Jeremy Silverman

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc C-reactive protein and familial risk for dementia: a phenotype for successful cognitive aging
    Jeremy M Silverman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, USA
    Neurology 79:1116-23. 2012
  2. pmc Mutation analysis of the NSD1 gene in patients with autism spectrum disorders and macrocephaly
    Joseph D Buxbaum
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, New York, USA
    BMC Med Genet 8:68. 2007
  3. pmc Increased longevity in offspring of mothers with Alzheimer's disease
    Jeremy M Silverman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Med Genet B Neuropsychiatr Genet 147:754-8. 2008
  4. ncbi request reprint Familial patterns of risk in very late-onset Alzheimer disease
    Jeremy M Silverman
    Department of Psychiatry, Box 1230, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Arch Gen Psychiatry 60:190-7. 2003
  5. ncbi request reprint A phenotype for genetic studies of successful cognitive aging
    Jeremy M Silverman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Med Genet B Neuropsychiatr Genet 147:167-73. 2008
  6. pmc Identifying families with likely genetic protective factors against Alzheimer disease
    J M Silverman
    Department of Psychiatry, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Am J Hum Genet 64:832-8. 1999
  7. ncbi request reprint Variability of familial risk of Alzheimer disease across the late life span
    Jeremy M Silverman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arch Gen Psychiatry 62:565-73. 2005
  8. ncbi request reprint Autism-related routines and rituals associated with a mitochondrial aspartate/glutamate carrier SLC25A12 polymorphism
    Jeremy M Silverman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Med Genet B Neuropsychiatr Genet 147:408-10. 2008
  9. ncbi request reprint Symptom domains in autism and related conditions: evidence for familiality
    Jeremy M Silverman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Med Genet 114:64-73. 2002
  10. ncbi request reprint Has familial aggregation in Alzheimer's disease been overestimated?
    J M Silverman
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    Int J Geriatr Psychiatry 15:631-7. 2000

Research Grants

  1. Protective Cognitive Phenotypes in Costa Rica
    Jeremy Silverman; Fiscal Year: 2005
  2. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Jeremy Silverman; Fiscal Year: 2002
  3. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Jeremy Silverman; Fiscal Year: 2006

Detail Information

Publications78

  1. pmc C-reactive protein and familial risk for dementia: a phenotype for successful cognitive aging
    Jeremy M Silverman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, USA
    Neurology 79:1116-23. 2012
    ....
  2. pmc Mutation analysis of the NSD1 gene in patients with autism spectrum disorders and macrocephaly
    Joseph D Buxbaum
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, New York, USA
    BMC Med Genet 8:68. 2007
    ..Sotos syndrome has been described in a number of patients with autism spectrum disorders, suggesting that NSD1 could be involved in other cases of autism and macrocephaly...
  3. pmc Increased longevity in offspring of mothers with Alzheimer's disease
    Jeremy M Silverman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Med Genet B Neuropsychiatr Genet 147:754-8. 2008
    ....
  4. ncbi request reprint Familial patterns of risk in very late-onset Alzheimer disease
    Jeremy M Silverman
    Department of Psychiatry, Box 1230, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Arch Gen Psychiatry 60:190-7. 2003
    ..Although genetic factors are implicated in AD with substantially earlier onset, the familial characteristics of high-incidence very late-onset AD (VLOAD, defined here as AD with onset age >/=85 years) remain unknown...
  5. ncbi request reprint A phenotype for genetic studies of successful cognitive aging
    Jeremy M Silverman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Med Genet B Neuropsychiatr Genet 147:167-73. 2008
    ..These results suggest that age 90 is an optimal age threshold to use for both men and women in genetic studies seeking to identify genes associated with successful cognitive aging...
  6. pmc Identifying families with likely genetic protective factors against Alzheimer disease
    J M Silverman
    Department of Psychiatry, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Am J Hum Genet 64:832-8. 1999
    ..Efforts to identify protective allele-bearing genes that are associated with very late-onset AD should target the families of nonagenarians and centenarians...
  7. ncbi request reprint Variability of familial risk of Alzheimer disease across the late life span
    Jeremy M Silverman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arch Gen Psychiatry 62:565-73. 2005
    ..The role of genetic factors in Alzheimer disease (AD) varies across the late life span, complicating efforts to quantify the risk of AD for relatives of probands with AD...
  8. ncbi request reprint Autism-related routines and rituals associated with a mitochondrial aspartate/glutamate carrier SLC25A12 polymorphism
    Jeremy M Silverman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Med Genet B Neuropsychiatr Genet 147:408-10. 2008
    ..No other significant differences were observed. The rs2056202 polymorphism may be associated with levels of routines and rituals in autism and related disorders...
  9. ncbi request reprint Symptom domains in autism and related conditions: evidence for familiality
    Jeremy M Silverman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Med Genet 114:64-73. 2002
    ..Making distinctions among families by the severity of these features may be useful for identifying more genetically homogeneous subgroups in studies targeted at genes for specific autism-related symptom domains...
  10. ncbi request reprint Has familial aggregation in Alzheimer's disease been overestimated?
    J M Silverman
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    Int J Geriatr Psychiatry 15:631-7. 2000
    ..The relationship between onset age and familial aggregation suggests that no single estimate of the age-dependent risk (survival curve) is uniformly appropriate for relatives of AD probands...
  11. ncbi request reprint Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism
    Nicolas Ramoz
    Laboratory of Molecular Neuropsychiatry, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Psychiatry 161:662-9. 2004
    ..In the present study, genes across the 2q24-q33 interval were analyzed to identify an autism susceptibility gene in this region...
  12. pmc Assessment and familial aggregation of psychosis in Alzheimer's disease from the National Institute on Aging Late Onset Alzheimer's Disease Family Study
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh, Biomedical Science Tower, Rm W 1645, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Brain 133:1155-62. 2010
    ..Future studies should examine the linkage and association of psychosis with genetic variation within these families...
  13. ncbi request reprint Lack of evidence for association of the serotonin transporter gene SLC6A4 with autism
    Nicolas Ramoz
    Laboratory of Molecular Neuropsychiatry, Department of Psychiatry, Seaver Autism Research Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 60:186-91. 2006
    ..Specific variants of the 5-HTT gene, SLC6A4, especially the insertion-deletion 5-HTTLPR promoter locus, have been found to modulate its expression and transporter function...
  14. doi request reprint An analysis of candidate autism loci on chromosome 2q24-q33: evidence for association to the STK39 gene
    Nicolas Ramoz
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1152-8. 2008
    ..In summary, we have observed further evidence for linkage and association between autism and loci within the 2q24-q33 region, including at STK39, a novel candidate gene for autism...
  15. ncbi request reprint Reduced processing resource availability in schizotypal personality disorder: evidence from a dual-task CPT study
    Patrick J Moriarty
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    J Clin Exp Neuropsychol 25:335-47. 2003
    ....
  16. pmc Type 2 diabetes is negatively associated with Alzheimer's disease neuropathology
    Michal Schnaider Beeri
    Department of Psychiatry, Mount Sinai School of Medicine, New York, USA
    J Gerontol A Biol Sci Med Sci 60:471-5. 2005
    ..The present descriptive study compared diabetic and nondiabetic subjects on the severity of neuritic plaques and neurofibrillary tangles (NFTs) in the cerebral cortex and in the hippocampus...
  17. pmc The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration
    Monica E Calkins
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Schizophr Bull 33:33-48. 2007
    ..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment...
  18. pmc Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia
    Neal R Swerdlow
    Department of Psychiatry, University of California San Diego, San Diego, California, USA
    Schizophr Res 92:237-51. 2007
    ..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies...
  19. ncbi request reprint Validation of the modified telephone interview for cognitive status (TICS-m) in Hebrew
    Michal Schnaider Beeri
    Mount Sinai School of Medicine, Biomathematical Sciences Department, One Gustave Levy Place, New York 10029 3945, USA
    Int J Geriatr Psychiatry 18:381-6. 2003
    ..The validity of the Hebrew version of the Telephone Interview for Cognitive Status-Modified (TICS-m) for Mild Cognitive Impairment (MCI), for dementia, and for cognitive impairment (either MCI or dementia) was investigated...
  20. ncbi request reprint Dexamethasone suppression test findings in subjects with personality disorders: associations with posttraumatic stress disorder and major depression
    Robert Grossman
    Department of Psychatry Bronx VeteransAffairs medical Center, Bronx, NY, USA
    Am J Psychiatry 160:1291-8. 2003
    ..To investigate the effect of PTSD, the authors conducted a 0.5-mg DST, which is more sensitive than the 1.0-mg DST for detection of increased cortisol suppression, in a group of subjects with personality disorders...
  21. doi request reprint Eye tracking performance and the boundaries of the schizophrenia spectrum
    Vivian Mitropoulou
    Mount Sinai School of Medicine Dept of Psychiatry, The James J Peters Veterans Affairs Medical Center, and VISN 3 MIRECC, NY, USA
    Psychiatry Res 186:18-22. 2011
    ..Indeed, SPD subjects comprise the only group not statistically different from schizophrenic patients in quantitative or qualitative ratings...
  22. pmc Non-synonymous variants in the AMACR gene are associated with schizophrenia
    Irina N Bespalova
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 124:208-15. 2010
    ..Therefore, AMACR is both a positional and functional candidate gene for susceptibility to schizophrenia...
  23. ncbi request reprint Cardiovascular risk factors for Alzheimer's disease
    Clive Rosendorff
    Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Am J Geriatr Cardiol 16:143-9. 2007
    ..If this is the case, the identification of modifiable risk factors for dementia becomes a research priority and early intervention aimed at reducing those cardiovascular risk factors a therapeutic imperative...
  24. ncbi request reprint Birth order effects on autism symptom domains
    Abraham Reichenberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Psychiatry Res 150:199-204. 2007
    ..Nevertheless, the findings suggest that genetic studies in autism using specific levels of familial autism traits as phenotypes should take into account their intercorrelations and birth order effects embedded in the instrument...
  25. ncbi request reprint Association analysis of the NrCAM gene in autism and in subsets of families with severe obsessive-compulsive or self-stimulatory behaviors
    Takeshi Sakurai
    Departments of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Psychiatr Genet 16:251-7. 2006
    ....
  26. pmc Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly
    Joseph D Buxbaum
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Am J Med Genet B Neuropsychiatr Genet 144:484-91. 2007
    ..Screening of PTEN mutations is warranted in patients with autism and pronounced macrocephaly, even in the absence of other features of PTEN-related tumor syndromes...
  27. ncbi request reprint Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Gen Psychiatry 64:1242-50. 2007
    ..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia...
  28. pmc Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of Schizophrenia
    Ann Olincy
    Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
    Schizophr Res 119:175-82. 2010
    ....
  29. doi request reprint Impact of APOE epsilon4 on the cognitive performance of a sample of non-demented Puerto Rican nonagenarians
    JOSE R CARRION-BARALT
    Mount Sinai School of Medicine, Department of Psychiatry, New York, NY, USA
    J Alzheimers Dis 18:533-40. 2009
    ..In conclusion, the results of this study suggest that, among these Puerto Rican non-demented nonagenarians, being an APOE epsilon4 allele carrier is associated with better cognition...
  30. pmc The neuropsychological performance of nondemented Puerto Rican nonagenarians
    JOSE R CARRION-BARALT
    Department of Psychiatry, Mount Sinai School of Medicine, New York, N Y, USA
    Dement Geriatr Cogn Disord 27:353-60. 2009
    ..This study sought to evaluate the neuropsychological performance of nondemented nonagenarians residing in Puerto Rico and to compare their results with those of a similar English-speaking sample from New York...
  31. pmc Better memory functioning associated with higher total and low-density lipoprotein cholesterol levels in very elderly subjects without the apolipoprotein e4 allele
    Rebecca West
    Mount Sinai School of Medicine, New York, NY, USA
    Am J Geriatr Psychiatry 16:781-5. 2008
    ..To examine the association of cholesterol with cognitive functioning in oldest old community dwelling individuals with and without the apolipoprotein e4 (APOE4) allele...
  32. pmc Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 64:1051-9. 2008
    ..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes...
  33. pmc Religious education and midlife observance are associated with dementia three decades later in Israeli men
    Michal Schnaider Beeri
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Clin Epidemiol 61:1161-8. 2008
    ..The aim of the study was to examine the association of religious education and observance with dementia among participants in the Israeli Ischemic Heart Disease study...
  34. pmc Protection against loss of innate defenses in adulthood by low advanced glycation end products (AGE) intake: role of the antiinflammatory AGE receptor-1
    Helen Vlassara
    Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 94:4483-91. 2009
    ..Whereas AGE receptor-1 (AGER1) reduces OS/infl in animals, this has not been assessed in normal humans...
  35. pmc Clinical dementia rating performed several years prior to death predicts regional Alzheimer's neuropathology
    Michal Schnaider Beeri
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dement Geriatr Cogn Disord 25:392-8. 2008
    ..To assess the relationships between early and late antemortem measures of dementia severity and Alzheimer disease (AD) neuropathology severity...
  36. pmc Relationship between whole blood serotonin and repetitive behaviors in autism
    Alexander Kolevzon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Psychiatry Res 175:274-6. 2010
    ..No significant associations were found between serotonin level and the primary behavioral outcome measures. However, a significant inverse relationship between serotonin level and self-injury was demonstrated...
  37. pmc Number of children is associated with neuropathology of Alzheimer's disease in women
    Michal Schnaider Beeri
    The Mount Sinai School of Medicine, Department of Psychiatry, New York, NY 10029, USA
    Neurobiol Aging 30:1184-91. 2009
    ..To examine the association between number of born children and neuropathology of Alzheimer's disease (AD)...
  38. pmc The effects of cardiovascular risk factors on cognitive compromise
    Michal Schnaider Beeri
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Dialogues Clin Neurosci 11:201-12. 2009
    ..This may be crucial for understanding the effects on cognition of drugs and other approaches, such as lifestyle change, for treating these risk factors...
  39. ncbi request reprint Familial symptom domains in monozygotic siblings with autism
    Alexander Kolevzon
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Med Genet B Neuropsychiatr Genet 129:76-81. 2004
    ....
  40. ncbi request reprint Effects of acute metabolic stress on the dopaminergic and pituitary-adrenal axis activity in patients with schizotypal personality disorder
    Vivian Mitropoulou
    Department of Psychiatry, Mt Sinai School of Medicine Clinical Reseach Center, New York, NY 10029, USA
    Schizophr Res 70:27-31. 2004
    ..We hypothesized that SPD patients would demonstrate comparable or lower DA and HPA responses after 2-DG to HV...
  41. ncbi request reprint Neurobiologic function and temperament in subjects with personality disorders
    Vivian Mitropoulou
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:725-30. 2003
    ....
  42. pmc Relationship between body height and dementia
    Michal Schnaider Beeri
    Mt Sinai School of Medicine, Department of Psychiatry, One Gustave Levy Place, Box 1230, New York, NY 10029, USA
    Am J Geriatr Psychiatry 13:116-23. 2005
    ..Body height is affected by childhood conditions that promote growth. The authors examine the relationship of height in midlife and subsequent dementia, Alzheimer disease (AD), and vascular dementia...
  43. ncbi request reprint Cross-domain variability of cognitive performance in very old nursing home residents and community dwellers: relationship to functional status
    Michael A Rapp
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Gerontology 51:206-12. 2005
    ..Recent evidence suggests that cross-domain variability in cognition may be related to subsequent cognitive decline beyond mean performance levels in cognitive tasks...
  44. ncbi request reprint Relationship of neuropsychological performance to functional status in nursing home residents and community-dwelling older adults
    Michael A Rapp
    Dept of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Pl, Box 1240, New York, NY 10029 6574, USA
    Am J Geriatr Psychiatry 13:450-9. 2005
    ..The authors examined the association between neuropsychological tests of executive functioning and episodic memory and functional disability in nursing home residents versus community-dwelling older adults...
  45. ncbi request reprint Fine mapping of the 5p13 locus linked to schizophrenia and schizotypal personality disorder in a Puerto Rican family
    Irina N Bespalova
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Psychiatr Genet 15:205-10. 2005
    ....
  46. ncbi request reprint Deficient attentional modulation of the startle response in patients with schizotypal personality disorder
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1505, New York, NY 10029, USA
    Am J Psychiatry 160:1621-6. 2003
    ..The purpose of this study was to examine automatic sensorimotor gating and controlled attentional modulation of the startle eye blink response in unmedicated subjects with schizotypal personality disorder...
  47. ncbi request reprint Blunted hormone responses to Ipsapirone are associated with trait impulsivity in personality disorder patients
    Michael J Minzenberg
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Neuropsychopharmacology 31:197-203. 2006
    ..In addition, D(2) receptor dysfunction may play a role in impulsivity, whereas 5-HT(1A) cell-body autoreceptor function may be spared in these disorders...
  48. ncbi request reprint Obsessive-compulsive behaviors in parents of multiplex autism families
    Eric Hollander
    Department of Psychiatry and Seaver Autism Research Center, Box 1230, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Psychiatry Res 117:11-6. 2003
    ..Dichotomizing autistic probands by severity and type of repetitive behaviors (circumscribed interests and compulsive rituals) may yield more homogenous groups, which could be helpful in genetic linkage studies...
  49. ncbi request reprint Neuropsychological performance in schizotypal personality disorder: importance of working memory
    Vivian Mitropoulou
    Clinical Research Center, Box 1027, Mt Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Am J Psychiatry 162:1896-903. 2005
    ....
  50. ncbi request reprint Dispositional impulsivity in normal and abnormal samples
    Janine D Flory
    Department of Psychiatry, Box 1230, One Gustave Levy Place, Mount Sinai School of Medicine, New York, NY 10029, United States
    J Psychiatr Res 40:438-47. 2006
    ..Results from these analyses also lend support to a large body of work that demonstrates that normal and abnormal personality features are related...
  51. ncbi request reprint Differential metabolic rates in prefrontal and temporal Brodmann areas in schizophrenia and schizotypal personality disorder
    Monte S Buchsbaum
    Neuroscience PET Laboratory, Department of Psychiatry, Mt Sinai School of Medicine, Box 1505, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Schizophr Res 54:141-50. 2002
    ..Metabolic rates in Brodmann area 10 were distinctly higher in SPD patients than in either normal volunteers or schizophrenic patients...
  52. pmc Cingulate and temporal lobe fractional anisotropy in schizotypal personality disorder
    Erin A Hazlett
    Mental Illness Research, Education and Clinical Center VISN 3, James J Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Neuroimage 55:900-8. 2011
    ..Lower fractional anisotropy (FA), a measure of white-matter integrity within prefrontal, temporal, and cingulate regions has been reported in schizophrenia but has been little studied in SPD...
  53. pmc Memory activation in healthy nonagenarians
    Michal Schnaider Beeri
    Mount Sinai School of Medicine, Department of Psychiatry, One Gustave Levy Place, Box 1230, New York, NY 10029, USA
    Neurobiol Aging 32:515-23. 2011
    ..Further investigation of brain activation patterns in the oldest old is warranted...
  54. pmc Mutation analysis of the C1QTNF3 gene in patients with schizophrenia
    Irina Bespalova
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Psychiatry Res 179:235-7. 2010
    ..Genotyping of the shared variants in a Puerto Rican sample of 118 cases and 136 controls did not reveal either allelic or genotype association with schizophrenia...
  55. ncbi request reprint The relationship of borderline personality disorder to posttraumatic stress disorder and traumatic events
    Julia A Golier
    Department of Psychiatry, Veterans Affairs Medical Center 116 A, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Am J Psychiatry 160:2018-24. 2003
    ..The authors examined the relationship of borderline personality disorder to posttraumatic stress disorder (PTSD) with respect to the role of trauma and its timing...
  56. ncbi request reprint No major schizophrenia locus detected on chromosome 1q in a large multicenter sample
    Douglas F Levinson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 296:739-41. 2002
    ..If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small...
  57. ncbi request reprint Neuropsychological performance in schizotypal personality disorder: evidence regarding diagnostic specificity
    Vivian Mitropoulou
    Mt Sinai School of Medicine, Department of Psychiatry, The Bronx Veterans Affairs Medical Center, New York, New York, USA
    Biol Psychiatry 52:1175-82. 2002
    ..We investigated the neuropsychological profile in SPD patients compared with two comparison groups: healthy volunteers (HV) and patients who met criteria for another non-schizophrenia spectrum personality disorder (NSS)...
  58. ncbi request reprint Effects of season of birth on autism spectrum disorders: fact or fiction?
    Alexander Kolevzon
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1230, New York, NY 10029, USA
    Am J Psychiatry 163:1288-90. 2006
    ..This study attempted to examine the relationship between month and season of birth and risk for autism spectrum disorders...
  59. ncbi request reprint A case-control study of the seasonality effects on schizophrenic births on a tropical island
    JOSE R CARRION-BARALT
    Department of Psychiatry, Box 1230, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Schizophr Res 71:145-53. 2004
    ..66, p=0.010), and temperature 5 months earlier (r=0.64, p=0.013) that remained significant after correcting for multiple comparisons...
  60. ncbi request reprint Family-based association study of TPH1 and TPH2 polymorphisms in autism
    Nicolas Ramoz
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Med Genet B Neuropsychiatr Genet 141:861-7. 2006
    ..Thus, it appears unlikely that the TPH1 and TPH2 genes play a significant role in the susceptibility to autism or to autism endophenotypes including sOCB and SSB...
  61. pmc Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional loci
    Joseph H Lee
    Gertrude H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Neurol 65:1518-26. 2008
    ..To identify putative genetic loci related to the risk of late-onset Alzheimer disease (LOAD)...
  62. ncbi request reprint Risperidone in the treatment of schizotypal personality disorder
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10468, USA
    J Clin Psychiatry 64:628-34. 2003
    ..In addition, if SPD patients respond to an antipsychotic medication, this will provide support for the notion of a commonality in treatment response between SPD and schizophrenia...
  63. ncbi request reprint Characterizing affective instability in borderline personality disorder
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Am J Psychiatry 159:784-8. 2002
    ..The authors also examined the subjective intensity with which moods are experienced and the association between instability and intensity of affect...
  64. ncbi request reprint Advancing paternal age and autism
    Abraham Reichenberg
    Department of Psychiatry and Seaver Center for Autism Research, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Arch Gen Psychiatry 63:1026-32. 2006
    ..Maternal and paternal ages are associated with neurodevelopmental disorders...
  65. ncbi request reprint Abuse and neglect in childhood: relationship to personality disorder diagnoses
    Linda M Bierer
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:737-54. 2003
    ..Most of these findings have been generated from inpatient clinical samples...
  66. ncbi request reprint Seasonality effects on schizophrenic births in multiplex families in a tropical island
    JOSE R CARRION-BARALT
    Department of Psychiatry, Box 1230, Mt Sinai School of Medicine, New York, NY 10029, USA
    Psychiatry Res 142:93-7. 2006
    ....
  67. ncbi request reprint The role of childhood trauma in differences in affective instability in those with personality disorders
    Marianne Goodman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:763-70. 2003
    ..This study examined the relationship of self-reported histories of childhood trauma to measures of affective instability in a sample of unmedicated outpatients with various personality disorders (n=174)...
  68. ncbi request reprint Successful multi-site measurement of antisaccade performance deficits in schizophrenia
    Allen D Radant
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States
    Schizophr Res 89:320-9. 2007
    ..These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies...
  69. pmc Normal homocysteine levels in well-functioning oldest-old individuals despite low kidney function
    Michal Schnaider Beeri
    J Am Geriatr Soc 54:1623-5. 2006
  70. pmc Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample
    Brian K Suarez
    Department of Psychiatry and Genetics, Washington University, St Louis, MO, USA
    Am J Hum Genet 78:315-33. 2006
    ..3-p15.2, 5p15.2-q13.3, 10p15.3-p14, 10q25.3-q26.3, and 11p13-q23.3. The highest increase in Z(lr) scores was observed for 5p14.1-q12.1, where the maximum Z(lr) increased from 2.77 initially to 3.80 after fine mapping in the EA families...
  71. ncbi request reprint Mapping autism risk loci using genetic linkage and chromosomal rearrangements
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Nat Genet 39:319-28. 2007
    ..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs...
  72. pmc Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia
    Jubao Duan
    Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University, Evanston, IL, USA
    Am J Hum Genet 75:624-38. 2004
    ..These data provide strong preliminary evidence that TRAR4 is a candidate gene for schizophrenia; replication is currently being attempted in additional clinical samples...
  73. ncbi request reprint Context-processing deficits in schizotypal personality disorder
    Deanna M Barch
    Department of Psychology, Washington University, Campus Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    J Abnorm Psychol 113:556-68. 2004
    ..Context processing was strongly associated with working memory and selective attention performance in the SPD individuals...
  74. doi request reprint No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics
    Alan R Sanders
    Department of Psychiatry and Behavioural Sciences, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201 3137, USA
    Am J Psychiatry 165:497-506. 2008
    ....
  75. pmc Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia
    William P Horan
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 6968, USA
    Schizophr Res 103:218-28. 2008
    ....
  76. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia
    Cathryn M Lewis
    Division of Genetics and Development, Guy s, King s and St Thomas School of Medicine, London, UK
    Am J Hum Genet 73:34-48. 2003
    ..There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations...
  77. ncbi request reprint Tolerance of MRI procedures by the oldest old
    Daniel E Wollman
    Institute on Aging, Jewish Home for the Elderly, Fairfield, CT 06484, USA
    Magn Reson Imaging 22:1299-304. 2004
    ..The study aimed to evaluate the feasibility and discomfort of magnetic resonance imaging (MRI) procedures in the oldest-old subjects (age > 90 years) using a survey design in a university-affiliated neuroimaging research center...
  78. pmc Consortium to Establish a Registry for Alzheimer's Disease (CERAD): the first twenty years
    Gerda G Fillenbaum
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC, USA
    Alzheimers Dement 4:96-109. 2008
    ..CERAD materials and data remain available for those wishing to use them...

Research Grants9

  1. Protective Cognitive Phenotypes in Costa Rica
    Jeremy Silverman; Fiscal Year: 2005
    ..Ultimately, a greatly enlarged longitudinal/genetic study using this population will identify new phenotypes for molecular genetic studies aimed at identifying genes with genetic protective variants. ..
  2. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Jeremy Silverman; Fiscal Year: 2002
    ..Power analyses suggest that this study would have excellent power to detect loci associated with lambda sibs of 1.4, and moderate power for a value of 1.3, i.e., loci with relatively small etiologic effects. ..
  3. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Jeremy Silverman; Fiscal Year: 2006
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..