Eric A Sobie

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. doi request reprint Regression methods for parameter sensitivity analysis: applications to cardiac arrhythmia mechanisms
    Eric A Sobie
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:4657-60. 2011
  2. pmc Comprehensive analyses of ventricular myocyte models identify targets exhibiting favorable rate dependence
    Megan A Cummins
    Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
    PLoS Comput Biol 10:e1003543. 2014
  3. pmc Dynamic local changes in sarcoplasmic reticulum calcium: physiological and pathophysiological roles
    Eric A Sobie
    Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
    J Mol Cell Cardiol 52:304-11. 2012
  4. pmc Excitation-contraction coupling gain in ventricular myocytes: insights from a parsimonious model
    Eric A Sobie
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
    J Physiol 587:1293-9. 2009
  5. pmc Systems biology--biomedical modeling
    Eric A Sobie
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci Signal 4:tr2. 2011
  6. pmc Novel approach to real-time flash photolysis and confocal [Ca2+] imaging
    Eric A Sobie
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1215, New York, NY 10029, USA
    Pflugers Arch 454:663-73. 2007
  7. ncbi request reprint An introduction to dynamical systems
    Eric A Sobie
    Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci Signal 4:tr6. 2011
  8. ncbi request reprint An introduction to MATLAB
    Eric A Sobie
    Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci Signal 4:tr7. 2011
  9. pmc Parameter sensitivity analysis in electrophysiological models using multivariable regression
    Eric A Sobie
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biophys J 96:1264-74. 2009
  10. ncbi request reprint Bistability in biochemical signaling models
    Eric A Sobie
    Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci Signal 4:tr10. 2011

Collaborators

Detail Information

Publications45

  1. doi request reprint Regression methods for parameter sensitivity analysis: applications to cardiac arrhythmia mechanisms
    Eric A Sobie
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:4657-60. 2011
    ..We describe new approaches that can begin to address these limitations, and show how these can provide novel insight into mathematical models of cardiac myocytes...
  2. pmc Comprehensive analyses of ventricular myocyte models identify targets exhibiting favorable rate dependence
    Megan A Cummins
    Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
    PLoS Comput Biol 10:e1003543. 2014
    ..Overall, this study provides new insights, both specific and general, into the determinants of AP duration rate dependence, and illustrates a strategy for the design of potentially beneficial antiarrhythmic drugs. ..
  3. pmc Dynamic local changes in sarcoplasmic reticulum calcium: physiological and pathophysiological roles
    Eric A Sobie
    Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
    J Mol Cell Cardiol 52:304-11. 2012
    ..We conclude with a discussion of experimental and computational advances that will help to resolve controversies. This article is part of a special issue entitled "Local Signaling in Myocytes."..
  4. pmc Excitation-contraction coupling gain in ventricular myocytes: insights from a parsimonious model
    Eric A Sobie
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
    J Physiol 587:1293-9. 2009
    ..This procedure helps to reconcile contradictory results obtained in recent studies; moreover, this new model should be a useful tool for understanding changes in gain that occur physiologically and in disease...
  5. pmc Systems biology--biomedical modeling
    Eric A Sobie
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci Signal 4:tr2. 2011
    ..We anticipate that such approaches will apply throughout the biomedical sciences and that courses such as the one described here will become a core requirement of many graduate programs in the biological and biomedical sciences...
  6. pmc Novel approach to real-time flash photolysis and confocal [Ca2+] imaging
    Eric A Sobie
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1215, New York, NY 10029, USA
    Pflugers Arch 454:663-73. 2007
    ..This relatively simple and inexpensive system is, therefore, a useful tool for examining local signaling in the heart and other tissues...
  7. ncbi request reprint An introduction to dynamical systems
    Eric A Sobie
    Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci Signal 4:tr6. 2011
    ..A problem set is included that (i) requires students to implement an ODE model of biochemical reactions using MATLAB and (ii) allows them to explore dynamical systems concepts...
  8. ncbi request reprint An introduction to MATLAB
    Eric A Sobie
    Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci Signal 4:tr7. 2011
    ..The principles are illustrated through the analysis of experimental data, specifically measurements of intracellular calcium concentration in live cells obtained using confocal microscopy...
  9. pmc Parameter sensitivity analysis in electrophysiological models using multivariable regression
    Eric A Sobie
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biophys J 96:1264-74. 2009
    ..The general strategy may also suggest methods for integrating traditional quantitative models with large-scale data sets obtained using high-throughput technologies...
  10. ncbi request reprint Bistability in biochemical signaling models
    Eric A Sobie
    Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci Signal 4:tr10. 2011
    ..Using these programs as a template, the assignment requires the students to implement a model from the literature and analyze the stability of this model's steady states...
  11. ncbi request reprint Computational modeling of the cell cycle
    Eric A Sobie
    Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci Signal 4:tr11. 2011
    ..The lecture concludes with a demonstration of how this model can be implemented in the scientific programming language MATLAB and includes a problem set...
  12. pmc Predicting local SR Ca(2+) dynamics during Ca(2+) wave propagation in ventricular myocytes
    Hena R Ramay
    Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA
    Biophys J 98:2515-23. 2010
    ..These simulations help to delineate what changes in [Ca(2+)] are possible during SR Ca(2+)release, and they broaden our understanding of the regulatory role played by dynamic changes in [Ca(2+)](SR)...
  13. ncbi request reprint Teaching resources. Using web-based discussion forums as a model of the peer-review process and a tool for assessment
    Sherry L Jenkins
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci Signal 1:tr2. 2008
    ....
  14. pmc Mathematical model of the neonatal mouse ventricular action potential
    Linda J Wang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA
    Am J Physiol Heart Circ Physiol 294:H2565-75. 2008
    ..This new model can therefore be used for testing hypotheses and obtaining a better quantitative understanding of differences between neonatal and adult physiology...
  15. pmc Regression analysis for constraining free parameters in electrophysiological models of cardiac cells
    Amrita X Sarkar
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA
    PLoS Comput Biol 6:e1000914. 2010
    ..More generally, this method shows promise as a tool to define model parameters, in electrophysiology and in other biological fields...
  16. pmc Decoding myocardial Ca²⁺ signals across multiple spatial scales: a role for sensitivity analysis
    Young Seon Lee
    Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
    J Mol Cell Cardiol 58:92-9. 2013
    ..We conclude with a discussion of unresolved questions that are likely to be addressed over the next several years...
  17. pmc Parameter sensitivity analysis of stochastic models provides insights into cardiac calcium sparks
    Young Seon Lee
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA
    Biophys J 104:1142-50. 2013
    ..This approach is therefore an effective, efficient, and predictive method for analyzing stochastic mathematical models to gain biological insight...
  18. pmc Unique properties of the ATP-sensitive K⁺ channel in the mouse ventricular cardiac conduction system
    Li Bao
    Department of Pediatrics, NYU School of Medicine, New York, NY 10016, USA
    Circ Arrhythm Electrophysiol 4:926-35. 2011
    ..Conclusions- These data imply a differential electrophysiological response (and possible contribution to arrhythmias) of the ventricular CCS to K(ATP) channel opening during periods of ischemia...
  19. pmc Restitution of Ca(2+) release and vulnerability to arrhythmias
    Eric A Sobie
    Division of Pediatric Cardiology, New York University School of Medicine, New York, New York, USA
    J Cardiovasc Electrophysiol 17:S64-S70. 2006
    ..In particular, we discuss factors that may contribute to unstable Ca(2+) release and speculate about how instability in CICR may contribute to the development of arrhythmias under pathological conditions...
  20. pmc Recovery of cardiac calcium release is controlled by sarcoplasmic reticulum refilling and ryanodine receptor sensitivity
    Hena R Ramay
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1215, New York, NY 10029, USA
    Cardiovasc Res 91:598-605. 2011
    ..We investigated local recovery of SR Ca(2+) release using experimental measurements and mathematical modelling...
  21. pmc Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-κB pathway
    Thomas J Larocca
    Cardiovascular Research Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Physiol Heart Circ Physiol 303:H353-67. 2012
    ..In addition, our studies reveal a novel role of CXCR4 in the diabetic heart by regulating NCX1 expression via a NF-κB-dependent mechanism...
  22. pmc Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis
    Amrita X Sarkar
    Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Heart Rhythm 8:1749-55. 2011
    ..However, the mechanisms underlying this interindividual variability are not understood quantitatively...
  23. pmc Physiologic gating properties of unitary cardiac L-type Ca2+ channels
    Ira R Josephson
    Department of Physiology and Pharmacology, CUNY Medical School, City College of New York, New York, NY 10031, USA
    Biochem Biophys Res Commun 396:763-6. 2010
    ..Moreover, they provide insight into local Ca(2+)-induced Ca(2+) release and a more accurate basis for mathematical modeling of excitation-contraction coupling in cardiac myocytes...
  24. ncbi request reprint Identification and purification of human induced pluripotent stem cell-derived atrial-like cardiomyocytes based on sarcolipin expression
    Rebecca Josowitz
    The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
    PLoS ONE 9:e101316. 2014
    ..These purified cells may find many applications, including in the study of atrial-specific pathologies and chamber-specific lineage development. ..
  25. ncbi request reprint Expression of a sorcin missense mutation in the heart modulates excitation-contraction coupling
    Leon P Collis
    Division of Pediatric Cardiology, New York University School of Medicine, New York, NY 10016, USA
    FASEB J 21:475-87. 2007
    ..Our results also suggest that additional factors may be responsible for the development of cardiac hypertrophy and hypertension in humans expressing the L112-sorcin sequence variant...
  26. pmc Complex and rate-dependent beat-to-beat variations in Ca2+ transients of canine Purkinje cells
    Young Seon Lee
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
    J Mol Cell Cardiol 50:662-9. 2011
    ..These results offer new insight into how Ca(2+) release is normally regulated in Purkinje cells and provide clues regarding how disruptions in this regulation may lead to deleterious consequences such as arrhythmias...
  27. pmc beta-Adrenergic receptor activation induces internalization of cardiac Cav1.2 channel complexes through a beta-arrestin 1-mediated pathway
    Rachele Lipsky
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 283:17221-6. 2008
    ....
  28. pmc Alterations in T-tubule and dyad structure in heart disease: challenges and opportunities for computational analyses
    Eva Polakova
    Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1215, New York, NY 10029, USA
    Cardiovasc Res 98:233-9. 2013
    ....
  29. pmc Inquiry learning. Integrating content detail and critical reasoning by peer review
    Ravi Iyengar
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 319:1189-90. 2008
  30. pmc Multifaceted roles of miR-1s in repressing the fetal gene program in the heart
    Yusheng Wei
    1 Mindich Child Health and Development Institute, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1040, New York, NY 10029, USA 2 Current address College of Life Sciences, Peking University, Beijing 100871, China
    Cell Res 24:278-92. 2014
    ..We conclude that miR-1 and its primary target Errβ act together to regulate the transition from prenatal to neonatal stages by repressing the cardiac fetal gene program. Loss of this regulation leads to a neonatal DCM. ..
  31. pmc Exploiting mathematical models to illuminate electrophysiological variability between individuals
    Amrita X Sarkar
    Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Physiol 590:2555-67. 2012
    ..These strategies may be applicable not just in cardiac electrophysiology, but in a wide range of disciplines...
  32. pmc Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes
    Perundurai S Dhandapany
    Departments of Pediatrics and Genetics and Genomic Sciences and the Child Health and Development Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Mol Cell Cardiol 51:4-15. 2011
    ..This article is part of a Special Issue entitled 'Possible Editorial'...
  33. ncbi request reprint Local Ca(2+) signaling and EC coupling in heart: Ca(2+) sparks and the regulation of the [Ca(2+)](i) transient
    Silvia Guatimosim
    Medical Biotechnology Center and Institute of Molecular Cardiology, University of Maryland Biotechnology Institute, 725 W Lombard Street, Baltimore, MD 21201, USA
    J Mol Cell Cardiol 34:941-50. 2002
    ..Finally integrative calcium signaling in heart is presented in the context of normal heart function and heart failure...
  34. pmc Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calcium-induced calcium release
    Eric A Sobie
    Medical Biotechnology Center, University of Maryland Biotechnology Center, Baltimore, Maryland 21201, USA
    Biophys J 83:59-78. 2002
    ..This new model of Ca(2+) spark behavior provides a "proof of principle" test of a new hypothesis for Ca(2+) spark termination and reproduces critical features of Ca(2+) sparks observed experimentally...
  35. pmc A probability density approach to modeling local control of calcium-induced calcium release in cardiac myocytes
    George S B Williams
    Department of Applied Science, College of William and Mary, Williamsburg, Virginia 23187, USA
    Biophys J 92:2311-28. 2007
    ....
  36. pmc Local recovery of Ca2+ release in rat ventricular myocytes
    Eric A Sobie
    Medical Biotechnology Center, 725 W Lombard Street, Baltimore, MD 21201, USA
    J Physiol 565:441-7. 2005
    ....
  37. ncbi request reprint Twenty years of calcium imaging: cell physiology to dye for
    Harm J Knot
    Department of Pharmacology and Therapeutics and Division of Cardiology College of Medicine, University of Florida, Gainesville, FL, USA
    Mol Interv 5:112-27. 2005
    ....
  38. pmc Calcium biology of the transverse tubules in heart
    Long Sheng Song
    Medical Biotechnology Center and the Institute of Molecular Cardiology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA
    Ann N Y Acad Sci 1047:99-111. 2005
    ..Three issues are examined in this presentation: (1) normal Ca(2+)-induced Ca(2+) release and Ca(2+) sparks, (2) abnormal SR Ca(2+) release in disease, and (3) the triggering and propagation of waves of elevated [Ca(2+)](i)...
  39. pmc The Ca 2+ leak paradox and rogue ryanodine receptors: SR Ca 2+ efflux theory and practice
    Eric A Sobie
    Medical Biotechnology Center, University of Maryland Biotechnology Institute, 725 W Lombard Street, Baltimore, MD 21201, USA
    Prog Biophys Mol Biol 90:172-85. 2006
    ..Taken together, these two features may provide a framework that allows for an improved understanding of cardiac Ca(2+) signaling...
  40. pmc Photochemical gating of intracellular Ca2+ release channels
    Jiahong Ni
    Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA
    J Am Chem Soc 129:5316-7. 2007
  41. pmc Allosteric activation of Na+-Ca2+ exchange by L-type Ca2+ current augments the trigger flux for SR Ca2+ release in ventricular myocytes
    Eric A Sobie
    Biophys J 94:L54-6. 2008
    ..These results help to resolve seemingly contradictory results obtained previously and have implications for our understanding of the triggering of Ca(2+) release in heart cells under various conditions...
  42. pmc Moment closure for local control models of calcium-induced calcium release in cardiac myocytes
    George S B Williams
    Department of Applied Science, College of William and Mary, Williamsburg, Virginia, USA
    Biophys J 95:1689-703. 2008
    ..We conclude by applying the moment-closure approach to study the restitution of Ca2+-induced Ca2+ release during simulated two-pulse voltage-clamp protocols...
  43. pmc New insights into the structure and function of couplons
    John H B Bridge
    Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA
    J Physiol 586:3735. 2008
  44. pmc Orphaned ryanodine receptors in the failing heart
    Long Sheng Song
    Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 103:4305-10. 2006
    ..We conclude that the increased spatial dispersion of the TTs and orphaned RyRs lead to the loss of local control and Ca(2+) instability in heart failure...
  45. ncbi request reprint Ca2+ sparks in heart muscle
    Jonathan W Lederer
    Institute of Molecular Cardiology, Medical Biotechnology Center University of Maryland Biotechnology Institute, Baltimore 21201, USA
    J Muscle Res Cell Motil 25:602-3. 2004