G J Randolph

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes
    Claudia Jakubzick
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 205:2839-50. 2008
  2. pmc Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes
    Chunfeng Qu
    Dept of Gene and Cell Medicine, Mt Sinai School of Medicine, Box 1496, 1425 Madison Ave, New York, NY 10029, USA
    J Exp Med 200:1231-41. 2004
  3. pmc Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery
    Frank Tacke
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 203:583-97. 2006
  4. pmc Antigen presentation by monocytes and monocyte-derived cells
    Gwendalyn J Randolph
    Department of Gene and Cell Medicine and the Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Opin Immunol 20:52-60. 2008
  5. ncbi request reprint Dendritic-cell trafficking to lymph nodes through lymphatic vessels
    Gwendalyn J Randolph
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1496, New York, New York 10029, USA
    Nat Rev Immunol 5:617-28. 2005
  6. ncbi request reprint Migration of dendritic cell subsets and their precursors
    Gwendalyn J Randolph
    Department of Gene and Cell Medicine, Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Annu Rev Immunol 26:293-316. 2008
  7. pmc The fate of monocytes in atherosclerosis
    G J Randolph
    Department of Gene and Cell Medicine, and the Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Thromb Haemost 7:28-30. 2009
  8. ncbi request reprint Factors and signals that govern the migration of dendritic cells via lymphatics: recent advances
    Gwendalyn J Randolph
    Department of Gene and Cell Medicine, Mt Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Springer Semin Immunopathol 26:273-87. 2005
  9. pmc Emigration of monocyte-derived cells to lymph nodes during resolution of inflammation and its failure in atherosclerosis
    Gwendalyn J Randolph
    Department of Gene and Cell Medicine, and the Immunology Institute, 1425 Madison Avenue, Mount Sinai School of Medicine, New York 10029, USA
    Curr Opin Lipidol 19:462-8. 2008
  10. ncbi request reprint Dendritic cell migration to lymph nodes: cytokines, chemokines, and lipid mediators
    G J Randolph
    Institute for Gene Therapy and Molecular Medicine, Mt Sinai School of Medicine, 1425 Madison Avenue, Box 1496, New York, NY 10029, USA
    Semin Immunol 13:267-74. 2001

Research Grants

  1. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2010
  2. Differentiation/migratory fate of monocyte-derived cells
    Gwendalyn J Randolph; Fiscal Year: 2010
  3. Pathways that regulate monocyte/dendritic cell migration
    Gwendalyn J Randolph; Fiscal Year: 2010
  4. Differentiation/migratory fate of monocyte-derived cells
    Gwendalyn Randolph; Fiscal Year: 2009
  5. Pathways that regulate monocyte/dendritic cell migration
    Gwendalyn Randolph; Fiscal Year: 2007
  6. Differentiation/migratory fate of monocyte-derived cells
    Gwendalyn Randolph; Fiscal Year: 2003
  7. Dendritic cell migration in atheroscelrosis
    Gwendalyn Randolph; Fiscal Year: 2004
  8. Differentiation/migratory fate of monocyte-derived cells
    Gwendalyn Randolph; Fiscal Year: 2007
  9. Pathways that regulate monocyte/dendritic cell migration
    Gwendalyn Randolph; Fiscal Year: 2009

Detail Information

Publications50

  1. pmc Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes
    Claudia Jakubzick
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 205:2839-50. 2008
    ..Instead, our analysis suggests that nonlymphoid organ DCs comprise a major population of DCs within lymph nodes only after introduction of an inflammatory stimulus...
  2. pmc Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes
    Chunfeng Qu
    Dept of Gene and Cell Medicine, Mt Sinai School of Medicine, Box 1496, 1425 Madison Ave, New York, NY 10029, USA
    J Exp Med 200:1231-41. 2004
    ..When these monocyte-derived DCs exit skin to emigrate to LNs, they use not only CCR7 but also CCR8, which was not previously recognized to participate in migration to LNs...
  3. pmc Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery
    Frank Tacke
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 203:583-97. 2006
    ..These data reveal that immature monocytes unexpectedly sample antigen from the bone marrow environment and that they can present these antigens after they leave the bone marrow...
  4. pmc Antigen presentation by monocytes and monocyte-derived cells
    Gwendalyn J Randolph
    Department of Gene and Cell Medicine and the Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Opin Immunol 20:52-60. 2008
    ....
  5. ncbi request reprint Dendritic-cell trafficking to lymph nodes through lymphatic vessels
    Gwendalyn J Randolph
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1496, New York, New York 10029, USA
    Nat Rev Immunol 5:617-28. 2005
    ....
  6. ncbi request reprint Migration of dendritic cell subsets and their precursors
    Gwendalyn J Randolph
    Department of Gene and Cell Medicine, Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Annu Rev Immunol 26:293-316. 2008
    ..Finally, to gain a more molecular appreciation of the specialized migratory properties of DCs, we review the signaling cascades that govern the process of DC migration...
  7. pmc The fate of monocytes in atherosclerosis
    G J Randolph
    Department of Gene and Cell Medicine, and the Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Thromb Haemost 7:28-30. 2009
    ..All of these points of intervention will be briefly discussed in this article...
  8. ncbi request reprint Factors and signals that govern the migration of dendritic cells via lymphatics: recent advances
    Gwendalyn J Randolph
    Department of Gene and Cell Medicine, Mt Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Springer Semin Immunopathol 26:273-87. 2005
    ....
  9. pmc Emigration of monocyte-derived cells to lymph nodes during resolution of inflammation and its failure in atherosclerosis
    Gwendalyn J Randolph
    Department of Gene and Cell Medicine, and the Immunology Institute, 1425 Madison Avenue, Mount Sinai School of Medicine, New York 10029, USA
    Curr Opin Lipidol 19:462-8. 2008
    ..This review compares the fate of monocyte-derived cells that enter atherosclerotic plaques with those that accumulate at other sites of inflammation...
  10. ncbi request reprint Dendritic cell migration to lymph nodes: cytokines, chemokines, and lipid mediators
    G J Randolph
    Institute for Gene Therapy and Molecular Medicine, Mt Sinai School of Medicine, 1425 Madison Avenue, Box 1496, New York, NY 10029, USA
    Semin Immunol 13:267-74. 2001
    ..Indeed, MRP1 and the related multidrug resistance protein 1 (MDR1, p-glycoprotein, ABCB1) may control the intracellular and extracellular accumulation of key signaling lipids that regulate dendritic cell migration...
  11. pmc Is maturation required for Langerhans cell migration?
    Gwendalyn J Randolph
    Carl C Icahn Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    J Exp Med 196:413-6. 2002
  12. pmc The CD16(+) (FcgammaRIII(+)) subset of human monocytes preferentially becomes migratory dendritic cells in a model tissue setting
    Gwendalyn J Randolph
    The Carl C Icahn Institute for Gene Therapy and Molecular Medicine, Mt Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    J Exp Med 196:517-27. 2002
    ..We propose that CD16(+) monocytes may contribute significantly to precursors for DCs that transiently survey tissues and migrate to lymph nodes via afferent lymphatic vessels...
  13. ncbi request reprint The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes
    D F Robbiani
    Department of Pathology and Immunology Program Weill Medical College and Graduate School of Medical Sciences of Cornell University, New York, NY 10029, USA
    Cell 103:757-68. 2000
    ..Thus, MRP-1 regulates DC migration to lymph nodes, apparently by transporting LTC(4), which in turn promotes chemotaxis to CCL19 and mobilization of DCs from the epidermis...
  14. ncbi request reprint Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking
    G J Randolph
    Department of Pathology, Cornell University Medical College, 1300 York Avenue, Room C 420, New York, NY 10021, USA
    Science 282:480-3. 1998
    ..Monocytes that remained in the subendothelial matrix became macrophages. Therefore, monocytes have two potential fates associated with distinct patterns of migration...
  15. ncbi request reprint Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations
    Claudia Jakubzick
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 180:3019-27. 2008
    ..Overall, these data demonstrate that the two circulating subsets of monocytes give rise to distinct tissue DC populations...
  16. pmc A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels
    G J Randolph
    Department of Pathology, Cornell University Medical College, 1300 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 95:6924-9. 1998
    ....
  17. pmc In vivo analysis of dendritic cell development and homeostasis
    Kang Liu
    Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA
    Science 324:392-7. 2009
    ..Further cDC development involves cell division, which is controlled in part by regulatory T cells and fms-like tyrosine kinase receptor-3...
  18. ncbi request reprint Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo
    G J Randolph
    Department of Pathology, Weill Medical College of Cornell University, New York, USA
    Immunity 11:753-61. 1999
    ..Thus, a substantial minority of inflammatory monocytes carry phagocytosed particles to lymph nodes and differentiate into DCs...
  19. pmc Origin of the lamina propria dendritic cell network
    Milena Bogunovic
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Immunity 31:513-25. 2009
    ..Altogether, these results underline the diverse origin of the lamina propria DC network and identify mucosal DCs that arise from pre-DCs as key sentinels of the gut immune system...
  20. doi request reprint MHC class I/peptide transfer between dendritic cells overcomes poor cross-presentation by monocyte-derived APCs that engulf dying cells
    Chunfeng Qu
    Department of Gene and Cell Medicine and Institute for Immunology, Icahn Medical Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 182:3650-9. 2009
    ..These data reveal a way in which migratory monocyte-derived DCs and other DCs, like lymph node resident DCs, both mediate cross-presentation...
  21. ncbi request reprint Migration of leukocytes across endothelium and beyond: molecules involved in the transmigration and fate of monocytes
    W A Muller
    Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Leukoc Biol 66:698-704. 1999
    ..We postulate that a major source of DC in lymph nodes is cells derived from monocytes that enter a tissue via the blood and leave several days later via afferent lymphatic channels...
  22. ncbi request reprint Inflammation, lymphatic function, and dendritic cell migration
    Veronique Angeli
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Lymphat Res Biol 4:217-28. 2006
    ....
  23. ncbi request reprint Role of tissue factor in adhesion of mononuclear phagocytes to and trafficking through endothelium in vitro
    G J Randolph
    Department of Pathology, Cornell University Medical College, New York, NY, USA
    Blood 92:4167-77. 1998
    ..This binding was blocked by anti-TF MoAb, suggesting that endothelial cells bear a receptor for TF. These data suggest that mononuclear phagocytes use TF, perhaps as an adhesive protein, to exit sites of inflammation...
  24. ncbi request reprint A novel model of demyelinating encephalomyelitis induced by monocytes and dendritic cells
    Glaucia C Furtado
    Immunobiology Center, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Immunol 177:6871-9. 2006
    ..We propose that alterations in the numbers or function of monocytes and DC coupled to dysregulated expression of chemokines in the neural tissues, favors development of CNS autoimmune disease...
  25. pmc Optimization of methods to study pulmonary dendritic cell migration reveals distinct capacities of DC subsets to acquire soluble versus particulate antigen
    Claudia Jakubzick
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, NY, New York 10029, United States
    J Immunol Methods 337:121-31. 2008
    ..This finding suggests that changes in the physical presentation of the same antigen delivered to the airway during natural immune responses or vaccinations may markedly affect the character of the T cell response that ensues...
  26. ncbi request reprint Migratory fate and differentiation of blood monocyte subsets
    Frank Tacke
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, USA
    Immunobiology 211:609-18. 2006
    ..Fortunately, the rate of progress in the study of monocyte fate is rapidly picking up pace, giving rise to the expectation that we will soon know much more about the biology of monocytes in the steady state and inflammation...
  27. ncbi request reprint Autocrine type I IFN and contact with endothelium promote the presentation of influenza A virus by monocyte-derived APC
    Chunfeng Qu
    Carl C Icahn Institute for Gene Therapy and Molecular Medicine, Mt Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 170:1010-8. 2003
    ..However, when infected with live influenza virus, the role of type I IFN in mediating differentiation and Ag-presenting capacity is expendable, apparently due to other mechanisms of virus-mediated activation...
  28. ncbi request reprint Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization
    Veronique Angeli
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunity 21:561-74. 2004
    ..In this context, HDL and PAFAH maintain a normally functional DC compartment...
  29. ncbi request reprint Langerhans cells arise from monocytes in vivo
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Immunol 7:265-73. 2006
    ..These results identify Gr-1(hi) monocytes as the direct precursors for LCs in vivo and establish the importance of the CSF-1 receptor in this process...
  30. ncbi request reprint Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts
    Jordi C Ochando
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Nat Immunol 7:652-62. 2006
    ..Thus, alloantigen-presenting pDCs home to the lymph nodes in tolerogenic conditions, where they mediate alloantigen-specific Treg cell development and allograft tolerance...
  31. ncbi request reprint B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization
    Veronique Angeli
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Immunity 24:203-15. 2006
    ..Knowledge that DC migration from the periphery is augmented by B cell-dependent signals reveals new potential strategies to increase DC migration during vaccination...
  32. ncbi request reprint Modulation of dendritic cell trafficking to and from the airways
    Claudia Jakubzick
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    J Immunol 176:3578-84. 2006
    ....
  33. pmc Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice
    Eugene Trogan
    Marc and Ruti Bell Vascular Biology Program, Leon H Charney Division of Cardiology Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 103:3781-6. 2006
    ..Taken with the other gene expression data, these results in vivo point to complex relationships among the immune system, nuclear hormone receptors, and inflammation during regression...
  34. pmc ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Science 328:1689-93. 2010
    ..The findings indicate that ABCA1, ABCG1, and HDL inhibit the proliferation of hematopoietic stem and multipotential progenitor cells and connect expansion of these populations with leukocytosis and accelerated atherosclerosis...
  35. pmc Regulation of the migration and survival of monocyte subsets by chemokine receptors and its relevance to atherosclerosis
    Emmanuel L Gautier
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Arterioscler Thromb Vasc Biol 29:1412-8. 2009
    ..Finally, we discuss how this knowledge may be useful clinically, emphasizing that CX3CR1 may in particular be a viable target for therapeutic manipulation of monocyte-derived cell fate in cardiovascular disease...
  36. doi request reprint Methods to study pulmonary dendritic cell migration
    Claudia Jakubzick
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Biol 595:371-82. 2010
    ..Our protocol describes how to label and track pulmonary dendritic cells from the airway and lung to the mediastinal lymph nodes and reveals how to avoid pitfalls and suboptimal assays...
  37. pmc RGD peptide functionalized and reconstituted high-density lipoprotein nanoparticles as a versatile and multimodal tumor targeting molecular imaging probe
    Wei Chen
    Translational and Molecular Imaging Institute, Department of Radiology and Medicine, Mt Sinai School of Medicine, New York, NY 10029, USA
    FASEB J 24:1689-99. 2010
    ..This study demonstrates the ability to reroute HDL from its natural targets to tumor blood vessels and its potential for multimodal imaging of tumor-associated processes...
  38. doi request reprint Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanism
    Simona Podgrabinska
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 183:1767-79. 2009
    ..Together, these data demonstrate a direct role of LECs in the modulation of immune response and suggest a function of the lymphatic endothelium in preventing undesired immune reactions in inflammatory conditions...
  39. ncbi request reprint FTY720-enhanced T cell homing is dependent on CCR2, CCR5, CCR7, and CXCR4: evidence for distinct chemokine compartments
    Adam C Yopp
    Carl C Icahn Center for Gene Therapy and Molecular Medicine, and Recanti Miller Transplantation Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 173:855-65. 2004
    ..These results indicate that FTY720- and sphingosine 1-phosphate receptor-stimulated T cell migration are dependent on the restricted usage of chemokine receptor-ligand pairs within discrete anatomic compartments...
  40. pmc Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques
    Jaime Llodra
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 101:11779-84. 2004
    ..Thus, progression of atherosclerotic plaques may result not only from robust monocyte recruitment into arterial walls but also from reduced emigration of these cells from lesions...
  41. ncbi request reprint Migratory dendritic cells: sometimes simply ferries?
    Gwendalyn J Randolph
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunity 25:15-8. 2006
    ..In this issue, Allan et al. (2006) conclude that transport of herpes-virus antigens to lymph nodes by dendritic cells is crucial for antiviral immunity, but migrating DCs do not present herpes antigens to CD8(+) lymphocytes...
  42. pmc Comparison of gene expression profiles between human and mouse monocyte subsets
    Molly A Ingersoll
    Department of Gene and Cell Medicine and Immunology Institute, Mount Sinai School of Medicine, New York, NY, USA
    Blood 115:e10-9. 2010
    ..Thus, whereas human and mouse monocyte subsets are far more broadly conserved than currently recognized, important differences between the species deserve consideration when models of human disease are studied in mice...
  43. pmc Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques
    Frank Tacke
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 117:185-94. 2007
    ..Thus, antagonizing CX3CR1 may be effective therapeutically in ameliorating CCR2(+) monocyte recruitment to plaques without impairing their CCR2-dependent responses to inflammation overall...
  44. pmc FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes
    Shaun M Honig
    Carl C Icahn Center for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 111:627-37. 2003
    ....
  45. ncbi request reprint Human 6-sulfo LacNAc-expressing dendritic cells are principal producers of early interleukin-12 and are controlled by erythrocytes
    Knut Schakel
    Institute of Immunology, OncoRay, Biological and Molecular Targeting, Medical Faculty, Technische Universitat Dresden, 01307 Dresden, Germany
    Immunity 24:767-77. 2006
    ..While strictly controlled in the blood by erythrocytes, the high IL-12- and TNF-alpha-producing capacity of slanDC in tissues may be critical in fighting off pathogens; if uncontrolled, it may lead to adverse inflammatory reactions...
  46. ncbi request reprint Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling
    Jacqueline D Shields
    Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne 1015, Switzerland
    Cancer Cell 11:526-38. 2007
    ..Computational modeling revealed that transcellular gradients of CCR7 ligand were created under flow to drive this response. This illustrates how tumor cells may be guided to lymphatics during metastasis...
  47. pmc Lipopolysaccharide or whole bacteria block the conversion of inflammatory monocytes into dendritic cells in vivo
    Gianluca Rotta
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti, 435, 20141 Milano, Italy
    J Exp Med 198:1253-63. 2003
    ....
  48. ncbi request reprint Signaling protein SWAP-70 is required for efficient B cell homing to lymphoid organs
    Glen Pearce
    Institute of Physiological Chemistry, Dresden University of Technology, 01307 Dresden, Germany
    Nat Immunol 7:827-34. 2006
    ..During attachment, Swap70-/- B cells showed defective polarization and did not form uropods or stabilize lamellipodia at a defined region. Thus, SWAP-70 selectively regulates processes essential for B cell entry into lymph nodes...
  49. ncbi request reprint Exploiting lymphatic transport and complement activation in nanoparticle vaccines
    Sai T Reddy
    Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Nat Biotechnol 25:1159-64. 2007
    ..Using nanoparticles conjugated to the model antigen ovalbumin, we demonstrate generation of humoral and cellular immunity in mice in a size- and complement-dependent manner...
  50. ncbi request reprint The fibroblast: sentinel cell and local immune modulator in tumor tissue
    Tobias Silzle
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Int J Cancer 108:173-80. 2004
    ..The role of TAF-dependent ECM remodeling and TAF-derived peptide growth factors, cytokines, and chemokines in the immune modulation is stressed and the idea of TAF as an important therapeutic target is emphasized...

Research Grants20

  1. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2010
    ..Several promising tools that may ultimately lead to valuable insight into how lymphatic disorders could be treated will be explored in this proposal. ..
  2. Differentiation/migratory fate of monocyte-derived cells
    Gwendalyn J Randolph; Fiscal Year: 2010
    ....
  3. Pathways that regulate monocyte/dendritic cell migration
    Gwendalyn J Randolph; Fiscal Year: 2010
    ..We will study this possibility and its relevance to artery wall DCs that accumulate in prelesional areas. ..
  4. Differentiation/migratory fate of monocyte-derived cells
    Gwendalyn Randolph; Fiscal Year: 2009
    ..More work is needed to unravel this surprising finding and understand its impact on the immune system (aim 3). ..
  5. Pathways that regulate monocyte/dendritic cell migration
    Gwendalyn Randolph; Fiscal Year: 2007
    ..We will study this possibility and its relevance to artery wall DCs that accumulate in prelesional areas. ..
  6. Differentiation/migratory fate of monocyte-derived cells
    Gwendalyn Randolph; Fiscal Year: 2003
    ..The second aim will determine whether all monocytes, or just a subset of cells, have the capacity to differentiate into DC. The third aim will explore the roles of the transmembrane transporter proteins in DC migration and maturation. ..
  7. Dendritic cell migration in atheroscelrosis
    Gwendalyn Randolph; Fiscal Year: 2004
    ....
  8. Differentiation/migratory fate of monocyte-derived cells
    Gwendalyn Randolph; Fiscal Year: 2007
    ..More work is needed to unravel this surprising finding and understand its impact on the immune system (aim 3). ..
  9. Pathways that regulate monocyte/dendritic cell migration
    Gwendalyn Randolph; Fiscal Year: 2009
    ..We will study this possibility and its relevance to artery wall DCs that accumulate in prelesional areas. ..