Andrew G Sikora

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Sensitization to the mitochondrial pathway of apoptosis augments melanoma tumor cell responses to conventional chemotherapeutic regimens
    R A Anvekar
    Mount Sinai School of Medicine, Department of Oncological Sciences, New York, NY 100129, USA
    Cell Death Dis 3:e420. 2012
  2. pmc A patient-centered approach to counseling patients with head and neck cancer undergoing human papillomavirus testing: a clinician's guide
    Amy Chu
    Department of Otolaryngology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1189, New York, New York 10029, USA
    Oncologist 18:180-9. 2013
  3. pmc Targeted inhibition of inducible nitric oxide synthase inhibits growth of human melanoma in vivo and synergizes with chemotherapy
    Andrew G Sikora
    Department of Melanoma Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 16:1834-44. 2010
  4. pmc Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2
    Esther López-Rivera
    Authors Affiliations Departments of Otolaryngology, Dermatology, Immunology, and Oncological Sciences Division of Hematology and Oncology, Department of Medicine, Department of Otolaryngology, The Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai The Tisch Cancer Institute Department of Genetics and Genomic Sciences, One Gustave L Levy Place, New York, New York and Departments of Melanoma Medical Oncology and Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas
    Cancer Res 74:1067-78. 2014
  5. pmc Molecular pathways: inflammation-associated nitric-oxide production as a cancer-supporting redox mechanism and a potential therapeutic target
    Elizabeth A Grimm
    Authors Affiliations Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas and Departments of Otolaryngology, Immunology, Oncological Science, and Dermatology, Mount Sinai School of Medicine, New York, New York
    Clin Cancer Res 19:5557-63. 2013
  6. pmc Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release
    Padmini Jayaraman
    Department of Otolaryngology, Mount Sinai School of Medicine, New York, NY 10028, USA
    J Immunol 188:5365-76. 2012
  7. doi request reprint Prognostic significance of p16 in locoregionally advanced head and neck cancer treated with concurrent 5-fluorouracil, hydroxyurea, cetuximab and intensity-modulated radiation therapy
    Charles C L Tong
    Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Oncol Rep 27:1580-6. 2012
  8. doi request reprint Synchronous cancers in patients with head and neck cancer: risks in the era of human papillomavirus-associated oropharyngeal cancer
    Kunal S Jain
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer 119:1832-7. 2013
  9. doi request reprint Conference scene: immune effector mechanisms in tumor immunity
    Andrew G Sikora
    Departments of Otolaryngology, Immunology, Oncological Sciences and Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunotherapy 4:141-3. 2012
  10. doi request reprint Recognizing and reversing the immunosuppressive tumor microenvironment of head and neck cancer
    Charles C L Tong
    Department of Otolaryngology, Head and Neck Surgery, The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1189, New York, NY, USA
    Immunol Res 54:266-74. 2012

Collaborators

Detail Information

Publications21

  1. pmc Sensitization to the mitochondrial pathway of apoptosis augments melanoma tumor cell responses to conventional chemotherapeutic regimens
    R A Anvekar
    Mount Sinai School of Medicine, Department of Oncological Sciences, New York, NY 100129, USA
    Cell Death Dis 3:e420. 2012
    ..Our data indicate that ABT-737 may be a beneficial adjuvant therapy to improve melanoma response rates when conventional chemotherapy is the only option...
  2. pmc A patient-centered approach to counseling patients with head and neck cancer undergoing human papillomavirus testing: a clinician's guide
    Amy Chu
    Department of Otolaryngology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1189, New York, New York 10029, USA
    Oncologist 18:180-9. 2013
    ..Based on the current state of the literature, this article is intended to be a reference for physicians to effectively manage psychosocial outcomes when diagnosing patients with HPV-associated OPC...
  3. pmc Targeted inhibition of inducible nitric oxide synthase inhibits growth of human melanoma in vivo and synergizes with chemotherapy
    Andrew G Sikora
    Department of Melanoma Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 16:1834-44. 2010
    ..We tested the hypothesis that targeted iNOS inhibition would interfere with human melanoma growth and survival in vivo in a preclinical model...
  4. pmc Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2
    Esther López-Rivera
    Authors Affiliations Departments of Otolaryngology, Dermatology, Immunology, and Oncological Sciences Division of Hematology and Oncology, Department of Medicine, Department of Otolaryngology, The Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai The Tisch Cancer Institute Department of Genetics and Genomic Sciences, One Gustave L Levy Place, New York, New York and Departments of Melanoma Medical Oncology and Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas
    Cancer Res 74:1067-78. 2014
    ..This model is consistent with the known association of iNOS overexpression and poor prognosis in melanoma and other cancers...
  5. pmc Molecular pathways: inflammation-associated nitric-oxide production as a cancer-supporting redox mechanism and a potential therapeutic target
    Elizabeth A Grimm
    Authors Affiliations Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas and Departments of Otolaryngology, Immunology, Oncological Science, and Dermatology, Mount Sinai School of Medicine, New York, New York
    Clin Cancer Res 19:5557-63. 2013
    ..We contend that selected antioxidants be considered as part of the cancer treatment approach, as they are likely to provide a novel and mechanistically justified addition for therapeutic benefit...
  6. pmc Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release
    Padmini Jayaraman
    Department of Otolaryngology, Mount Sinai School of Medicine, New York, NY 10028, USA
    J Immunol 188:5365-76. 2012
    ..These data suggest a critical role for tumor-expressed iNOS in the recruitment and induction of functional MDSC by modulation of tumor VEGF secretion and upregulation of STAT3 and ROS in MDSC...
  7. doi request reprint Prognostic significance of p16 in locoregionally advanced head and neck cancer treated with concurrent 5-fluorouracil, hydroxyurea, cetuximab and intensity-modulated radiation therapy
    Charles C L Tong
    Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Oncol Rep 27:1580-6. 2012
    ..The most common grade 3-4 toxicities were mucositis (46%), leukopenia (18%), anemia (18%) and dermatitis (17%). Concurrent 5-FU, HU, cetuximab and SIB-IMRT is a highly active regimen, particularly in patients with p16-positive disease...
  8. doi request reprint Synchronous cancers in patients with head and neck cancer: risks in the era of human papillomavirus-associated oropharyngeal cancer
    Kunal S Jain
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer 119:1832-7. 2013
    ....
  9. doi request reprint Conference scene: immune effector mechanisms in tumor immunity
    Andrew G Sikora
    Departments of Otolaryngology, Immunology, Oncological Sciences and Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunotherapy 4:141-3. 2012
    ..The conference built on these early successes and aimed to push further into the uncharted territories of successful cancer immunotherapy...
  10. doi request reprint Recognizing and reversing the immunosuppressive tumor microenvironment of head and neck cancer
    Charles C L Tong
    Department of Otolaryngology, Head and Neck Surgery, The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1189, New York, NY, USA
    Immunol Res 54:266-74. 2012
    ..This article outlines significant immune-suppressive mechanisms in the HNSCC tumor microenvironment and potential approaches to enhancing the antitumor immune response...
  11. pmc Discrimination of benign and neoplastic mucosa with a high-resolution microendoscope (HRME) in head and neck cancer
    Peter M Vila
    Department of Otolaryngology Head and Neck Surgery, Mount Sinai School of Medicine, New York, NY, USA
    Ann Surg Oncol 19:3534-9. 2012
    ..Our goal was to determine the accuracy and inter-rater reliability of head and neck cancer specialists using high-resolution microendoscopic (HRME) images to discriminate between cancerous and benign mucosa...
  12. pmc IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity
    Andrew G Sikora
    Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 182:7398-407. 2009
    ....
  13. pmc The increasing incidence of thyroid cancer: the influence of access to care
    Luc G T Morris
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Thyroid 23:885-91. 2013
    ..To conclude that overdiagnosis is occurring, evidence for an association between access to health care and the incidence of cancer is necessary...
  14. pmc Targeting immune suppressing myeloid-derived suppressor cells in oncology
    Johnny Kao
    Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, United States
    Crit Rev Oncol Hematol 77:12-9. 2011
    ..Since c-kit can be readily inhibited by several small molecule inhibitors including imatinib, sunitinib and dasatinib, targeting immune suppressing cells can be readily accomplished in the clinic...
  15. pmc Predictors of survival in mucosal melanoma of the head and neck
    Daniel Jethanamest
    Department of Otolaryngology Head and Neck Surgery, New York University School of Medicine, New York, NY, USA
    Ann Surg Oncol 18:2748-56. 2011
    ..In order to identify factors predictive of survival, we analyzed MMHN outcomes in a large US cohort...
  16. pmc Optical imaging with a high-resolution microendoscope to identify cholesteatoma of the middle ear
    Lauren L Levy
    Department of Otolaryngology Head and Neck Surgery, Mount Sinai School of Medicine, New York, New York 10029, USA
    Laryngoscope 123:1016-20. 2013
    ....
  17. doi request reprint Transoral robotic surgery for the management of oropharyngeal minor salivary gland tumors
    Nathaniel L Villanueva
    Department of Otolaryngology Head and Neck Surgery, Mount Sinai School of Medicine, New York, New York
    Head Neck 36:28-33. 2014
    ..In this study we report our preliminary experience with the use of transoral robotic surgery (TORS) for the management of minor salivary gland malignancies of the oropharynx and outcomes...
  18. pmc T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation
    - Jianjun Yang
    Department of Medicine, Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 210:1447-62. 2013
    ..These results suggest that NO derived from iNOS in activated T cells plays a negative role in the regulation of T(H)17 cell differentiation and highlight the importance of intrinsic programs for the control of T(H)17 immune responses...
  19. doi request reprint Transoral robotic resection and reconstruction for head and neck cancer
    Eric M Genden
    Mount Sinai School of Medicine, Department of Otolaryngology Head and Neck Surgery, New York, New York 10029, USA
    Laryngoscope 121:1668-74. 2011
    ..To evaluate the patterns of failure, survival, and functional outcomes for patients treated with transoral robotic surgery (TORS) and compare these results with those from a cohort of patients treated with concurrent chemoradiation (CRT)...
  20. ncbi request reprint Thyroglossal duct cyst carcinoma: case report and review of the literature
    David W Jang
    Department of Otolaryngology Head and Neck Surgery, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1189, New York, NY 10029, USA
    Ear Nose Throat J 92:E12-4. 2013
    ..Histologic analysis after a Sistrunk procedure revealed a small focus of papillary carcinoma within the TGDC. The patient subsequently underwent total thyroidectomy with no evidence of carcinoma on histologic examination. ..
  21. pmc Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice
    Chengwen Liu
    Department of Melanoma Medical Oncology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 118:1165-75. 2008
    ..Our data thus demonstrated that activated pDCs are capable of initiating effective and systemic antitumor immunity through the orchestration of an immune cascade involving the sequential activation of NK cells, cDCs, and CD8(+) T cells...