Stuart Sealfon

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. doi request reprint RNA and DNA microarrays
    Stuart C Sealfon
    Neurology, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Biol 671:3-34. 2011
  2. pmc Functional selectivity in GPCR heterocomplexes
    J Gonzalez-Maeso
    Department Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Mini Rev Med Chem 12:851-5. 2012
  3. pmc Reconstruction of regulatory networks through temporal enrichment profiling and its application to H1N1 influenza viral infection
    Elena Zaslavsky
    Center for Translational Systems Biology and Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    BMC Bioinformatics 14:S1. 2013
  4. pmc β-catenin regulates GnRH-induced FSHβ gene expression
    Qian Wang
    Department of Neurology, Center for Translational Systems Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Endocrinol 27:224-37. 2013
  5. pmc Signaling network of dendritic cells in response to pathogens: a community-input supported knowledgebase
    Sonali Patil
    Center for Translational Systems Biology and Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    BMC Syst Biol 4:137. 2010
  6. pmc BioPP: a tool for web-publication of biological networks
    Ganesh A Viswanathan
    Center for Translational Systems Biology and Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    BMC Bioinformatics 8:168. 2007
  7. pmc Misty Mountain clustering: application to fast unsupervised flow cytometry gating
    ISTVAN P SUGAR
    Department of Neurology and Center for Translational Systems Biology, Mount Sinai School of Medicine, New York, NY, USA
    BMC Bioinformatics 11:502. 2010
  8. ncbi request reprint Teaching resources. G-protein-coupled receptors
    Stuart C Sealfon
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci STKE 2005:tr11. 2005
  9. pmc Coregulation mapping based on individual phenotypic variation in response to virus infection
    German Nudelman
    Center for Translational Systems Biology and Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunome Res 6:2. 2010
  10. ncbi request reprint Agonist-trafficking and hallucinogens
    Javier Gonzalez-Maeso
    Departments of Psychiatry, Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Med Chem 16:1017-27. 2009

Research Grants

  1. Interdisciplinary Training in Drug Abuse Research
    Stuart Sealfon; Fiscal Year: 2006
  2. GnRH Receptor Signaling Specificity
    Stuart Sealfon; Fiscal Year: 2005
  3. MOLECULAR MECHANISM OF AGONISM AT THE GNRH RECEPTOR
    Stuart Sealfon; Fiscal Year: 2000
  4. GnRH Receptor Signaling Specificity
    Stuart C Sealfon; Fiscal Year: 2010

Collaborators

Detail Information

Publications52

  1. doi request reprint RNA and DNA microarrays
    Stuart C Sealfon
    Neurology, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Biol 671:3-34. 2011
    ..This chapter provides an overview of the methodology and applications of RNA and DNA microarrays in various areas of biological research...
  2. pmc Functional selectivity in GPCR heterocomplexes
    J Gonzalez-Maeso
    Department Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Mini Rev Med Chem 12:851-5. 2012
    ..Recent studies implicate these complexes in the responses to some therapeutic drugs and drugs of abuse, and raise the possibility that they may be involved in mediating functional selectivity...
  3. pmc Reconstruction of regulatory networks through temporal enrichment profiling and its application to H1N1 influenza viral infection
    Elena Zaslavsky
    Center for Translational Systems Biology and Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    BMC Bioinformatics 14:S1. 2013
    ..Identifying the underlying transcriptional network driving these changes, and how this program is altered by virally-encoded immune antagonists, is a fundamental challenge in systems immunology...
  4. pmc β-catenin regulates GnRH-induced FSHβ gene expression
    Qian Wang
    Department of Neurology, Center for Translational Systems Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Endocrinol 27:224-37. 2013
    ..Furthermore, knockdown of Brms1L significantly attenuated GnRH-induced FSHβ expression. Thus, our findings indicate that the expression of Brms1L depends on β-catenin activity and contributes to FSHβ induction by GnRH...
  5. pmc Signaling network of dendritic cells in response to pathogens: a community-input supported knowledgebase
    Sonali Patil
    Center for Translational Systems Biology and Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    BMC Syst Biol 4:137. 2010
    ..Current pathway diagrams lack either comprehensiveness, or an open-access editorial interface. Hence, there is a need for a dependable, expertly curated knowledgebase that integrates this information into a map of signaling networks...
  6. pmc BioPP: a tool for web-publication of biological networks
    Ganesh A Viswanathan
    Center for Translational Systems Biology and Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    BMC Bioinformatics 8:168. 2007
    ..The BioPP suite is available for private use and for depositing knowledge-bases into a newly created public repository...
  7. pmc Misty Mountain clustering: application to fast unsupervised flow cytometry gating
    ISTVAN P SUGAR
    Department of Neurology and Center for Translational Systems Biology, Mount Sinai School of Medicine, New York, NY, USA
    BMC Bioinformatics 11:502. 2010
    ..Various unsupervised heuristic approaches that have been developed such as affinity propagation are too expensive to be applied to datasets on the order of 106 points that are often generated by high throughput experiments...
  8. ncbi request reprint Teaching resources. G-protein-coupled receptors
    Stuart C Sealfon
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci STKE 2005:tr11. 2005
    ..quot; The lecture begins with a discussion of the major classes of GPCRs and then proceeds to describe the mechanisms of receptor diversity, ligand interaction, desensitization, coupling, and mutations associated with human diseases...
  9. pmc Coregulation mapping based on individual phenotypic variation in response to virus infection
    German Nudelman
    Center for Translational Systems Biology and Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunome Res 6:2. 2010
    ..CONCLUSIONS: MDS mapping based on correlation in conjunction with TF enrichment analysis represents a useful computational method to generate predictions underlying gene coregulation across a population...
  10. ncbi request reprint Agonist-trafficking and hallucinogens
    Javier Gonzalez-Maeso
    Departments of Psychiatry, Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Med Chem 16:1017-27. 2009
    ..In this review, we summarize the current knowledge, as well as unresolved questions, regarding agonist-trafficking and the mechanism of action of hallucinogenic drugs...
  11. ncbi request reprint p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition
    Venugopalan D Nair
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 281:39550-60. 2006
    ..These results suggest that abnormalities in p53 signaling play a role in dopaminergic cell death induced by proteasome inhibition and may be relevant to neurodegeneration in PD...
  12. ncbi request reprint Chronic exposure to TNF-alpha increases airway mucus gene expression in vivo
    Paula J Busse
    Division of Clinical Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 116:1256-63. 2005
    ..TNF-alpha increases the expression of these genes in vitro but has not been investigated in vivo...
  13. doi request reprint Multiple testing and its applications to microarrays
    Yongchao Ge
    Department of Neurology and Center for Translational Systems Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Stat Methods Med Res 18:543-63. 2009
    ..The advantages and disadvantages of these methods are discussed. These methods are applied to gene expression data from two microarray studies and the properties of these multiple testing procedures are compared...
  14. pmc Identification of a serotonin/glutamate receptor complex implicated in psychosis
    Javier Gonzalez-Maeso
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 452:93-7. 2008
    ..These regulatory changes indicate that the 2AR-mGluR2 complex may be involved in the altered cortical processes of schizophrenia, and this complex is therefore a promising new target for the treatment of psychosis...
  15. ncbi request reprint Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression
    Charles V Mobbs
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Neurochem Res 29:1093-103. 2004
    ....
  16. doi request reprint Validation of efficient high-throughput plasmid and siRNA transfection of human monocyte-derived dendritic cells without cell maturation
    Robert Bowles
    Center for Translational Systems Biology and Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Immunol Methods 363:21-8. 2010
    ..RIG-I knockdown caused a 75% reduction in the induction of IFNβ mRNA compared with the negative control siRNA. This protocol should be a valuable tool for probing the immune response pathways activated in human DCs...
  17. ncbi request reprint Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex
    Javier Gonzalez-Maeso
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 23:8836-43. 2003
    ..Our results demonstrate that chemicals acting at the 5-HT2AR induce specific cellular response patterns in vivo that are reflected in unique changes in the somatosensory cortex transcriptome...
  18. pmc Antiviral response dictated by choreographed cascade of transcription factors
    Elena Zaslavsky
    Center for Translational Systems Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 184:2908-17. 2010
    ..More generally, our results show how a genetic program can be temporally controlled through a single regulatory network to achieve the large-scale genetic reprogramming characteristic of cell-state transitions...
  19. ncbi request reprint Acute induction of gene expression in brain and liver by insulin-induced hypoglycemia
    Jason W Mastaitis
    Fishberg Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Diabetes 54:952-8. 2005
    ....
  20. ncbi request reprint Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations
    Cassandra Prioleau
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 277:36577-84. 2002
    ..These results suggest that Y7.53 and Y7.60 contribute to a common functional microdomain connecting helices 7 and 8 that influences the switching of the 5HT2C receptor among multiple active and inactive conformations...
  21. ncbi request reprint Antiviral-activated dendritic cells: a paracrine-induced response state
    Antonio V Borderia
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
    J Immunol 181:6872-81. 2008
    ..Although further in vivo study is needed, the characteristics of the AVDC suggest that it is well suited to play a role in the early innate-adaptive transition of the immune system...
  22. ncbi request reprint Validated genomic approach to study differentially expressed genes in complex tissues
    Elisa Wurmbach
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurochem Res 27:1027-33. 2002
    ....
  23. ncbi request reprint Monitoring G-protein-coupled receptor signaling with DNA microarrays and real-time polymerase chain reaction
    Tony Yuen
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Methods Enzymol 345:556-69. 2002
  24. doi request reprint Psychedelics and schizophrenia
    Javier Gonzalez-Maeso
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Trends Neurosci 32:225-32. 2009
    ..Recent results on the receptor, signalling and circuit mechanisms underlying the response to psychedelic and antipsychotic drugs might lead to unification of the serotonin and glutamate neurochemical hypotheses of schizophrenia...
  25. doi request reprint A comprehensive evaluation of human plasmacytoid dendritic cells using small volumes of human blood
    Hannah Phipps-Yonas
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
    J Interferon Cytokine Res 28:501-7. 2008
    ..In addition, we have used multiplex enzyme-linked immunosorbent assays to measure secreted proteins. We demonstrate the validity of this technique and document its potential for use with blood from human study populations...
  26. pmc Getting started in biological pathway construction and analysis
    Ganesh A Viswanathan
    Center for Translational Systems Biology and Department of Neurology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Comput Biol 4:e16. 2008
  27. ncbi request reprint Agonist-specific transactivation of phosphoinositide 3-kinase signaling pathway mediated by the dopamine D2 receptor
    Venugopalan D Nair
    Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Biol Chem 278:47053-61. 2003
    ..These results support the hypothesis that specific dopamine agonists stabilize distinct conformations of the D2 receptor that differ in their coupling to G-proteins and to a cytoprotective c-Src/EGFR-mediated PI-3 kinase/Akt pathway...
  28. pmc Chromosome-specific and noisy IFNB1 transcription in individual virus-infected human primary dendritic cells
    Jianzhong Hu
    Department of Microbiology, Mount Sinai School of Medicine, New York 10029, USA
    Nucleic Acids Res 35:5232-41. 2007
    ....
  29. pmc Influenza virus evades innate and adaptive immunity via the NS1 protein
    Ana Fernandez-Sesma
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Virol 80:6295-304. 2006
    ..Our observations also support the potential use of NS1 mutant influenza viruses as live attenuated influenza virus vaccines...
  30. pmc Accuracy and calibration of commercial oligonucleotide and custom cDNA microarrays
    Tony Yuen
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nucleic Acids Res 30:e48. 2002
    ..Our study demonstrates systematic bias of microarray measurements and identifies a calibration function that improves the accuracy of cDNA array data...
  31. ncbi request reprint Epsilon-sarcoglycan immunoreactivity and mRNA expression in mouse brain
    Pokman Chan
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Comp Neurol 482:50-73. 2005
    ..The distribution of epsilon-sarcoglycan in the mouse brain suggests that the symptom complex of M-D may be related to the effects of decreased epsilon-sarcoglycan activity on the development or function of monoaminergic neurons...
  32. pmc Plato's cave algorithm: inferring functional signaling networks from early gene expression shadows
    Yishai Shimoni
    Department of Neurology and Center for Translational Systems Biology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Comput Biol 6:e1000828. 2010
    ..PLACA uses the results of experiments that are feasible for any signaling network to predict the functional topology of the network and to identify novel relationships...
  33. ncbi request reprint Early single cell bifurcation of pro- and antiapoptotic states during oxidative stress
    Venugopalan D Nair
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 279:27494-501. 2004
    ..These studies suggest that the individual cell rapidly and stochastically processes the oxidative stress stimulus, leading to an all-or-none cytoprotective or pro-apoptotic signaling response...
  34. pmc Noise propagation and scaling in regulation of gonadotrope biosynthesis
    Frederique Ruf
    Department of Neurology, Mount Sinai School of Medicine, New York, New York, USA
    Biophys J 93:4474-80. 2007
    ..These results explain the basis for variation in cellular responses in an important mammalian signaling pathway leading to gene induction...
  35. ncbi request reprint Focused microarray analysis
    Elisa Wurmbach
    Department of Neurology, Mount Sinai School of Medicine, Box 1137, 1 Gustave L Levy Place, New York, NY 10029, USA
    Methods 31:306-16. 2003
    ..3-fold differences in transcript expression between RNA samples from treatment- and control groups and was applicable to highly heterogenous tissue sources such as hypothalamus and cerebral cortex...
  36. ncbi request reprint Structure of the GnRH receptor-stimulated signaling network: insights from genomics
    Frederique Ruf
    Department of Neurology, Box 1137, Mount Sinai School of Medicine, New York, NY 10029, USA
    Front Neuroendocrinol 24:181-99. 2003
    ..We propose that information transfer in the gonadotrope depends on robust signaling modules that serve to integrate events at different time scales across cytoplasmic and nuclear compartments...
  37. ncbi request reprint Coupling of GnRH concentration and the GnRH receptor-activated gene program
    Tony Yuen
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Endocrinol 16:1145-53. 2002
    ....
  38. pmc Immune response modeling of interferon beta-pretreated influenza virus-infected human dendritic cells
    Liang Qiao
    Department of Neurology, Mount Sinai School of Medicine, New York, New York, USA
    Biophys J 98:505-14. 2010
    ....
  39. pmc Interferon-beta pretreatment of conventional and plasmacytoid human dendritic cells enhances their activation by influenza virus
    Hannah Phipps-Yonas
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
    PLoS Pathog 4:e1000193. 2008
    ..This strongly suggests that type I IFN functions not only to reduce viral replication in these immune cells, but also to promote greater DC activation during influenza virus infections...
  40. pmc Group II metabotropic glutamate receptors and schizophrenia
    Jose L Moreno
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Mol Life Sci 66:3777-85. 2009
    ..This paper reviews the status of general knowledge of mGluR2 and mGluR3 in the psychopharmacology, genetics and neuropathology of schizophrenia...
  41. ncbi request reprint Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior
    Javier Gonzalez-Maeso
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuron 53:439-52. 2007
    ..These studies identify the long-elusive neural and signaling mechanisms responsible for the unique effects of hallucinogens...
  42. pmc Characterization of a MAPK scaffolding protein logic gate in gonadotropes
    Soon Gang Choi
    Center for Translational Systems Biology and Department of Neurology, Mount Sinai School of Medicine, Annenberg 14 94, Box 1137, One Gustave L Levy Place, New York, New York 10029, USA
    Mol Endocrinol 25:1027-39. 2011
    ..We propose that PEA-15 represents a novel point of convergence of the PKC and MAPK/ERK pathways under GnRH stimulation. PKC, ERK, and PEA-15 form an AND logic gate that shapes the response of the gonadotrope cell to GnRH...
  43. pmc Activation of phosphoinositide 3-kinase by D2 receptor prevents apoptosis in dopaminergic cell lines
    Venugopalan D Nair
    Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Biochem J 373:25-32. 2003
    ..These studies indicate that certain dopamine agonists can complex with D(2) receptors to preferentially transactivate neuroprotective signalling pathways and to mediate increased cell survival...
  44. ncbi request reprint Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation
    Panayiotis Tsokas
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 25:5833-43. 2005
    ..These results suggest a mechanism whereby synaptic stimulation, by signaling through the mTOR pathway, produces an increase in dendritic translational capacity that contributes to LTP maintenance...
  45. ncbi request reprint Mixed analog/digital gonadotrope biosynthetic response to gonadotropin-releasing hormone
    Frederique Ruf
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 281:30967-78. 2006
    ..The hybrid response mechanism improves the reliability of noisy reproductive signal transmission from the brain to the pituitary...
  46. pmc Novel Nipah virus immune-antagonism strategy revealed by experimental and computational study
    Jeremy Seto
    Center for Translational Systems Biology, Department of Neurology, Mount Sinai School of Medicine, 1 Gustave Levy Place, Box 1137, Annenberg Building 14 94B, Box 1137, New York, NY 10029, USA
    J Virol 84:10965-73. 2010
    ..These results suggest that Nipah virus has evolved a unique immune-antagonist strategy that benefits from controlled expression of multiple antagonist proteins with various potencies...
  47. pmc Research resource: Gonadotropin-releasing hormone receptor-mediated signaling network in LbetaT2 cells: a pathway-based web-accessible knowledgebase
    Marc Y Fink
    Center for Translational Systems Biology and Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Endocrinol 24:1863-71. 2010
    ..The GnRHR-signaling network is openly accessible at http://tsb.mssm.edu/pathwayPublisher/GnRHR_Pathway/GnRHR_Pathway_ index.html...
  48. ncbi request reprint Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice
    Noelia V Weisstaub
    Department of Biology, Columbia University and the New York State Psychiatric Institute, New York, NY 10032, USA
    Science 313:536-40. 2006
    ..These findings indicate a specific role for cortical 5HT2AR function in the modulation of conflict anxiety, consistent with models of cortical, "top-down" influences on risk assessment...
  49. pmc Microtranscriptome regulation by gonadotropin-releasing hormone
    Tony Yuen
    Department of Neurology, Mount Sinai School of Medicine, New York, NY, United States
    Mol Cell Endocrinol 302:12-7. 2009
    ..These findings suggest the importance of the microtranscriptome in gene control in the gonadotrope and implicate miR-132 and miR-212 in the regulation of GnRH-stimulated biosynthetic response...
  50. pmc Receptor pair for schizophrenia
    Stuart C Sealfon
    Pediatr Res 64:1. 2008
  51. ncbi request reprint Bone morphogenetic protein 2 and activin A synergistically stimulate follicle-stimulating hormone beta subunit transcription
    Katharine B Lee
    Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6
    J Mol Endocrinol 38:315-30. 2007
    ..Because BMP2 is expressed in the adult mouse pituitary, it may act as critical paracrine co-regulator of FSH synthesis by gonadotropes...
  52. ncbi request reprint CXC chemokine receptors on human oligodendrocytes: implications for multiple sclerosis
    Kakuri M Omari
    Department of Pathology Neuropathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, F 140, Bronx, NY 10461, USA
    Brain 128:1003-15. 2005
    ....

Research Grants15

  1. Interdisciplinary Training in Drug Abuse Research
    Stuart Sealfon; Fiscal Year: 2006
    ..The institution provides a fertile environment for this training program as well as specific resources to enhance this important educational endeavor. ..
  2. GnRH Receptor Signaling Specificity
    Stuart Sealfon; Fiscal Year: 2005
    ..These parallel investigations are highly synergistic and may result in fundamental new insight into the mechanisms underlying signaling specificity of the GnRHR system. ..
  3. MOLECULAR MECHANISM OF AGONISM AT THE GNRH RECEPTOR
    Stuart Sealfon; Fiscal Year: 2000
    ..Al these interrelated investigations seek novel insight into the molecular mechanisms underlying the action of GnRH analogs and can provide the basis for the rational design of novel therapeutic approaches to modulate receptor activity. ..
  4. GnRH Receptor Signaling Specificity
    Stuart C Sealfon; Fiscal Year: 2010
    ..The goal of this research is to generate detailed datasets and predictive models of these cells to help improve the treatment of these conditions. ..