Hugh Sampson

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint Clinical practice. Peanut allergy
    Hugh A Sampson
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10538, USA
    N Engl J Med 346:1294-9. 2002
  2. ncbi request reprint Improving in-vitro tests for the diagnosis of food hypersensitivity
    Hugh A Sampson
    Division of Pediatric Allergy and Immunology, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, New York 10538, USA
    Curr Opin Allergy Clin Immunol 2:257-61. 2002
  3. doi request reprint Peanut oral immunotherapy: is it ready for clinical practice?
    Hugh A Sampson
    Kurt Hirschhorn Professor of Pediatrics, Mount Sinai School of Medicine, New York, NY Electronic address
    J Allergy Clin Immunol Pract 1:15-21. 2013
  4. pmc The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study population
    James E Gern
    University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    BMC Pulm Med 9:17. 2009
  5. pmc Standardization and performance evaluation of mononuclear cell cytokine secretion assays in a multicenter study
    Wayne G Shreffler
    Mount Sinai School of Medicine, Division of Pediatric Allergy and Immunology, New York, NY, USA
    BMC Immunol 7:29. 2006
  6. ncbi request reprint The evaluation and management of food allergy in atopic dermatitis
    Hugh A Sampson
    Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, New York, USA
    Clin Dermatol 21:183-92. 2003
  7. ncbi request reprint Anaphylaxis and emergency treatment
    Hugh A Sampson
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Pediatrics 111:1601-8. 2003
  8. ncbi request reprint Update on food allergy
    Hugh A Sampson
    Department of Pediatrics and Immunobiology, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 113:805-19; quiz 820. 2004
  9. ncbi request reprint Symposium on the definition and management of anaphylaxis: summary report
    Hugh A Sampson
    Mount Sinai School of Medicine, Department of Pediatrics, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 115:584-91. 2005
  10. ncbi request reprint Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium
    Hugh A Sampson
    Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 117:391-7. 2006

Detail Information

Publications89

  1. ncbi request reprint Clinical practice. Peanut allergy
    Hugh A Sampson
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10538, USA
    N Engl J Med 346:1294-9. 2002
  2. ncbi request reprint Improving in-vitro tests for the diagnosis of food hypersensitivity
    Hugh A Sampson
    Division of Pediatric Allergy and Immunology, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, New York 10538, USA
    Curr Opin Allergy Clin Immunol 2:257-61. 2002
    ..However, new developments in in-vitro technologies have improved the capabilities of these tests to diagnose IgE-mediated reactivity and perhaps predict the development of future 'tolerance', i.e. 'outgrowing' the allergy...
  3. doi request reprint Peanut oral immunotherapy: is it ready for clinical practice?
    Hugh A Sampson
    Kurt Hirschhorn Professor of Pediatrics, Mount Sinai School of Medicine, New York, NY Electronic address
    J Allergy Clin Immunol Pract 1:15-21. 2013
    ..Appropriately designed, prospective clinical trials are urgently needed to determine whether OIT is a safe, effective form of therapy for food allergy. ..
  4. pmc The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study population
    James E Gern
    University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    BMC Pulm Med 9:17. 2009
    ..This paper describes the study design, methods, and population of the Urban Environment and Childhood Asthma (URECA) study, which was established to investigate the immunologic causes of asthma among inner-city children...
  5. pmc Standardization and performance evaluation of mononuclear cell cytokine secretion assays in a multicenter study
    Wayne G Shreffler
    Mount Sinai School of Medicine, Division of Pediatric Allergy and Immunology, New York, NY, USA
    BMC Immunol 7:29. 2006
    ....
  6. ncbi request reprint The evaluation and management of food allergy in atopic dermatitis
    Hugh A Sampson
    Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, New York, USA
    Clin Dermatol 21:183-92. 2003
  7. ncbi request reprint Anaphylaxis and emergency treatment
    Hugh A Sampson
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Pediatrics 111:1601-8. 2003
    ....
  8. ncbi request reprint Update on food allergy
    Hugh A Sampson
    Department of Pediatrics and Immunobiology, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 113:805-19; quiz 820. 2004
    ....
  9. ncbi request reprint Symposium on the definition and management of anaphylaxis: summary report
    Hugh A Sampson
    Mount Sinai School of Medicine, Department of Pediatrics, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 115:584-91. 2005
  10. ncbi request reprint Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium
    Hugh A Sampson
    Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 117:391-7. 2006
    ....
  11. ncbi request reprint Persistent protective effect of heat-killed Escherichia coli producing "engineered," recombinant peanut proteins in a murine model of peanut allergy
    Xiu Min Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 112:159-67. 2003
    ..Peanut allergy (PNA) is a life-threatening food allergy for which there is no definitive treatment...
  12. doi request reprint Food Allergy Herbal Formula-2 silences peanut-induced anaphylaxis for a prolonged posttreatment period via IFN-gamma-producing CD8+ T cells
    Kamal D Srivastava
    Department of Pediatrics, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY, USA
    J Allergy Clin Immunol 123:443-51. 2009
    ..We previously reported that Food Allergy Herbal Formula (FAHF)-2) protected peanut-allergic mice against anaphylactic reactions as long as 4 weeks posttherapy. This formula is now in clinical trials in the United States...
  13. ncbi request reprint The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reactions in a murine model of peanut allergy
    Kamal D Srivastava
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 115:171-8. 2005
    ..There is no curative therapy for this disorder. We previously found that an herbal formula, food allergy herbal formula (FAHF)-1, blocked peanut-induced anaphylaxis in a murine model when challenged immediately posttherapy...
  14. ncbi request reprint Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes
    Wayne G Shreffler
    Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai Medical Center, Box 1198, One Gustave L Levy Place, New York, NY 10029, USA
    J Allergy Clin Immunol 113:776-82. 2004
    ..Mapping of large numbers of epitopes by using individual patient sera has been impractical with current techniques...
  15. ncbi request reprint Genetic susceptibility to food allergy is linked to differential TH2-TH1 responses in C3H/HeJ and BALB/c mice
    Vivian Morafo
    Department of Pediatrics, Mount Sinai School of Medicine, New York 10029 6574, USA
    J Allergy Clin Immunol 111:1122-8. 2003
    ..Appropriate murine models of food allergy would be useful in understanding the mechanisms underlying food allergy in human subjects...
  16. ncbi request reprint Food allergen sensitization in inner-city children with asthma
    Julie Wang
    Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai Hospital, New York, NY, USA
    J Allergy Clin Immunol 115:1076-80. 2005
    ..Asthma continues to be an increasing cause of morbidity in the pediatric population, and studies have shown an association between food sensitivity and asthma...
  17. ncbi request reprint New approaches for the treatment of anaphylaxis
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Novartis Found Symp 257:248-60; discussion 260-4, 276-85. 2004
    ..These studies suggest that treatment of patients with anti-IgE therapy may represent an effective long-term approach for management of food-induced anaphylaxis...
  18. ncbi request reprint Immunomodulatory effect of the antiasthma Chinese herbal formula MSSM-002 on TH2 cells
    Kamal Srivastava
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    J Allergy Clin Immunol 113:268-76. 2004
    ..However, the mechanisms underlying these effects are largely unknown...
  19. doi request reprint The role of immunoglobulin E-binding epitopes in the characterization of food allergy
    Jing Lin
    Department of Pediatric Allergy and Immunology, Jaffe Food Allergy Research Institute, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Curr Opin Allergy Clin Immunol 9:357-63. 2009
    ..The goal of this article is to review recent developments in the methods for IgE epitope mapping and the role of IgE-binding epitopes in the characterization of food allergy...
  20. ncbi request reprint Food allergy therapy
    Anna Nowak-Wegrzyn
    Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, One G Levy Place, Box 1198, New York, NY 10029, USA
    Immunol Allergy Clin North Am 24:705-25, viii. 2004
    ..Animal models of food allergy are invaluable in testing new therapies for food allergy...
  21. ncbi request reprint Skin prick test to egg white provides additional diagnostic utility to serum egg white-specific IgE antibody concentration in children
    Adina Kay Knight
    Department of Medicine, Division of Clinical Immunology, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 117:842-7. 2006
    ..OFCs have inherent risks, and diagnostic criteria indicating high likelihood of passing would be clinically useful...
  22. doi request reprint Pharmacological and immunological effects of individual herbs in the Food Allergy Herbal Formula-2 (FAHF-2) on peanut allergy
    Jacob D Kattan
    Department of Pediatrics, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Phytother Res 22:651-9. 2008
    ....
  23. ncbi request reprint Identification of an 11S globulin as a major hazelnut food allergen in hazelnut-induced systemic reactions
    Kirsten Beyer
    Division of Pediatric Allergy and Immunology and the Jaffe Institute for Food Allergy, The Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 110:517-23. 2002
    ..Little information is available regarding the identification of pollen-independent hazelnut allergens...
  24. pmc Towards a cure for food allergy
    Justin M Skripak
    Mount Sinai School of Medicine, New York, NY, United States
    Curr Opin Immunol 20:690-6. 2008
    ..Allergen non-specific approaches include biologics to suppress free total IgE levels (e.g. anti-IgE antibody) or to induce more general immune suppression (Chinese herbal medication)...
  25. ncbi request reprint Measurement of peptide-specific IgE as an additional tool in identifying patients with clinical reactivity to peanuts
    Kirsten Beyer
    Division of Pediatric Allergy and Immunology and Jaffe Institute for Food Allergy, The Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 112:202-7. 2003
    ..Diagnostic decision levels of food-specific IgE antibody concentrations have been described. However, many patients still need to undergo oral peanut challenges because their IgE levels are in the nondiagnostic level...
  26. doi request reprint Constituents of the anti-asthma herbal formula ASHMI(TM) synergistically inhibit IL-4 and IL-5 secretion by murine Th2 memory cells, and eotaxin by human lung fibroblasts in vitro
    Bolleddula Jayaprakasam
    Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    J Integr Med 11:195-205. 2013
    ..This study was designed to determine if the anti-inflammatory effects of individual herbal constituents of ASHMI(TM) exhibited synergy...
  27. pmc Safety and tolerability of an antiasthma herbal Formula (ASHMI) in adult subjects with asthma: a randomized, double-blinded, placebo-controlled, dose-escalation phase I study
    Kristin Kelly-Pieper
    Division of Pediatric Pulmonary Medicine, Columbia University, New York, NY, USA
    J Altern Complement Med 15:735-43. 2009
    ..A novel three-herb antiasthma herbal medicine intervention (ASHMI; Sino-Lion Pharmaceutical Company; Shan Dong China) was demonstrated to be effective and safe in a murine model of asthma and in a preliminary clinical study in China...
  28. ncbi request reprint The potential use of Chinese herbal medicines in treating allergic asthma
    Xiu Min Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Ann Allergy Asthma Immunol 93:S35-44. 2004
    ....
  29. ncbi request reprint Food allergy as a risk factor for asthma morbidity in adults
    Stephen H Berns
    Division of General Internal Medicine, Mount Sinai School of Medicine, New York, NY, USA
    J Asthma 44:377-81. 2007
    ..The objective of this study was to evaluate the relationship between food allergy and asthma morbidity in adults...
  30. ncbi request reprint Peanut allergy: emerging concepts and approaches for an apparent epidemic
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    J Allergy Clin Immunol 120:491-503; quiz 504-5. 2007
    ..Among the therapeutic strategies reviewed are sublingual and oral immunotherapy, anti-IgE, Chinese herbal medicine, and vaccine strategies...
  31. doi request reprint Food allergy
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 125:S116-25. 2010
    ..Improved therapeutic strategies under study include oral and sublingual immunotherapy, Chinese herbal medicine, anti-IgE antibodies, and modified vaccines...
  32. doi request reprint Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein
    Wayne G Shreffler
    Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, New York, NY 10029, USA
    J Allergy Clin Immunol 123:43-52.e7. 2009
    ..About 70% of children with milk allergy tolerate extensively heated milk (HM) products and outgrow their allergy earlier than those who react to HM...
  33. pmc Mediator release assay for assessment of biological potency of German cockroach allergen extracts
    Anna H Nowak-Wegrzyn
    Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 123:949-955.e1. 2009
    ..Cockroach is an important allergen in inner-city asthma. The diagnosis and treatment of cockroach allergy has been impeded by the lack of standardized cockroach extracts...
  34. ncbi request reprint Esophageal subepithelial fibrosis in children with eosinophilic esophagitis
    Mirna Chehade
    Department of Pediatric Gastroenterology and Nutrition, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Pediatr Gastroenterol Nutr 45:319-28. 2007
    ..Our goal was to determine the prevalence of esophageal fibrosis in children with EE, to determine whether it is specific for EE, and to correlate it with clinical and pathological features...
  35. ncbi request reprint Epidemiology and etiology of eosinophilic esophagitis
    Mirna Chehade
    Pediatric Gastroenterology and Nutrition, Mount Sinai School of Medicine, New York, NY 10029, USA
    Gastrointest Endosc Clin N Am 18:33-44; viii. 2008
    ..In this article, available evidence on the epidemiology and etiology of EE is discussed...
  36. doi request reprint Sarcoplasmic calcium-binding protein is an EF-hand-type protein identified as a new shrimp allergen
    Rosalia Ayuso
    Division of Allergy and Immunology and the Jaffe Food Allergy Research Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1198, New York, NY 10029, USA
    J Allergy Clin Immunol 124:114-20. 2009
    ..Shellfish allergy is a long-lasting disorder usually persisting throughout life. Despite its high prevalence, there is limited information about allergenic shrimp proteins...
  37. doi request reprint Tolerance to extensively heated milk in children with cow's milk allergy
    Anna Nowak-Wegrzyn
    Department of Pediatrics and Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 122:342-7, 347.e1-2. 2008
    ....
  38. doi request reprint Food allergy: recent advances in pathophysiology and treatment
    Scott H Sicherer
    The Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Annu Rev Med 60:261-77. 2009
    ....
  39. doi request reprint The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy
    Jennifer M Maloney
    Mount Sinai School of Medicine, New York, NY, USA
    J Allergy Clin Immunol 122:145-51. 2008
    ..The gold standard for diagnosing food allergy is the double-blind, placebo-controlled food challenge. Diagnostic food-specific IgE levels might assist in diagnosing food allergies and circumventing the need for food challenges...
  40. doi request reprint Use of multiple doses of epinephrine in food-induced anaphylaxis in children
    Kirsi M Järvinen
    Division of Pediatric Allergy and Immunology and Jaffe Institute for Food Allergy, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 122:133-8. 2008
    ..Food allergy is the most common cause of anaphylaxis outside the hospital setting...
  41. doi request reprint Myosin light chain is a novel shrimp allergen, Lit v 3
    Rosalia Ayuso
    Division of Allergy and Immunology and the Jaffe Food Allergy Research Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 122:795-802. 2008
    ..Shellfish allergy is a prevalent, long-lasting disorder usually persisting throughout life. Few options are available for treatment, and avoidance is the only therapy recommended...
  42. doi request reprint Correlation of serum allergy (IgE) tests performed by different assay systems
    Julie Wang
    Department of Pediatrics, Division of Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 121:1219-24. 2008
    ..In vitro testing is commonly used to diagnose and manage allergies. Clinical reactivity has been correlated with food-specific IgE levels by using the ImmunoCAP (Phadia, Uppsala, Sweden)...
  43. pmc Development of a novel peptide microarray for large-scale epitope mapping of food allergens
    Jing Lin
    Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 124:315-22, 322.e1-3. 2009
    ..The peptide microarray is a novel assay that facilitates high-throughput screening of peptides with a small quantity of sample...
  44. doi request reprint The role of lymphocytes in eosinophilic gastrointestinal disorders
    Mirna Chehade
    Pediatric Gastroenterology and Nutrition, Box 1198, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Immunol Allergy Clin North Am 29:149-58, xii. 2009
    ..This article discusses the concept of oral tolerance, the available evidence for the role that lymphocytes play in the induction and pathogenesis of EGIDs, and the evidence for a potential breach in oral tolerance in EGIDs...
  45. pmc Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy
    Julie Wang
    Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 125:695-702, 702.e1-702.e6. 2010
    ..Results from large-scale epitope mapping with a peptide microarray have been shown to correlate with clinical features of milk allergy...
  46. ncbi request reprint Food anaphylaxis
    Julie Wang
    Department of Pediatrics, Division of Allergy and Immunology, Mount Sinai Hospital, New York, NY, USA
    Clin Exp Allergy 37:651-60. 2007
    ..Several novel tools are currently being investigated, which will potentially aid in the diagnosis and treatment of food-induced anaphylaxis...
  47. ncbi request reprint Novel approaches to immunotherapy for food allergy
    Xiu Min Li
    Mount Sinai School of Medicine, New York, New York, USA
    Clin Allergy Immunol 18:663-79. 2004
  48. ncbi request reprint Determination of food specific IgE levels over time can predict the development of tolerance in cow's milk and hen's egg allergy
    Lynette P C Shek
    Division of Pediatric Allergy and Immunology, The Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 114:387-91. 2004
    ..The majority of children with cow's milk and hen's egg allergy develop clinical tolerance with time. However, there are no good indices to predict when and in whom this occurs...
  49. ncbi request reprint Prevalence of seafood allergy in the United States determined by a random telephone survey
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 114:159-65. 2004
    ..Seafood allergy is potentially severe, but the prevalence of this group of food allergies in the US population has not been determined...
  50. doi request reprint Perennial allergen-specific immunoglobulin E levels among inner-city elderly asthmatics
    Paula Jane Busse
    Division of Clinical Immunology, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, U S A
    J Asthma 47:781-5. 2010
    ..The aim of this study was to access the prevalence of sensitization to indoor allergens in older compared to younger inner-city adults with persistent asthma...
  51. ncbi request reprint Food-induced anaphylaxis
    Hugh A Sampson
    Division of Allergy and Immunology, Department of Pediatrics, Box 1198, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Novartis Found Symp 257:161-71; discussion 171-6, 207-10, 276-85. 2004
    ....
  52. pmc Maternal consumption of peanut during pregnancy is associated with peanut sensitization in atopic infants
    Scott H Sicherer
    Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY, USA
    J Allergy Clin Immunol 126:1191-7. 2010
    ..Peanut allergy is typically severe, lifelong, and prevalent...
  53. ncbi request reprint B-cell epitopes as a screening instrument for persistent cow's milk allergy
    Kirsi Marjut Järvinen
    Division of Pediatric Allergy and Immunology, Jaffe Institute for Food Allergy, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
    J Allergy Clin Immunol 110:293-7. 2002
    ....
  54. ncbi request reprint Food protein-induced enterocolitis syndrome caused by solid food proteins
    Anna Nowak-Wegrzyn
    Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Pediatrics 111:829-35. 2003
    ..Infantile food protein-induced enterocolitis syndrome (FPIES) is a severe, cell-mediated gastrointestinal food hypersensitivity typically provoked by cow's milk or soy. Solid foods are rarely considered a cause...
  55. pmc Epinephrine treatment is infrequent and biphasic reactions are rare in food-induced reactions during oral food challenges in children
    Kirsi M Järvinen
    Division of Pediatric Allergy and Immunology and the Jaffe Institute for Food Allergy, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 124:1267-72. 2009
    ..Data about epinephrine use and biphasic reactions in childhood food-induced anaphylaxis during oral food challenges are scarce...
  56. ncbi request reprint Soy immunotherapy for peanut-allergic mice: modulation of the peanut-allergic response
    Laurent Pons
    Department of Pediatrics, Division of Pediatric Allergy and Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Allergy Clin Immunol 114:915-21. 2004
    ..So far, peanut-specific IT has been unsuccessful because of the side effects of therapy. Soybean seed storage proteins share significant homology with the respective peanut allergens...
  57. pmc Safety, tolerability, and immunologic effects of a food allergy herbal formula in food allergic individuals: a randomized, double-blinded, placebo-controlled, dose escalation, phase 1 study
    Julie Wang
    Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Ann Allergy Asthma Immunol 105:75-84. 2010
    ..A new herbal product, called food allergy herbal formula 2 (FAHF-2), has been demonstrated to have a high safety profile and potent long-term efficacy in a murine model of peanut-induced anaphylaxis...
  58. pmc Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 125:1077-1083.e8. 2010
    ..Immune features of infants with food allergy have not been delineated...
  59. ncbi request reprint The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro
    Wayne G Shreffler
    Jaffe Food Allergy Institute, Department of Pediatrics, Division of Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 177:3677-85. 2006
    ..Both PNAg and purified Ara h 1 induced Erk 1/2 phosphorylation of MDDCs, consistent with previous reports on the effect of Th2 adjuvants on DCs...
  60. doi request reprint US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 125:1322-6. 2010
    ..Allergy to peanuts and tree nuts (TNs) is the leading cause of fatal allergic reactions in the United States, and the prevalence appears to be increasing...
  61. ncbi request reprint Allergic eosinophilic gastroenteritis with protein-losing enteropathy: intestinal pathology, clinical course, and long-term follow-up
    Mirna Chehade
    Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Pediatr Gastroenterol Nutr 42:516-21. 2006
    ..Our goals were to describe the response to therapy and the long-term outcome of patients in this subgroup and to evaluate their gastric and intestinal biopsies for distinguishing features that might explain their protein and blood loss...
  62. ncbi request reprint 9. Food allergy
    Scott H Sicherer
    The Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 117:S470-5. 2006
    ..Currently, management of food allergies consists of educating the patient to avoid ingesting the responsible allergen and to initiate therapy in case of an unintended ingestion...
  63. ncbi request reprint Novel approaches for the treatment of food allergy
    Xiu Min Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Curr Opin Allergy Clin Immunol 2:273-8. 2002
    ....
  64. ncbi request reprint IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2
    Wayne G Shreffler
    Jaffe Food Allergy Institute, Department of Pediatrics, Division of Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 116:893-9. 2005
    ..Microarray technology offers advantages of scale and parallel design over previous methods of epitope mapping...
  65. doi request reprint Greater epitope recognition of shrimp allergens by children than by adults suggests that shrimp sensitization decreases with age
    Rosalia Ayuso
    Division of Allergy and Immunology and the Jaffe Food Allergy Research Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 125:1286-1293.e3. 2010
    ..Shellfish allergy is a long-lasting disorder typically affecting adults. Despite its high prevalence, there is limited information about allergenic shrimp proteins and the epitopes implicated in such allergic reactions...
  66. ncbi request reprint Engineered recombinant peanut protein and heat-killed Listeria monocytogenes coadministration protects against peanut-induced anaphylaxis in a murine model
    Xiu Min Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 170:3289-95. 2003
    ..These results show that immunotherapy with modified PN proteins and HKLM is effective for treating PN allergy in this model, and may be a potential approach for treating PNA...
  67. doi request reprint The Sophora flavescens flavonoid compound trifolirhizin inhibits acetylcholine induced airway smooth muscle contraction
    Nan Yang
    Department of Pediatrics, Center for Chinese Herbal Therapy for Asthma and Allergy, Mount Sinai School of Medicine, New York, NY 10029, United States
    Phytochemistry 95:259-67. 2013
    ....
  68. ncbi request reprint Human milk-specific mucosal lymphocytes of the gastrointestinal tract display a TH2 cytokine profile
    Kirsten Beyer
    Division of Pediatric Allergy and Immunology and Jaffe Institute for Food Allergy, The Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 109:707-13. 2002
    ..The immunologic reactions appear to involve T cells that are activated by specific food proteins...
  69. ncbi request reprint Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study
    Scott H Sicherer
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 112:1203-7. 2003
    ..Allergy to peanuts and tree nuts (TNs) is the leading cause of fatal and near-fatal food allergic reactions. Peanut allergy appears to be increasing in prevalence...
  70. ncbi request reprint Lack of association between indoor allergen sensitization and asthma morbidity in inner-city adults
    Juan P Wisnivesky
    Division of General Internal Medicine, Critical Care and Sleep Medicine, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 120:113-20. 2007
    ..Sensitivity and exposure to indoor allergens is associated with increased asthma morbidity in inner-city children. However, it is unknown whether sensitization is associated with worse asthma in adults...
  71. ncbi request reprint Effect of anti-IgE therapy in patients with peanut allergy
    Donald Y M Leung
    National Jewish Medical and Research Center, Denver, USA
    N Engl J Med 348:986-93. 2003
    ..TNX-901 is a humanized IgG1 monoclonal antibody against IgE that recognizes and masks an epitope in the CH3 region of IgE responsible for binding to the high-affinity Fc(epsilon) receptor on mast cells and basophils...
  72. doi request reprint Mapping of the IgE and IgG4 sequential epitopes of milk allergens with a peptide microarray-based immunoassay
    Inmaculada Cerecedo
    Servicio de Alergologia, Hospital Universitario Ramon y Cajal, Madrid, Spain
    J Allergy Clin Immunol 122:589-94. 2008
    ..Peptide microarray analysis is a novel method that can provide useful information on the nature of specific allergies...
  73. doi request reprint New visions for food allergy: an iPAC summary and future trends
    Philippe A Eigenmann
    Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland
    Pediatr Allergy Immunol 19:26-39. 2008
    ....
  74. ncbi request reprint Identification of sesame seed allergens by 2-dimensional proteomics and Edman sequencing: seed storage proteins as common food allergens
    Kirsten Beyer
    Division of Pediatric Allergy and Immunology and the Jaffe Institute for Food Allergy, The Mount Sinai School of Medicine, New York 10029 6574, USA
    J Allergy Clin Immunol 110:154-9. 2002
    ..Sesame seed allergy is becoming increasingly prevalent, probably because of its use in international fast-food and bakery products. Despite this fact, few studies have focused on the identification of its major allergenic proteins...
  75. ncbi request reprint Peanut allergy
    S Paul Kuwayama
    N Engl J Med 347:1534-5; author reply 1534-5. 2002
  76. ncbi request reprint Contamination of dry powder inhalers for asthma with milk proteins containing lactose
    Anna Nowak-Wegrzyn
    J Allergy Clin Immunol 113:558-60. 2004
  77. ncbi request reprint Milk-induced urticaria is associated with the expansion of T cells expressing cutaneous lymphocyte antigen
    Kirsten Beyer
    Division of Pediatric Allergy and Immunology and the Jaffe Institute for Food Allergy, The Mount Sinai School of Medicine, New York 10029 6574, USA
    J Allergy Clin Immunol 109:688-93. 2002
    ..T cells expressing cutaneous lymphocyte antigen (CLA), a unique skin-homing receptor, are known to play an important role in AD. In contrast, the role of lymphocytes in patients with milk-induced urticaria is unclear...
  78. ncbi request reprint Food allergy: when mucosal immunity goes wrong
    Hugh A Sampson
    J Allergy Clin Immunol 115:139-41. 2005
  79. ncbi request reprint Ana o 3, an important cashew nut (Anacardium occidentale L.) allergen of the 2S albumin family
    Jason M Robotham
    Department of Biological Science, Institute of Molecular Physics, Florida State University, Tallahassee, FL 32306 4370, USA
    J Allergy Clin Immunol 115:1284-90. 2005
    ..Cashew nut allergy is the second most commonly reported tree nut allergy in the United States. We have previously cloned and characterized major cashew allergens belonging to the vicilin and legumin families of seed storage proteins...
  80. ncbi request reprint Predictive value of skin prick tests using recombinant allergens for diagnosis of peanut allergy
    Catherine Astier
    EA3999 Allergic Diseases Diagnosis and Therapeutics Department of Internal Medicine, Clinical Immunology and Allergology, University Hospital, Central Hospital, 15 rue du Bois de la Champelle, 54500 Vandoeuvre les Nancy, France
    J Allergy Clin Immunol 118:250-6. 2006
    ..Recombinant DNA technology allows production of pure biochemically characterized proteins. Their usefulness for peanut allergy diagnosis is not established...
  81. ncbi request reprint Further fatalities caused by anaphylactic reactions to food, 2001-2006
    S Allan Bock
    J Allergy Clin Immunol 119:1016-8. 2007
  82. ncbi request reprint Identification of 2 new sesame seed allergens: Ses i 6 and Ses i 7
    Kirsten Beyer
    J Allergy Clin Immunol 119:1554-6. 2007
  83. ncbi request reprint Risk assessment in anaphylaxis: current and future approaches
    F Estelle R Simons
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada, and Department of Respiratory Medicine, Brighton General Hospital, Belfast, UK
    J Allergy Clin Immunol 120:S2-24. 2007
    ....
  84. ncbi request reprint CD4 T cells activated in the mesenteric lymph node mediate gastrointestinal food allergy in mice
    Adina Kay Knight
    The Division of Allergy and Immunology Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1234-43. 2007
    ..A gut-homing phenotype induced in the MLN and selective upregulation of Th2 chemoattractants are likely important factors in the gastrointestinal recruitment of pathological Th2-skewed CD4(+) T cells in food allergy...
  85. doi request reprint Enzyme-linked immunosorbent assay (ELISA) for detection of sulfur-rich protein (SRP) in soybeans (Glycine max L.) and certain other edible plant seeds
    Erin K Monaghan
    Department of Nutrition, Food and Exercise Sciences and Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
    J Agric Food Chem 56:765-77. 2008
    ..4-3.6 residues/100 residues), which satisfies the FAO/WHO recommended pattern for sulfur amino acids in both adults and children (2-5 years old). The results suggest the presence of constitutive SRPs in several dry beans and oilseeds...
  86. doi request reprint Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy
    Annebeth E Flinterman
    Department of Dermatology Allergology, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Allergy Clin Immunol 121:737-743.e10. 2008
    ..Better understanding of the relationship between antibody response to peanut and clinical sensitivity might lead to more accurate prognostication...
  87. doi request reprint Hypoallergenicity and effects on growth and tolerance of a new amino acid-based formula with docosahexaenoic acid and arachidonic acid
    Wesley Burks
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    J Pediatr 153:266-71. 2008
    ..In study 2, to evaluate the hypoallergenicity of this new AAF in infants and children with confirmed cow's milk allergy (CMA)...
  88. doi request reprint The role of wheat omega-5 gliadin IgE antibodies as a diagnostic tool for wheat allergy in childhood
    Kirsten Beyer
    J Allergy Clin Immunol 122:419-21. 2008
  89. ncbi request reprint Modification of peanut allergen Ara h 3: effects on IgE binding and T cell stimulation
    Pat Rabjohn
    Department of Biochemistry and Molecular Biology, Arkansas Children s Hospital Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Int Arch Allergy Immunol 128:15-23. 2002
    ..Mutational analysis of the Ara h 3 IgE-binding epitopes with synthetic peptides revealed that single amino acid changes at critical residues could diminish IgE binding...

Research Grants10

  1. Immunologic Basis of Cow Milk Induced Hypersensitvities
    Hugh Sampson; Fiscal Year: 2007
    ..abstract_text> ..
  2. Institute for Translational Research, Education & Experimental Therapeutics
    Hugh Sampson; Fiscal Year: 2006
    ..This Institute will provide access to breakthrough technologies and supportive resources and personnel to expedite translational research. ..
  3. Core--Vector, Protein and Mechanistic
    Hugh Sampson; Fiscal Year: 2005
    ..abstract_text> ..
  4. IMMUNOMODULATION OF FOOD ALLERGY BY DNA BASED IMMUNITY
    Hugh Sampson; Fiscal Year: 2002
    ....