L Pick

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Functional dissection of the mouse Hox-a5 gene
    J J Zhao
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    EMBO J 15:1313-22. 1996
  2. pmc Multiple proteins interact with the fushi tarazu proximal enhancer
    W Han
    Brookdale Center for Molecular Biology, Mt Sinai School of Medicine, New York, New York 10029
    Mol Cell Biol 13:5549-59. 1993
  3. ncbi How does the fushi tarazu gene activate engrailed in the Drosophila embryo?
    P A Lawrence
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Dev Genet 23:28-34. 1998
  4. ncbi Segmentation: painting stripes from flies to vertebrates
    L Pick
    Brookdale Center for Developmental and Molecular Biology, Mt Sinai School of Medicine, New York, NY 10029, USA
    Dev Genet 23:1-10. 1998
  5. ncbi The nuclear receptor Ftz-F1 and homeodomain protein Ftz interact through evolutionarily conserved protein domains
    M Yussa
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mech Dev 107:39-53. 2001
  6. pmc A binding site for multiple transcriptional activators in the fushi tarazu proximal enhancer is essential for gene expression in vivo
    W Han
    Brookdale Center for Developmental and Molecular Biology, Mt Sinai School of Medicine, New York, New York 10029, USA
    Mol Cell Biol 18:3384-94. 1998
  7. ncbi A double interaction screen identifies positive and negative ftz gene regulators and ftz-interacting proteins
    Y Yu
    The Brookdale Center of the Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mech Dev 83:95-105. 1999
  8. ncbi Drosophila fushi tarazu. a gene on the border of homeotic function
    U Löhr
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Curr Biol 11:1403-12. 2001
  9. ncbi The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz
    Y Yu
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 385:552-5. 1997
  10. ncbi Non-periodic cues generate seven ftz stripes in the Drosophila embryo
    Y Yu
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mech Dev 50:163-75. 1995

Collaborators

Detail Information

Publications17

  1. pmc Functional dissection of the mouse Hox-a5 gene
    J J Zhao
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    EMBO J 15:1313-22. 1996
    ..Our results suggest that this type of protein-protein interaction may be essential for the biological activities of Hox-a5 and Scr...
  2. pmc Multiple proteins interact with the fushi tarazu proximal enhancer
    W Han
    Brookdale Center for Molecular Biology, Mt Sinai School of Medicine, New York, New York 10029
    Mol Cell Biol 13:5549-59. 1993
    ....
  3. ncbi How does the fushi tarazu gene activate engrailed in the Drosophila embryo?
    P A Lawrence
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Dev Genet 23:28-34. 1998
    ..Further, varying the amount of Ftz protein has no effect on en expression. Finally, embryos lacking the even-skipped gene have normal levels of Ftz but do not express en. Our observations appear to rule out the threshold hypothesis...
  4. ncbi Segmentation: painting stripes from flies to vertebrates
    L Pick
    Brookdale Center for Developmental and Molecular Biology, Mt Sinai School of Medicine, New York, NY 10029, USA
    Dev Genet 23:1-10. 1998
  5. ncbi The nuclear receptor Ftz-F1 and homeodomain protein Ftz interact through evolutionarily conserved protein domains
    M Yussa
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mech Dev 107:39-53. 2001
    ..Ftz, on the other hand, influences Ftz-F1 activity by interacting with its AF-2 domain in a manner that mimics a nuclear receptor coactivator...
  6. pmc A binding site for multiple transcriptional activators in the fushi tarazu proximal enhancer is essential for gene expression in vivo
    W Han
    Brookdale Center for Developmental and Molecular Biology, Mt Sinai School of Medicine, New York, New York 10029, USA
    Mol Cell Biol 18:3384-94. 1998
    ..The finding of repeated binding sites for multiple nuclear proteins underscores the high degree of redundancy built into embryonic gene regulatory networks...
  7. ncbi A double interaction screen identifies positive and negative ftz gene regulators and ftz-interacting proteins
    Y Yu
    The Brookdale Center of the Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mech Dev 83:95-105. 1999
    ..The DIS should be a generally useful method to identify DNA binding transcriptional regulators and protein partners of previously characterized DNA binding proteins...
  8. ncbi Drosophila fushi tarazu. a gene on the border of homeotic function
    U Löhr
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Curr Biol 11:1403-12. 2001
    ..If these genes arose from a homeotic ancestor, their functional properties must have changed significantly during the evolution of modern Drosophila...
  9. ncbi The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz
    Y Yu
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 385:552-5. 1997
    ..Cooperative interaction between homeodomain proteins and cofactors of different classes may serve as a general mechanism to increase HOX protein specificity and to broaden the range of target sites they regulate...
  10. ncbi Non-periodic cues generate seven ftz stripes in the Drosophila embryo
    Y Yu
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mech Dev 50:163-75. 1995
    ..This multi-level regulation provides a back-up system that ensures the development of seven stripes in the blastoderm...
  11. ncbi Targeted ribozymes reveal a conserved function of the Drosophila paired gene in sensory organ development
    C E Vanario-Alonso
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mech Dev 53:323-8. 1995
    ..These studies reveal a role for prd in sensory organ development that appears to be conserved in PAX genes throughout the animal kingdom...
  12. ncbi Multiple regulatory elements direct the complex expression pattern of the Drosophila segmentation gene paired
    T Gutjahr
    Institute for Molecular Biology II, University of Zurich, Switzerland
    Mech Dev 48:119-28. 1994
    ..Regulation during separate but overlapping phases of expression by separable regulatory regions might be a general characteristic of segmentation genes...
  13. ncbi Analysis of the ftz upstream element: germ layer-specific enhancers are independently autoregulated
    L Pick
    Department of Cell Biology, University of Basel, Switzerland
    Genes Dev 4:1224-39. 1990
    ..We suggest that ftz protein acts in combination with germ layer-restricted transcription factors directly and positively to regulate the transcription of its own gene...
  14. pmc Nuclear scaffold attachment stimulates, but is not essential for ARS activity in Saccharomyces cerevisiae: analysis of the Drosophila ftz SAR
    B Amati
    Swiss Institute for Experimental Cancer Research ISREC, Epalinges s Lausanne
    EMBO J 9:4007-16. 1990
    ..Efficient interaction with nuclear scaffolds from both yeast and Drosophila requires a minimal length of SAR DNA that contains reiteration of a narrow minor groove structure of the double helix...
  15. ncbi Generating loss-of-function phenotypes of the fushi tarazu gene with a targeted ribozyme in Drosophila
    J J Zhao
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029
    Nature 365:448-51. 1993
    ..The involvement of ftz in neurogenesis was verified by activation of the ribozyme during the early phase of formation of the central nervous system...
  16. ncbi The mouse Hox-1.3 gene is functionally equivalent to the Drosophila Sex combs reduced gene
    J J Zhao
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029 6574
    Genes Dev 7:343-54. 1993
    ..3. The results suggest that mouse Hox-1.3 cannot only substitute functionally for Drosophila Scr in the determination of external structures but also can participate in the regulatory hierarchy of insect organogenesis...
  17. ncbi In vivo analysis of the helix-turn-helix motif of the fushi tarazu homeo domain of Drosophila melanogaster
    K Furukubo-Tokunaga
    Department of Cell Biology, University of Basel, Swtizerland
    Genes Dev 6:1082-96. 1992
    ....