Wayne G Shreffler

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study population
    James E Gern
    University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    BMC Pulm Med 9:17. 2009
  2. doi request reprint Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein
    Wayne G Shreffler
    Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, New York, NY 10029, USA
    J Allergy Clin Immunol 123:43-52.e7. 2009
  3. pmc Standardization and performance evaluation of mononuclear cell cytokine secretion assays in a multicenter study
    Wayne G Shreffler
    Mount Sinai School of Medicine, Division of Pediatric Allergy and Immunology, New York, NY, USA
    BMC Immunol 7:29. 2006
  4. ncbi request reprint The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro
    Wayne G Shreffler
    Jaffe Food Allergy Institute, Department of Pediatrics, Division of Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 177:3677-85. 2006
  5. ncbi request reprint Evaluation of basophil activation in food allergy: present and future applications
    Wayne G Shreffler
    Mount Sinai School of Medicine, Division of Pediatric Allergy and Immunology, Department of Pediatrics, New York 10029, USA
    Curr Opin Allergy Clin Immunol 6:226-33. 2006
  6. ncbi request reprint IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2
    Wayne G Shreffler
    Jaffe Food Allergy Institute, Department of Pediatrics, Division of Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 116:893-9. 2005
  7. pmc Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy
    Julie Wang
    Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 125:695-702, 702.e1-702.e6. 2010
  8. pmc Development of a novel peptide microarray for large-scale epitope mapping of food allergens
    Jing Lin
    Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 124:315-22, 322.e1-3. 2009
  9. pmc Epinephrine treatment is infrequent and biphasic reactions are rare in food-induced reactions during oral food challenges in children
    Kirsi M Järvinen
    Division of Pediatric Allergy and Immunology and the Jaffe Institute for Food Allergy, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 124:1267-72. 2009
  10. pmc Basophil reactivity, wheal size, and immunoglobulin levels distinguish degrees of cow's milk tolerance
    Lara S Ford
    Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 131:180-6.e1-3. 2013

Research Grants

Collaborators

Detail Information

Publications24

  1. pmc The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study population
    James E Gern
    University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    BMC Pulm Med 9:17. 2009
    ..This paper describes the study design, methods, and population of the Urban Environment and Childhood Asthma (URECA) study, which was established to investigate the immunologic causes of asthma among inner-city children...
  2. doi request reprint Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein
    Wayne G Shreffler
    Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, New York, NY 10029, USA
    J Allergy Clin Immunol 123:43-52.e7. 2009
    ..About 70% of children with milk allergy tolerate extensively heated milk (HM) products and outgrow their allergy earlier than those who react to HM...
  3. pmc Standardization and performance evaluation of mononuclear cell cytokine secretion assays in a multicenter study
    Wayne G Shreffler
    Mount Sinai School of Medicine, Division of Pediatric Allergy and Immunology, New York, NY, USA
    BMC Immunol 7:29. 2006
    ....
  4. ncbi request reprint The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro
    Wayne G Shreffler
    Jaffe Food Allergy Institute, Department of Pediatrics, Division of Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 177:3677-85. 2006
    ..Both PNAg and purified Ara h 1 induced Erk 1/2 phosphorylation of MDDCs, consistent with previous reports on the effect of Th2 adjuvants on DCs...
  5. ncbi request reprint Evaluation of basophil activation in food allergy: present and future applications
    Wayne G Shreffler
    Mount Sinai School of Medicine, Division of Pediatric Allergy and Immunology, Department of Pediatrics, New York 10029, USA
    Curr Opin Allergy Clin Immunol 6:226-33. 2006
    ..Direct and passive basophil activation tests may address these needs. In addition, measuring basophil activation ex vivo may be useful for monitoring patients with food allergies...
  6. ncbi request reprint IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2
    Wayne G Shreffler
    Jaffe Food Allergy Institute, Department of Pediatrics, Division of Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 116:893-9. 2005
    ..Microarray technology offers advantages of scale and parallel design over previous methods of epitope mapping...
  7. pmc Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy
    Julie Wang
    Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 125:695-702, 702.e1-702.e6. 2010
    ..Results from large-scale epitope mapping with a peptide microarray have been shown to correlate with clinical features of milk allergy...
  8. pmc Development of a novel peptide microarray for large-scale epitope mapping of food allergens
    Jing Lin
    Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 124:315-22, 322.e1-3. 2009
    ..The peptide microarray is a novel assay that facilitates high-throughput screening of peptides with a small quantity of sample...
  9. pmc Epinephrine treatment is infrequent and biphasic reactions are rare in food-induced reactions during oral food challenges in children
    Kirsi M Järvinen
    Division of Pediatric Allergy and Immunology and the Jaffe Institute for Food Allergy, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 124:1267-72. 2009
    ..Data about epinephrine use and biphasic reactions in childhood food-induced anaphylaxis during oral food challenges are scarce...
  10. pmc Basophil reactivity, wheal size, and immunoglobulin levels distinguish degrees of cow's milk tolerance
    Lara S Ford
    Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 131:180-6.e1-3. 2013
    ..In our previous study about 75% of children with cow's milk allergy tolerated baked milk products, which improved their prognosis and quality of life...
  11. pmc Clinical efficacy and immune regulation with peanut oral immunotherapy
    Stacie M Jones
    Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children s Hospital, Little Rock, Ark, USA
    J Allergy Clin Immunol 124:292-300, 300.e1-97. 2009
    ..Oral immunotherapy (OIT) has been thought to induce clinical desensitization to allergenic foods, but trials coupling the clinical response and immunologic effects of peanut OIT have not been reported...
  12. doi request reprint Tolerance to extensively heated milk in children with cow's milk allergy
    Anna Nowak-Wegrzyn
    Department of Pediatrics and Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 122:342-7, 347.e1-2. 2008
    ....
  13. pmc Identification of IgE sequential epitopes of lentil (Len c 1) by means of peptide microarray immunoassay
    Andrea Vereda
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 126:596-601.e1. 2010
    ..Lentils are often responsible for allergic reactions to legumes in Mediterranean children. Although the primary sequence of the major allergen Len c 1 is known, the location of the IgE-binding epitopes remains undefined...
  14. doi request reprint Immunologic changes in children with egg allergy ingesting extensively heated egg
    Heather Lemon-Mule
    Department of Pediatrics, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 122:977-983.e1. 2008
    ..Prior studies have suggested that heated egg might be tolerated by some children with egg allergy...
  15. pmc Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy
    Niya Wanich
    Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 123:789-94.e20. 2009
    ..Children with milk allergy who tolerate heat-denatured milk (HM) have less severe reactions and outgrow the condition earlier than those who react to HM, which might be related to differences in IgE-dependent effector cell function...
  16. doi request reprint Microarrayed allergen molecules for diagnostics of allergy
    Jing Lin
    Division of Pediatric Allergy, Mount Sinai School of Medicine, Box 1198, One Gustave L Levy Place, New York, NY 10029, USA
    Methods Mol Biol 524:259-72. 2009
    ....
  17. ncbi request reprint Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes
    Wayne G Shreffler
    Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai Medical Center, Box 1198, One Gustave L Levy Place, New York, NY 10029, USA
    J Allergy Clin Immunol 113:776-82. 2004
    ..Mapping of large numbers of epitopes by using individual patient sera has been impractical with current techniques...
  18. pmc Oral immunotherapy for treatment of egg allergy in children
    A Wesley Burks
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27599 7220, USA
    N Engl J Med 367:233-43. 2012
    ..For egg allergy, dietary avoidance is the only currently approved treatment. We evaluated oral immunotherapy using egg-white powder for the treatment of children with egg allergy...
  19. ncbi request reprint Skin prick test to egg white provides additional diagnostic utility to serum egg white-specific IgE antibody concentration in children
    Adina Kay Knight
    Department of Medicine, Division of Clinical Immunology, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 117:842-7. 2006
    ..OFCs have inherent risks, and diagnostic criteria indicating high likelihood of passing would be clinically useful...
  20. doi request reprint T(H)2 adjuvants: implications for food allergy
    M Cecilia Berin
    Department of Pediatrics, Division of Allergy and Immunology, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 121:1311-20; quiz 1321-2. 2008
    ....
  21. ncbi request reprint Lack of association of HLA class II alleles with peanut allergy
    Wayne G Shreffler
    The Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, New York, USA
    Ann Allergy Asthma Immunol 96:865-9. 2006
    ..Objective: To determine possible genotypic associations of HLA class II with peanut allergy and attempt replication of previously reported associations...
  22. doi request reprint Food allergy and complementary feeding
    Wayne G Shreffler
    Food Allergy Center, Divisions of Allergy and Gastroenterology, Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Nestle Nutr Workshop Ser Pediatr Program 68:141-9; discussion 150-2. 2011
    ..In the meantime, multiple health considerations, not allergy alone, should be involved in decisions regarding nutritional intake, including common allergenic foods, during the period of transition to the family diet...
  23. doi request reprint Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy
    Annebeth E Flinterman
    Department of Dermatology Allergology, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Allergy Clin Immunol 121:737-743.e10. 2008
    ..Better understanding of the relationship between antibody response to peanut and clinical sensitivity might lead to more accurate prognostication...
  24. doi request reprint Mapping of the IgE and IgG4 sequential epitopes of milk allergens with a peptide microarray-based immunoassay
    Inmaculada Cerecedo
    Servicio de Alergologia, Hospital Universitario Ramon y Cajal, Madrid, Spain
    J Allergy Clin Immunol 122:589-94. 2008
    ..Peptide microarray analysis is a novel method that can provide useful information on the nature of specific allergies...

Research Grants3

  1. Mechanisms of peanut (A. hypogaea) glycan adjuvanticity.
    Wayne Shreffler; Fiscal Year: 2007
    ..Better understanding of the mechanisms that contribute to the establishment of allergic responses may eventually be used in novel preventative or therapeutic strategies. ..