Research Topics
| Daphne SimeonSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
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Detail Information
Publications
De-constructing depersonalization: further evidence for symptom clustersDaphne Simeon
Department of Psychiatry, Mount Sinai School of Medicine, Psychiatry Box 1230, One Gustave L Levy Place, New York, NY 10029, USA
Psychiatry Res 157:303-6. 2008....
Alexithymia, absorption, and cognitive failures in depersonalization disorder: a comparison to posttraumatic stress disorder and healthy volunteersDaphne Simeon
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
J Nerv Ment Dis 197:492-8. 2009..In conclusion, the link between depersonalization and alexithymia appeared to be specific rather than broadly related to early trauma or to trauma-spectrum psychopathology...
Dissociation versus posttraumatic stress: cortisol and physiological correlates in adults highly exposed to the World Trade Center attack on 9/11Daphne Simeon
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, United States
Psychiatry Res 161:325-9. 2008..This small study emphasizes the importance of dissecting the neurobiology of posttraumatic stress versus dissociative traumatic responses...
A preliminary study of cortisol and norepinephrine reactivity to psychosocial stress in borderline personality disorder with high and low dissociationDaphne Simeon
Department of Psychiatry, Mount Sinai School of Medicine, Psychiatry Box 1230, One Gustave L Levy Place, New York, NY 10029, USA
Psychiatry Res 149:177-84. 2007..In conclusion, despite its small sample size this pilot study suggests that dissociative symptomatology may be a marker of heightened biological vulnerability to stress in BPD, and merits further study...
Dissociative disorders in DSM-5David Spiegel
Department of Psychiatry, Stanford University, Palo Alto, California, USA
Depress Anxiety 28:E17-45. 2011..The periodic revision of the DSM provides an opportunity to revisit the assumptions underlying specific diagnoses and the empirical support, or lack of it, for the defining diagnostic criteria...
Is depersonalization disorder initiated by illicit drug use any different? A survey of 394 adultsDaphne Simeon
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
J Clin Psychiatry 70:1358-64. 2009..The goal of this study was to systematically compare a large sample of individuals with drug-initiated (D) versus non-drug-initiated (ND) chronic depersonalization...
Hypothalamic-pituitary-adrenal axis function in dissociative disorders, post-traumatic stress disorder, and healthy volunteersDaphne Simeon
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Biol Psychiatry 61:966-73. 2007..This study investigated basal and stress-induced hypothalamic-pituitary-adrenal (HPA)-axis alterations in dissociative disorders (DDs)...
Cognitive functioning in depersonalization disorderOrna Guralnik
Department of Psychiatry, Mount Sinai School of Medicine, New York City, New York 10029, USA
J Nerv Ment Dis 195:983-8. 2007..Dissociation severity was significantly correlated with processing slowness and distractibility. We conclude that DPD is associated with cognitive disruptions in early perceptual and attentional processes...
Examination of the pathological dissociation taxon in depersonalization disorderDaphne Simeon
Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box #1230, New York, N.Y. 10029, USA
J Nerv Ment Dis 191:738-44. 2003..As previously, we continue to recommend a low taxon cutoff score (13) for the sensitive detection of depersonalization disorder. The inference that pathologic dissociation is a unitary and categorical entity is also discussed...
Dissociation and posttraumatic stress 1 year after the World Trade Center disaster: follow-up of a longitudinal surveyDaphne Simeon
Mount Sinai School of Medicine, Department of Psychiatry, New York, NY 10029, USA
J Clin Psychiatry 66:231-7. 2005..We conducted a 1-year follow-up of an original mail survey of early reactions to the World Trade Center disaster...
Factors associated with resilience in healthy adultsDaphne Simeon
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Psychoneuroendocrinology 32:1149-52. 2007..We conclude that in young adults without manifest psychiatric disorder, resilience was associated with developmental, biological, and cognitive measures which merit further investigation...
Dissociative disorders in DSM-5David Spiegel
Department of Psychiatry, Stanford University, Palo Alto, California, USA
Depress Anxiety 28:824-52. 2011..The periodic revision of the DSM provides an opportunity to revisit the assumptions underlying specific diagnoses and the empirical support, or lack of it, for the defining diagnostic criteria...
Fluoxetine therapy in depersonalisation disorder: randomised controlled trialDaphne Simeon
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
Br J Psychiatry 185:31-6. 2004..Despite anecdotal reports that serotonin reuptake inhibitors may improve depersonalisation, there is no proven efficacious treatment for depersonalisation disorder...
Feeling unreal: a depersonalization disorder update of 117 casesDaphne Simeon
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
J Clin Psychiatry 64:990-7. 2003..In this report, we systematically elucidate the phenomenology, precipitants, antecedents, comorbidity, and treatment history in such a series...
Relationship of personality to dissociation and childhood trauma in borderline personality disorderDaphne Simeon
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
CNS Spectr 8:755-62. 2003..The purpose of this study was to investigate the relationship between dissociation and childhood trauma in BPD and to explore the relationships of dissociation and trauma to various personality features of BPD...
Temporal disintegration in depersonalization disorderDaphne Simeon
Mount Sinai School of Medicine, Box 1230, One Gustave L Levy Place, New York, NY 10029, USA
J Trauma Dissociation 8:11-24. 2007..We conclude that the experience of temporal disintegration in DPD is not directly related to the core symptoms of depersonalization/derealization, but exists when the depersonalized experience involves more prominent absorption...
Peritraumatic reactions associated with the World Trade Center disasterDaphne Simeon
Psychiatry Box 1229, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Am J Psychiatry 160:1702-5. 2003..The World Trade Center disaster was of unprecedented magnitude and impact in U.S. history. The authors conducted a pilot survey investigating these effects...
Personality factors associated with dissociation: temperament, defenses, and cognitive schemataDaphne Simeon
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
Am J Psychiatry 159:489-91. 2002..The purpose of this study was to investigate temperamental, psychodynamic, and cognitive factors associated with dissociation...
Oxytocin can hinder trust and cooperation in borderline personality disorderJennifer Bartz
Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1230, New York, NY 10029, USA
Soc Cogn Affect Neurosci 6:556-63. 2011..Although popularly dubbed the 'hormone of love', these data suggest a more circumspect answer to the question of who will benefit from OXT...
An open-label trial of divalproex extended-release in the treatment of borderline personality disorderDaphne Simeon
Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
CNS Spectr 12:439-43. 2007..Divalproex extended-release (ER) is used widely in clinical practice, which leads to the question of its efficacy and tolerability in treating BPD...
An open-label trial of venlafaxine in body dysmorphic disorderAndrea Allen
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
CNS Spectr 13:138-44. 2008..This open-label trial examines venlafaxine's efficacy in BDD and is the first known study of this serotonin-norepinephrine reuptake inhibitor in BDD...
Skin conductance and memory fragmentation after exposure to an emotional film clip in depersonalization disorderTimo Giesbrecht
Albert Einstein College of Medicine, Beth Israel Medical Center, New York, NY, USA
Psychiatry Res 177:342-9. 2010..Apparently, emotional responding in DPD is characterized by a shortened latency to peak with subsequent flattening and is accompanied by memory fragmentation in the light of otherwise unremarkable memory functioning...
Depersonalisation disorder: a contemporary overviewDaphne Simeon
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
CNS Drugs 18:343-54. 2004..Overall, novel therapeutic approaches are clearly needed to help individuals experiencing this refractory disorder...
Relationships between obsessive-compulsive symptomatology and severity of psychosis in schizophrenia: a systematic review and meta-analysisRuth Cunill
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
J Clin Psychiatry 70:70-82. 2009..In this report, we aim to integrate the findings of prior studies by means of a systematic review followed by a meta-analysis...
Temporo-parietal junction stimulation in the treatment of depersonalization disorderAntonio Mantovani
Division of Brain Stimulation and Therapeutic Modulation, Department of Psychiatry, Columbia University New York State Psychiatric Institute, New York 10032, USA
Psychiatry Res 186:138-40. 2011..After 3weeks of right temporo-parietal junction (TPJ) rTMS, 6/12 patients responded. Five responders received 3 more weeks of right TPJ rTMS showing 68% DPD symptoms improvement. Right TPJ rTMS was safe and effective...
Should OCD leave the anxiety disorders in DSM-V? The case for obsessive compulsive-related disordersEric Hollander
Seaver and New York Autism Center of Excellence, Mount Sinai School of Medicine, New York, NY 10029, USA
Depress Anxiety 25:317-29. 2008..There are both advantages and disadvantages in creating a new diagnostic category in DSM-V, and these are discussed in this article...
An open trial of naltrexone in the treatment of depersonalization disorderDaphne Simeon
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
J Clin Psychopharmacol 25:267-70. 2005..These findings are potentially promising in a highly treatment-refractory disorder for which no treatment guidelines exist and warrant a randomized controlled trial...
Basal norepinephrine in depersonalization disorderDaphne Simeon
Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Psychiatry Res 121:93-7. 2003..The findings are in concordance with the few reports on autonomic blunting in dissociation and merit further investigation...
Predictors of patient and caregiver distress in an adult sample with bipolar disorder seeking family treatmentAllison M R Lee
Department of Psychiatry, Beth Israel Medical Center, 317 East 17th Street, New York, NY 10003, USA
J Nerv Ment Dis 199:18-24. 2011..Future research should further clarify the complex relationships between caregiver and patient symptoms and attitudes...
Trichotillomania and skin-picking: a phenomenological comparisonChristine Lochner
Department of Psychiatry, MRC Unit on Stress and Anxiety Disorder, University of Stellenbosch, Tygerberg, Cape Town, South Africa
Depress Anxiety 15:83-6. 2002..Future work to assess the implications of overlap for clinical evaluation and intervention in the two conditions may be useful...
Acute dissociation predicts rapid habituation of skin conductance responses to aversive auditory probesTimo Giesbrecht
Department of Experimental Psychology, Maastricht University, Maastricht, The Netherlands
J Trauma Stress 21:247-50. 2008..Our findings contribute to the growing body of evidence indicating that subjective feelings of acute dissociation have their objective concomitants, notably fast habituation of physiologic responses...
Scientific study of the dissociative disordersConstance Dalenberg
Psychother Psychosom 76:400-1; author reply 401-3. 2007
Role of fantasy proneness, imaginative involvement, and psychological absorption in depersonalization disorderRoss Levin
Ferkauf Graduate School of Psychology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Nerv Ment Dis 192:69-71. 2004
