Mihaela Stefan

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Novel variant of thyroglobulin promoter triggers thyroid autoimmunity through an epigenetic interferon alpha-modulated mechanism
    Mihaela Stefan
    Division of Endocrinology, Department of Medicine, Mount Sinai Medical Center, New York, New York 10029, USA
    J Biol Chem 286:31168-79. 2011
  2. pmc Genetic analysis of interferon induced thyroiditis (IIT): evidence for a key role for MHC and apoptosis related genes and pathways
    Alia Hasham
    Division of Endocrinology, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    J Autoimmun 44:61-70. 2013
  3. pmc Fine mapping of loci linked to autoimmune thyroid disease identifies novel susceptibility genes
    Yaron Tomer
    Department of Medicine, Division of Endocrinology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 98:E144-52. 2013
  4. pmc DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology
    Mihaela Stefan
    Division of Endocrinology, Mount Sinai School of Medicine, New York, NY 10029, USA James J Peters Veterans Administration Medical Center, Bronx, NY 10468, USA
    J Autoimmun 50:33-7. 2014
  5. pmc IFN-α mediates the development of autoimmunity both by direct tissue toxicity and through immune cell recruitment mechanisms
    Nagako Akeno
    Division of Endocrinology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 186:4693-706. 2011
  6. pmc Tg.2098 is a major human thyroglobulin T-cell epitope
    Francesca Menconi
    Department of Medicine, Division of Endocrinology, Mount Sinai School of Medicine, New York, NY, USA
    J Autoimmun 35:45-51. 2010

Collaborators

Detail Information

Publications6

  1. pmc Novel variant of thyroglobulin promoter triggers thyroid autoimmunity through an epigenetic interferon alpha-modulated mechanism
    Mihaela Stefan
    Division of Endocrinology, Department of Medicine, Mount Sinai Medical Center, New York, New York 10029, USA
    J Biol Chem 286:31168-79. 2011
    ..These results reveal a new mechanism of interaction between environmental (IFNα) and genetic (TG) factors to trigger AITD...
  2. pmc Genetic analysis of interferon induced thyroiditis (IIT): evidence for a key role for MHC and apoptosis related genes and pathways
    Alia Hasham
    Division of Endocrinology, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    J Autoimmun 44:61-70. 2013
    ..1), HLA (6p21.3), and TAP1 (6p21.3) that may be involved in the pathogenesis of IIT. Immune-regulation and apoptosis emerged as the predominant mechanisms underlying the etiology of IIT. ..
  3. pmc Fine mapping of loci linked to autoimmune thyroid disease identifies novel susceptibility genes
    Yaron Tomer
    Department of Medicine, Division of Endocrinology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 98:E144-52. 2013
    ..We have previously identified three loci on chromosomes 10q, 12q, and 14q that showed strong linkage with AITD, HT, and GD, respectively...
  4. pmc DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology
    Mihaela Stefan
    Division of Endocrinology, Mount Sinai School of Medicine, New York, NY 10029, USA James J Peters Veterans Administration Medical Center, Bronx, NY 10468, USA
    J Autoimmun 50:33-7. 2014
    ..Our findings suggest that abnormalities of DNA methylation patterns, known to regulate gene transcription, may be involved in the pathogenesis of T1D. ..
  5. pmc IFN-α mediates the development of autoimmunity both by direct tissue toxicity and through immune cell recruitment mechanisms
    Nagako Akeno
    Division of Endocrinology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 186:4693-706. 2011
    ..Taken together, our data demonstrate that the induction of tissue inflammation and autoimmunity by IFN-α involves direct tissue toxic effects as well as provocation of destructive bystander immune responses...
  6. pmc Tg.2098 is a major human thyroglobulin T-cell epitope
    Francesca Menconi
    Department of Medicine, Division of Endocrinology, Mount Sinai School of Medicine, New York, NY, USA
    J Autoimmun 35:45-51. 2010
    ..Taken together these findings suggest that Tg.2098, a strong and specific binder to the disease-associated HLA-DRbeta-Arg74, is a major human T-cell epitope and participant in the pathoetiology of AITD...