Andrew J Sharp

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. doi Whole genome methylation profiling by immunoprecipitation of methylated DNA
    Andrew J Sharp
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Biol 925:69-78. 2012
  2. pmc Detection of parent-of-origin specific expression quantitative trait loci by cis-association analysis of gene expression in trios
    Paras Garg
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 7:e41695. 2012
  3. pmc Dynamics of DNA methylation in recent human and great ape evolution
    Irene Hernando-Herraez
    Institute of Evolutionary Biology UPF CSIC, PRBB, Barcelona, Spain
    PLoS Genet 9:e1003763. 2013
  4. pmc Methylation profiling in individuals with uniparental disomy identifies novel differentially methylated regions on chromosome 15
    Andrew J Sharp
    Department of Genetic Medicine and Development, University of Geneva, Geneva 1211, Switzerland
    Genome Res 20:1271-8. 2010
  5. pmc DNA methylation profiles of human active and inactive X chromosomes
    Andrew J Sharp
    Department of Genetic Medicine and Development, University of Geneva, 1211 Geneva 4, Switzerland
    Genome Res 21:1592-600. 2011
  6. pmc Rapid multiplexed genotyping of simple tandem repeats using capture and high-throughput sequencing
    Audrey Guilmatre
    Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
    Hum Mutat 34:1304-11. 2013
  7. pmc DNA methylation profiling in X;autosome translocations supports a role for L1 repeats in the spread of X chromosome inactivation
    Neeta Bala Tannan
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, USA
    Hum Mol Genet 23:1224-36. 2014
  8. doi Tandem repeat sequence variation as causative cis-eQTLs for protein-coding gene expression variation: the case of CSTB
    Christelle Borel
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
    Hum Mutat 33:1302-9. 2012
  9. pmc The complex SNP and CNV genetic architecture of the increased risk of congenital heart defects in Down syndrome
    M Reza Sailani
    Department of Genetic Medicine and Development, University of Geneva, Geneva 1211, Switzerland
    Genome Res 23:1410-21. 2013
  10. pmc Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains
    Jimmy L Huynh
    1 Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA 2 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Neurosci 17:121-30. 2014

Collaborators

Detail Information

Publications16

  1. doi Whole genome methylation profiling by immunoprecipitation of methylated DNA
    Andrew J Sharp
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Biol 925:69-78. 2012
    ....
  2. pmc Detection of parent-of-origin specific expression quantitative trait loci by cis-association analysis of gene expression in trios
    Paras Garg
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 7:e41695. 2012
    ..Our method represents a novel approach that can identify imprinted regulatory elements that control gene expression, suggesting novel PofO effects in the human genome...
  3. pmc Dynamics of DNA methylation in recent human and great ape evolution
    Irene Hernando-Herraez
    Institute of Evolutionary Biology UPF CSIC, PRBB, Barcelona, Spain
    PLoS Genet 9:e1003763. 2013
    ..We conclude that epigenetic alterations are an important force during primate evolution and have been under-explored in evolutionary comparative genomics. ..
  4. pmc Methylation profiling in individuals with uniparental disomy identifies novel differentially methylated regions on chromosome 15
    Andrew J Sharp
    Department of Genetic Medicine and Development, University of Geneva, Geneva 1211, Switzerland
    Genome Res 20:1271-8. 2010
    ..Application of this methodology to other chromosomes for which UPD has been reported will allow the systematic identification of imprinted sites throughout the genome...
  5. pmc DNA methylation profiles of human active and inactive X chromosomes
    Andrew J Sharp
    Department of Genetic Medicine and Development, University of Geneva, 1211 Geneva 4, Switzerland
    Genome Res 21:1592-600. 2011
    ..Our study provides a detailed analysis of the epigenetic profile of active and inactive X chromosomes...
  6. pmc Rapid multiplexed genotyping of simple tandem repeats using capture and high-throughput sequencing
    Audrey Guilmatre
    Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
    Hum Mutat 34:1304-11. 2013
    ..Altogether, our STR capture assay represents a cost-effective method that enables multiplexed genotyping of thousands of STR loci suitable for large-scale population studies...
  7. pmc DNA methylation profiling in X;autosome translocations supports a role for L1 repeats in the spread of X chromosome inactivation
    Neeta Bala Tannan
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, USA
    Hum Mol Genet 23:1224-36. 2014
    ..These results are consistent with a potential causal relationship between DNA sequence features such as L1s and the spread of XCI, lending strong support to Mary Lyon's 'repeat hypothesis'. ..
  8. doi Tandem repeat sequence variation as causative cis-eQTLs for protein-coding gene expression variation: the case of CSTB
    Christelle Borel
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
    Hum Mutat 33:1302-9. 2012
    ..More broadly, we propose that polymorphic tandem repeats may represent the causative variation of a fraction of cis-eQTLs in the genome...
  9. pmc The complex SNP and CNV genetic architecture of the increased risk of congenital heart defects in Down syndrome
    M Reza Sailani
    Department of Genetic Medicine and Development, University of Geneva, Geneva 1211, Switzerland
    Genome Res 23:1410-21. 2013
    ..In addition, a yet-unidentified genetic variation in the rest of the genome may contribute to this complex genetic architecture. ..
  10. pmc Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains
    Jimmy L Huynh
    1 Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA 2 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Neurosci 17:121-30. 2014
    ..Thus, epigenomic changes in genes affecting oligodendrocyte susceptibility to damage are detected in pathology-free areas of multiple sclerosis-affected brains. ..
  11. pmc Digital genotyping of macrosatellites and multicopy genes reveals novel biological functions associated with copy number variation of large tandem repeats
    Manisha Brahmachary
    Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
    PLoS Genet 10:e1004418. 2014
    ..We suggest that future studies of tandem repeat loci will lead to many novel insights into their role in modulating both genomic and phenotypic diversity. ..
  12. doi Evaluation of PRDM9 variation as a risk factor for recurrent genomic disorders and chromosomal non-disjunction
    Christelle Borel
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hum Genet 131:1519-24. 2012
    ....
  13. pmc Detection of genomic variation by selection of a 9 mb DNA region and high throughput sequencing
    Sergey I Nikolaev
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
    PLoS ONE 4:e6659. 2009
    ....
  14. pmc Genome-wide analysis of parent-of-origin effects in non-syndromic orofacial clefts
    Paras Garg
    Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Hess Center for Science and Medicine, New York, NY, USA
    Eur J Hum Genet 22:822-30. 2014
    ..5 × 10(-7), paternal-specific P=0.17). Overall, we conclude from this analysis that there are subtle hints of PofO effects in orofacial clefting. ..
  15. doi Emerging themes and new challenges in defining the role of structural variation in human disease
    Andrew J Sharp
    Department of Genetic Medicine and Development, University of Geneva Medical School, University Medical Center CMU, Geneva, Switzerland
    Hum Mutat 30:135-44. 2009
    ....