Research Topics
| D M SimpsonSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
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Detail Information
Publications
Severity of HIV-associated neuropathy is associated with plasma HIV-1 RNA levelsDavid M Simpson
Department of Neurology, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1052, New York, NY 10029, USA
AIDS 16:407-12. 2002..Further studies are needed to determine if aggressive use of antiretroviral drugs, including the use of dideoxynucleosides, may be of benefit to prevent or improve peripheral neuropathy...
Virologic outcomes of HAART with concurrent use of cytochrome P450 enzyme-inducing antiepileptics: a retrospective case control studyJason F Okulicz
Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
AIDS Res Ther 8:18. 2011..abstract:..- Selected peripheral neuropathies associated with human immunodeficiency virus infection and antiretroviral therapyDavid M Simpson
Department of Neurology and Clinical Neurophysiology, Neuro AIDS Research Program, The Mount Sinai Medical Center, New York, New York 10029, USA
J Neurovirol 8:33-41. 2002..The clinical, electrophysiologic, and pathologic features of these disorders will be described along with a discussion of theories of pathogenesis and results of treatment to date... - Neuromuscular complications in HIVSusama Verma
Mount Sinai Medical Center, One Gustave L Levy Place, New York, NY 10029, USA
Curr Neurol Neurosci Rep 4:62-7. 2004..Electromyography and muscle biopsy are helpful tests for diagnosis. Treatment of HIV myopathy includes corticosteroids, nonsteroidal anti-inflammatory agents, and intravenous immunoglobulin... - A placebo-controlled trial of lamotrigine for painful HIV-associated neuropathyD M Simpson
Mount Sinai Medical Center, New York, NY 10029, USA
Neurology 54:2115-9. 2000..To investigate the analgesic efficacy of lamotrigine in the treatment of painful HIV-associated distal sensory polyneuropathy (DSP)... - Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trialD M Simpson
Mount Sinai School of Medicine, New York, NY, USA
Neurology 74:413-20. 2010..Pregabalin is effective in several neuropathic pain syndromes. This trial evaluated its efficacy, safety, and tolerability for treatment of painful HIV-associated neuropathy... 
Botulinum neurotoxin versus tizanidine in upper limb spasticity: a placebo-controlled studyD M Simpson
Clinical Neurophysiology Laboratories and Neuro AIDS Program, The Mount Sinai Medical Center, New York, NY 10029, USA
J Neurol Neurosurg Psychiatry 80:380-5. 2009..While spasticity is commonly treated with oral agents or botulinum neurotoxin (BoNT) injection, these treatments have not been systematically compared...- Controlled trial of high-concentration capsaicin patch for treatment of painful HIV neuropathyDavid M Simpson
Clinical Neurophysiology Laboratories and Neuro AIDS Program, The Mount Sinai Medical Center, New York, NY 10029, USA
Neurology 70:2305-13. 2008..Capsaicin desensitizes cutaneous nociceptors resulting in reduced pain. We report a placebo-controlled study of a high-concentration capsaicin dermal patch (NGX-4010) for the treatment of painful HIV-DSP... - HIV-associated PML: changing epidemiology and clinical approachDavid M Simpson
Neuro AIDS Research Program, Clinical Neurophysiology Laboratories, Mount Sinai Medical Center, New York, NY, USA
Cleve Clin J Med 78:S24-7. 2011..The standard of care for HIV-associated PML is HAART to achieve immunologic recovery and optimal HIV virologic control. The prognosis of PML has improved greatly since the advent of HAART... - An open-label pilot study of high-concentration capsaicin patch in painful HIV neuropathyDavid M Simpson
Mount Sinai School of Medicine, New York, NY 10029, USA
J Pain Symptom Manage 35:299-306. 2008..No safety concerns were identified. Controlled studies of NGX-4010 for the treatment of painful HIV-associated neuropathy are warranted... - HIV neuropathy natural history cohort study: assessment measures and risk factorsD M Simpson
Mount Sinai Hospital, New York, NY, USA
Neurology 66:1679-87. 2006..Distal sensory polyneuropathy (DSP) is the most common neurologic complication of human immunodeficiency virus (HIV) infection. Risk factors for DSP have not been adequately defined in the era of highly active antiretroviral therapy... - Fentanyl buccal tablet for the relief of breakthrough pain in opioid-tolerant adult patients with chronic neuropathic pain: a multicenter, randomized, double-blind, placebo-controlled studyDavid M Simpson
Mount Sinai School of Medicine, New York, New York 10029, USA
Clin Ther 29:588-601. 2007..The fentanyl buccal tablet (FBT) provides a rapid onset of analgesia (10-15 minutes) by enhancing fentanyl absorption across the buccal mucosa... - Long-term safety of NGX-4010, a high-concentration capsaicin patch, in patients with peripheral neuropathic painDavid M Simpson
Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
J Pain Symptom Manage 39:1053-64. 2010..Current treatment options are often limited by poor tolerability... - A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection. AIDS Clinical Trials Group Team 291J C McArthur
Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
Neurology 54:1080-8. 2000..To evaluate the safety and efficacy of recombinant human nerve growth factor (rhNGF) in HIV-associated sensory neuropathy (SN) within a multicenter, placebo-controlled, randomized trial (ACTG 291)... - Lamotrigine for HIV-associated painful sensory neuropathies: a placebo-controlled trialD M Simpson
Mount Sinai School of Medicine (Dr. Simpson, New York, NY
Neurology 60:1508-14. 2003..Additional research is warranted to understand the differing response among patients receiving neurotoxic antiretroviral therapy compared with those not receiving neurotoxic antiretroviral therapy... - Correlates of epidermal nerve fiber densities in HIV-associated distal sensory polyneuropathyL Zhou
Department of Neurology, Johns Hopkins University, Baltimore, MD 21287 7609, USA
Neurology 68:2113-9. 2007..To demonstrate the relationship between epidermal nerve fiber density (ENFD) in the leg and the phenotype of HIV-associated distal sensory polyneuropathy (HIV-DSP) in a multicenter prospective study (ACTG A5117)... - Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathyG Schifitto
Department of Neurology, University of Rochester, NY 14642, USA
Neurology 57:1313-6. 2001..However, there was no improvement of neuropathy severity as assessed by neurologic examination, quantitative sensory testing, and epidermal nerve fiber density... - Association of self-reported painful symptoms with clinical and neurophysiologic signs in HIV-associated sensory neuropathyJ Robinson-Papp
Department of Neurology, Mount Sinai, School of Medicine, New York, NY 10029, USA
Pain 151:732-6. 2010..This finding holds true regardless of demographic factors, depression or substance use history... - Assessment: Botulinum neurotoxin for the treatment of movement disorders (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of NeurologyD M Simpson
Department of Neurology, Mount Sinai Medical Center, New York, NY, USA
Neurology 70:1699-706. 2008..To perform an evidence-based review of the safety and efficacy of botulinum neurotoxin (BoNT) in the treatment of movement disorders... - Myopathies associated with human immunodeficiency virus and zidovudine: can their effects be distinguished?D M Simpson
Department of Neurology, Mount Sinai Medical Center, New York, NY
Neurology 43:971-6. 1993..Twelve of 13 patients improved with prednisone. Although it is difficult to distinguish the myopathies of HIV and ZDV by clinical or pathologic criteria, in the majority of our patients, myopathy is due to HIV rather than ZDV... - HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathyD B Clifford
Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
Neurology 52:623-5. 1999..This is an improvement in prognosis compared with recent historic experience and correlated with HIV RNA viral load reductions. We conclude that current HIV therapy is important in improving the outlook of PML in the setting of HIV... - Assessment: Botulinum neurotoxin for the treatment of spasticity (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of NeurologyD M Simpson
Department of Neurology, Mount Sinai Medical Center, New York, NY, USA
Neurology 70:1691-8. 2008..To perform an evidence-based review of the safety and efficacy of botulinum neurotoxin (BoNT) in the treatment of adult and childhood spasticity... - Peptide T in the treatment of painful distal neuropathy associated with AIDS: results of a placebo-controlled trial. The Peptide T Neuropathy Study GroupD M Simpson
Department of Neurology, Mount Sinai Medical Center, New York, NY 10029, USA
Neurology 47:1254-9. 1996..To assess the safety and efficacy of Peptide T in the treatment of painful distal symmetrical polyneuropathy (DSP) associated with human immunodeficiency virus (HIV) infection... - HIV-associated distal sensory polyneuropathy in the era of highly active antiretroviral therapy: the Manhattan HIV Brain BankSusan Morgello
Department of Pathology, The Mount Sinai Medical Center, New York, NY 10029, USA
Arch Neurol 61:546-51. 2004.... - Effects of hepatic function and hepatitis C virus on the nervous system assessment of advanced-stage HIV-infected individualsSusan Morgello
Department of Pathology, Mount Sinai Medical Center, New York, NY 10029, USA
AIDS 19:S116-22. 2005..To examine the effects of liver function and hepatitis C virus (HCV) serostatus on neurological, neuropsychological, and psychiatric abnormalities in an advanced-stage HIV-infected cohort... - Thalidomide for the treatment of esophageal aphthous ulcers in patients with human immunodeficiency virus infection. National Institute of Allergy and Infectious Disease AIDS Clinical Trials GroupJ M Jacobson
Mount Sinai Medical Center, New York, NY 10029, USA
J Infect Dis 180:61-7. 1999..Thalidomide is effective in healing aphthous ulceration of the esophagus in patients infected with HIV... - Hereditary neuropathy and vocal cord paralysis in a man with childhood diphtheriaB D Reichler
Department of Neurology, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1052, New York, New York 10029, USA
Muscle Nerve 23:132-7. 2000.... - The role of somatosensory evoked potentials in the diagnosis of AIDS-associated myelopathyM Tagliati
Department of Neurology, Clinical Neurophysiology, The Mount Sinai Medical Center, New York, NY 10003, USA
Neurology 54:1477-82. 2000..Somatosensory evoked potentials (SEPs) have been successfully used to evaluate central conduction in a number of diseases involving the spinal cord... - AIDS and AIDS-treatment neuropathiesD Williams
Neuro-AIDS Research Program, Mount Sinai School of Medicine, 1 Gustave Levy Place, Box 1052, New York, NY 10029, USA
Curr Neurol Neurosci Rep 1:533-8. 2001..Treatment of AIDS neuropathies is directed toward relief of symptoms, however, new evidence suggests that aggressive antiretroviral therapy may also be effective... - Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathyM Polydefkis
Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
Neurology 58:115-9. 2002..To explore the relationship between intraepidermal nerve fiber (IENF) density in HIV-associated sensory neuropathy (HIV-SN) to measurements of neuropathy severity and progression of HIV disease... - Human immunodeficiency virus-associated dementia: review of pathogenesis, prophylaxis, and treatment studies of zidovudine therapyD M Simpson
Department of Neurology, Mount Sinai Medical Center, New York, New York 10029, USA
Clin Infect Dis 29:19-34. 1999..Zidovudine has been associated with improved neuropsychological functioning in children with progressive encephalopathy, but optimum dosing levels, duration of effect, and prophylactic potential remain to be demonstrated... - Controlling neuropathic pain in HIVSusama Verma
Department of Neurology, Mount Sinai Medical Center, One Gustave L. Levy Place, New York, NY 10029, USA
Curr HIV/AIDS Rep 1:136-41. 2004..We review treatment options for painful HIV neuropathy, including experimental agents studied in recent and ongoing clinical trials... - Randomized controlled trial of IVIg in untreated chronic inflammatory demyelinating polyradiculoneuropathyJ R Mendell
Department of Neurology, Ohio State University, Columbus 43210, USA
Neurology 56:445-9. 2001..This study provides data supporting IVIg as the initial treatment for CIDP... - Neurological manifestations of HIV-1 infection in the HAART eraA P Geraci
Neuro-AIDS Research Program, Departments of Neurology and Clinical Neurophysiology, Mount Sinai Medical Center, New York, NY 10029, USA
Compr Ther 27:232-41. 2001..Improved prophylaxis and antiretroviral therapies have modified the approach to neurologic disease in the setting of AIDS... - JC virus granule cell neuronopathy: A novel clinical syndrome distinct from progressive multifocal leukoencephalopathyIgor J Koralnik
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Ann Neurol 57:576-80. 2005..We propose to call this novel syndrome JCV granule cell neuronopathy (JCV GCN)... - Differential effects of HIV infected macrophages on dorsal root ganglia neurons and axonsKatrin Hahn
Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
Exp Neurol 210:30-40. 2008..These observations suggest a differential effect on the axon and cell body. Different mechanisms of injury may be operative in these two structures... - A randomized controlled trial of 5% lidocaine gel for HIV-associated distal symmetric polyneuropathyLydia Estanislao
Department of Neurology and Clinical Neurophysiology, Mount Sinai Medical Center, New York, NY 10029, USA
J Acquir Immune Defic Syndr 37:1584-6. 2004..18) did not differ compared with those without (1.10) (P = 0.358). There were no significant adverse effects. CONCLUSION: Lidocaine 5% gel is a safe but ineffective agent in the treatment of pain in HIV-associated DSP... - HIV-associated neuropathic pain: epidemiology, pathophysiology and managementSusama Verma
Department of Neurology, Neuro-AIDS Research Program, The Mount Sinai Medical Center, New York, New York 10029, USA
CNS Drugs 19:325-34. 2005..We review the clinical manifestations, epidemiology, pathophysiology and management strategies for HIV-associated DSP... - Antiretroviral rounds. First holiday was a disaster: should she take another?Lydia Estanislao
Mount Sinai Medical Center, New York City, USA
AIDS Clin Care 16:40-1. 2004 - Motor function and human immunodeficiency virus-associated cognitive impairment in a highly active antiretroviral therapy-era cohortJessica Robinson-Papp
Departments of Pathology, Mount Sinai Medical Center, Box 1052, One Gustave L Levy Place, New York, NY 10029, USA
Arch Neurol 65:1096-101. 2008..Cognitive impairment has long been recognized as a manifestation of human immunodeficiency virus (HIV) infection. However, highly active antiretroviral therapy (HAART) has altered the neurologic manifestations of HIV... - Neuromuscular complications of human immunodeficiency virus infectionJessica Robinson-Papp
Department of Neurology, Mount Sinai Medical Center, Box 1052, New York, NY 10029, USA
Phys Med Rehabil Clin N Am 19:81-96, vi-vii. 2008.... - Safety profile of treatment in diabetic peripheral neuropathic painJessica Robinson-Papp
Mount Sinai School of Medicine, New York, New York, USA
Pain Med 8:S43-9. 2007..In this article we review the safety profile of agents commonly used in the treatment of DPNP... - A placebo-controlled study of memantine for the treatment of human immunodeficiency virus-associated sensory neuropathyGiovanni Schifitto
University of Rochester, Rochester, New York 14620, USA
J Neurovirol 12:328-31. 2006..Results were similar to those of other pilot studies of memantine for neuropathic pain unrelated to HIV, suggesting that memantine is ineffective for the symptomatic treatment of HIV-associated SDSP... - Diagnosis and management of HIV-associated neuropathyAlejandra Gonzalez-Duarte
The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1187, New York, NY 10029 6574, USA
Neurol Clin 26:821-32, x. 2008..This article highlights the risk factors, pathogenesis, pathology, clinical features, diagnostic studies, differential diagnosis, and treatment of HIV-associated neuropathy... - Anatomical localization of motor endplate bands in the human biceps brachiiAsif Amirali
Department of Otolaryngology, Mount Sinai School of Medicine, New York, New York, USA
J Clin Neuromuscul Dis 9:306-12. 2007..This study localized the motor endplate bands (MEB) within human biceps brachii (BB) muscles in relation to external landmarks... - Regional patterns of brain metabolites in AIDS dementia complexConstantin T Yiannoutsos
Division of Biostatistics, Indiana University School of Medicine, 1050 Wishard Boulevard, RG 4101, Indianapolis, IN 46202, USA
Neuroimage 23:928-35. 2004..We conclude that by using factor analysis, we are able to combine multiple metabolites across brain regions in a biologically plausible manner and construct a predictive model of ADC adjusting for relevant factors such as age... - Peripheral neuropathies associated with HIV and hepatitis C co-infection: a reviewLydia B Estanislao
Department of Neurology (NeuroAIDS Research Program, Mount Sinai Medical Center, New York, NY 10029, USA
AIDS 19:S135-9. 2005..It is not known whether there are additive or synergistic effects on the peripheral nerve by these two viruses. There is a need for studies to further elucidate the mechanisms involved... - Managing HIV peripheral neuropathyAlejandra Gonzalez Duarte
Department of Clinical Neurophysiology, Mount Sinai School of Medicine, Annenberg 2nd Floor, Box 1052, New York, NY 10029, USA
Curr HIV/AIDS Rep 4:114-8. 2007..Sustained virologic control may improve DSP. Novel therapies such as -acetyl-l-carnitine or neurotrophic factors are being studied for treatment of DSP... - Heart-rate and blood-pressure variability during psychophysiological tasks involving speech: influence of respirationAlessandro Beda
Biomedical Engineering Programme COPPE, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Psychophysiology 44:767-78. 2007..Furthermore, a number of subjects with long respiratory period at rest were identified, whose presence in the sample can bias the estimation of baseline rest values...
Research Grants
- MIDCAREER INVESTIGATOR AWARD IN NEURO-AIDS RESEARCHDavid Simpson; Fiscal Year: 2005..The Neuro-Adherence Program will assess the affect of neurological disease on patients' adherence to medical regimens, and the impact of education and support groups on adherence. ..