Affiliation: Mount Sinai School of Medicine
Country: USA


  1. Guo N, DeAngelis V, Zhu C, Schuchman E, Simonaro C. Pentosan Polysulfate Treatment of Mucopolysaccharidosis Type IIIA Mice. JIMD Rep. 2018;: pubmed publisher
    ..Consistent with these neuropathological findings, we also observed significant improvements in the hyperactivity/anxiety and learning behaviors of the MPS IIIA mice treated with early subQ PPS. ..
  2. Simonaro C, Ge Y, Eliyahu E, He X, Jepsen K, Schuchman E. Involvement of the Toll-like receptor 4 pathway and use of TNF-alpha antagonists for treatment of the mucopolysaccharidoses. Proc Natl Acad Sci U S A. 2010;107:222-7 pubmed publisher
    ..These studies revealed the important role of TLR4 signaling in MPS bone and joint disease and suggest that targeting TNF-alpha may have positive therapeutic effects. ..