulate water and sodium balance...

..9 and 1 g/kg/d most likely would be an appropriate protein intake without exposing the patient to excessive phosphorus load...

..Together with previous evidence from diabetics and renal failure patients, these data suggest that dietary AGEs may play an important role in the causation of chronic diseases associated with underlying inflammation...

..Moreover, dietary restriction of AGE is an effective and feasible method to reduce excess toxic AGE and possibly cardiovascular associated mortality...

..AGEs are readily derived from heat-treated foods. We propose that the excess consumption of certain AGEs via the diet enhances OS and inflammatory responses in healthy adults, especially in elderly persons...

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..Further investigation of the effect of modifying serum bicarbonate concentration on nutritional markers is needed to test these hypotheses...

..CONCLUSIONS: Exposure to daily dietary glycoxidants enhances LDL-induced vascular toxicity via redox-sensitive mitogen-activated protein kinase activation. This can be prevented by dietary AGE restriction...

..The implication is that there may be a therapeutic role for anti-AGE interventions in the management of this common clinical condition...

..This finding opens the possibility for using anti-AGE strategies in the prevention and treatment of CVD in patients with chronic renal failure...

..The purpose of this study was to determine the association between 25-hydroxyvitamin D (25(OH)D) levels and the prevalence of peripheral arterial disease (PAD) in the general United States population...

..CONCLUSIONS: The results indicate that diet can be a significant environmental source of AGEs, which may constitute a chronic risk factor for cardiovascular and kidney damage...

..The high prevalence of arteriovenous fistulas, despite so many comorbid conditions, suggests that the presence of a skilled and experienced surgeon may be more predictive of better dialysis access than other factors...

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..Subset analyses of both the HEMO and DOPPS studies have shown that obese hemodialysis patients have a lower prevalence of functioning AVF. Doppler ultrasound may increase the prevalence of functioning AVF in obese subjects...

..The new dAGE database provides a valuable instrument for estimating dAGE intake and for guiding food choices to reduce dAGE intake...

..Coupled with low cerebral oxygenation levels and atherosclerosis, this may contribute significantly to the etiology of the observed cerebral atrophy, cognitive deficits, and high stroke prevalence...

..Although high body mass index (BMI) is a risk factor for hypertension, diabetes, and cardiovascular disease, limited data exist on the association of overweight and obesity with early stages of kidney disease...

..These data suggest that the changes in renal function in normal aging may be subject to control and this subject deserves renewed attention...

..Whereas AGE receptor-1 (AGER1) reduces OS/infl in animals, this has not been assessed in normal humans...

..The use of arteriovenous fistulas in the Mount Sinai outpatient hemodialysis program has increased from 15% to 43% (p<0.001) and substantially limited catheter use since 1998, when the multidisciplinary program began...

..An increased understanding of the mechanisms of formation and interaction of AGEs has allowed the development of several potential anti-AGE approaches...

..Elevated serum cystatin C may identify patients with 'preclinical' kidney disease not detected by traditional serum creatinine measurements...

..Future research should consider dietary AGE as a potential therapeutic target for kidney disease in obesity, diabetes, and perhaps other causes of chronic kidney disease...

..In both humans and mice, there was an inverse correlation between the AGER1 to RAGE ratio and the levels of OS...

..No study specifically examined mineral metabolism trends in a generalizable sample of patients at increased CKD risk...

..Prospective outcome and controlled studies are needed to further support this relationship...

..If larger and longer studies confirm the hypothesis that one or both of these interventions reduce progression of CKD, it could represent a new paradigm in the management of complications in the type 2 diabetes patient with CKD...

..In summary, patients with diabetes seem to be as good candidates for arteriovenous fistula placement as patients without diabetes. Additional studies are required to determine the long-term outcome of fistulae in patients with diabetes...

..To prospectively evaluate the efficacy and safety of reteplase with percutaneous transluminal angioplasty (PTA) in the treatment of thrombosed polytetrafluoroethylene hemodialysis arteriovenous grafts (AVGs)...

..Secondary benefits of this methodology and implications for social work practice and research are discussed...

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..This could hold true for eye and vascular lesions and for skin. Further studies supporting these results could reveal the first real treatment option for PXE...

..3% (p < .0001). These data suggest that fistulae do dilate acutely after hand squeezing exercise and that this exercise should continue to be recommended...

..siRNA for FOXO4 abolished AGE-BSA-induced apoptosis of podocytes. Our study suggests that an AGE-RAGE interaction contributes to podocyte apoptosis by activation of the FOXO4 transcription factor...

..In summary, creatinine clearance measurements provide a good estimate of phosphorus clearance and how much dietary phosphorus and therefore protein can be tolerated...

..We suggest that the synergistic effects of a sudden, extreme alkalemia and the localized tissue hypoxia that resulted from extensive microvascular thrombi secondary to TTP caused the patient's hyperlactatemia...

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..Alagebrium (ALT-711) has been shown to improve renal dysfunction in animal models of diabetes...

..05). These results demonstrate that the development of insulin resistance and type 2 diabetes during prolonged high-fat feeding are linked to the excess AGEs/advanced lipoxidation end products inherent in fatty diets...

..This commonly held view that women have less adequate vasculature for AVF placement than men has not been shown objectively in the literature...

..This is a retrospective study of reteplase efficacy for restoration of flow in occluded and poorly functioning hemodialysis catheters...

..This effect may be due to the antioxidant properties of LZ, which is possibly linked to the AGE-binding domain region of the molecule...

..Long-term studies are in progress and will help establish definitive causality between age-related disease states and modern dietary practices in Western societies...

..The postprandial excursions in glucose, insulin, and triglycerides were similar between both meals. A meal rich in AGEs induces acute endothelial and adipocyte dysfunction. These effects were prevented by changing the cooking method...

..The most important message is that simple changes in culinary technique rather than in the food nutrient composition may be the most important part of preventing CVD in this population...

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..An advanced glycation endproducts (AGEs)-rich diet induces significant increases in inflammatory and endothelial dysfunction markers in type 2 diabetes mellitus (T2DM)...

..Our goal is to convey an understanding of the phosphorus content of the current American diet to better equip nephrologists in their attempt to control hyperphosphatemia...

..These guidelines are welcome, but they may be impractical for the majority of dialysis patients. The impact of these guidelines in improving the parameters of bone metabolism and disease among dialysis patients remains to be determined...

..Consequently, clinicians impose uniform dietary and fluid restrictions to limit IDWG, hoping to avoid symptomatic intravascular volume overload...