Avner Schlessinger

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint Determinants of Substrate and Cation Transport in the Human Na+/Dicarboxylate Cotransporter NaDC3
    Avner Schlessinger
    From the Department of Pharmacology and Systems Therapeutics, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029 and
    J Biol Chem 289:16998-7008. 2014
  2. pmc SLC classification: an update
    A Schlessinger
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA
    Clin Pharmacol Ther 94:19-23. 2013
  3. pmc Molecular modeling and ligand docking for solute carrier (SLC) transporters
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, 1700 4th Street, San Francisco, CA 94158, USA
    Curr Top Med Chem 13:843-56. 2013
  4. pmc Structural basis for alternating access of a eukaryotic calcium/proton exchanger
    Andrew B Waight
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA
    Nature 499:107-10. 2013
  5. pmc High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA
    J Biol Chem 287:37745-56. 2012
  6. pmc Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, and California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:15810-5. 2011
  7. pmc Ligand discovery from a dopamine D3 receptor homology model and crystal structure
    Jens Carlsson
    Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA
    Nat Chem Biol 7:769-78. 2011
  8. ncbi request reprint Natively unstructured regions in proteins identified from contact predictions
    Avner Schlessinger
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA
    Bioinformatics 23:2376-84. 2007
  9. pmc ModBase, a database of annotated comparative protein structure models, and associated resources
    Ursula Pieper
    Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences, University of California at San Francisco, CA 94158, USA
    Nucleic Acids Res 39:D465-74. 2011
  10. pmc Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function
    Ligong Chen
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA
    J Pharmacol Exp Ther 335:42-50. 2010

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Determinants of Substrate and Cation Transport in the Human Na+/Dicarboxylate Cotransporter NaDC3
    Avner Schlessinger
    From the Department of Pharmacology and Systems Therapeutics, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029 and
    J Biol Chem 289:16998-7008. 2014
    ..The structural model of NaDC3 provides a framework for understanding substrate selectivity and the Na(+)-coupled anion transport mechanism by the human SLC13 family and other key solute carrier transporters. ..
  2. pmc SLC classification: an update
    A Schlessinger
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA
    Clin Pharmacol Ther 94:19-23. 2013
    ..Here, we comprehensively compare the SLC sequences and structures and discuss the applicability of structure-based ligand discovery to key SLC members...
  3. pmc Molecular modeling and ligand docking for solute carrier (SLC) transporters
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, 1700 4th Street, San Francisco, CA 94158, USA
    Curr Top Med Chem 13:843-56. 2013
    ..We conclude by discussing future directions in the discovery of the SLC transporter ligands...
  4. pmc Structural basis for alternating access of a eukaryotic calcium/proton exchanger
    Andrew B Waight
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA
    Nature 499:107-10. 2013
    ....
  5. pmc High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA
    J Biol Chem 287:37745-56. 2012
    ..Our combined approach may be useful for characterizing interactions between small molecules and other membrane proteins, as well as for describing substrate specificities in other protein families...
  6. pmc Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, and California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:15810-5. 2011
    ..The observations highlight the utility of virtual screening against a comparative model, even when the target shares less than 30% sequence identity with its template structure and no known ligands in the primary binding site...
  7. pmc Ligand discovery from a dopamine D3 receptor homology model and crystal structure
    Jens Carlsson
    Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA
    Nat Chem Biol 7:769-78. 2011
    ..3 to 3.0 μM. One of the new ligands from the homology model screen was optimized for affinity to 81 nM. The feasibility of docking screens against modeled GPCRs more generally is considered...
  8. ncbi request reprint Natively unstructured regions in proteins identified from contact predictions
    Avner Schlessinger
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA
    Bioinformatics 23:2376-84. 2007
    ..Low propensity for the formation of internal residue contacts has been previously used to predict natively unstructured regions...
  9. pmc ModBase, a database of annotated comparative protein structure models, and associated resources
    Ursula Pieper
    Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences, University of California at San Francisco, CA 94158, USA
    Nucleic Acids Res 39:D465-74. 2011
    ..org/modeval), the PCSS server for predicting which peptides bind to a given protein (http://salilab.org/pcss) and the FoXS server for calculating and fitting Small Angle X-ray Scattering profiles (http://salilab.org/foxs)...
  10. pmc Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function
    Ligong Chen
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA
    J Pharmacol Exp Ther 335:42-50. 2010
    ..This study suggests that nonsynonymous variants of OCT1 in Chinese and Japanese populations may affect the differential response to metformin...
  11. pmc Protein secondary structure appears to be robust under in silico evolution while protein disorder appears not to be
    Christian Schaefer
    Department of Biochemistry and Molecular Biophysics, Center for Computational Biology and Bioinformatics C2B2, Columbia University, 1130 St Nicholas Ave, New York, NY 10032, USA
    Bioinformatics 26:625-31. 2010
    ....
  12. pmc Improved disorder prediction by combination of orthogonal approaches
    Avner Schlessinger
    CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America
    PLoS ONE 4:e4433. 2009
    ..In sustained cross-validation, MD not only outperforms its origins, but it also compares favorably to other state-of-the-art prediction methods in a variety of tests that we applied...
  13. pmc Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1
    Ethan G Geier
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 110:5480-5. 2013
    ..Finally, two of our hits inhibited proliferation of a cancer cell line by distinct mechanisms, providing useful chemical tools to characterize the role of LAT-1 in cancer metabolism...
  14. doi request reprint Protein disorder--a breakthrough invention of evolution?
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, and California Institute for Quantitative Biosciences, University of California San Francisco, CA, USA
    Curr Opin Struct Biol 21:412-8. 2011
    ..We need new advanced computational methods to study this new milestone in the advance of protein biology...
  15. pmc Function of human Rh based on structure of RhCG at 2.1 A
    Franz Gruswitz
    Department of Biochemistry and Biophysics, S412C Genentech Hall, Center for the Structure of Membrane Proteins, and Membrane Protein Expression Center, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 107:9638-43. 2010
    ..Models of the erythrocyte Rh complex based on our RhCG structure suggest that the erythrocytic Rh complex is composed of stochastically assembled heterotrimers of RhAG, RhD, and RhCE...
  16. pmc Comparison of human solute carriers
    Avner Schlessinger
    Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, University of California, San Francisco, California
    Protein Sci 19:412-28. 2010
    ..The classification scheme will inform future attempts directed at modeling the structures of the solute carriers, a prerequisite for describing the substrate specificities of the individual families...
  17. pmc Crystal structure of a eukaryotic phosphate transporter
    Bjørn P Pedersen
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA
    Nature 496:533-6. 2013
    ..The PiPT structure demonstrates and expands on principles of substrate transport by the MFS transporters and illuminates principles of phosphate uptake in particular...
  18. pmc Natively unstructured loops differ from other loops
    Avner Schlessinger
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, USA
    PLoS Comput Biol 3:e140. 2007
    ..The comparative analysis between NORSnet and DISOPRED2 suggested that long unstructured loops are a major part of unstructured regions in molecular networks...
  19. pmc Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin
    Ligong Chen
    Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, San Francisco, California 94158, USA
    Pharmacogenet Genomics 20:687-99. 2010
    ....
  20. ncbi request reprint PROFbval: predict flexible and rigid residues in proteins
    Avner Schlessinger
    CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street BB217, New York, NY 10032, USA
    Bioinformatics 22:891-3. 2006
    ..The server also assigns a reliability index for each prediction. For example, PROFbval correctly identifies residues in active sites on the surface of enzymes as particularly rigid...
  21. pmc Integrative structure modeling of macromolecular assemblies from proteomics data
    Keren Lasker
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA
    Mol Cell Proteomics 9:1689-702. 2010
    ..Correspondingly, integrative computational methods are being developed to provide descriptions of protein complexes at varying levels of accuracy and resolution, ranging from complex compositions to detailed atomic structures...