Scott J Russo

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression
    Sam A Golden
    Fishberg Department of Neuroscience and Friedman Brain Institute, Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Med 19:337-44. 2013
  2. pmc Neurobiology of resilience
    Scott J Russo
    Department of Neuroscience, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 15:1475-84. 2012
  3. pmc The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens
    Scott J Russo
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Trends Neurosci 33:267-76. 2010
  4. pmc Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway
    Jessica J Walsh
    1 Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA 2 Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Neurosci 17:27-9. 2014
  5. pmc Effects of inhibitor of κB kinase activity in the nucleus accumbens on emotional behavior
    Daniel J Christoffel
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
    Neuropsychopharmacology 37:2615-23. 2012
  6. pmc Essential role of the histone methyltransferase G9a in cocaine-induced plasticity
    Ian Maze
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
    Science 327:213-6. 2010
  7. pmc Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons
    David M Dietz
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA
    Nat Neurosci 15:891-6. 2012
  8. pmc IκB kinase regulates social defeat stress-induced synaptic and behavioral plasticity
    Daniel J Christoffel
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 31:314-21. 2011
  9. pmc Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
    Dipesh Chaudhury
    Department of Pharmacology and Systems Therapeutics, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 493:532-6. 2013
  10. pmc Repressive epigenetic changes at the mGlu2 promoter in frontal cortex of 5-HT2A knockout mice
    Mitsumasa Kurita
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    Mol Pharmacol 83:1166-75. 2013

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Detail Information

Publications28

  1. pmc Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression
    Sam A Golden
    Fishberg Department of Neuroscience and Friedman Brain Institute, Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Med 19:337-44. 2013
    ..Taken together, our data identify epigenetic regulation of RAC1 in the NAc as a disease mechanism in depression and reveal a functional role for Rac1 in rodents in regulating stress-related behaviors...
  2. pmc Neurobiology of resilience
    Scott J Russo
    Department of Neuroscience, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 15:1475-84. 2012
    ..The therapeutic implications of these findings are important and can pave the way for an innovative approach to drug development for a range of stress-related syndromes...
  3. pmc The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens
    Scott J Russo
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Trends Neurosci 33:267-76. 2010
    ..We define areas where future investigation can provide a more detailed picture of drug-induced synaptic reorganization, including ultrastructural, electrophysiological and behavioral studies...
  4. pmc Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway
    Jessica J Walsh
    1 Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA 2 Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Neurosci 17:27-9. 2014
    ..This stress gating of BDNF signaling is mediated by corticotrophin-releasing factor (CRF) acting in the NAc. These results unravel a stress context-detecting function of the brain's mesolimbic circuit. ..
  5. pmc Effects of inhibitor of κB kinase activity in the nucleus accumbens on emotional behavior
    Daniel J Christoffel
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
    Neuropsychopharmacology 37:2615-23. 2012
    ..These data show that IκK in NAc is a critical regulator of both depressive- and anxiety-like states and may do so by promoting the formation of immature excitatory synapses...
  6. pmc Essential role of the histone methyltransferase G9a in cocaine-induced plasticity
    Ian Maze
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
    Science 327:213-6. 2010
    ....
  7. pmc Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons
    David M Dietz
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA
    Nat Neurosci 15:891-6. 2012
    ..These findings establish that Rac1 signaling mediates structural and behavioral plasticity in response to cocaine exposure...
  8. pmc IκB kinase regulates social defeat stress-induced synaptic and behavioral plasticity
    Daniel J Christoffel
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 31:314-21. 2011
    ..These studies establish a causal role for IKK in regulating stress-induced adaptive plasticity and may present a novel target for drug development in the treatment of mood and anxiety disorders in humans...
  9. pmc Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
    Dipesh Chaudhury
    Department of Pharmacology and Systems Therapeutics, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 493:532-6. 2013
    ..Overall, these studies reveal novel firing-pattern- and neural-circuit-specific mechanisms of depression...
  10. pmc Repressive epigenetic changes at the mGlu2 promoter in frontal cortex of 5-HT2A knockout mice
    Mitsumasa Kurita
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    Mol Pharmacol 83:1166-75. 2013
    ..Together, these observations suggest that 5-HT(2A) receptor-dependent signaling epigenetically affects mGlu2 transcription in mouse frontal cortex...
  11. pmc BDNF is a negative modulator of morphine action
    Ja Wook Koo
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 338:124-8. 2012
    ..These findings provide insight into the molecular basis of morphine-induced neuroadaptations in the brain's reward circuitry...
  12. pmc Subregional, dendritic compartment, and spine subtype specificity in cocaine regulation of dendritic spines in the nucleus accumbens
    Dani Dumitriu
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 32:6957-66. 2012
    ....
  13. pmc Drug experience epigenetically primes Fosb gene inducibility in rat nucleus accumbens
    Diane Damez-Werno
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 32:10267-72. 2012
    ..These results provide new insight into the chromatin dynamics at the Fosb promoter and reveal a novel mechanism for primed Fosb induction in NAc upon reexposure to cocaine...
  14. pmc Kalirin-7 mediates cocaine-induced AMPA receptor and spine plasticity, enabling incentive sensitization
    Xiaoting Wang
    Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Neurosci 33:11012-22. 2013
    ....
  15. pmc HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity
    Mitsumasa Kurita
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 15:1245-54. 2012
    ..These observations support the view of HDAC2 as a promising new target for schizophrenia treatment...
  16. doi request reprint Transcriptional mechanisms: underlying addiction-related structural plasticity
    Ian Maze
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA
    Mol Interv 10:219-30. 2010
    ..In this review, we will discuss recent advances in our understanding of chromatin regulation by cocaine, as well as the consequences of such regulation on structural plasticity and its functional relevance to drug addiction...
  17. pmc Neurotrophic factors and structural plasticity in addiction
    Scott J Russo
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Neuropharmacology 56:73-82. 2009
    ..This review discusses recent advances in our understanding of how BDNF and its signaling pathways regulate structural and behavioral plasticity in the context of drug addiction...
  18. pmc Paternal transmission of stress-induced pathologies
    David M Dietz
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA
    Biol Psychiatry 70:408-14. 2011
    ..Here, we focused on possible paternal transmission with the social defeat stress paradigm...
  19. pmc A standardized protocol for repeated social defeat stress in mice
    Sam A Golden
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA
    Nat Protoc 6:1183-91. 2011
    ..The automated detection of social avoidance allows a marked increase in throughput, reproducibility and quantitative analysis. This protocol is highly adaptable, but in its most common form it requires 3-4 weeks for completion...
  20. pmc Antidepressant actions of histone deacetylase inhibitors
    Herbert E Covington
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 29:11451-60. 2009
    ....
  21. pmc Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons
    Michelle S Mazei-Robison
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuron 72:977-90. 2011
    ..Together, these findings demonstrate a novel role for AKT-mTORC2 signaling in mediating neuroadaptations to opiate drugs of abuse...
  22. pmc Hippocampal GluA1-containing AMPA receptors mediate context-dependent sensitization to morphine
    Yan Xia
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurosci 31:16279-91. 2011
    ....
  23. pmc Structural and synaptic plasticity in stress-related disorders
    Daniel J Christoffel
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Rev Neurosci 22:535-49. 2011
    ..Finally, we end by discussing recent brain imaging studies in human depression within the context of these basic findings to provide insight into the underlying mechanisms leading to neural dysfunction in depression...
  24. pmc The brain reward circuitry in mood disorders
    Scott J Russo
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA edu
    Nat Rev Neurosci 14:609-25. 2013
    ..We also discuss some of the molecular and cellular underpinnings of this framework, ranging from adaptations in glutamatergic synapses and neurotrophic factors to transcriptional and epigenetic mechanisms...
  25. pmc Prenatal stress induces schizophrenia-like alterations of serotonin 2A and metabotropic glutamate 2 receptors in the adult offspring: role of maternal immune system
    Terrell Holloway
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 33:1088-98. 2013
    ..These data strengthen pathophysiological hypotheses that propose an early neurodevelopmental origin for schizophrenia and other psychiatric disorders...
  26. ncbi request reprint Progesterone does not affect cocaine-induced conditioned place preference or locomotor activity in male rats
    Scott J Russo
    Department of Psychology, Hunter College, New York, NY 10065, USA
    Ethn Dis 20:S1-73-7. 2010
    ..The present study aimed to determine if, as occurs in female rats, progesterone attenuates cocaine-induced reward and psychomotor responses in male rats...
  27. pmc Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward
    Scott J Russo
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 29:3529-37. 2009
    ..Together, these studies establish a direct role for NFkappaB pathways in the NAc to regulate structural and behavioral plasticity to cocaine...
  28. pmc Role of nuclear factor kappaB in ovarian hormone-mediated stress hypersensitivity in female mice
    Quincey LaPlant
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Biol Psychiatry 65:874-80. 2009
    ..The molecular mechanisms of stress-induced depressive behaviors have been characterized extensively in male rodents; however, much less is known about female subjects, despite the fact that human depression is far more prevalent in women...

Research Grants1