D M Simpson

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint Severity of HIV-associated neuropathy is associated with plasma HIV-1 RNA levels
    David M Simpson
    Department of Neurology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Box 1052, New York, NY 10029, USA
    AIDS 16:407-12. 2002
  2. pmc NGX-4010, a capsaicin 8% patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: integrated analysis of two phase III, randomized, controlled trials
    Stephen Brown
    AIDS Research Alliance, Los Angeles, CA, USA
    AIDS Res Ther 10:5. 2013
  3. pmc Virologic outcomes of HAART with concurrent use of cytochrome P450 enzyme-inducing antiepileptics: a retrospective case control study
    Jason F Okulicz
    Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    AIDS Res Ther 8:18. 2011
  4. ncbi request reprint Neuromuscular complications in HIV
    Susama Verma
    Mount Sinai Medical Center, One Gustave L Levy Place, New York, NY 10029, USA
    Curr Neurol Neurosci Rep 4:62-7. 2004
  5. ncbi request reprint Selected peripheral neuropathies associated with human immunodeficiency virus infection and antiretroviral therapy
    David M Simpson
    Department of Neurology and Clinical Neurophysiology, Neuro AIDS Research Program, The Mount Sinai Medical Center, New York, New York 10029, USA
    J Neurovirol 8:33-41. 2002
  6. ncbi request reprint HIV neuropathy natural history cohort study: assessment measures and risk factors
    D M Simpson
    Mount Sinai Hospital, New York, NY, USA
    Neurology 66:1679-87. 2006
  7. ncbi request reprint An open-label pilot study of high-concentration capsaicin patch in painful HIV neuropathy
    David M Simpson
    Mount Sinai School of Medicine, New York, NY 10029, USA
    J Pain Symptom Manage 35:299-306. 2008
  8. ncbi request reprint Fentanyl buccal tablet for the relief of breakthrough pain in opioid-tolerant adult patients with chronic neuropathic pain: a multicenter, randomized, double-blind, placebo-controlled study
    David M Simpson
    Mount Sinai School of Medicine, New York, New York 10029, USA
    Clin Ther 29:588-601. 2007
  9. ncbi request reprint A placebo-controlled trial of lamotrigine for painful HIV-associated neuropathy
    D M Simpson
    Mount Sinai Medical Center, New York, NY 10029, USA
    Neurology 54:2115-9. 2000
  10. doi request reprint Controlled trial of high-concentration capsaicin patch for treatment of painful HIV neuropathy
    David M Simpson
    Clinical Neurophysiology Laboratories and Neuro AIDS Program, The Mount Sinai Medical Center, New York, NY 10029, USA
    Neurology 70:2305-13. 2008

Research Grants

Detail Information

Publications50

  1. ncbi request reprint Severity of HIV-associated neuropathy is associated with plasma HIV-1 RNA levels
    David M Simpson
    Department of Neurology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Box 1052, New York, NY 10029, USA
    AIDS 16:407-12. 2002
    ..To determine if there is an association between plasma HIV-1 RNA levels and severity of HIV-associated distal symmetrical polyneuropathy (DSP)...
  2. pmc NGX-4010, a capsaicin 8% patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: integrated analysis of two phase III, randomized, controlled trials
    Stephen Brown
    AIDS Research Alliance, Los Angeles, CA, USA
    AIDS Res Ther 10:5. 2013
    ..Data from two phase III, double-blind studies were integrated to further analyze the efficacy and safety of NGX-4010 and explore the effect of demographic and baseline factors on NGX-4010 treatment in HIV-DSP...
  3. pmc Virologic outcomes of HAART with concurrent use of cytochrome P450 enzyme-inducing antiepileptics: a retrospective case control study
    Jason F Okulicz
    Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    AIDS Res Ther 8:18. 2011
    ..abstract:..
  4. ncbi request reprint Neuromuscular complications in HIV
    Susama Verma
    Mount Sinai Medical Center, One Gustave L Levy Place, New York, NY 10029, USA
    Curr Neurol Neurosci Rep 4:62-7. 2004
    ..Electromyography and muscle biopsy are helpful tests for diagnosis. Treatment of HIV myopathy includes corticosteroids, nonsteroidal anti-inflammatory agents, and intravenous immunoglobulin...
  5. ncbi request reprint Selected peripheral neuropathies associated with human immunodeficiency virus infection and antiretroviral therapy
    David M Simpson
    Department of Neurology and Clinical Neurophysiology, Neuro AIDS Research Program, The Mount Sinai Medical Center, New York, New York 10029, USA
    J Neurovirol 8:33-41. 2002
    ..The clinical, electrophysiologic, and pathologic features of these disorders will be described along with a discussion of theories of pathogenesis and results of treatment to date...
  6. ncbi request reprint HIV neuropathy natural history cohort study: assessment measures and risk factors
    D M Simpson
    Mount Sinai Hospital, New York, NY, USA
    Neurology 66:1679-87. 2006
    ..Distal sensory polyneuropathy (DSP) is the most common neurologic complication of human immunodeficiency virus (HIV) infection. Risk factors for DSP have not been adequately defined in the era of highly active antiretroviral therapy...
  7. ncbi request reprint An open-label pilot study of high-concentration capsaicin patch in painful HIV neuropathy
    David M Simpson
    Mount Sinai School of Medicine, New York, NY 10029, USA
    J Pain Symptom Manage 35:299-306. 2008
    ..No safety concerns were identified. Controlled studies of NGX-4010 for the treatment of painful HIV-associated neuropathy are warranted...
  8. ncbi request reprint Fentanyl buccal tablet for the relief of breakthrough pain in opioid-tolerant adult patients with chronic neuropathic pain: a multicenter, randomized, double-blind, placebo-controlled study
    David M Simpson
    Mount Sinai School of Medicine, New York, New York 10029, USA
    Clin Ther 29:588-601. 2007
    ..The fentanyl buccal tablet (FBT) provides a rapid onset of analgesia (10-15 minutes) by enhancing fentanyl absorption across the buccal mucosa...
  9. ncbi request reprint A placebo-controlled trial of lamotrigine for painful HIV-associated neuropathy
    D M Simpson
    Mount Sinai Medical Center, New York, NY 10029, USA
    Neurology 54:2115-9. 2000
    ..To investigate the analgesic efficacy of lamotrigine in the treatment of painful HIV-associated distal sensory polyneuropathy (DSP)...
  10. doi request reprint Controlled trial of high-concentration capsaicin patch for treatment of painful HIV neuropathy
    David M Simpson
    Clinical Neurophysiology Laboratories and Neuro AIDS Program, The Mount Sinai Medical Center, New York, NY 10029, USA
    Neurology 70:2305-13. 2008
    ..Capsaicin desensitizes cutaneous nociceptors resulting in reduced pain. We report a placebo-controlled study of a high-concentration capsaicin dermal patch (NGX-4010) for the treatment of painful HIV-DSP...
  11. doi request reprint HIV-associated PML: changing epidemiology and clinical approach
    David M Simpson
    Neuro AIDS Research Program, Clinical Neurophysiology Laboratories, Mount Sinai Medical Center, New York, NY, USA
    Cleve Clin J Med 78:S24-7. 2011
    ..The standard of care for HIV-associated PML is HAART to achieve immunologic recovery and optimal HIV virologic control. The prognosis of PML has improved greatly since the advent of HAART...
  12. doi request reprint Long-term safety of NGX-4010, a high-concentration capsaicin patch, in patients with peripheral neuropathic pain
    David M Simpson
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Pain Symptom Manage 39:1053-64. 2010
    ..Current treatment options are often limited by poor tolerability...
  13. pmc Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trial
    D M Simpson
    Mount Sinai School of Medicine, New York, NY, USA
    Neurology 74:413-20. 2010
    ..Pregabalin is effective in several neuropathic pain syndromes. This trial evaluated its efficacy, safety, and tolerability for treatment of painful HIV-associated neuropathy...
  14. doi request reprint Botulinum neurotoxin versus tizanidine in upper limb spasticity: a placebo-controlled study
    D M Simpson
    Clinical Neurophysiology Laboratories and Neuro AIDS Program, The Mount Sinai Medical Center, New York, NY 10029, USA
    J Neurol Neurosurg Psychiatry 80:380-5. 2009
    ..While spasticity is commonly treated with oral agents or botulinum neurotoxin (BoNT) injection, these treatments have not been systematically compared...
  15. ncbi request reprint A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection. AIDS Clinical Trials Group Team 291
    J C McArthur
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Neurology 54:1080-8. 2000
    ..To evaluate the safety and efficacy of recombinant human nerve growth factor (rhNGF) in HIV-associated sensory neuropathy (SN) within a multicenter, placebo-controlled, randomized trial (ACTG 291)...
  16. ncbi request reprint Lamotrigine for HIV-associated painful sensory neuropathies: a placebo-controlled trial
    D M Simpson
    Mount Sinai School of Medicine Dr Simpson, New York, NY
    Neurology 60:1508-14. 2003
    ..To evaluate the efficacy and tolerability of lamotrigine (LTG) for the treatment of pain in HIV-associated sensory neuropathies...
  17. ncbi request reprint Correlates of epidermal nerve fiber densities in HIV-associated distal sensory polyneuropathy
    L Zhou
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287 7609, USA
    Neurology 68:2113-9. 2007
    ..To demonstrate the relationship between epidermal nerve fiber density (ENFD) in the leg and the phenotype of HIV-associated distal sensory polyneuropathy (HIV-DSP) in a multicenter prospective study (ACTG A5117)...
  18. ncbi request reprint Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy
    G Schifitto
    Department of Neurology, University of Rochester, NY 14642, USA
    Neurology 57:1313-6. 2001
    ..However, there was no improvement of neuropathy severity as assessed by neurologic examination, quantitative sensory testing, and epidermal nerve fiber density...
  19. pmc Association of self-reported painful symptoms with clinical and neurophysiologic signs in HIV-associated sensory neuropathy
    J Robinson-Papp
    Department of Neurology, Mount Sinai, School of Medicine, New York, NY 10029, USA
    Pain 151:732-6. 2010
    ..This finding holds true regardless of demographic factors, depression or substance use history...
  20. doi request reprint Assessment: Botulinum neurotoxin for the treatment of movement disorders (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
    D M Simpson
    Department of Neurology, Mount Sinai Medical Center, New York, NY, USA
    Neurology 70:1699-706. 2008
    ..To perform an evidence-based review of the safety and efficacy of botulinum neurotoxin (BoNT) in the treatment of movement disorders...
  21. ncbi request reprint Myopathies associated with human immunodeficiency virus and zidovudine: can their effects be distinguished?
    D M Simpson
    Department of Neurology, Mount Sinai Medical Center, New York, NY
    Neurology 43:971-6. 1993
    ..Twelve of 13 patients improved with prednisone. Although it is difficult to distinguish the myopathies of HIV and ZDV by clinical or pathologic criteria, in the majority of our patients, myopathy is due to HIV rather than ZDV...
  22. ncbi request reprint HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy
    D B Clifford
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Neurology 52:623-5. 1999
    ..This is an improvement in prognosis compared with recent historic experience and correlated with HIV RNA viral load reductions. We conclude that current HIV therapy is important in improving the outlook of PML in the setting of HIV...
  23. doi request reprint Assessment: Botulinum neurotoxin for the treatment of spasticity (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
    D M Simpson
    Department of Neurology, Mount Sinai Medical Center, New York, NY, USA
    Neurology 70:1691-8. 2008
    ..To perform an evidence-based review of the safety and efficacy of botulinum neurotoxin (BoNT) in the treatment of adult and childhood spasticity...
  24. ncbi request reprint Peptide T in the treatment of painful distal neuropathy associated with AIDS: results of a placebo-controlled trial. The Peptide T Neuropathy Study Group
    D M Simpson
    Department of Neurology, Mount Sinai Medical Center, New York, NY 10029, USA
    Neurology 47:1254-9. 1996
    ..To assess the safety and efficacy of Peptide T in the treatment of painful distal symmetrical polyneuropathy (DSP) associated with human immunodeficiency virus (HIV) infection...
  25. ncbi request reprint Effects of hepatic function and hepatitis C virus on the nervous system assessment of advanced-stage HIV-infected individuals
    Susan Morgello
    Department of Pathology, Mount Sinai Medical Center, New York, NY 10029, USA
    AIDS 19:S116-22. 2005
    ..To examine the effects of liver function and hepatitis C virus (HCV) serostatus on neurological, neuropsychological, and psychiatric abnormalities in an advanced-stage HIV-infected cohort...
  26. ncbi request reprint HIV-associated distal sensory polyneuropathy in the era of highly active antiretroviral therapy: the Manhattan HIV Brain Bank
    Susan Morgello
    Department of Pathology, The Mount Sinai Medical Center, New York, NY 10029, USA
    Arch Neurol 61:546-51. 2004
    ....
  27. ncbi request reprint The role of somatosensory evoked potentials in the diagnosis of AIDS-associated myelopathy
    M Tagliati
    Department of Neurology, Clinical Neurophysiology, The Mount Sinai Medical Center, New York, NY 10003, USA
    Neurology 54:1477-82. 2000
    ..Somatosensory evoked potentials (SEPs) have been successfully used to evaluate central conduction in a number of diseases involving the spinal cord...
  28. ncbi request reprint AIDS and AIDS-treatment neuropathies
    D Williams
    Neuro-AIDS Research Program, Mount Sinai School of Medicine, 1 Gustave Levy Place, Box 1052, New York, NY 10029, USA
    Curr Neurol Neurosci Rep 1:533-8. 2001
    ..Treatment of AIDS neuropathies is directed toward relief of symptoms, however, new evidence suggests that aggressive antiretroviral therapy may also be effective...
  29. ncbi request reprint Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy
    M Polydefkis
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Neurology 58:115-9. 2002
    ..To explore the relationship between intraepidermal nerve fiber (IENF) density in HIV-associated sensory neuropathy (HIV-SN) to measurements of neuropathy severity and progression of HIV disease...
  30. ncbi request reprint Hereditary neuropathy and vocal cord paralysis in a man with childhood diphtheria
    B D Reichler
    Department of Neurology, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1052, New York, New York 10029, USA
    Muscle Nerve 23:132-7. 2000
    ....
  31. ncbi request reprint Thalidomide for the treatment of esophageal aphthous ulcers in patients with human immunodeficiency virus infection. National Institute of Allergy and Infectious Disease AIDS Clinical Trials Group
    J M Jacobson
    Mount Sinai Medical Center, New York, NY 10029, USA
    J Infect Dis 180:61-7. 1999
    ..Thalidomide is effective in healing aphthous ulceration of the esophagus in patients infected with HIV...
  32. ncbi request reprint Human immunodeficiency virus-associated dementia: review of pathogenesis, prophylaxis, and treatment studies of zidovudine therapy
    D M Simpson
    Department of Neurology, Mount Sinai Medical Center, New York, New York 10029, USA
    Clin Infect Dis 29:19-34. 1999
    ..Zidovudine has been associated with improved neuropsychological functioning in children with progressive encephalopathy, but optimum dosing levels, duration of effect, and prophylactic potential remain to be demonstrated...
  33. ncbi request reprint Controlling neuropathic pain in HIV
    Susama Verma
    Department of Neurology, Mount Sinai Medical Center, One Gustave L Levy Place, New York, NY 10029, USA
    Curr HIV/AIDS Rep 1:136-41. 2004
    ..We review treatment options for painful HIV neuropathy, including experimental agents studied in recent and ongoing clinical trials...
  34. ncbi request reprint Neurological manifestations of HIV-1 infection in the HAART era
    A P Geraci
    Neuro-AIDS Research Program, Departments of Neurology and Clinical Neurophysiology, Mount Sinai Medical Center, New York, NY 10029, USA
    Compr Ther 27:232-41. 2001
    ..Improved prophylaxis and antiretroviral therapies have modified the approach to neurologic disease in the setting of AIDS...
  35. ncbi request reprint Randomized controlled trial of IVIg in untreated chronic inflammatory demyelinating polyradiculoneuropathy
    J R Mendell
    Department of Neurology, Ohio State University, Columbus 43210, USA
    Neurology 56:445-9. 2001
    ..This study provides data supporting IVIg as the initial treatment for CIDP...
  36. ncbi request reprint JC virus granule cell neuronopathy: A novel clinical syndrome distinct from progressive multifocal leukoencephalopathy
    Igor J Koralnik
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Ann Neurol 57:576-80. 2005
    ..We propose to call this novel syndrome JCV granule cell neuronopathy (JCV GCN)...
  37. ncbi request reprint HIV-associated neuropathic pain: epidemiology, pathophysiology and management
    Susama Verma
    Department of Neurology, Neuro AIDS Research Program, The Mount Sinai Medical Center, New York, New York 10029, USA
    CNS Drugs 19:325-34. 2005
    ..We review the clinical manifestations, epidemiology, pathophysiology and management strategies for HIV-associated DSP...
  38. pmc Differential effects of HIV infected macrophages on dorsal root ganglia neurons and axons
    Katrin Hahn
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Exp Neurol 210:30-40. 2008
    ..These observations suggest a differential effect on the axon and cell body. Different mechanisms of injury may be operative in these two structures...
  39. ncbi request reprint A randomized controlled trial of 5% lidocaine gel for HIV-associated distal symmetric polyneuropathy
    Lydia Estanislao
    Department of Neurology and Clinical Neurophysiology, Mount Sinai Medical Center, New York, NY 10029, USA
    J Acquir Immune Defic Syndr 37:1584-6. 2004
    ..To investigate the analgesic efficacy and safety of 5% lidocaine gel in painful HIV-associated distal sensory polyneuropathy (DSP)...
  40. ncbi request reprint Antiretroviral rounds. First holiday was a disaster: should she take another?
    Lydia Estanislao
    Mount Sinai Medical Center, New York City, USA
    AIDS Clin Care 16:40-1. 2004
  41. pmc Motor function and human immunodeficiency virus-associated cognitive impairment in a highly active antiretroviral therapy-era cohort
    Jessica Robinson-Papp
    Departments of Pathology, Mount Sinai Medical Center, Box 1052, One Gustave L Levy Place, New York, NY 10029, USA
    Arch Neurol 65:1096-101. 2008
    ..Cognitive impairment has long been recognized as a manifestation of human immunodeficiency virus (HIV) infection. However, highly active antiretroviral therapy (HAART) has altered the neurologic manifestations of HIV...
  42. ncbi request reprint Safety profile of treatment in diabetic peripheral neuropathic pain
    Jessica Robinson-Papp
    Mount Sinai School of Medicine, New York, New York, USA
    Pain Med 8:S43-9. 2007
    ..In this article we review the safety profile of agents commonly used in the treatment of DPNP...
  43. ncbi request reprint A placebo-controlled study of memantine for the treatment of human immunodeficiency virus-associated sensory neuropathy
    Giovanni Schifitto
    University of Rochester, Rochester, New York 14620, USA
    J Neurovirol 12:328-31. 2006
    ..Results were similar to those of other pilot studies of memantine for neuropathic pain unrelated to HIV, suggesting that memantine is ineffective for the symptomatic treatment of HIV-associated SDSP...
  44. doi request reprint Neuromuscular complications of human immunodeficiency virus infection
    Jessica Robinson-Papp
    Department of Neurology, Mount Sinai Medical Center, Box 1052, New York, NY 10029, USA
    Phys Med Rehabil Clin N Am 19:81-96, vi-vii. 2008
    ....
  45. doi request reprint Diagnosis and management of HIV-associated neuropathy
    Alejandra Gonzalez-Duarte
    The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1187, New York, NY 10029 6574, USA
    Neurol Clin 26:821-32, x. 2008
    ..This article highlights the risk factors, pathogenesis, pathology, clinical features, diagnostic studies, differential diagnosis, and treatment of HIV-associated neuropathy...
  46. ncbi request reprint Anatomical localization of motor endplate bands in the human biceps brachii
    Asif Amirali
    Department of Otolaryngology, Mount Sinai School of Medicine, New York, New York, USA
    J Clin Neuromuscul Dis 9:306-12. 2007
    ..This study localized the motor endplate bands (MEB) within human biceps brachii (BB) muscles in relation to external landmarks...
  47. ncbi request reprint Managing HIV peripheral neuropathy
    Alejandra Gonzalez-Duarte
    Department of Clinical Neurophysiology, Mount Sinai School of Medicine, Annenberg 2nd Floor, Box 1052, New York, NY 10029, USA
    Curr HIV/AIDS Rep 4:114-8. 2007
    ..Sustained virologic control may improve DSP. Novel therapies such as -acetyl-l-carnitine or neurotrophic factors are being studied for treatment of DSP...
  48. ncbi request reprint Heart-rate and blood-pressure variability during psychophysiological tasks involving speech: influence of respiration
    Alessandro Beda
    Biomedical Engineering Programme COPPE, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Psychophysiology 44:767-78. 2007
    ..Furthermore, a number of subjects with long respiratory period at rest were identified, whose presence in the sample can bias the estimation of baseline rest values...
  49. ncbi request reprint Peripheral neuropathies associated with HIV and hepatitis C co-infection: a review
    Lydia B Estanislao
    Department of Neurology NeuroAIDS Research Program, Mount Sinai Medical Center, New York, NY 10029, USA
    AIDS 19:S135-9. 2005
    ..It is not known whether there are additive or synergistic effects on the peripheral nerve by these two viruses. There is a need for studies to further elucidate the mechanisms involved...
  50. ncbi request reprint Regional patterns of brain metabolites in AIDS dementia complex
    Constantin T Yiannoutsos
    Division of Biostatistics, Indiana University School of Medicine, 1050 Wishard Boulevard, RG 4101, Indianapolis, IN 46202, USA
    Neuroimage 23:928-35. 2004
    ..We conclude that by using factor analysis, we are able to combine multiple metabolites across brain regions in a biologically plausible manner and construct a predictive model of ADC adjusting for relevant factors such as age...

Research Grants1

  1. MIDCAREER INVESTIGATOR AWARD IN NEURO-AIDS RESEARCH
    David Simpson; Fiscal Year: 2005
    ..The Neuro-Adherence Program will assess the affect of neurological disease on patients' adherence to medical regimens, and the impact of education and support groups on adherence. ..