Scott J Russo

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi Neurobiology of resilience
    Scott J Russo
    Department of Neuroscience, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 15:1475-84. 2012
  2. ncbi The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens
    Scott J Russo
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Trends Neurosci 33:267-76. 2010
  3. ncbi Effects of inhibitor of κB kinase activity in the nucleus accumbens on emotional behavior
    Daniel J Christoffel
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
    Neuropsychopharmacology 37:2615-23. 2012
  4. ncbi Essential role of the histone methyltransferase G9a in cocaine-induced plasticity
    Ian Maze
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
    Science 327:213-6. 2010
  5. ncbi Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
    Dipesh Chaudhury
    Department of Pharmacology and Systems Therapeutics, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 493:532-6. 2013
  6. ncbi BDNF is a negative modulator of morphine action
    Ja Wook Koo
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 338:124-8. 2012
  7. ncbi Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons
    David M Dietz
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA
    Nat Neurosci 15:891-6. 2012
  8. ncbi IκB kinase regulates social defeat stress-induced synaptic and behavioral plasticity
    Daniel J Christoffel
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 31:314-21. 2011
  9. ncbi Drug experience epigenetically primes Fosb gene inducibility in rat nucleus accumbens
    Diane Damez-Werno
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 32:10267-72. 2012
  10. ncbi Subregional, dendritic compartment, and spine subtype specificity in cocaine regulation of dendritic spines in the nucleus accumbens
    Dani Dumitriu
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 32:6957-66. 2012

Research Grants

  1. Mechanisms of structural plasticity in stress-related disorders
    Scott J Russo; Fiscal Year: 2011

Collaborators

Detail Information

Publications24

  1. ncbi Neurobiology of resilience
    Scott J Russo
    Department of Neuroscience, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 15:1475-84. 2012
    ..The therapeutic implications of these findings are important and can pave the way for an innovative approach to drug development for a range of stress-related syndromes...
  2. ncbi The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens
    Scott J Russo
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Trends Neurosci 33:267-76. 2010
    ..We define areas where future investigation can provide a more detailed picture of drug-induced synaptic reorganization, including ultrastructural, electrophysiological and behavioral studies...
  3. ncbi Effects of inhibitor of κB kinase activity in the nucleus accumbens on emotional behavior
    Daniel J Christoffel
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
    Neuropsychopharmacology 37:2615-23. 2012
    ..These data show that IκK in NAc is a critical regulator of both depressive- and anxiety-like states and may do so by promoting the formation of immature excitatory synapses...
  4. ncbi Essential role of the histone methyltransferase G9a in cocaine-induced plasticity
    Ian Maze
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
    Science 327:213-6. 2010
    ....
  5. ncbi Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
    Dipesh Chaudhury
    Department of Pharmacology and Systems Therapeutics, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 493:532-6. 2013
    ..Overall, these studies reveal novel firing-pattern- and neural-circuit-specific mechanisms of depression...
  6. ncbi BDNF is a negative modulator of morphine action
    Ja Wook Koo
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 338:124-8. 2012
    ..These findings provide insight into the molecular basis of morphine-induced neuroadaptations in the brain's reward circuitry...
  7. ncbi Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons
    David M Dietz
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA
    Nat Neurosci 15:891-6. 2012
    ..These findings establish that Rac1 signaling mediates structural and behavioral plasticity in response to cocaine exposure...
  8. ncbi IκB kinase regulates social defeat stress-induced synaptic and behavioral plasticity
    Daniel J Christoffel
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 31:314-21. 2011
    ..These studies establish a causal role for IKK in regulating stress-induced adaptive plasticity and may present a novel target for drug development in the treatment of mood and anxiety disorders in humans...
  9. ncbi Drug experience epigenetically primes Fosb gene inducibility in rat nucleus accumbens
    Diane Damez-Werno
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 32:10267-72. 2012
    ..These results provide new insight into the chromatin dynamics at the Fosb promoter and reveal a novel mechanism for primed Fosb induction in NAc upon reexposure to cocaine...
  10. ncbi Subregional, dendritic compartment, and spine subtype specificity in cocaine regulation of dendritic spines in the nucleus accumbens
    Dani Dumitriu
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 32:6957-66. 2012
    ....
  11. ncbi Transcriptional mechanisms: underlying addiction-related structural plasticity
    Ian Maze
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA
    Mol Interv 10:219-30. 2010
    ..In this review, we will discuss recent advances in our understanding of chromatin regulation by cocaine, as well as the consequences of such regulation on structural plasticity and its functional relevance to drug addiction...
  12. ncbi HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity
    Mitsumasa Kurita
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 15:1245-54. 2012
    ..These observations support the view of HDAC2 as a promising new target for schizophrenia treatment...
  13. ncbi Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression
    Sam A Golden
    Fishberg Department of Neuroscience and Friedman Brain Institute, Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Med 19:337-44. 2013
    ..Taken together, our data identify epigenetic regulation of RAC1 in the NAc as a disease mechanism in depression and reveal a functional role for Rac1 in rodents in regulating stress-related behaviors...
  14. ncbi Neurotrophic factors and structural plasticity in addiction
    Scott J Russo
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Neuropharmacology 56:73-82. 2009
    ..This review discusses recent advances in our understanding of how BDNF and its signaling pathways regulate structural and behavioral plasticity in the context of drug addiction...
  15. ncbi Hippocampal GluA1-containing AMPA receptors mediate context-dependent sensitization to morphine
    Yan Xia
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurosci 31:16279-91. 2011
    ....
  16. ncbi Paternal transmission of stress-induced pathologies
    David M Dietz
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA
    Biol Psychiatry 70:408-14. 2011
    ..Here, we focused on possible paternal transmission with the social defeat stress paradigm...
  17. ncbi Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons
    Michelle S Mazei-Robison
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuron 72:977-90. 2011
    ..Together, these findings demonstrate a novel role for AKT-mTORC2 signaling in mediating neuroadaptations to opiate drugs of abuse...
  18. ncbi Structural and synaptic plasticity in stress-related disorders
    Daniel J Christoffel
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Rev Neurosci 22:535-49. 2011
    ..Finally, we end by discussing recent brain imaging studies in human depression within the context of these basic findings to provide insight into the underlying mechanisms leading to neural dysfunction in depression...
  19. ncbi A standardized protocol for repeated social defeat stress in mice
    Sam A Golden
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA
    Nat Protoc 6:1183-91. 2011
    ..The automated detection of social avoidance allows a marked increase in throughput, reproducibility and quantitative analysis. This protocol is highly adaptable, but in its most common form it requires 3-4 weeks for completion...
  20. ncbi Prenatal stress induces schizophrenia-like alterations of serotonin 2A and metabotropic glutamate 2 receptors in the adult offspring: role of maternal immune system
    Terrell Holloway
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 33:1088-98. 2013
    ..These data strengthen pathophysiological hypotheses that propose an early neurodevelopmental origin for schizophrenia and other psychiatric disorders...
  21. ncbi Antidepressant actions of histone deacetylase inhibitors
    Herbert E Covington
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 29:11451-60. 2009
    ....
  22. ncbi Progesterone does not affect cocaine-induced conditioned place preference or locomotor activity in male rats
    Scott J Russo
    Department of Psychology, Hunter College, New York, NY 10065, USA
    Ethn Dis 20:S1-73-7. 2010
    ..The present study aimed to determine if, as occurs in female rats, progesterone attenuates cocaine-induced reward and psychomotor responses in male rats...
  23. ncbi Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward
    Scott J Russo
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 29:3529-37. 2009
    ..Together, these studies establish a direct role for NFkappaB pathways in the NAc to regulate structural and behavioral plasticity to cocaine...
  24. ncbi Role of nuclear factor kappaB in ovarian hormone-mediated stress hypersensitivity in female mice
    Quincey LaPlant
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Biol Psychiatry 65:874-80. 2009
    ..The molecular mechanisms of stress-induced depressive behaviors have been characterized extensively in male rodents; however, much less is known about female subjects, despite the fact that human depression is far more prevalent in women...

Research Grants1

  1. Mechanisms of structural plasticity in stress-related disorders
    Scott J Russo; Fiscal Year: 2011
    ....