Research Topics
Species | Wayne G ShrefflerSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study populationJames E Gern
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
BMC Pulm Med 9:17. 2009..This paper describes the study design, methods, and population of the Urban Environment and Childhood Asthma (URECA) study, which was established to investigate the immunologic causes of asthma among inner-city children...
Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk proteinWayne G Shreffler
Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, New York, NY 10029, USA
J Allergy Clin Immunol 123:43-52.e7. 2009..About 70% of children with milk allergy tolerate extensively heated milk (HM) products and outgrow their allergy earlier than those who react to HM...- Standardization and performance evaluation of mononuclear cell cytokine secretion assays in a multicenter studyWayne G Shreffler
Mount Sinai School of Medicine, Division of Pediatric Allergy and Immunology, New York, NY, USA
BMC Immunol 7:29. 2006.... 
The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitroWayne G Shreffler
Jaffe Food Allergy Institute, Department of Pediatrics, Division of Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA
J Immunol 177:3677-85. 2006..Both PNAg and purified Ara h 1 induced Erk 1/2 phosphorylation of MDDCs, consistent with previous reports on the effect of Th2 adjuvants on DCs...- Evaluation of basophil activation in food allergy: present and future applicationsWayne G Shreffler
Mount Sinai School of Medicine, Division of Pediatric Allergy and Immunology, Department of Pediatrics, New York 10029, USA
Curr Opin Allergy Clin Immunol 6:226-33. 2006..Direct and passive basophil activation tests may address these needs. In addition, measuring basophil activation ex vivo may be useful for monitoring patients with food allergies... - IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2Wayne G Shreffler
Jaffe Food Allergy Institute, Department of Pediatrics, Division of Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA
J Allergy Clin Immunol 116:893-9. 2005..Microarray technology offers advantages of scale and parallel design over previous methods of epitope mapping... - Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergyJulie Wang
Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
J Allergy Clin Immunol 125:695-702, 702.e1-702.e6. 2010..Results from large-scale epitope mapping with a peptide microarray have been shown to correlate with clinical features of milk allergy... - Development of a novel peptide microarray for large-scale epitope mapping of food allergensJing Lin
Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
J Allergy Clin Immunol 124:315-22, 322.e1-3. 2009..The peptide microarray is a novel assay that facilitates high-throughput screening of peptides with a small quantity of sample... - Epinephrine treatment is infrequent and biphasic reactions are rare in food-induced reactions during oral food challenges in childrenKirsi M Järvinen
Division of Pediatric Allergy and Immunology and the Jaffe Institute for Food Allergy, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
J Allergy Clin Immunol 124:1267-72. 2009..Data about epinephrine use and biphasic reactions in childhood food-induced anaphylaxis during oral food challenges are scarce... - Basophil reactivity, wheal size, and immunoglobulin levels distinguish degrees of cow's milk toleranceLara S Ford
Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
J Allergy Clin Immunol 131:180-6.e1-3. 2013..In our previous study about 75% of children with cow's milk allergy tolerated baked milk products, which improved their prognosis and quality of life... - Clinical efficacy and immune regulation with peanut oral immunotherapyStacie M Jones
Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children s Hospital, Little Rock, Ark, USA
J Allergy Clin Immunol 124:292-300, 300.e1-97. 2009..Oral immunotherapy (OIT) has been thought to induce clinical desensitization to allergenic foods, but trials coupling the clinical response and immunologic effects of peanut OIT have not been reported... - Tolerance to extensively heated milk in children with cow's milk allergyAnna Nowak-Wegrzyn
Department of Pediatrics and Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
J Allergy Clin Immunol 122:342-7, 347.e1-2. 2008.... - Identification of IgE sequential epitopes of lentil (Len c 1) by means of peptide microarray immunoassayAndrea Vereda
Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
J Allergy Clin Immunol 126:596-601.e1. 2010..Lentils are often responsible for allergic reactions to legumes in Mediterranean children. Although the primary sequence of the major allergen Len c 1 is known, the location of the IgE-binding epitopes remains undefined... - Immunologic changes in children with egg allergy ingesting extensively heated eggHeather Lemon-Mule
Department of Pediatrics, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
J Allergy Clin Immunol 122:977-983.e1. 2008..Prior studies have suggested that heated egg might be tolerated by some children with egg allergy... - Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergyNiya Wanich
Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
J Allergy Clin Immunol 123:789-94.e20. 2009..Children with milk allergy who tolerate heat-denatured milk (HM) have less severe reactions and outgrow the condition earlier than those who react to HM, which might be related to differences in IgE-dependent effector cell function... - Microarrayed allergen molecules for diagnostics of allergyJing Lin
Division of Pediatric Allergy, Mount Sinai School of Medicine, Box 1198, One Gustave L Levy Place, New York, NY 10029, USA
Methods Mol Biol 524:259-72. 2009.... - Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopesWayne G Shreffler
Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai Medical Center, Box 1198, One Gustave L. Levy Place, New York, NY 10029, USA
J Allergy Clin Immunol 113:776-82. 2004..This qualitative difference in epitope diversity might provide prognostic information about the patient... - Oral immunotherapy for treatment of egg allergy in childrenA Wesley Burks
Department of Pediatrics, Duke University Medical Center, Durham, NC 27599 7220, USA
N Engl J Med 367:233-43. 2012..For egg allergy, dietary avoidance is the only currently approved treatment. We evaluated oral immunotherapy using egg-white powder for the treatment of children with egg allergy... - Skin prick test to egg white provides additional diagnostic utility to serum egg white-specific IgE antibody concentration in childrenAdina Kay Knight
Department of Medicine, Division of Clinical Immunology, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
J Allergy Clin Immunol 117:842-7. 2006..CLINICAL IMPLICATIONS: The size of the egg white SPT wheal response might provide the clinician with additional information to determine the timing of egg OFC in children with low egg white-specific IgE antibody levels... - T(H)2 adjuvants: implications for food allergyM Cecilia Berin
Department of Pediatrics, Division of Allergy and Immunology, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
J Allergy Clin Immunol 121:1311-20; quiz 1321-2. 2008.... - Lack of association of HLA class II alleles with peanut allergyWayne G Shreffler
The Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, New York, USA
Ann Allergy Asthma Immunol 96:865-9. 2006..Objective: To determine possible genotypic associations of HLA class II with peanut allergy and attempt replication of previously reported associations... - Food allergy and complementary feedingWayne G Shreffler
Food Allergy Center, Divisions of Allergy and Gastroenterology, Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Nestle Nutr Workshop Ser Pediatr Program 68:141-9; discussion 150-2. 2011..In the meantime, multiple health considerations, not allergy alone, should be involved in decisions regarding nutritional intake, including common allergenic foods, during the period of transition to the family diet... - Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergyAnnebeth E Flinterman
Department of Dermatology Allergology, University Medical Centre Utrecht, Utrecht, The Netherlands
J Allergy Clin Immunol 121:737-743.e10. 2008..Better understanding of the relationship between antibody response to peanut and clinical sensitivity might lead to more accurate prognostication... - Mapping of the IgE and IgG4 sequential epitopes of milk allergens with a peptide microarray-based immunoassayInmaculada Cerecedo
Servicio de Alergologia, Hospital Universitario Ramon y Cajal, Madrid, Spain
J Allergy Clin Immunol 122:589-94. 2008..Peptide microarray analysis is a novel method that can provide useful information on the nature of specific allergies...
Research Grants
- Mechanisms of peanut (A. hypogaea) glycan adjuvanticity.Wayne Shreffler; Fiscal Year: 2007..Better understanding of the mechanisms that contribute to the establishment of allergic responses may eventually be used in novel preventative or therapeutic strategies. ..