Genomes and Genes
An Qiang Sun
Affiliation: Mount Sinai School of Medicine
- A 14-amino acid sequence with a beta-turn structure is required for apical membrane sorting of the rat ileal bile acid transporterAn Qiang Sun
Department of Pediatrics and Structural Biology Program, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
J Biol Chem 278:4000-9. 2003....
- Association of the 16-kDa subunit c of vacuolar proton pump with the ileal Na+-dependent bile acid transporter: protein-protein interaction and intracellular traffickingAn Qiang Sun
Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 279:16295-300. 2004..Thus, these results suggest that the apical membrane localization of Asbt is mediated in part by the vacuolar proton pump associated apical sorting machinery...
- Identification of functionally relevant residues of the rat ileal apical sodium-dependent bile acid cotransporterAn Qiang Sun
Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
J Biol Chem 281:16410-8. 2006..Cys-270 is not essential for the transport process. These studies provide new details about the amino acid residues of Asbt involved in binding and transport of bile acids and Na(+)...
- Protein-protein interactions and membrane localization of the human organic solute transporterAn Qiang Sun
Dept of Pediatrics, Box 1664, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029 6574, USA
Am J Physiol Gastrointest Liver Physiol 292:G1586-93. 2007..The extracellular amino-terminal fragment of hOST-alpha may contain important information for the assembly of the heterodimer and trafficking to the plasma membrane...
- Membrane trafficking of the human organic anion-transporting polypeptide C (hOATPC)An Qiang Sun
Department of Pediatrics, Mount Sinai School of Medicine, PO Box 1664, One Gustave L Levy Place, New York, NY 10029 6574, USA
Pharm Res 25:463-74. 2008....
- Inflammatory-mediated repression of the rat ileal sodium-dependent bile acid transporter by c-fos nuclear translocationFrank Chen
Division of Pediatric Gastroenterology, Nutrition and Liver Diseases, Department of Pediatrics and the Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029, USA
Gastroenterology 123:2005-16. 2002..Ileal malabsorption of bile salts is observed in Crohn's ileitis. We define the transcriptional mechanisms involved in cytokine-mediated repression of the rat apical sodium-dependent bile acid transporter (ASBT)...
- Identification of functionally relevant lysine residues that modulate human farnesoid X receptor activationAn Qiang Sun
Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Mol Pharmacol 83:1078-86. 2013..In conclusion, four highly conserved lysine residues of hFXR, K122, K210, K339, and K460, have been identified that play a critical role in FXR target gene regulation and molecular interaction (protein-protein and protein-DNA)...
- The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptorTamara Frankenberg
Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
Hepatology 48:1896-905. 2008..Benign recurrent intrahepatic cholestasis emanates from a partially functional FIC1 protein. Phosphorylation of FXR is an important mechanism for regulating its activity...
- Membrane topology structure of human high-affinity, sodium-dependent dicarboxylate transporterXue Yuan Bai
Department of Biochemistry and Molecular Biology, Chinese PLA Institute of Nephrology, Chinese PLA General Hospital and Military Medical Postgraduate College, 28 Fuxing Rd, Beijing 100853, China
FASEB J 21:2409-17. 2007..Our results support the topography of 11 transmembrane domains with an extracellular C terminus and an intracellular N terminus of NaDC3, and for the first time provide experimental evidence for a novel topological model for NaDC3...
- Functional role of the C terminus of human organic anion transporter hOAT1Wen Xu
Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
J Biol Chem 281:31178-83. 2006..Together, our results are the first to highlight the central role of the C terminus of hOAT1 in the function of this transporter...
- Transporter-mediated bile acid uptake causes Ca2+-dependent cell death in rat pancreatic acinar cellsJoo Young Kim
Department of Pharmacology and Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea
Gastroenterology 122:1941-53. 2002....