Avner Schlessinger

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. doi request reprint SLC classification: an update
    A Schlessinger
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA
    Clin Pharmacol Ther 94:19-23. 2013
  2. ncbi request reprint Molecular modeling and ligand docking for solute carrier (SLC) transporters
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, 1700 4th Street, San Francisco, CA 94158, USA
    Curr Top Med Chem 13:843-56. 2013
  3. pmc Structural basis for alternating access of a eukaryotic calcium/proton exchanger
    Andrew B Waight
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA
    Nature 499:107-10. 2013
  4. pmc High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA
    J Biol Chem 287:37745-56. 2012
  5. pmc Ligand discovery from a dopamine D3 receptor homology model and crystal structure
    Jens Carlsson
    Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA
    Nat Chem Biol 7:769-78. 2011
  6. pmc Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1
    Ethan G Geier
    Departments of Bioengineering and Therapeutic Sciences and Pharmaceutical Chemistry, California Institute for Quantitative Biosciences, and Graduate Group in Biophysics, University of California, San Francisco, CA 94158
    Proc Natl Acad Sci U S A 110:5480-5. 2013
  7. pmc Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, and California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:15810-5. 2011
  8. pmc Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function
    Ligong Chen
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA
    J Pharmacol Exp Ther 335:42-50. 2010
  9. pmc Crystal structure of a eukaryotic phosphate transporter
    Bjørn P Pedersen
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA
    Nature 496:533-6. 2013
  10. pmc ModBase, a database of annotated comparative protein structure models, and associated resources
    Ursula Pieper
    Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences, University of California at San Francisco, CA 94158, USA
    Nucleic Acids Res 39:D465-74. 2011

Collaborators

Detail Information

Publications15

  1. doi request reprint SLC classification: an update
    A Schlessinger
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA
    Clin Pharmacol Ther 94:19-23. 2013
    ..Here, we comprehensively compare the SLC sequences and structures and discuss the applicability of structure-based ligand discovery to key SLC members...
  2. ncbi request reprint Molecular modeling and ligand docking for solute carrier (SLC) transporters
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, 1700 4th Street, San Francisco, CA 94158, USA
    Curr Top Med Chem 13:843-56. 2013
    ..We conclude by discussing future directions in the discovery of the SLC transporter ligands...
  3. pmc Structural basis for alternating access of a eukaryotic calcium/proton exchanger
    Andrew B Waight
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA
    Nature 499:107-10. 2013
    ....
  4. pmc High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA
    J Biol Chem 287:37745-56. 2012
    ..Our combined approach may be useful for characterizing interactions between small molecules and other membrane proteins, as well as for describing substrate specificities in other protein families...
  5. pmc Ligand discovery from a dopamine D3 receptor homology model and crystal structure
    Jens Carlsson
    Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA
    Nat Chem Biol 7:769-78. 2011
    ..3 to 3.0 μM. One of the new ligands from the homology model screen was optimized for affinity to 81 nM. The feasibility of docking screens against modeled GPCRs more generally is considered...
  6. pmc Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1
    Ethan G Geier
    Departments of Bioengineering and Therapeutic Sciences and Pharmaceutical Chemistry, California Institute for Quantitative Biosciences, and Graduate Group in Biophysics, University of California, San Francisco, CA 94158
    Proc Natl Acad Sci U S A 110:5480-5. 2013
    ..Finally, two of our hits inhibited proliferation of a cancer cell line by distinct mechanisms, providing useful chemical tools to characterize the role of LAT-1 in cancer metabolism...
  7. pmc Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, and California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:15810-5. 2011
    ..The observations highlight the utility of virtual screening against a comparative model, even when the target shares less than 30% sequence identity with its template structure and no known ligands in the primary binding site...
  8. pmc Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function
    Ligong Chen
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA
    J Pharmacol Exp Ther 335:42-50. 2010
    ..This study suggests that nonsynonymous variants of OCT1 in Chinese and Japanese populations may affect the differential response to metformin...
  9. pmc Crystal structure of a eukaryotic phosphate transporter
    Bjørn P Pedersen
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA
    Nature 496:533-6. 2013
    ..The PiPT structure demonstrates and expands on principles of substrate transport by the MFS transporters and illuminates principles of phosphate uptake in particular...
  10. pmc ModBase, a database of annotated comparative protein structure models, and associated resources
    Ursula Pieper
    Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences, University of California at San Francisco, CA 94158, USA
    Nucleic Acids Res 39:D465-74. 2011
    ..org/modeval), the PCSS server for predicting which peptides bind to a given protein (http://salilab.org/pcss) and the FoXS server for calculating and fitting Small Angle X-ray Scattering profiles (http://salilab.org/foxs)...
  11. pmc Function of human Rh based on structure of RhCG at 2.1 A
    Franz Gruswitz
    Department of Biochemistry and Biophysics, S412C Genentech Hall, Center for the Structure of Membrane Proteins, and Membrane Protein Expression Center, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 107:9638-43. 2010
    ..Models of the erythrocyte Rh complex based on our RhCG structure suggest that the erythrocytic Rh complex is composed of stochastically assembled heterotrimers of RhAG, RhD, and RhCE...
  12. doi request reprint Protein disorder--a breakthrough invention of evolution?
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, and California Institute for Quantitative Biosciences, University of California San Francisco, CA, USA
    Curr Opin Struct Biol 21:412-8. 2011
    ..We need new advanced computational methods to study this new milestone in the advance of protein biology...
  13. pmc Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin
    Ligong Chen
    Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, San Francisco, California 94158, USA
    Pharmacogenet Genomics 20:687-99. 2010
    ....
  14. pmc Comparison of human solute carriers
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, University of California, San Francisco, California
    Protein Sci 19:412-28. 2010
    ..The classification scheme will inform future attempts directed at modeling the structures of the solute carriers, a prerequisite for describing the substrate specificities of the individual families...
  15. pmc Integrative structure modeling of macromolecular assemblies from proteomics data
    Keren Lasker
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA
    Mol Cell Proteomics 9:1689-702. 2010
    ..Correspondingly, integrative computational methods are being developed to provide descriptions of protein complexes at varying levels of accuracy and resolution, ranging from complex compositions to detailed atomic structures...