W G Tatton

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi Neuroprotection by deprenyl and other propargylamines: glyceraldehyde-3-phosphate dehydrogenase rather than monoamine oxidase B
    W Tatton
    Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA
    J Neural Transm 110:509-15. 2003
  2. ncbi Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells
    W G Tatton
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Pharmacol Exp Ther 301:753-64. 2002
  3. ncbi Apoptosis and anti-apoptosis signalling in glaucomatous retinopathy
    W G Tatton
    Department of Ophthalmology, Mount Sinai Medical Center, New York, New York 10029, USA
    Eur J Ophthalmol 11:S12-22. 2001
  4. ncbi Maintaining mitochondrial membrane impermeability. an opportunity for new therapy in glaucoma?
    W G Tatton
    Departments of Ophthalmology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Surv Ophthalmol 45:S277-83; discussuin S295-6. 2001
  5. ncbi Apoptosis in Parkinson's disease: signals for neuronal degradation
    William G Tatton
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann Neurol 53:S61-70; discussion S70-2. 2003
  6. ncbi Reduced mitochondrial membrane potential and altered responsiveness of a mitochondrial membrane megachannel in p53-induced senescence
    M M Sugrue
    Department of Pediatrics, Division of Hematology Oncology, Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York, 10029 6574, USA
    Biochem Biophys Res Commun 261:123-30. 1999
  7. ncbi Apoptotic mechanisms in neurodegeneration: possible relevance to glaucoma
    W G Tatton
    Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA
    Eur J Ophthalmol 9:S22-9. 1999
  8. ncbi Ovarian steroids reduce apoptosis induced by trophic insufficiency in nerve growth factor-differentiated PC12 cells and axotomized rat facial motoneurons
    N J MacLusky
    Center for Reproductive Sciences, Department of Obstetrics and Gynecology, Columbia Presbyterian Medical Center, 622 West 168th Street, New York, NY 10032 3702, USA
    Neuroscience 118:741-54. 2003
  9. ncbi Retinal damage after 3 to 4 months of elevated intraocular pressure in a rat glaucoma model
    T W Mittag
    Departments of Ophthalmology and Neurology, Mount Sinai School of Medicine, New York University, New York 10029 6574, USA
    Invest Ophthalmol Vis Sci 41:3451-9. 2000
  10. ncbi Reduced apoptosis after nerve growth factor and serum withdrawal: conversion of tetrameric glyceraldehyde-3-phosphate dehydrogenase to a dimer
    G W Carlile
    Department of Neurology, Mount Sinai School of Medicine, New York, New York, USA
    Mol Pharmacol 57:2-12. 2000

Collaborators

Detail Information

Publications14

  1. ncbi Neuroprotection by deprenyl and other propargylamines: glyceraldehyde-3-phosphate dehydrogenase rather than monoamine oxidase B
    W Tatton
    Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA
    J Neural Transm 110:509-15. 2003
    ..Anti-apoptotic propargylamines that do not inhibit MAO-B are now in PD clinical trial...
  2. ncbi Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells
    W G Tatton
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Pharmacol Exp Ther 301:753-64. 2002
    ....
  3. ncbi Apoptosis and anti-apoptosis signalling in glaucomatous retinopathy
    W G Tatton
    Department of Ophthalmology, Mount Sinai Medical Center, New York, New York 10029, USA
    Eur J Ophthalmol 11:S12-22. 2001
    ....
  4. ncbi Maintaining mitochondrial membrane impermeability. an opportunity for new therapy in glaucoma?
    W G Tatton
    Departments of Ophthalmology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Surv Ophthalmol 45:S277-83; discussuin S295-6. 2001
    ..Several anti-apoptotic agents are being evaluated for use in glaucoma, including brimonidine and propargylamines, which oppose mitochondrially dependent apoptosis through pathways involving phosphorylated Akt...
  5. ncbi Apoptosis in Parkinson's disease: signals for neuronal degradation
    William G Tatton
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann Neurol 53:S61-70; discussion S70-2. 2003
    ..Based on the above, it seems unlikely that apoptosis does not contribute to PD neuronal loss, and the definition of the premitochondrial signaling pathways may allow for the development and testing of an apoptosis-based PD therapy...
  6. ncbi Reduced mitochondrial membrane potential and altered responsiveness of a mitochondrial membrane megachannel in p53-induced senescence
    M M Sugrue
    Department of Pediatrics, Division of Hematology Oncology, Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York, 10029 6574, USA
    Biochem Biophys Res Commun 261:123-30. 1999
    ..Therefore, regulation of the closure of the mitochondrial PTP in the presence of decreased DeltaPsi(M) may be a decisional checkpoint in distinguishing between growth arrest pathways...
  7. ncbi Apoptotic mechanisms in neurodegeneration: possible relevance to glaucoma
    W G Tatton
    Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA
    Eur J Ophthalmol 9:S22-9. 1999
    ..The favorable effects of deprenyl on neuronal apoptosis suggests the therapeutic potential of designing compounds with the capacity to alter the configurations of pro-apoptosis or anti-apoptotic proteins...
  8. ncbi Ovarian steroids reduce apoptosis induced by trophic insufficiency in nerve growth factor-differentiated PC12 cells and axotomized rat facial motoneurons
    N J MacLusky
    Center for Reproductive Sciences, Department of Obstetrics and Gynecology, Columbia Presbyterian Medical Center, 622 West 168th Street, New York, NY 10032 3702, USA
    Neuroscience 118:741-54. 2003
    ....
  9. ncbi Retinal damage after 3 to 4 months of elevated intraocular pressure in a rat glaucoma model
    T W Mittag
    Departments of Ophthalmology and Neurology, Mount Sinai School of Medicine, New York University, New York 10029 6574, USA
    Invest Ophthalmol Vis Sci 41:3451-9. 2000
    ..Flatmounts of fixed, dye-labeled retinas were examined by epifluorescence, confocal, or interference contrast microscopy...
  10. ncbi Reduced apoptosis after nerve growth factor and serum withdrawal: conversion of tetrameric glyceraldehyde-3-phosphate dehydrogenase to a dimer
    G W Carlile
    Department of Neurology, Mount Sinai School of Medicine, New York, New York, USA
    Mol Pharmacol 57:2-12. 2000
    ..These actions on GAPDH, rather than MAO-B inhibition, may contribute to the improvements in Parkinson's and Huntington's diseases found with DEP treatment...
  11. ncbi Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway
    Y Jing
    Rochelle Belfer Chemotherapy Foundation Laboratory, Division of Neoplastic Diseases, Department of Medicine, Mount Sinai Medical Center, New York, NY, USA
    Blood 94:2102-11. 1999
    ....
  12. ncbi Motor cortical potentials precede long-latency EMG activity evoked by imposed displacements of the human wrist
    C D MacKinnon
    Department of Physical Therapy, University of Toronto, Canada
    Exp Brain Res 131:477-90. 2000
    ..We interpret these results as suggesting that instruction-dependent modulation of the M2 response occurs downstream from inputs to the primary motor cortex...
  13. ncbi Mitochondrial membrane potential in aging cells
    M M Sugrue
    Department of Pediatrics, Mount Sinai School of Medicine of NYU, New York, N Y 10029, USA
    Biol Signals Recept 10:176-88. 2001
    ..Finally, we speculate on the mechanisms and functional significance of decreased DeltaPsi(M) in aging...
  14. ncbi (-)-Deprenyl alters the survival of adult murine facial motoneurons after axotomy: increases in vulnerable C57BL strain but decreases in motor neuron degeneration mutants
    C Oh
    Department of Physiology, University of Toronto, Ontario, Canada
    J Neurosci Res 38:64-74. 1994
    ..01 mg/kg) but would decrease as the dosage exceeded that necessary to produce toxic concentrations of the metabolites of (-)-deprenyl (1.0 mg/kg in this study)...