D Simeon

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint Role of fantasy proneness, imaginative involvement, and psychological absorption in depersonalization disorder
    Ross Levin
    Ferkauf Graduate School of Psychology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Nerv Ment Dis 192:69-71. 2004
  2. ncbi request reprint De-constructing depersonalization: further evidence for symptom clusters
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, Psychiatry Box 1230, One Gustave L Levy Place, New York, NY 10029, USA
    Psychiatry Res 157:303-6. 2008
  3. pmc Hypothalamic-pituitary-adrenal axis function in dissociative disorders, post-traumatic stress disorder, and healthy volunteers
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biol Psychiatry 61:966-73. 2007
  4. ncbi request reprint An open trial of naltrexone in the treatment of depersonalization disorder
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Clin Psychopharmacol 25:267-70. 2005
  5. ncbi request reprint Dissociation and posttraumatic stress 1 year after the World Trade Center disaster: follow-up of a longitudinal survey
    Daphne Simeon
    Mount Sinai School of Medicine, Department of Psychiatry, New York, NY 10029, USA
    J Clin Psychiatry 66:231-7. 2005
  6. ncbi request reprint Fluoxetine therapy in depersonalisation disorder: randomised controlled trial
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Br J Psychiatry 185:31-6. 2004
  7. ncbi request reprint Temporal disintegration in depersonalization disorder
    Daphne Simeon
    Mount Sinai School of Medicine, Box 1230, One Gustave L Levy Place, New York, NY 10029, USA
    J Trauma Dissociation 8:11-24. 2007
  8. ncbi request reprint An open-label trial of divalproex extended-release in the treatment of borderline personality disorder
    Daphne Simeon
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    CNS Spectr 12:439-43. 2007
  9. ncbi request reprint Relationship of personality to dissociation and childhood trauma in borderline personality disorder
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:755-62. 2003
  10. ncbi request reprint Feeling unreal: a depersonalization disorder update of 117 cases
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Clin Psychiatry 64:990-7. 2003

Research Grants

  1. Dissociation: HPA Axis and Cognition
    Daphne Simeon; Fiscal Year: 2004

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Role of fantasy proneness, imaginative involvement, and psychological absorption in depersonalization disorder
    Ross Levin
    Ferkauf Graduate School of Psychology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Nerv Ment Dis 192:69-71. 2004
  2. ncbi request reprint De-constructing depersonalization: further evidence for symptom clusters
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, Psychiatry Box 1230, One Gustave L Levy Place, New York, NY 10029, USA
    Psychiatry Res 157:303-6. 2008
    ....
  3. pmc Hypothalamic-pituitary-adrenal axis function in dissociative disorders, post-traumatic stress disorder, and healthy volunteers
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biol Psychiatry 61:966-73. 2007
    ..This study investigated basal and stress-induced hypothalamic-pituitary-adrenal (HPA)-axis alterations in dissociative disorders (DDs)...
  4. ncbi request reprint An open trial of naltrexone in the treatment of depersonalization disorder
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Clin Psychopharmacol 25:267-70. 2005
    ..These findings are potentially promising in a highly treatment-refractory disorder for which no treatment guidelines exist and warrant a randomized controlled trial...
  5. ncbi request reprint Dissociation and posttraumatic stress 1 year after the World Trade Center disaster: follow-up of a longitudinal survey
    Daphne Simeon
    Mount Sinai School of Medicine, Department of Psychiatry, New York, NY 10029, USA
    J Clin Psychiatry 66:231-7. 2005
    ..We conducted a 1-year follow-up of an original mail survey of early reactions to the World Trade Center disaster...
  6. ncbi request reprint Fluoxetine therapy in depersonalisation disorder: randomised controlled trial
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Br J Psychiatry 185:31-6. 2004
    ..Despite anecdotal reports that serotonin reuptake inhibitors may improve depersonalisation, there is no proven efficacious treatment for depersonalisation disorder...
  7. ncbi request reprint Temporal disintegration in depersonalization disorder
    Daphne Simeon
    Mount Sinai School of Medicine, Box 1230, One Gustave L Levy Place, New York, NY 10029, USA
    J Trauma Dissociation 8:11-24. 2007
    ..We conclude that the experience of temporal disintegration in DPD is not directly related to the core symptoms of depersonalization/derealization, but exists when the depersonalized experience involves more prominent absorption...
  8. ncbi request reprint An open-label trial of divalproex extended-release in the treatment of borderline personality disorder
    Daphne Simeon
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    CNS Spectr 12:439-43. 2007
    ..Divalproex extended-release (ER) is used widely in clinical practice, which leads to the question of its efficacy and tolerability in treating BPD...
  9. ncbi request reprint Relationship of personality to dissociation and childhood trauma in borderline personality disorder
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:755-62. 2003
    ..The purpose of this study was to investigate the relationship between dissociation and childhood trauma in BPD and to explore the relationships of dissociation and trauma to various personality features of BPD...
  10. ncbi request reprint Feeling unreal: a depersonalization disorder update of 117 cases
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Clin Psychiatry 64:990-7. 2003
    ..In this report, we systematically elucidate the phenomenology, precipitants, antecedents, comorbidity, and treatment history in such a series...
  11. ncbi request reprint Factors associated with resilience in healthy adults
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Psychoneuroendocrinology 32:1149-52. 2007
    ..We conclude that in young adults without manifest psychiatric disorder, resilience was associated with developmental, biological, and cognitive measures which merit further investigation...
  12. ncbi request reprint Basal norepinephrine in depersonalization disorder
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Psychiatry Res 121:93-7. 2003
    ..The findings are in concordance with the few reports on autonomic blunting in dissociation and merit further investigation...
  13. ncbi request reprint Peritraumatic reactions associated with the World Trade Center disaster
    Daphne Simeon
    Psychiatry Box 1229, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Am J Psychiatry 160:1702-5. 2003
    ..The World Trade Center disaster was of unprecedented magnitude and impact in U.S. history. The authors conducted a pilot survey investigating these effects...
  14. doi request reprint Dissociation versus posttraumatic stress: cortisol and physiological correlates in adults highly exposed to the World Trade Center attack on 9/11
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, United States
    Psychiatry Res 161:325-9. 2008
    ..This small study emphasizes the importance of dissecting the neurobiology of posttraumatic stress versus dissociative traumatic responses...
  15. ncbi request reprint Hypothalamic-pituitary-adrenal axis dysregulation in depersonalization disorder
    D Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Neuropsychopharmacology 25:793-5. 2001
    ..The purpose of this preliminary study was to investigate HPA axis function in dissociation...
  16. ncbi request reprint Development of a depersonalization severity scale
    D Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    J Trauma Stress 14:341-9. 2001
    ..The DSS had high convergent and discriminant validity and was sensitive to treatment change. The DES was also sensitive to treatment change. We recommend piloting the DSS in future treatment trials of trauma-spectrum disorders...
  17. ncbi request reprint The role of childhood interpersonal trauma in depersonalization disorder
    D Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York 10029, USA
    Am J Psychiatry 158:1027-33. 2001
    ..The purpose of this study was to systematically investigate the role of childhood interpersonal trauma in depersonalization disorder...
  18. ncbi request reprint Feeling unreal: a PET study of depersonalization disorder
    D Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Psychiatry 157:1782-8. 2000
    ..The goal of this study was to assess brain glucose metabolism and its relationship to dissociation measures and clinical symptoms in DSM-IV depersonalization disorder...
  19. ncbi request reprint A preliminary study of cortisol and norepinephrine reactivity to psychosocial stress in borderline personality disorder with high and low dissociation
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, Psychiatry Box 1230, One Gustave L Levy Place, New York, NY 10029, USA
    Psychiatry Res 149:177-84. 2007
    ..In conclusion, despite its small sample size this pilot study suggests that dissociative symptomatology may be a marker of heightened biological vulnerability to stress in BPD, and merits further study...
  20. doi request reprint Alexithymia, absorption, and cognitive failures in depersonalization disorder: a comparison to posttraumatic stress disorder and healthy volunteers
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    J Nerv Ment Dis 197:492-8. 2009
    ..In conclusion, the link between depersonalization and alexithymia appeared to be specific rather than broadly related to early trauma or to trauma-spectrum psychopathology...
  21. doi request reprint Oxytocin administration attenuates stress reactivity in borderline personality disorder: a pilot study
    D Simeon
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine and Beth Israel Medical Center, 317 East 17th Street, New York, NY, USA
    Psychoneuroendocrinology 36:1418-21. 2011
    ..013). Results suggest that oxytocin may have a beneficial impact on emotional regulation in BPD, which merits further investigation and could have important treatment implications...
  22. doi request reprint Is depersonalization disorder initiated by illicit drug use any different? A survey of 394 adults
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    J Clin Psychiatry 70:1358-64. 2009
    ..The goal of this study was to systematically compare a large sample of individuals with drug-initiated (D) versus non-drug-initiated (ND) chronic depersonalization...
  23. ncbi request reprint Personality factors associated with dissociation: temperament, defenses, and cognitive schemata
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Am J Psychiatry 159:489-91. 2002
    ..The purpose of this study was to investigate temperamental, psychodynamic, and cognitive factors associated with dissociation...
  24. doi request reprint Should OCD leave the anxiety disorders in DSM-V? The case for obsessive compulsive-related disorders
    Eric Hollander
    Seaver and New York Autism Center of Excellence, Mount Sinai School of Medicine, New York, NY 10029, USA
    Depress Anxiety 25:317-29. 2008
    ..There are both advantages and disadvantages in creating a new diagnostic category in DSM-V, and these are discussed in this article...
  25. ncbi request reprint An open-label trial of venlafaxine in body dysmorphic disorder
    Andrea Allen
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    CNS Spectr 13:138-44. 2008
    ..This open-label trial examines venlafaxine's efficacy in BDD and is the first known study of this serotonin-norepinephrine reuptake inhibitor in BDD...
  26. ncbi request reprint Feeling unreal: cognitive processes in depersonalization
    O Guralnik
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Psychiatry 157:103-9. 2000
    ..Depersonalized individuals often report difficulties in perception, concentration, and memory; however, data on their cognitive profiles are lacking...
  27. ncbi request reprint Cognitive functioning in depersonalization disorder
    Orna Guralnik
    Department of Psychiatry, Mount Sinai School of Medicine, New York City, New York 10029, USA
    J Nerv Ment Dis 195:983-8. 2007
    ..Dissociation severity was significantly correlated with processing slowness and distractibility. We conclude that DPD is associated with cognitive disruptions in early perceptual and attentional processes...
  28. ncbi request reprint Examination of the pathological dissociation taxon in depersonalization disorder
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1230, New York, N Y 10029, USA
    J Nerv Ment Dis 191:738-44. 2003
    ..As previously, we continue to recommend a low taxon cutoff score (13) for the sensitive detection of depersonalization disorder. The inference that pathologic dissociation is a unitary and categorical entity is also discussed...
  29. ncbi request reprint Depersonalisation disorder: a contemporary overview
    Daphne Simeon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Drugs 18:343-54. 2004
    ..Overall, novel therapeutic approaches are clearly needed to help individuals experiencing this refractory disorder...
  30. ncbi request reprint Relationships between obsessive-compulsive symptomatology and severity of psychosis in schizophrenia: a systematic review and meta-analysis
    Ruth Cunill
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    J Clin Psychiatry 70:70-82. 2009
    ..In this report, we aim to integrate the findings of prior studies by means of a systematic review followed by a meta-analysis...
  31. doi request reprint Skin conductance and memory fragmentation after exposure to an emotional film clip in depersonalization disorder
    Timo Giesbrecht
    Albert Einstein College of Medicine, Beth Israel Medical Center, New York, NY, USA
    Psychiatry Res 177:342-9. 2010
    ..Apparently, emotional responding in DPD is characterized by a shortened latency to peak with subsequent flattening and is accompanied by memory fragmentation in the light of otherwise unremarkable memory functioning...
  32. ncbi request reprint Scientific study of the dissociative disorders
    Constance Dalenberg
    Psychother Psychosom 76:400-1; author reply 401-3. 2007
  33. ncbi request reprint Trichotillomania and skin-picking: a phenomenological comparison
    Christine Lochner
    Department of Psychiatry, MRC Unit on Stress and Anxiety Disorder, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Depress Anxiety 15:83-6. 2002
    ..Future work to assess the implications of overlap for clinical evaluation and intervention in the two conditions may be useful...
  34. doi request reprint Acute dissociation predicts rapid habituation of skin conductance responses to aversive auditory probes
    Timo Giesbrecht
    Department of Experimental Psychology, Maastricht University, Maastricht, The Netherlands
    J Trauma Stress 21:247-50. 2008
    ..Our findings contribute to the growing body of evidence indicating that subjective feelings of acute dissociation have their objective concomitants, notably fast habituation of physiologic responses...

Research Grants5

  1. Dissociation: HPA Axis and Cognition
    Daphne Simeon; Fiscal Year: 2004
    ..At the conclusion of the study, the three groups will be compared with respect to HPA axis function, cognition, childhood/lifetime trauma, symptomatology, and their interrelations. ..