Affiliation: Mount Sinai School of Medicine
- Chemokine receptors in vascular smooth muscleAlison D Schecter
The Zena and Michael A Wiener Cardiovascular Institute, New York, NY 14642, USA
Microcirculation 10:265-72. 2003..It is likely that SMC are increasingly recognized as potential targets for chemokines, and that these effects may influence a variety of normal and pathological processes involving SMC such as atherosclerosis and arterial injury...
- MCP-1-dependent signaling in CCR2(-/-) aortic smooth muscle cellsAlison D Schecter
The Cardiovascular Institute, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
J Leukoc Biol 75:1079-85. 2004..This alternative receptor may be important in mediating some of the effects of MCP-1 in atherosclerotic arteries and in other inflammatory processes...
- CCL11 (Eotaxin) induces CCR3-dependent smooth muscle cell migrationRavindra B Kodali
Zena and Michael A Wiener Cardiovascular Institute and Department of Medicine, The Mount Sinai School of Medicine, New York, NY, USA
Arterioscler Thromb Vasc Biol 24:1211-6. 2004..The major receptor for CCL11 is CCR3, which is found on leukocytes and on some nonleukocytic cells. We sought to determine whether vascular smooth muscle cells (SMCs) possessed functional CCR3...
- CXCR4 modulates contractility in adult cardiac myocytesRobert T Pyo
Zena and Michael A Wiener Cardiovascular Institute, The Mount Sinai School of Medicine, New York, NY 10029, USA
J Mol Cell Cardiol 41:834-44. 2006..The specific mechanism of action involves alterations of calcium channel activity on the membrane. The presence of functional CXCR4 on cardiac myocytes introduces a new target for treating cardiac dysfunction...
- Ambient air particulate matter exposure and tissue factor expression in atherosclerosisQinghua Sun
Division of Environmental Health Sciences, The Ohio State University, Columbus, Ohio, USA
Inhal Toxicol 20:127-37. 2008..TF mRNA expression increased rapidly (within 1 h) in response to SRM PM. We conclude that in vivo and in vitro exposure to ambient air PM(2.5) induces TF expression...
- Human immunodeficiency virus (HIV) infects human arterial smooth muscle cells in vivo and in vitro: implications for the pathogenesis of HIV-mediated vascular diseaseEliseo A Eugenin
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
Am J Pathol 172:1100-11. 2008..Our data suggest that direct infection of human arterial SMCs by HIV represents a potential mechanism in a multifactorial paradigm to explain the exacerbated atherosclerosis and vasculopathy reported in individuals infected with HIV...
- MCP-1, TISSUE FACTOR, AND VASCULAR SMOOTH MUSCLEALISON SCHECTER; Fiscal Year: 2002..The receptor will be expressed in COS cells to study the properties of the new receptor in mammalian cells and, in particular, to examine its coupling to TF induction. ..
- HIV, Chemokine Receptors, and Vascular Smooth MuscleALISON SCHECTER; Fiscal Year: 2007..Furthermore, given that HIV patients appear to have accelerated atherosclerosis, these studies will provide potential mechanism(s) responsible for HIV-associated vasculopathies. ..