Weiping Qin

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Differential alterations in gene expression profiles contribute to time-dependent effects of nandrolone to prevent denervation atrophy
    Weiping Qin
    Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J, Peters VA Medical Center, 130 West Kingsbridge Road, Bronx, New York 10468, USA
    BMC Genomics 11:596. 2010
  2. pmc The central nervous system (CNS)-independent anti-bone-resorptive activity of muscle contraction and the underlying molecular and cellular signatures
    Weiping Qin
    Departments of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 288:13511-21. 2013
  3. pmc PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx, NY, USA
    Arch Neurol 66:352-61. 2009
  4. doi request reprint Protection against dexamethasone-induced muscle atrophy is related to modulation by testosterone of FOXO1 and PGC-1α
    Weiping Qin
    Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J Peters VA Medical Center, Bronx, NY, USA
    Biochem Biophys Res Commun 403:473-8. 2010
  5. doi request reprint Bone and muscle loss after spinal cord injury: organ interactions
    Weiping Qin
    Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J Peters Veterans Affairs Medical Center, Bronx, New York, USA
    Ann N Y Acad Sci 1211:66-84. 2010
  6. doi request reprint Evolving concepts in neurogenic osteoporosis
    Weiping Qin
    Center of Excellence for the Medical Consequences of Spinal Cord Injury, Bronx, NY 10468, USA
    Curr Osteoporos Rep 8:212-8. 2010
  7. ncbi request reprint Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathology
    Zhong Zhao
    Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
    FASEB J 19:2081-2. 2005
  8. pmc Anabolic steroids reduce spinal cord injury-related bone loss in rats associated with increased Wnt signaling
    Li Sun
    Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY, USA
    J Spinal Cord Med 36:616-22. 2013
  9. doi request reprint Nandrolone slows hindlimb bone loss in a rat model of bone loss due to denervation
    Christopher P Cardozo
    James J Peters VA Medical Center, Bronx, NY, USA
    Ann N Y Acad Sci 1192:303-6. 2010
  10. ncbi request reprint Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
    Lap Ho
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    FASEB J 18:902-4. 2004

Detail Information

Publications22

  1. pmc Differential alterations in gene expression profiles contribute to time-dependent effects of nandrolone to prevent denervation atrophy
    Weiping Qin
    Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J, Peters VA Medical Center, 130 West Kingsbridge Road, Bronx, New York 10468, USA
    BMC Genomics 11:596. 2010
    ..Affymetrix microarrays were used to profile gene expression changes due to nandrolone at 7 and 35 days and to identify major gene expression changes in denervated muscle between 7 and 35 days...
  2. pmc The central nervous system (CNS)-independent anti-bone-resorptive activity of muscle contraction and the underlying molecular and cellular signatures
    Weiping Qin
    Departments of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 288:13511-21. 2013
    ..Mechanisms by which muscle regulates bone are poorly understood...
  3. pmc PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx, NY, USA
    Arch Neurol 66:352-61. 2009
    ....
  4. doi request reprint Protection against dexamethasone-induced muscle atrophy is related to modulation by testosterone of FOXO1 and PGC-1α
    Weiping Qin
    Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J Peters VA Medical Center, Bronx, NY, USA
    Biochem Biophys Res Commun 403:473-8. 2010
    ..Regulation of FOXO1, PGC-1α and p38 MAPK by testosterone may represent a novel mechanism by which this agent protects against dexamethasone-induced muscle atrophy...
  5. doi request reprint Bone and muscle loss after spinal cord injury: organ interactions
    Weiping Qin
    Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J Peters Veterans Affairs Medical Center, Bronx, New York, USA
    Ann N Y Acad Sci 1211:66-84. 2010
    ..Adiposity and marrow fat are increased after SCI with intriguing, though poorly understood, implications for the function of skeletal muscle and bone cells...
  6. doi request reprint Evolving concepts in neurogenic osteoporosis
    Weiping Qin
    Center of Excellence for the Medical Consequences of Spinal Cord Injury, Bronx, NY 10468, USA
    Curr Osteoporos Rep 8:212-8. 2010
    ..The relative importance of, and interactions between autonomic, sensory, and peripheral nervous system actions on bone mass are also not clear in healthy individuals, and less so in pathologic states...
  7. ncbi request reprint Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathology
    Zhong Zhao
    Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
    FASEB J 19:2081-2. 2005
    ....
  8. pmc Anabolic steroids reduce spinal cord injury-related bone loss in rats associated with increased Wnt signaling
    Li Sun
    Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY, USA
    J Spinal Cord Med 36:616-22. 2013
    ..Hypogonadism is common in men after SCI and may exacerbate bone loss. The anabolic steroid nandrolone reduces bone loss due to microgravity or nerve transection...
  9. doi request reprint Nandrolone slows hindlimb bone loss in a rat model of bone loss due to denervation
    Christopher P Cardozo
    James J Peters VA Medical Center, Bronx, NY, USA
    Ann N Y Acad Sci 1192:303-6. 2010
    ..This study offers a potential novel pharmacological strategy for use of nandrolone to reduce bone loss in severe disuse- and denervation-related bone loss, such as that which occurs after spinal cord injury...
  10. ncbi request reprint Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
    Lap Ho
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    FASEB J 18:902-4. 2004
    ....
  11. pmc REDD1 is a major target of testosterone action in preventing dexamethasone-induced muscle loss
    Yong Wu
    Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J Peters VA Medical Center, 953 Southern Boulevard, Bronx, New York 10468, USA
    Endocrinology 151:1050-9. 2010
    ..These data suggest that testosterone blocks dexamethasone-induced changes in expression of REDD1 and other genes that collectively would otherwise down-regulate mTOR activity and hence also down-regulate protein synthesis...
  12. pmc Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer's disease-type amyloid neuropathology and spatial memory deterioration
    Weiping Qin
    Department of Psychiatry, Mount Sinnai School of Medicine, New York, NY 10029, USA
    Ann N Y Acad Sci 1147:335-47. 2008
    ..This study provides a novel metabolic pathway for prevention and/or treatment of AD...
  13. ncbi request reprint Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease
    Jun Wang
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    FASEB J 19:659-61. 2005
    ....
  14. ncbi request reprint Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 281:21745-54. 2006
    ..The study provides a potentially novel pharmacological strategy for AD prevention and/or treatment...
  15. doi request reprint Nandrolone reduces activation of Notch signaling in denervated muscle associated with increased Numb expression
    Xin Hua Liu
    Center of Excellence for Medical Consequences of Spinal Cord Injury, James J Peter VA Medical Center, Bronx, NY 10468, USA
    Biochem Biophys Res Commun 414:165-9. 2011
    ....
  16. doi request reprint Nandrolone, an anabolic steroid, stabilizes Numb protein through inhibition of mdm2 in C2C12 myoblasts
    Xin Hua Liu
    National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J Peter VA Medical Center, Bronx, New York 10468, USA
    J Androl 33:1216-23. 2012
    ....
  17. doi request reprint Dependence of dexamethasone-induced Akt/FOXO1 signaling, upregulation of MAFbx, and protein catabolism upon the glucocorticoid receptor
    Weidong Zhao
    Center of Excellence for the Medical Consequences of SCI, James J Peters VA Medical Center, Room 1E 02, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Biochem Biophys Res Commun 378:668-72. 2009
    ..The findings establish a requirement for the GR in activating molecular signals that promote muscle protein catabolism...
  18. ncbi request reprint Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus)
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Alzheimers Dis 10:417-22. 2006
    ..Collectively, the study suggests that investigation of the role of CR in non-human primates may provide a valuable approach for further clarifying the role of CR in AD...
  19. ncbi request reprint Caloric intake and Alzheimer's disease. Experimental approaches and therapeutic implications
    Giulio Maria Pasinetti
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Interdiscip Top Gerontol 35:159-75. 2007
    ....
  20. pmc S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    PLoS ONE 4:e4183. 2009
    ....
  21. ncbi request reprint Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity
    Weiping Qin
    Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:50970-7. 2003
    ....
  22. ncbi request reprint Is there a future for cyclo-oxygenase inhibitors in Alzheimer's disease?
    Lap Ho
    Department of Psychiatry, The Mount Sinai School of Medicine, Neuroinflammation Research Laboratories, New York, New York 10029, USA
    CNS Drugs 20:85-98. 2006
    ....