Genomes and Genes
M B Taubman
Affiliation: Mount Sinai School of Medicine
- Regulation of the procoagulant response to arterial injuryM B Taubman
Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
Thromb Haemost 82:801-5. 1999..These studies suggest that the cellular processing of TF may be an important target for inhibiting thrombotic complications associated with arterial injury and acute coronary events...
- Tissue factor in the pathogenesis of atherosclerosisM B Taubman
Mount Sinai School of Medicine, New York, NY, USA
Thromb Haemost 78:200-4. 1997..Finally, the recent crystallization of TF (55) and the TF:VIIa (56) should provide important new insights into the design of molecules for directly inhibiting TF...
- Intimal tissue factor activity is released from the arterial wall after injuryP L Giesen
Division of Thrombosis Research, The Mount Sinai School of Medicine, New York, NY, USA
Thromb Haemost 83:622-8. 2000..The exposed TF activity was rapidly washed into the perfusate, rendering the luminal surface inactive. The loss of luminal TF into the circulation may attenuate thrombosis at sites of arterial injury...
- Induction of IG9 monocyte adhesion molecule expression in smooth muscle and endothelial cells after balloon arterial injury in cholesterol-fed rabbitsT M Calderon
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
Arterioscler Thromb Vasc Biol 20:1293-300. 2000..Thus, the expression of IG9 by SMCs as well as by ECs may be an important factor in the accumulation of foam cells in atherosclerotic plaque development after arterial injury...
- Dexamethasone inhibits macrophage accumulation after balloon arterial injury in cholesterol fed rabbitsM Poon
The Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, 10029, USA
Atherosclerosis 155:371-80. 2001..004) in the injured arterial wall (media+intima). Glucocorticoids may be useful in attenuating the inflammatory response and subsequent foam-cell accumulation after arterial injury...
- The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned mediumN S Haque
Department of Medicine, Divisions of Hematology and Cardiology, and the Department of Pathology, The Mount Sinai School of Medicine, New York, NY 10029, USA
Blood 97:39-45. 2001..These results indicate that CCR8 is an endothelial receptor that may modulate endothelial function...
- Expression of Q227L-Galpha(s) inhibits intimal vessel wall hyperplasia after balloon injuryW Holness
Departments of Pharmacology, Medicine, and Pathology, and the Cardiovascular Research Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
Proc Natl Acad Sci U S A 98:1288-93. 2001....
- Effect of p27 deficiency and rapamycin on intimal hyperplasia: in vivo and in vitro studies using a p27 knockout mouse modelM Roque
Cardiovascular Biology Research Laboratories, Mount Sinai School of Medicine, New York City, New York 10029 6574, USA
Lab Invest 81:895-903. 2001..The inhibitory effect of rapamycin on intimal hyperplasia occurred via a p27-independent mechanism. The in vitro data showed that this effect was mediated through decreased proliferation and enhanced apoptosis...
- Identification of active tissue factor in human coronary atheromaJ D Marmur
Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
Circulation 94:1226-32. 1996..Recent observations suggest that thrombosis in vivo is initiated via the tissue factor (TF) pathway. The TF activity of human coronary atheroma has not been reported...
- Apolipoprotein(a) induces monocyte chemotactic activity in human vascular endothelial cellsM Poon
Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
Circulation 96:2514-9. 1997..Elevated levels of lipoprotein(a) [Lp(a)] are associated with premature atherosclerosis; however, the mechanisms are not known. Recruitment of monocytes to the blood vessel wall is an early event in atherogenesis...
- Identification and characterization of murine alternatively spliced tissue factorV Y Bogdanov
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
J Thromb Haemost 4:158-67. 2006..These studies demonstrate that masTF contributes to the pool of total TF and may thus play an important role in mediating TF-dependent processes...
- SM-20 is a novel growth factor-responsive gene regulated during skeletal muscle development and differentiationM C Moschella
The Michael A and Zena Wiener Cardiovascular Institute, Department of Medicine, The Mount Sinai School of Medicine, New York, NY 10029, USA
Gene Expr 8:59-66. 1999..SM-20 thus represents a novel intracellular protein that is regulated during skeletal muscle differentiation and development...
- Identification of a novel dexamethasone-sensitive RNA-destabilizing region on rat monocyte chemoattractant protein 1 mRNAM Poon
The Zena and Michael A Wiener Cardiovascular Institute and Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Mol Cell Biol 19:6471-8. 1999..The 224-nt region conferred Dex sensitivity to heterologous mRNA. These studies provide new insights into the molecular mechanisms underlying the effect of glucocorticoids on gene expression...
- HIV envelope gp120 activates human arterial smooth muscle cellsA D Schecter
Zena and Michael A Wiener Cardiovascular Institute and Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
Proc Natl Acad Sci U S A 98:10142-7. 2001..The activation of smooth muscle cells by gp120 may play an important role in the vascular, thrombotic, and inflammatory responses to HIV infection...
- CC chemokine I-309 is the principal monocyte chemoattractant induced by apolipoprotein(a) in human vascular endothelial cellsN S Haque
Division of Hematology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Circulation 102:786-92. 2000..We previously reported that Lp(a) stimulated human vascular endothelial cells to produce monocyte chemotactic activity. The apolipoprotein(a) [apo(a)] portion of Lp(a) was the active moiety...
- Osteopontin deficiency in rat vascular smooth muscle cells is associated with an inability to adhere to collagen and increased apoptosisA S Weintraub
Department of Pediatrics, The Mount Sinai School of Medicine, New York, New York 10029, USA
Lab Invest 80:1603-15. 2000..The data suggest that OPN-deficient VSMC have two distinct abnormalities: an alpha1beta1-mediated inability to adhere normally to collagen and an increased propensity for apoptosis...
- Cloning of the rat tissue factor cDNA and promoter: identification of a serum-response regionO Taby
Department of Medicine Divisions of Cardiology and Thrombosis Research, Mount Sinai School of Medicine, New York, NY 10029, USA
Thromb Haemost 76:697-702. 1996....
- Rapamycin inhibits vascular smooth muscle cell migrationM Poon
Cardiovascular Institute, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
J Clin Invest 98:2277-83. 1996..0001). Thus, in addition to being a potent immunosuppressant and antiproliferative, rapamycin also inhibits SMC migration...
- SM-20 is a novel 40-kd protein whose expression in the arterial wall is restricted to smooth muscleS D Wax
Department of Medicine, Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York, USA
Lab Invest 74:797-808. 1996..Thus, SM-20 encodes a protein which serves as a novel SMC-specific marker within the vessel wall...