P E Purdue

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi Peroxisome biogenesis
    P E Purdue
    Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Annu Rev Cell Dev Biol 17:701-52. 2001
  2. ncbi Pex18p is constitutively degraded during peroxisome biogenesis
    P E Purdue
    Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, 1190 Fifth Ave, New York, NY 10029 6574, USA
    J Biol Chem 276:47684-9. 2001
  3. pmc Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway
    P E Purdue
    Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, New York 10029 6574
    J Cell Biol 143:1859-69. 1998
  4. ncbi Eci1p uses a PTS1 to enter peroxisomes: either its own or that of a partner, Dci1p
    X Yang
    Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Eur J Cell Biol 80:126-38. 2001
  5. ncbi Rhizomelic chondrodysplasia punctata, a peroxisomal biogenesis disorder caused by defects in Pex7p, a peroxisomal protein import receptor: a minireview
    P E Purdue
    Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Neurochem Res 24:581-6. 1999
  6. ncbi Identification of peroxisomal membrane ghosts with an epitope-tagged integral membrane protein in yeast mutants lacking peroxisomes
    P E Purdue
    Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, NY 10029, USA
    Yeast 11:1045-60. 1995
  7. ncbi Rhizomelic chondrodysplasia punctata is caused by deficiency of human PEX7, a homologue of the yeast PTS2 receptor
    P E Purdue
    Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Nat Genet 15:381-4. 1997
  8. ncbi Molecular evolution of alanine/glyoxylate aminotransferase 1 intracellular targeting. Analysis of the marmoset and rabbit genes
    P E Purdue
    Biochemical Genetics Research Group, Clinical Research Centre, Harrow, England
    Eur J Biochem 207:757-66. 1992
  9. pmc Mistargeting of peroxisomal L-alanine:glyoxylate aminotransferase to mitochondria in primary hyperoxaluria patients depends upon activation of a cryptic mitochondrial targeting sequence by a point mutation
    P E Purdue
    Biochemical Genetics Research Group, Clinical Research Centre, Harrow, Middlesex, United Kingdom
    Proc Natl Acad Sci U S A 88:10900-4. 1991
  10. pmc Enzymological and mutational analysis of a complex primary hyperoxaluria type 1 phenotype involving alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting and intraperoxisomal aggregation
    C J Danpure
    Biochemical Genetics Research Group, Medical Research Council Clinical Research Centre, Harrow, Middlesex, United Kingdom
    Am J Hum Genet 53:417-32. 1993

Collaborators

  • X Yang
  • C J Danpure
  • T G Knott
  • G M Birdsey
  • I M Gallagher
  • K E Sinclair
  • M J Lumb
  • Y Takada
  • H Esumi
  • N Kaneko

Detail Information

Publications15

  1. ncbi Peroxisome biogenesis
    P E Purdue
    Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Annu Rev Cell Dev Biol 17:701-52. 2001
    ....
  2. ncbi Pex18p is constitutively degraded during peroxisome biogenesis
    P E Purdue
    Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, 1190 Fifth Ave, New York, NY 10029 6574, USA
    J Biol Chem 276:47684-9. 2001
    ..These data represent, to the best of our knowledge, the first instance of an organelle biogenesis factor that is degraded constitutively and rapidly...
  3. pmc Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway
    P E Purdue
    Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, New York 10029 6574
    J Cell Biol 143:1859-69. 1998
    ..Pex18p and Pex21p are weakly homologous to each other and display partial functional redundancy, indicating that they constitute a two-member peroxin family specifically required for Pex7p and PTS2 targeting...
  4. ncbi Eci1p uses a PTS1 to enter peroxisomes: either its own or that of a partner, Dci1p
    X Yang
    Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Eur J Cell Biol 80:126-38. 2001
    ..Thus, Eci1p can be targeted to peroxisomes by its own PTS1 or as a hetero-oligomer with Dcilp. These data demonstrate a novel, redundant targeting pathway for Eci1p...
  5. ncbi Rhizomelic chondrodysplasia punctata, a peroxisomal biogenesis disorder caused by defects in Pex7p, a peroxisomal protein import receptor: a minireview
    P E Purdue
    Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Neurochem Res 24:581-6. 1999
    ....
  6. ncbi Identification of peroxisomal membrane ghosts with an epitope-tagged integral membrane protein in yeast mutants lacking peroxisomes
    P E Purdue
    Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, NY 10029, USA
    Yeast 11:1045-60. 1995
    ..Gold-labelled membranes were clearly visible in both mutants: in peb2 the labelled membrane vesicles were generally much smaller than those in peb4, which resembled normal peroxisomes in size...
  7. ncbi Rhizomelic chondrodysplasia punctata is caused by deficiency of human PEX7, a homologue of the yeast PTS2 receptor
    P E Purdue
    Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Nat Genet 15:381-4. 1997
    ..These results imply that several peroxisomal proteins are targeted by PTS2 signals and that the various biochemical and clinical defects in RCDP result from a defect in the receptor for this class of PTS...
  8. ncbi Molecular evolution of alanine/glyoxylate aminotransferase 1 intracellular targeting. Analysis of the marmoset and rabbit genes
    P E Purdue
    Biochemical Genetics Research Group, Clinical Research Centre, Harrow, England
    Eur J Biochem 207:757-66. 1992
    ....
  9. pmc Mistargeting of peroxisomal L-alanine:glyoxylate aminotransferase to mitochondria in primary hyperoxaluria patients depends upon activation of a cryptic mitochondrial targeting sequence by a point mutation
    P E Purdue
    Biochemical Genetics Research Group, Clinical Research Centre, Harrow, Middlesex, United Kingdom
    Proc Natl Acad Sci U S A 88:10900-4. 1991
    ..These results are discussed with reference to the AGT targeting defect in primary hyperoxaluria and also in relation to the highly unusual species specificity of subcellular distribution of AGT among mammals...
  10. pmc Enzymological and mutational analysis of a complex primary hyperoxaluria type 1 phenotype involving alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting and intraperoxisomal aggregation
    C J Danpure
    Biochemical Genetics Research Group, Medical Research Council Clinical Research Centre, Harrow, Middlesex, United Kingdom
    Am J Hum Genet 53:417-32. 1993
    ..On the other hand, the Gly41-->Arg substitution, either in combination with the Pro11-->Leu polymorphism or by itself, is predicted to be responsible for the intraperoxisomal aggregation of the AGT protein...
  11. pmc Human peroxisomal L-alanine: glyoxylate aminotransferase. Evolutionary loss of a mitochondrial targeting signal by point mutation of the initiation codon
    Y Takada
    Biochemistry Division, National Cancer Center Research Institute, Tokyo, Japan
    Biochem J 268:517-20. 1990
    ....
  12. pmc The peroxisomal targeting sequence type 1 receptor, Pex5p, and the peroxisomal import efficiency of alanine:glyoxylate aminotransferase
    T G Knott
    MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, Gower Street, London WC1E 6BT, U K
    Biochem J 352:409-18. 2000
    ..They also suggest that the non-consensus PTS1 of human AGT might interact with HsPex5p very differently compared with the consensus PTS1, Ser-Lys-Leu...
  13. pmc Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1
    P E Purdue
    Biochemical Genetics Research Group, Clinical Research Centre, Harrow, Middlesex, United Kingdom
    J Cell Biol 111:2341-51. 1990
    ....
  14. ncbi A glycine-to-glutamate substitution abolishes alanine:glyoxylate aminotransferase catalytic activity in a subset of patients with primary hyperoxaluria type 1
    P E Purdue
    Biochemical Genetics Research Group, Clinical Research Centre, Harrow, Middlesex, United Kingdom
    Genomics 13:215-8. 1992
    ..However, the protein sequence in this region is highly conserved between different mammals, and the substitution at residue 82 is predicted to cause significant local structural alterations...
  15. ncbi Molecular evolution of alanine/glyoxylate aminotransferase 1 intracellular targeting. Analysis of the feline gene
    M J Lumb
    Biochemical Genetics Research Group, MRC Clinical Research Centre, Harrow, England
    Eur J Biochem 221:53-62. 1994
    ..A polypeptide in which the N-terminal 22 amino acids was absent could not be imported into mitochondria in vitro...