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Genomes and Genes | Eric A SobieSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
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Publications
Regression methods for parameter sensitivity analysis: applications to cardiac arrhythmia mechanismsEric A Sobie
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
Conf Proc IEEE Eng Med Biol Soc 2011:4657-60. 2011..We describe new approaches that can begin to address these limitations, and show how these can provide novel insight into mathematical models of cardiac myocytes...
Dynamic local changes in sarcoplasmic reticulum calcium: physiological and pathophysiological rolesEric A Sobie
Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
J Mol Cell Cardiol 52:304-11. 2012..We conclude with a discussion of experimental and computational advances that will help to resolve controversies. This article is part of a special issue entitled "Local Signaling in Myocytes."..- Excitation-contraction coupling gain in ventricular myocytes: insights from a parsimonious modelEric A Sobie
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
J Physiol 587:1293-9. 2009..This procedure helps to reconcile contradictory results obtained in recent studies; moreover, this new model should be a useful tool for understanding changes in gain that occur physiologically and in disease... - Parameter sensitivity analysis in electrophysiological models using multivariable regressionEric A Sobie
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
Biophys J 96:1264-74. 2009..The general strategy may also suggest methods for integrating traditional quantitative models with large-scale data sets obtained using high-throughput technologies... - Novel approach to real-time flash photolysis and confocal [Ca2+] imagingEric A Sobie
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1215, New York, NY 10029, USA
Pflugers Arch 454:663-73. 2007..This relatively simple and inexpensive system is, therefore, a useful tool for examining local signaling in the heart and other tissues... - Systems biology--biomedical modelingEric A Sobie
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
Sci Signal 4:tr2. 2011..We anticipate that such approaches will apply throughout the biomedical sciences and that courses such as the one described here will become a core requirement of many graduate programs in the biological and biomedical sciences... - An introduction to dynamical systemsEric A Sobie
Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA
Sci Signal 4:tr6. 2011..A problem set is included that (i) requires students to implement an ODE model of biochemical reactions using MATLAB and (ii) allows them to explore dynamical systems concepts... - An introduction to MATLABEric A Sobie
Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA
Sci Signal 4:tr7. 2011..The principles are illustrated through the analysis of experimental data, specifically measurements of intracellular calcium concentration in live cells obtained using confocal microscopy... - Bistability in biochemical signaling modelsEric A Sobie
Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA
Sci Signal 4:tr10. 2011..Using these programs as a template, the assignment requires the students to implement a model from the literature and analyze the stability of this model's steady states... - Computational modeling of the cell cycleEric A Sobie
Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA
Sci Signal 4:tr11. 2011..The lecture concludes with a demonstration of how this model can be implemented in the scientific programming language MATLAB and includes a problem set... - Predicting local SR Ca(2+) dynamics during Ca(2+) wave propagation in ventricular myocytesHena R Ramay
Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA
Biophys J 98:2515-23. 2010..These simulations help to delineate what changes in [Ca(2+)] are possible during SR Ca(2+)release, and they broaden our understanding of the regulatory role played by dynamic changes in [Ca(2+)](SR)... 
Teaching resources. Using web-based discussion forums as a model of the peer-review process and a tool for assessmentSherry L Jenkins
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
Sci Signal 1:tr2. 2008....- Mathematical model of the neonatal mouse ventricular action potentialLinda J Wang
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA
Am J Physiol Heart Circ Physiol 294:H2565-75. 2008..This new model can therefore be used for testing hypotheses and obtaining a better quantitative understanding of differences between neonatal and adult physiology... - Regression analysis for constraining free parameters in electrophysiological models of cardiac cellsAmrita X Sarkar
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA
PLoS Comput Biol 6:e1000914. 2010..More generally, this method shows promise as a tool to define model parameters, in electrophysiology and in other biological fields... - Unique properties of the ATP-sensitive K⁺ channel in the mouse ventricular cardiac conduction systemLi Bao
Department of Pediatrics, NYU School of Medicine, New York, NY 10016, USA
Circ Arrhythm Electrophysiol 4:926-35. 2011..Conclusions- These data imply a differential electrophysiological response (and possible contribution to arrhythmias) of the ventricular CCS to K(ATP) channel opening during periods of ischemia... - Restitution of Ca(2+) release and vulnerability to arrhythmiasEric A Sobie
Division of Pediatric Cardiology, New York University School of Medicine, New York, New York, USA
J Cardiovasc Electrophysiol 17:S64-S70. 2006..In particular, we discuss factors that may contribute to unstable Ca(2+) release and speculate about how instability in CICR may contribute to the development of arrhythmias under pathological conditions... - Recovery of cardiac calcium release is controlled by sarcoplasmic reticulum refilling and ryanodine receptor sensitivityHena R Ramay
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1215, New York, NY 10029, USA
Cardiovasc Res 91:598-605. 2011..We investigated local recovery of SR Ca(2+) release using experimental measurements and mathematical modelling... - Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-κB pathwayThomas J Larocca
Cardiovascular Research Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
Am J Physiol Heart Circ Physiol 303:H353-67. 2012..In addition, our studies reveal a novel role of CXCR4 in the diabetic heart by regulating NCX1 expression via a NF-κB-dependent mechanism... - Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysisAmrita X Sarkar
Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
Heart Rhythm 8:1749-55. 2011..However, the mechanisms underlying this interindividual variability are not understood quantitatively... - Physiologic gating properties of unitary cardiac L-type Ca2+ channelsIra R Josephson
Department of Physiology and Pharmacology, CUNY Medical School, City College of New York, New York, NY 10031, USA
Biochem Biophys Res Commun 396:763-6. 2010..Moreover, they provide insight into local Ca(2+)-induced Ca(2+) release and a more accurate basis for mathematical modeling of excitation-contraction coupling in cardiac myocytes... - Complex and rate-dependent beat-to-beat variations in Ca2+ transients of canine Purkinje cellsYoung Seon Lee
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
J Mol Cell Cardiol 50:662-9. 2011..These results offer new insight into how Ca(2+) release is normally regulated in Purkinje cells and provide clues regarding how disruptions in this regulation may lead to deleterious consequences such as arrhythmias... - Expression of a sorcin missense mutation in the heart modulates excitation-contraction couplingLeon P Collis
Division of Pediatric Cardiology, New York University School of Medicine, New York, NY 10016, USA
FASEB J 21:475-87. 2007..Our results also suggest that additional factors may be responsible for the development of cardiac hypertrophy and hypertension in humans expressing the L112-sorcin sequence variant... - beta-Adrenergic receptor activation induces internalization of cardiac Cav1.2 channel complexes through a beta-arrestin 1-mediated pathwayRachele Lipsky
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 283:17221-6. 2008.... - Parameter sensitivity analysis of stochastic models provides insights into cardiac calcium sparksYoung Seon Lee
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA
Biophys J 104:1142-50. 2013..This approach is therefore an effective, efficient, and predictive method for analyzing stochastic mathematical models to gain biological insight... - Inquiry learning. Integrating content detail and critical reasoning by peer reviewRavi Iyengar
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
Science 319:1189-90. 2008 - Exploiting mathematical models to illuminate electrophysiological variability between individualsAmrita X Sarkar
Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
J Physiol 590:2555-67. 2012..These strategies may be applicable not just in cardiac electrophysiology, but in a wide range of disciplines... - Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromesPerundurai S Dhandapany
Departments of Pediatrics and Genetics and Genomic Sciences and the Child Health and Development Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
J Mol Cell Cardiol 51:4-15. 2011..This article is part of a Special Issue entitled 'Possible Editorial'... - Local Ca(2+) signaling and EC coupling in heart: Ca(2+) sparks and the regulation of the [Ca(2+)](i) transientSilvia Guatimosim
Medical Biotechnology Center and Institute of Molecular Cardiology, University of Maryland Biotechnology Institute, 725 W. Lombard Street, Baltimore, MD 21201, USA
J Mol Cell Cardiol 34:941-50. 2002..Finally integrative calcium signaling in heart is presented in the context of normal heart function and heart failure... - Local recovery of Ca2+ release in rat ventricular myocytesEric A Sobie
Medical Biotechnology Center, 725 W. Lombard Street, Baltimore, MD 21201, USA
J Physiol 565:441-7. 2005.... - Twenty years of calcium imaging: cell physiology to dye forHarm J Knot
Department of Pharmacology and Therapeutics and Division of Cardiology College of Medicine, University of Florida, Gainesville, FL, USA
Mol Interv 5:112-27. 2005.... - Calcium biology of the transverse tubules in heartLong-Sheng Song
Medical Biotechnology Center and the Institute of Molecular Cardiology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA
Ann N Y Acad Sci 1047:99-111. 2005..Three issues are examined in this presentation: (1) normal Ca(2+)-induced Ca(2+) release and Ca(2+) sparks, (2) abnormal SR Ca(2+) release in disease, and (3) the triggering and propagation of waves of elevated [Ca(2+)](i)... - The Ca 2+ leak paradox and rogue ryanodine receptors: SR Ca 2+ efflux theory and practiceEric A Sobie
Medical Biotechnology Center, University of Maryland Biotechnology Institute, 725 W. Lombard Street, Baltimore, MD 21201, USA
Prog Biophys Mol Biol 90:172-85. 2006..Taken together, these two features may provide a framework that allows for an improved understanding of cardiac Ca(2+) signaling... - Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calcium-induced calcium releaseEric A Sobie
Medical Biotechnology Center, University of Maryland Biotechnology Center, Baltimore, Maryland 21201, USA
Biophys J 83:59-78. 2002..This new model of Ca(2+) spark behavior provides a "proof of principle" test of a new hypothesis for Ca(2+) spark termination and reproduces critical features of Ca(2+) sparks observed experimentally... - A probability density approach to modeling local control of calcium-induced calcium release in cardiac myocytesGeorge S B Williams
Department of Applied Science, College of William and Mary, Williamsburg, Virginia 23187, USA
Biophys J 92:2311-28. 2007.... - Photochemical gating of intracellular Ca2+ release channelsJiahong Ni
Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA
J Am Chem Soc 129:5316-7. 2007 - Allosteric activation of Na+-Ca2+ exchange by L-type Ca2+ current augments the trigger flux for SR Ca2+ release in ventricular myocytesEric A Sobie
Biophys J 94:L54-6. 2008..These results help to resolve seemingly contradictory results obtained previously and have implications for our understanding of the triggering of Ca(2+) release in heart cells under various conditions... - Moment closure for local control models of calcium-induced calcium release in cardiac myocytesGeorge S B Williams
Department of Applied Science, College of William and Mary, Williamsburg, Virginia, USA
Biophys J 95:1689-703. 2008..We conclude by applying the moment-closure approach to study the restitution of Ca2+-induced Ca2+ release during simulated two-pulse voltage-clamp protocols... - New insights into the structure and function of couplonsJohn H B Bridge
Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA
J Physiol 586:3735. 2008 - Ca2+ sparks in heart muscleJonathan W Lederer
Institute of Molecular Cardiology, Medical Biotechnology Center University of Maryland Biotechnology Institute, Baltimore 21201, USA
J Muscle Res Cell Motil 25:602-3. 2004 - Orphaned ryanodine receptors in the failing heartLong Sheng Song
Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
Proc Natl Acad Sci U S A 103:4305-10. 2006..We conclude that the increased spatial dispersion of the TTs and orphaned RyRs lead to the loss of local control and Ca(2+) instability in heart failure...