Sergei Sokol

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling
    Keiji Itoh
    Department of Microbiology and Molecular Genetics, Harvard Medical School, and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Biol 4:3. 2005
  2. pmc Wnt signaling through T-cell factor phosphorylation
    Sergei Y Sokol
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Res 21:1002-12. 2011
  3. pmc Maintaining embryonic stem cell pluripotency with Wnt signaling
    Sergei Y Sokol
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 138:4341-50. 2011
  4. ncbi request reprint WNTers in La Jolla
    Sergei Y Sokol
    Department of Molecular, Cell and Developmental Biology, Box 1020, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Development 134:3393-9. 2007
  5. ncbi request reprint Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development
    Olga Ossipova
    Department of Cancer Biology, Dana Farber Cancer Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Cell 8:829-41. 2005
  6. ncbi request reprint Regulation of Lethal giant larvae by Dishevelled
    Gretchen L Dollar
    Department of Molecular, Cell and Developmental Biology, Box 1020, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    Nature 437:1376-80. 2005
  7. pmc Strabismus regulates asymmetric cell divisions and cell fate determination in the mouse brain
    Blue B Lake
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Biol 185:59-66. 2009
  8. pmc PAR-1 phosphorylates Mind bomb to promote vertebrate neurogenesis
    Olga Ossipova
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dev Cell 17:222-33. 2009
  9. pmc The involvement of lethal giant larvae and Wnt signaling in bottle cell formation in Xenopus embryos
    Sun Cheol Choi
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dev Biol 336:68-75. 2009
  10. pmc Both the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesis
    Ian V Chia
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Genetics 181:1359-68. 2009

Research Grants

  1. Developmebnt of the vertebrate nervous system
    Sergei Y Sokol; Fiscal Year: 2010
  2. WNT SIGNAL TRANSDUCTION DURING SPECIFICATION IN XENOPUS
    Sergei Sokol; Fiscal Year: 2003
  3. Wnt signal transduction during Xenopus development
    Sergei Sokol; Fiscal Year: 2005
  4. Metastasis-associated kinase in Wnt signaling
    Sergei Sokol; Fiscal Year: 2007
  5. Development of the vertebrate nervous system
    Sergei Sokol; Fiscal Year: 2007
  6. Wnt signal transduction during Xenopus development
    Sergei Sokol; Fiscal Year: 2009
  7. Metastasis-associated kinase in Wnt signaling
    Sergei Y Sokol; Fiscal Year: 2010
  8. Wnt Signaling in Xenopus Embryonic Development
    Sergei Y Sokol; Fiscal Year: 2010
  9. PATTERNING OF THE DEVELOPING NERVOUS SYSTEM
    Sergei Sokol; Fiscal Year: 2004
  10. FRIZZLED RECEPTOR SIGNALING AND APOPTOSIS
    Sergei Sokol; Fiscal Year: 2004

Collaborators

  • Sangeeta Dhawan
  • Olga Ossipova
  • Marek Mlodzik
  • Keiji Itoh
  • Ian V Chia
  • Blue B Lake
  • Sun Cheol Choi
  • Jae Il Park
  • Hiroki Hikasa
  • Nina L Hunter
  • Gretchen L Dollar
  • Min Jung Kim
  • Frank Costantini
  • Lei Li
  • Sohee Jun
  • Pierre D McCrea
  • Susan M Dymecki
  • Hong Ji
  • Dongmin Gu
  • Ursula Weber
  • Barbara K Brott
  • Marianne J Ratcliffe
  • Gyu Un Bae

Detail Information

Publications12

  1. pmc Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling
    Keiji Itoh
    Department of Microbiology and Molecular Genetics, Harvard Medical School, and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Biol 4:3. 2005
    ..Although Dsh has been detected in a number of cellular compartments, the importance of its subcellular distribution for signaling remains to be determined...
  2. pmc Wnt signaling through T-cell factor phosphorylation
    Sergei Y Sokol
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Res 21:1002-12. 2011
    ..This review focuses on recent progress in the understanding of context-dependent post-translational regulation of TCF function by Wnt signaling...
  3. pmc Maintaining embryonic stem cell pluripotency with Wnt signaling
    Sergei Y Sokol
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 138:4341-50. 2011
    ..Although the results of recent studies of the Wnt/β-catenin pathway in ES cells appear to be surprising and controversial, they converge on the same conserved mechanism that leads to the inactivation of TCF3-mediated repression...
  4. ncbi request reprint WNTers in La Jolla
    Sergei Y Sokol
    Department of Molecular, Cell and Developmental Biology, Box 1020, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Development 134:3393-9. 2007
    ..Themes that dominated the meeting included the need for precise control over each step of the signal transduction mechanism and developing therapeutics for diseases caused by altered Wnt-signaling...
  5. ncbi request reprint Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development
    Olga Ossipova
    Department of Cancer Biology, Dana Farber Cancer Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Cell 8:829-41. 2005
    ..We conclude that PAR-1BY is required in the PCP branch and mediates Dsh membrane localization while PAR-1A and PAR-1BX are essential for canonical signaling to beta-catenin, possibly via targets other than Dishevelled...
  6. ncbi request reprint Regulation of Lethal giant larvae by Dishevelled
    Gretchen L Dollar
    Department of Molecular, Cell and Developmental Biology, Box 1020, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    Nature 437:1376-80. 2005
    ..These findings suggest a molecular basis for the regulation of cell polarity by Frizzled and Dishevelled...
  7. pmc Strabismus regulates asymmetric cell divisions and cell fate determination in the mouse brain
    Blue B Lake
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Biol 185:59-66. 2009
    ..These findings suggest that Stbm/Vangl2 functions to maintain cortical progenitors and regulates mitotic spindle orientation during asymmetric divisions in the vertebrate brain...
  8. pmc PAR-1 phosphorylates Mind bomb to promote vertebrate neurogenesis
    Olga Ossipova
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dev Cell 17:222-33. 2009
    ..These observations suggest a conserved mechanism for neuronal fate determination that might operate during asymmetric divisions of polarized neural progenitor cells...
  9. pmc The involvement of lethal giant larvae and Wnt signaling in bottle cell formation in Xenopus embryos
    Sun Cheol Choi
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dev Biol 336:68-75. 2009
    ..These results suggest a molecular link between Wnt5a and Lgl that is essential for apical constriction during vertebrate gastrulation...
  10. pmc Both the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesis
    Ian V Chia
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Genetics 181:1359-68. 2009
    ..Furthermore, many Axin(DeltaC6/DeltaC6) embryos that were heterozygous for a beta-catenin null mutation survived to term, demonstrating that early lethality was due to failure to negatively regulate beta-catenin...
  11. ncbi request reprint Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals
    Jae Il Park
    Department of Biochemistry and Molecular Biology and Program in Genes and Development, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Dev Cell 11:683-95. 2006
    ....
  12. ncbi request reprint Vertebrate homologues of Frodo are dynamically expressed during embryonic development in tissues undergoing extensive morphogenetic movements
    Nina L Hunter
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Dev Dyn 235:279-84. 2006
    ..Highly conserved dynamic expression patterns of Frodo homologues indicate a similar function for these proteins in different vertebrates...

Research Grants38

  1. Developmebnt of the vertebrate nervous system
    Sergei Y Sokol; Fiscal Year: 2010
    ..abstract_text> ..
  2. WNT SIGNAL TRANSDUCTION DURING SPECIFICATION IN XENOPUS
    Sergei Sokol; Fiscal Year: 2003
    ..Thus, studying the mechanisms of Wnt signal transduction, we hope to get insight into basic questions of axis specification and into molecular mechanisms of cancer. ..
  3. Wnt signal transduction during Xenopus development
    Sergei Sokol; Fiscal Year: 2005
    ..Since the Wnt pathways are inappropriately regulated in many cancers, the outcome of proposed experiments should provide insight into the key mechanisms of cell regulation as well as molecular origins of human cancer. ..
  4. Metastasis-associated kinase in Wnt signaling
    Sergei Sokol; Fiscal Year: 2007
    ..The knowledge of the molecular pathways that involve MAK should allow the design of small molecules, which can modulate its enzymatic activity, and may lead to the development of new anti-cancer therapies. ..
  5. Development of the vertebrate nervous system
    Sergei Sokol; Fiscal Year: 2007
    ..As the same signaling mechanisms operate multiple times during early embryonic development in all vertebrate embryos, the regulation of these processes should prove useful in the prevention and correction of human birth defects. ..
  6. Wnt signal transduction during Xenopus development
    Sergei Sokol; Fiscal Year: 2009
    ..Since the Wnt pathways are inappropriately regulated in many cancers, the outcome of proposed experiments should provide insight into the key mechanisms of cell regulation as well as molecular origins of human cancer. ..
  7. Metastasis-associated kinase in Wnt signaling
    Sergei Y Sokol; Fiscal Year: 2010
    ..The knowledge of the molecular pathways that involve MAK should allow the design of small molecules, which can modulate its enzymatic activity, and may lead to the development of new anti-cancer therapies. ..
  8. Wnt Signaling in Xenopus Embryonic Development
    Sergei Y Sokol; Fiscal Year: 2010
    ..Since Wnt pathways are activated in many human cancers, including colon carcinomas, melanomas and skin tumors, the proposed experiments are directly relevant to human disease. ..
  9. PATTERNING OF THE DEVELOPING NERVOUS SYSTEM
    Sergei Sokol; Fiscal Year: 2004
    ..A role of pre-existing polarity within ectoderm in anteroposterior neural patterning will be also evaluated. These experiments will shed more light on our knowledge of anteroposterior patterning of the vertebrate central nervous system. ..
  10. FRIZZLED RECEPTOR SIGNALING AND APOPTOSIS
    Sergei Sokol; Fiscal Year: 2004
    ..Proposed studies will identify the components involved in this novel pathway and should decipher new ways of controlling cell number in development and in disease. ..