Andrew G Sikora
Affiliation: Mount Sinai School of Medicine
- Sensitization to the mitochondrial pathway of apoptosis augments melanoma tumor cell responses to conventional chemotherapeutic regimensR A Anvekar
Mount Sinai School of Medicine, Department of Oncological Sciences, New York, NY 100129, USA
Cell Death Dis 3:e420. 2012..Our data indicate that ABT-737 may be a beneficial adjuvant therapy to improve melanoma response rates when conventional chemotherapy is the only option...
- A patient-centered approach to counseling patients with head and neck cancer undergoing human papillomavirus testing: a clinician's guideAmy Chu
Department of Otolaryngology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1189, New York, New York 10029, USA
Oncologist 18:180-9. 2013..Based on the current state of the literature, this article is intended to be a reference for physicians to effectively manage psychosocial outcomes when diagnosing patients with HPV-associated OPC...
- Targeted inhibition of inducible nitric oxide synthase inhibits growth of human melanoma in vivo and synergizes with chemotherapyAndrew G Sikora
Department of Melanoma Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Clin Cancer Res 16:1834-44. 2010..We tested the hypothesis that targeted iNOS inhibition would interfere with human melanoma growth and survival in vivo in a preclinical model...
- Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2Esther López-Rivera
Authors Affiliations Departments of Otolaryngology, Dermatology, Immunology, and Oncological Sciences Division of Hematology and Oncology, Department of Medicine, Department of Otolaryngology, The Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai The Tisch Cancer Institute Department of Genetics and Genomic Sciences, One Gustave L Levy Place, New York, New York and Departments of Melanoma Medical Oncology and Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas
Cancer Res 74:1067-78. 2014..This model is consistent with the known association of iNOS overexpression and poor prognosis in melanoma and other cancers...
- Molecular pathways: inflammation-associated nitric-oxide production as a cancer-supporting redox mechanism and a potential therapeutic targetElizabeth A Grimm
Authors Affiliations Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas and Departments of Otolaryngology, Immunology, Oncological Science, and Dermatology, Mount Sinai School of Medicine, New York, New York
Clin Cancer Res 19:5557-63. 2013..We contend that selected antioxidants be considered as part of the cancer treatment approach, as they are likely to provide a novel and mechanistically justified addition for therapeutic benefit...
- Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor releasePadmini Jayaraman
Department of Otolaryngology, Mount Sinai School of Medicine, New York, NY 10028, USA
J Immunol 188:5365-76. 2012..These data suggest a critical role for tumor-expressed iNOS in the recruitment and induction of functional MDSC by modulation of tumor VEGF secretion and upregulation of STAT3 and ROS in MDSC...
- Prognostic significance of p16 in locoregionally advanced head and neck cancer treated with concurrent 5-fluorouracil, hydroxyurea, cetuximab and intensity-modulated radiation therapyCharles C L Tong
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
Oncol Rep 27:1580-6. 2012..The most common grade 3-4 toxicities were mucositis (46%), leukopenia (18%), anemia (18%) and dermatitis (17%). Concurrent 5-FU, HU, cetuximab and SIB-IMRT is a highly active regimen, particularly in patients with p16-positive disease...
- Synchronous cancers in patients with head and neck cancer: risks in the era of human papillomavirus-associated oropharyngeal cancerKunal S Jain
Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Cancer 119:1832-7. 2013....
- Conference scene: immune effector mechanisms in tumor immunityAndrew G Sikora
Departments of Otolaryngology, Immunology, Oncological Sciences and Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
Immunotherapy 4:141-3. 2012..The conference built on these early successes and aimed to push further into the uncharted territories of successful cancer immunotherapy...
- Recognizing and reversing the immunosuppressive tumor microenvironment of head and neck cancerCharles C L Tong
Department of Otolaryngology, Head and Neck Surgery, The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1189, New York, NY, USA
Immunol Res 54:266-74. 2012..This article outlines significant immune-suppressive mechanisms in the HNSCC tumor microenvironment and potential approaches to enhancing the antitumor immune response...
- Discrimination of benign and neoplastic mucosa with a high-resolution microendoscope (HRME) in head and neck cancerPeter M Vila
Department of Otolaryngology Head and Neck Surgery, Mount Sinai School of Medicine, New York, NY, USA
Ann Surg Oncol 19:3534-9. 2012..Our goal was to determine the accuracy and inter-rater reliability of head and neck cancer specialists using high-resolution microendoscopic (HRME) images to discriminate between cancerous and benign mucosa...
- IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activityAndrew G Sikora
Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
J Immunol 182:7398-407. 2009....
- The increasing incidence of thyroid cancer: the influence of access to careLuc G T Morris
Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Thyroid 23:885-91. 2013..To conclude that overdiagnosis is occurring, evidence for an association between access to health care and the incidence of cancer is necessary...
- Targeting immune suppressing myeloid-derived suppressor cells in oncologyJohnny Kao
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, United States
Crit Rev Oncol Hematol 77:12-9. 2011..Since c-kit can be readily inhibited by several small molecule inhibitors including imatinib, sunitinib and dasatinib, targeting immune suppressing cells can be readily accomplished in the clinic...
- Predictors of survival in mucosal melanoma of the head and neckDaniel Jethanamest
Department of Otolaryngology Head and Neck Surgery, New York University School of Medicine, New York, NY, USA
Ann Surg Oncol 18:2748-56. 2011..In order to identify factors predictive of survival, we analyzed MMHN outcomes in a large US cohort...
- Optical imaging with a high-resolution microendoscope to identify cholesteatoma of the middle earLauren L Levy
Department of Otolaryngology Head and Neck Surgery, Mount Sinai School of Medicine, New York, New York 10029, USA
Laryngoscope 123:1016-20. 2013....
- Transoral robotic surgery for the management of oropharyngeal minor salivary gland tumorsNathaniel L Villanueva
Department of Otolaryngology Head and Neck Surgery, Mount Sinai School of Medicine, New York, New York
Head Neck 36:28-33. 2014..In this study we report our preliminary experience with the use of transoral robotic surgery (TORS) for the management of minor salivary gland malignancies of the oropharynx and outcomes...
- T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation- Jianjun Yang
Department of Medicine, Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
J Exp Med 210:1447-62. 2013..These results suggest that NO derived from iNOS in activated T cells plays a negative role in the regulation of T(H)17 cell differentiation and highlight the importance of intrinsic programs for the control of T(H)17 immune responses...
- Transoral robotic resection and reconstruction for head and neck cancerEric M Genden
Mount Sinai School of Medicine, Department of Otolaryngology Head and Neck Surgery, New York, New York 10029, USA
Laryngoscope 121:1668-74. 2011..To evaluate the patterns of failure, survival, and functional outcomes for patients treated with transoral robotic surgery (TORS) and compare these results with those from a cohort of patients treated with concurrent chemoradiation (CRT)...
- Thyroglossal duct cyst carcinoma: case report and review of the literatureDavid W Jang
Department of Otolaryngology Head and Neck Surgery, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1189, New York, NY 10029, USA
Ear Nose Throat J 92:E12-4. 2013..Histologic analysis after a Sistrunk procedure revealed a small focus of papillary carcinoma within the TGDC. The patient subsequently underwent total thyroidectomy with no evidence of carcinoma on histologic examination. ..
- Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in miceChengwen Liu
Department of Melanoma Medical Oncology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
J Clin Invest 118:1165-75. 2008..Our data thus demonstrated that activated pDCs are capable of initiating effective and systemic antitumor immunity through the orchestration of an immune cascade involving the sequential activation of NK cells, cDCs, and CD8(+) T cells...