An Qiang Sun

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi A 14-amino acid sequence with a beta-turn structure is required for apical membrane sorting of the rat ileal bile acid transporter
    An Qiang Sun
    Department of Pediatrics and Structural Biology Program, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Biol Chem 278:4000-9. 2003
  2. ncbi Association of the 16-kDa subunit c of vacuolar proton pump with the ileal Na+-dependent bile acid transporter: protein-protein interaction and intracellular trafficking
    An Qiang Sun
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 279:16295-300. 2004
  3. ncbi Identification of functionally relevant residues of the rat ileal apical sodium-dependent bile acid cotransporter
    An Qiang Sun
    Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Biol Chem 281:16410-8. 2006
  4. ncbi Protein-protein interactions and membrane localization of the human organic solute transporter
    An Qiang Sun
    Dept of Pediatrics, Box 1664, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029 6574, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1586-93. 2007
  5. ncbi Membrane trafficking of the human organic anion-transporting polypeptide C (hOATPC)
    An Qiang Sun
    Department of Pediatrics, Mount Sinai School of Medicine, PO Box 1664, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Pharm Res 25:463-74. 2008
  6. ncbi Inflammatory-mediated repression of the rat ileal sodium-dependent bile acid transporter by c-fos nuclear translocation
    Frank Chen
    Division of Pediatric Gastroenterology, Nutrition and Liver Diseases, Department of Pediatrics and the Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 123:2005-16. 2002
  7. doi Identification of functionally relevant lysine residues that modulate human farnesoid X receptor activation
    An Qiang Sun
    Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Mol Pharmacol 83:1078-86. 2013
  8. pmc The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor
    Tamara Frankenberg
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    Hepatology 48:1896-905. 2008
  9. ncbi Membrane topology structure of human high-affinity, sodium-dependent dicarboxylate transporter
    Xue Yuan Bai
    Department of Biochemistry and Molecular Biology, Chinese PLA Institute of Nephrology, Chinese PLA General Hospital and Military Medical Postgraduate College, 28 Fuxing Rd, Beijing 100853, China
    FASEB J 21:2409-17. 2007
  10. ncbi Functional role of the C terminus of human organic anion transporter hOAT1
    Wen Xu
    Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Biol Chem 281:31178-83. 2006

Collaborators

Detail Information

Publications11

  1. ncbi A 14-amino acid sequence with a beta-turn structure is required for apical membrane sorting of the rat ileal bile acid transporter
    An Qiang Sun
    Department of Pediatrics and Structural Biology Program, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Biol Chem 278:4000-9. 2003
    ....
  2. ncbi Association of the 16-kDa subunit c of vacuolar proton pump with the ileal Na+-dependent bile acid transporter: protein-protein interaction and intracellular trafficking
    An Qiang Sun
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 279:16295-300. 2004
    ..Thus, these results suggest that the apical membrane localization of Asbt is mediated in part by the vacuolar proton pump associated apical sorting machinery...
  3. ncbi Identification of functionally relevant residues of the rat ileal apical sodium-dependent bile acid cotransporter
    An Qiang Sun
    Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Biol Chem 281:16410-8. 2006
    ..Cys-270 is not essential for the transport process. These studies provide new details about the amino acid residues of Asbt involved in binding and transport of bile acids and Na(+)...
  4. ncbi Protein-protein interactions and membrane localization of the human organic solute transporter
    An Qiang Sun
    Dept of Pediatrics, Box 1664, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029 6574, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1586-93. 2007
    ..The extracellular amino-terminal fragment of hOST-alpha may contain important information for the assembly of the heterodimer and trafficking to the plasma membrane...
  5. ncbi Membrane trafficking of the human organic anion-transporting polypeptide C (hOATPC)
    An Qiang Sun
    Department of Pediatrics, Mount Sinai School of Medicine, PO Box 1664, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Pharm Res 25:463-74. 2008
    ....
  6. ncbi Inflammatory-mediated repression of the rat ileal sodium-dependent bile acid transporter by c-fos nuclear translocation
    Frank Chen
    Division of Pediatric Gastroenterology, Nutrition and Liver Diseases, Department of Pediatrics and the Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 123:2005-16. 2002
    ..Ileal malabsorption of bile salts is observed in Crohn's ileitis. We define the transcriptional mechanisms involved in cytokine-mediated repression of the rat apical sodium-dependent bile acid transporter (ASBT)...
  7. doi Identification of functionally relevant lysine residues that modulate human farnesoid X receptor activation
    An Qiang Sun
    Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Mol Pharmacol 83:1078-86. 2013
    ..In conclusion, four highly conserved lysine residues of hFXR, K122, K210, K339, and K460, have been identified that play a critical role in FXR target gene regulation and molecular interaction (protein-protein and protein-DNA)...
  8. pmc The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor
    Tamara Frankenberg
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    Hepatology 48:1896-905. 2008
    ..Benign recurrent intrahepatic cholestasis emanates from a partially functional FIC1 protein. Phosphorylation of FXR is an important mechanism for regulating its activity...
  9. ncbi Membrane topology structure of human high-affinity, sodium-dependent dicarboxylate transporter
    Xue Yuan Bai
    Department of Biochemistry and Molecular Biology, Chinese PLA Institute of Nephrology, Chinese PLA General Hospital and Military Medical Postgraduate College, 28 Fuxing Rd, Beijing 100853, China
    FASEB J 21:2409-17. 2007
    ..Our results support the topography of 11 transmembrane domains with an extracellular C terminus and an intracellular N terminus of NaDC3, and for the first time provide experimental evidence for a novel topological model for NaDC3...
  10. ncbi Functional role of the C terminus of human organic anion transporter hOAT1
    Wen Xu
    Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Biol Chem 281:31178-83. 2006
    ..Together, our results are the first to highlight the central role of the C terminus of hOAT1 in the function of this transporter...
  11. ncbi Transporter-mediated bile acid uptake causes Ca2+-dependent cell death in rat pancreatic acinar cells
    Joo Young Kim
    Department of Pharmacology and Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea
    Gastroenterology 122:1941-53. 2002
    ....