Research Topics
Species | BARRY S contact ROSENSTEINSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Identification of SNPs associated with susceptibility for development of adverse reactions to radiotherapyBarry S Rosenstein
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
Pharmacogenomics 12:267-75. 2011..This would permit personalization and optimization of the treatment plan for each cancer patient...- American Society for Radiation Oncology (ASTRO) survey of radiation biology educators in U.S. and Canadian radiation oncology residency programsBarry S Rosenstein
Department of Radiation Oncology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
Int J Radiat Oncol Biol Phys 75:896-905. 2009..To obtain, in a survey-based study, detailed information on the faculty currently responsible for teaching radiation biology courses to radiation oncology residents in the United States and Canada... - Biologic comparison of partial breast irradiation protocolsBarry S Rosenstein
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
Int J Radiat Oncol Biol Phys 60:1393-404. 2004.... - Screening for ATM sequence alterations in African-American women diagnosed with breast cancerAriel E Hirsch
Department of Radiation Oncology, New York University Medical Center, New York, NY, USA
Breast Cancer Res Treat 107:139-44. 2008..The goal of this study was to determine whether there is evidence that ATM is a breast cancer susceptibility gene in African-American women... - Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology studyJonine L Bernstein
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 307 E 63rd St Fl 3, New York, NY 10065, USA
J Natl Cancer Inst 102:475-83. 2010..We investigated whether genetic variants in ATM play a clinically significant role in radiation-induced contralateral breast cancer in women... - Variants in the ATM gene associated with a reduced risk of contralateral breast cancerPatrick Concannon
Department of Biochemistry and Molecular Genetics and Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908 0733, USA
Cancer Res 68:6486-91. 2008..1-0.6; c.6348-54T>C RR, 0.2; 95% CI, 0.1-0.8]. These data suggest that some alleles of ATM may exert an antineoplastic effect, perhaps by altering the activity of ATM as an initiator of DNA damage responses or a regulator of p53... - Possession of ATM sequence variants as predictor for late normal tissue responses in breast cancer patients treated with radiotherapyAlice Y Ho
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
Int J Radiat Oncol Biol Phys 69:677-84. 2007..The ATM gene product is a central component of cell cycle regulation and genomic surveillance. We hypothesized that DNA sequence alterations in ATM predict for adverse effects after external beam radiotherapy for early breast cancer... - ATM mutations in female breast cancer patients predict for an increase in radiation-induced late effectsChristopher M Iannuzzi
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
Int J Radiat Oncol Biol Phys 52:606-13. 2002..This study attempted to determine whether breast cancer patients who develop severe radiotherapy (RT)-induced effects are more likely to possess ATM mutations than patients who display normal radiation responses... - ATM sequence variants are predictive of adverse radiotherapy response among patients treated for prostate cancerJamie A Cesaretti
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
Int J Radiat Oncol Biol Phys 61:196-202. 2005.... - Genetic predictors of adverse radiotherapy effects: the Gene-PARE projectAlice Y Ho
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY, USA
Int J Radiat Oncol Biol Phys 65:646-55. 2006..CONCLUSIONS: It is anticipated that the Gene-PARE project will yield information that will allow radiation oncologists to use genetic data to optimize treatment on an individual basis... - ATM sequence variants and risk of radiation-induced subcutaneous fibrosis after postmastectomy radiotherapyChristian N Andreassen
Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
Int J Radiat Oncol Biol Phys 64:776-83. 2006.... - On the proposed association of the ATM variants 5557G>A and IVS38-8T>C and bilateral breast cancerBryan Langholz
Int J Cancer 119:724-5. 2006 - Designing and implementing quality control for multi-center screening of mutations in the ATM gene among women with breast cancerJonine L Bernstein
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Hum Mutat 21:542-50. 2003..Finally, we report novel mutations in the ATM gene identified both in patients with ataxia-telangiectasia and in patients with unilateral or bilateral breast cancer... - Toward a national consensus: teaching radiobiology to radiation oncology residentsElaine M Zeman
Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Int J Radiat Oncol Biol Phys 54:861-72. 2002.... - Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE studyJonine L Bernstein
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
Breast Cancer Res 6:R199-214. 2004..Three genes (ATM, BRCA1, and BRCA2) encode products that are essential for the normal cellular response to DSBs, but predispose to breast cancer when mutated... - A genetically determined dose-volume histogram predicts for rectal bleeding among patients treated with prostate brachytherapyJamie A Cesaretti
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
Int J Radiat Oncol Biol Phys 68:1410-6. 2007..To examine whether possession of genetic alterations in the ATM (ataxia telangiectasia) gene is associated with rectal bleeding in a dose-dependent and volume-dependent manner... - Association of single nucleotide polymorphisms in SOD2, XRCC1 and XRCC3 with susceptibility for the development of adverse effects resulting from radiotherapy for prostate cancerRyan J Burri
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York 10029, USA
Radiat Res 170:49-59. 2008..002). These results suggest that SNPs in the SOD2, XRCC1 and XRCC3 genes are associated with the development of late radiation injury in patients treated with radiation therapy for prostate adenocarcinoma... - Toward a consensus on radiobiology teaching to radiation oncology residentsJoseph R Dynlacht
Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Radiat Res 157:599-606. 2002.... - Biologically effective dose values for prostate brachytherapy: effects on PSA failure and posttreatment biopsy resultsRichard G Stock
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
Int J Radiat Oncol Biol Phys 64:527-33. 2006..To analyze the effect of biologically effective dose (BED) values on prostate-specific antigen (PSA) failure and posttreatment biopsy... - Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancerSarah L Kerns
Department of Pediatrics, New York University School of Medicine, New York, NY, USA
Int J Radiat Oncol Biol Phys 78:1292-300. 2010..To identify single nucleotide polymorphisms (SNPs) associated with erectile dysfunction (ED) among African-American prostate cancer patients treated with external beam radiation therapy... - Feasibility of accelerated whole-breast radiation in the treatment of patients with ductal carcinoma in situ of the breastClaire Constantine
Department of Radiation Oncology, New York University School of Medicine, New York, New York 10016, USA
Clin Breast Cancer 8:269-74. 2008..We report the results of a prospective trial investigating the use of accelerated, hypofractionated whole-breast radiation therapy after breast-conservation surgery for ductal carcinoma in situ (DCIS)... - p53 gene mutations in SKH-1 mouse tumors differentially induced by UVB and combined subcarcinogenic benzo[a]pyrene and UVAYongyin Wang
Department of Dermatology, Mount Sinai School of Medicine, New York, NY, USA
Photochem Photobiol 84:444-9. 2008..We show that individually subcarcinogenic levels of BaP and UVA synergistically induce a novel p53-mutation fingerprint. This fingerprint could serve as a prognostic indicator for the development of BaP-UVA-induced skin tumors... - Stereotactic radiosurgery for thoracic malignanciesJamie A Cesaretti
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York 10029, USA
Ann Thorac Surg 85:S785-91. 2008..The article closes with a discussion of multidisciplinary approaches that include radiosurgery which are on the therapeutic horizon... - TGFB1 single nucleotide polymorphisms are associated with adverse quality of life in prostate cancer patients treated with radiotherapyChristopher A Peters
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
Int J Radiat Oncol Biol Phys 70:752-9. 2008..To investigate whether the presence of single nucleotide polymorphisms (SNPs) located within TGFB1 might be predictive for the development of adverse quality-of-life outcomes in prostate cancer patients treated with radiotherapy... - Combined subcarcinogenic benzo[a]pyrene and UVA synergistically caused high tumor incidence and mutations in H-ras gene, but not p53, in SKH-1 hairless mouse skinYongyin Wang
Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
Int J Cancer 116:193-9. 2005..G-->A mutations induced by BaP or BaP-UVA at position 38 of codon 13 have not been reported previously. C-->T transitions were detected in p53 hot spots of exon 8 in 2 of 19 BaP-UVA-induced tumors but were not found in nontumor skin... - Cellular response to DNA damageJohnny Kao
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York 10029, USA
Ann N Y Acad Sci 1066:243-58. 2005..DNA damage repair is a dynamic field of research where the fruits of basic research often have important clinical implications... - Phase I-II trial of prone accelerated intensity modulated radiation therapy to the breast to optimally spare normal tissueSilvia C Formenti
Department of Radiation Oncology, Division of Biostatistics, New York University Cancer Institute and New York University School of Medicine, New York, NY 10016, USA
J Clin Oncol 25:2236-42. 2007..To report the clinical feasibility of a trial of accelerated whole-breast intensity modulated radiotherapy, with the patient in prone position, optimally to spare the heart and lung... - Radiation-induced side effects with or without systemic therapies: prime time for prediction of individual radiosensitivityDavid Azria
Int J Radiat Oncol Biol Phys 71:1293-4. 2008
Research Grants
- Genome-Wide Study to Identify SNPs and CNPs Associated with Radiation InjuryBARRY S contact ROSENSTEIN; Fiscal Year: 2010..The results of this project should provide a basis for a predictive screening assay to identify prostate cancer patients who are most likely to develop urinary morbidity, proctitis or ED following radiotherapy. ..