Research Topics
Species | Jason J RadleySummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
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Publications
5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrusJason J Radley
Department of Psychology, Princeton University, Princeton, NJ 08544, USA
Brain Res 955:264-7. 2002..This suggests that 5-HT(1A) receptor activity is important during naturally occurring cell proliferation in the dentate gyrus, and perhaps neurogenesis, and is one of the many factors involved in its regulation...- Pilocarpine-induced status epilepticus increases cell proliferation in the dentate gyrus of adult rats via a 5-HT1A receptor-dependent mechanismJason J Radley
Program in Neuroscience, Department of Psychology, Princeton University, Princeton, NJ 08544, USA
Brain Res 966:1-12. 2003.... - Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortexJ J Radley
Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
Neuroscience 125:1-6. 2004.... - Reversibility of apical dendritic retraction in the rat medial prefrontal cortex following repeated stressJason J Radley
Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
Exp Neurol 196:199-203. 2005..These results suggest that stress-induced dendritic plasticity in the medial PFC is reversible and may have implications for the functional recovery of medial PFC function following prolonged psychological stress... - Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional set-shiftingConor Liston
Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
J Neurosci 26:7870-4. 2006..This study provides the first direct evidence that dendritic remodeling in the prefrontal cortex may underlie the functional deficits in attentional control that are symptomatic of stress-related mental illnesses... 
Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spinesJason J Radley
Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
Brain Res 1134:87-94. 2007....
Stress risk factors and stress-related pathology: neuroplasticity, epigenetics and endophenotypesJason J Radley
Department of Psychology, University of Iowa, Iowa City, IA, USA
Stress 14:481-97. 2011..Together, the symposium highlighted emerging themes regarding the role of brain reorganization, individual differences, and epigenetics in determining stress plasticity and pathology...- Repeated stress induces dendritic spine loss in the rat medial prefrontal cortexJason J Radley
Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
Cereb Cortex 16:313-20. 2006..Dendritic atrophy and spine loss may be important cellular features of stress-related psychiatric disorders where the PFC is functionally impaired... - A common substrate for prefrontal and hippocampal inhibition of the neuroendocrine stress responseJason J Radley
Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
J Neurosci 31:9683-95. 2011..These findings support the view that stress-inhibitory influences of mPFC and HF are exerted principally via convergence onto a common relay, as opposed to a serial, parallel, or more complex multisynaptic network... - Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortexJason J Radley
Laboratory of Neuronal Structure and Function, Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Comp Neurol 507:1141-50. 2008..These results suggest a failure of spines to mature and stabilize following repeated stress and are likely to have major repercussions on function, receptor expression, and synaptic efficacy... - Repeated stress and structural plasticity in the brainJason J Radley
Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Ageing Res Rev 4:271-87. 2005..How functional impairments in these brain regions play a role in stress-related mental illnesses is discussed in this context. Finally, we discuss the cumulative impact of stress-induced structural plasticity in aging... - Regional differentiation of the medial prefrontal cortex in regulating adaptive responses to acute emotional stressJason J Radley
Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, and Foundation for Medical Research, La Jolla, California 92037, USA
J Neurosci 26:12967-76. 2006..These results suggest that dorsal and ventral aspects of the mPFC differentially regulate neuroendocrine and autonomic PVH outputs in response to emotional stress... - Noradrenergic innervation of the dorsal medial prefrontal cortex modulates hypothalamo-pituitary-adrenal responses to acute emotional stressJason J Radley
Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, Clayton Medical Research Foundation, La Jolla, California 92037, USA
J Neurosci 28:5806-16. 2008..These findings identify the LC as an upstream component of a circuitry providing for dorsal mPFC modulation of emotional stress-induced HPA activation... - Associative Pavlovian conditioning leads to an increase in spinophilin-immunoreactive dendritic spines in the lateral amygdalaJason J Radley
Laboratory for Neuronal Structure and Function, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Eur J Neurosci 24:876-84. 2006....