Silvia Smaldone

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Ha-Ras stabilization mediates pro-fibrotic signals in dermal fibroblasts
    Silvia Smaldone
    Mount Sinai School of Medicine, Department of Pharmacology and Systems Therapeutics, One Gustave L Levy Place, Box 1603, New York, NY 10029, USA
    Fibrogenesis Tissue Repair 4:8. 2011
  2. pmc Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation
    Harikiran Nistala
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10021, USA
    J Cell Biol 190:1107-21. 2010
  3. pmc Generation of Fbn1 conditional null mice implicates the extracellular microfibrils in osteoprogenitor recruitment
    Jason R Cook
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Genesis 50:635-41. 2012
  4. pmc Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production
    Harikiran Nistala
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10021, USA
    J Biol Chem 285:34126-33. 2010
  5. pmc Establishment of fibrillin-deficient osteoprogenitor cell lines identifies molecular abnormalities associated with extracellular matrix perturbation of osteogenic differentiation
    Silvia Smaldone
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Cell Tissue Res 344:511-7. 2011
  6. pmc Differential effects of alendronate and losartan therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome
    Harikiran Nistala
    Department of Pharmacology and Systems Therapeutics at the Mount Sinai School of Medicine, New York, NY 10029, USA
    Hum Mol Genet 19:4790-8. 2010
  7. pmc Fibrillin assemblies: extracellular determinants of tissue formation and fibrosis
    Jacopo Olivieri
    Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, USA
    Fibrogenesis Tissue Repair 3:24. 2010

Collaborators

Detail Information

Publications7

  1. pmc Ha-Ras stabilization mediates pro-fibrotic signals in dermal fibroblasts
    Silvia Smaldone
    Mount Sinai School of Medicine, Department of Pharmacology and Systems Therapeutics, One Gustave L Levy Place, Box 1603, New York, NY 10029, USA
    Fibrogenesis Tissue Repair 4:8. 2011
    ..abstract:..
  2. pmc Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation
    Harikiran Nistala
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10021, USA
    J Cell Biol 190:1107-21. 2010
    ..Together, these findings identify the extracellular microfibrils as critical regulators of bone formation through the modulation of endogenous TGF-β and BMP signaling...
  3. pmc Generation of Fbn1 conditional null mice implicates the extracellular microfibrils in osteoprogenitor recruitment
    Jason R Cook
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Genesis 50:635-41. 2012
    ..Fbn1(Lox/+) mice are, therefore, an informative genetic resource to further dissect MFS pathogenesis and the role of extracellular fibrillin-1 assemblies in organ development and homeostasis...
  4. pmc Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production
    Harikiran Nistala
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10021, USA
    J Biol Chem 285:34126-33. 2010
    ....
  5. pmc Establishment of fibrillin-deficient osteoprogenitor cell lines identifies molecular abnormalities associated with extracellular matrix perturbation of osteogenic differentiation
    Silvia Smaldone
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Cell Tissue Res 344:511-7. 2011
    ..Collectively, the data reiterated the notion that fibrillin-1 and fibrillin-2 exert opposite effects on osteoblast differentiation through the discrete modulation of a broad network of interacting signaling molecules...
  6. pmc Differential effects of alendronate and losartan therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome
    Harikiran Nistala
    Department of Pharmacology and Systems Therapeutics at the Mount Sinai School of Medicine, New York, NY 10029, USA
    Hum Mol Genet 19:4790-8. 2010
    ..Taken together, our findings shed new light on the pathogenesis of osteopenia in MFS, in addition to arguing for a multifaceted treatment strategy in this congenital disorder of the connective tissue...
  7. pmc Fibrillin assemblies: extracellular determinants of tissue formation and fibrosis
    Jacopo Olivieri
    Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, USA
    Fibrogenesis Tissue Repair 3:24. 2010
    ....