D P Perl

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint The neuropathology of manganese-induced Parkinsonism
    Daniel P Perl
    Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Neuropathol Exp Neurol 66:675-82. 2007
  2. ncbi request reprint Hippocampal and entorhinal cortex neurofibrillary tangle formation in Guamanian Chamorros free of overt neurologic dysfunction
    Daniel P Perl
    Neuropathology Division, Department of Pathology, Mount Sinai School of Medicine, Box 1134, One Gustave L Levy Place, New York, NY 10029, USA
    J Neuropathol Exp Neurol 62:381-8. 2003
  3. ncbi request reprint Practical approaches to stereology in the setting of aging- and disease-related brain banks
    D P Perl
    Department of Pathology Neuropathology Division, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Chem Neuroanat 20:7-19. 2000
  4. pmc Neuropathology of Alzheimer's disease
    Daniel P Perl
    Neuropathology Division, Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 77:32-42. 2010
  5. ncbi request reprint The role of the pathologist in translational and personalized medicine
    Daniel P Perl
    Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mt Sinai J Med 74:22-6. 2007
  6. ncbi request reprint Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease
    V Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Arch Neurol 55:1185-91. 1998
  7. ncbi request reprint Neuropeptide abnormalities in patients with early Alzheimer disease
    K L Davis
    Department of Psychiatry, Mount Sinai School of Medicine, and Jewish Home and Hospital, New York, NY 10029, USA
    Arch Gen Psychiatry 56:981-7. 1999
  8. ncbi request reprint Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer's disease
    T Bussiere
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 117:577-92. 2003
  9. ncbi request reprint Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease
    V Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Arch Neurol 56:713-8. 1999
  10. ncbi request reprint Occurrence of alpha-synuclein pathology in the cerebellum of Guamanian patients with parkinsonism-dementia complex
    Joseph Sebeo
    Neuropathology Division, Department of Pathology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1134, New York, NY 10029, USA
    Acta Neuropathol 107:497-503. 2004

Detail Information

Publications42

  1. ncbi request reprint The neuropathology of manganese-induced Parkinsonism
    Daniel P Perl
    Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Neuropathol Exp Neurol 66:675-82. 2007
    ..These pathologic findings do not support the notion that manganese causes PD but rather argues that manganese-induced parkinsonism and PD are distinct and separate disease entities...
  2. ncbi request reprint Hippocampal and entorhinal cortex neurofibrillary tangle formation in Guamanian Chamorros free of overt neurologic dysfunction
    Daniel P Perl
    Neuropathology Division, Department of Pathology, Mount Sinai School of Medicine, Box 1134, One Gustave L Levy Place, New York, NY 10029, USA
    J Neuropathol Exp Neurol 62:381-8. 2003
    ....
  3. ncbi request reprint Practical approaches to stereology in the setting of aging- and disease-related brain banks
    D P Perl
    Department of Pathology Neuropathology Division, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Chem Neuroanat 20:7-19. 2000
    ....
  4. pmc Neuropathology of Alzheimer's disease
    Daniel P Perl
    Neuropathology Division, Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 77:32-42. 2010
    ....
  5. ncbi request reprint The role of the pathologist in translational and personalized medicine
    Daniel P Perl
    Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mt Sinai J Med 74:22-6. 2007
    ....
  6. ncbi request reprint Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease
    V Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Arch Neurol 55:1185-91. 1998
    ..Do the classical neuropathological lesions of AD precede, follow, or occur in synchrony with the earliest signs of cognitive deterioration?..
  7. ncbi request reprint Neuropeptide abnormalities in patients with early Alzheimer disease
    K L Davis
    Department of Psychiatry, Mount Sinai School of Medicine, and Jewish Home and Hospital, New York, NY 10029, USA
    Arch Gen Psychiatry 56:981-7. 1999
    ..To determine the relation between level of SLI and CRF-IR in different cerebrocortical regions to the earliest signs of cognitive deterioration in AD...
  8. ncbi request reprint Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer's disease
    T Bussiere
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 117:577-92. 2003
    ....
  9. ncbi request reprint Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease
    V Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Arch Neurol 56:713-8. 1999
    ..Identification of the lesions that are most closely associated with the earliest symptoms of Alzheimer disease is crucial to the understanding of the disease process and the development of treatment strategies to affect its progression...
  10. ncbi request reprint Occurrence of alpha-synuclein pathology in the cerebellum of Guamanian patients with parkinsonism-dementia complex
    Joseph Sebeo
    Neuropathology Division, Department of Pathology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1134, New York, NY 10029, USA
    Acta Neuropathol 107:497-503. 2004
    ..These findings demonstrate that the alpha-synuclein pathology in PDC of Guam affects not only the amygdala, but also the cerebellum, where it appears to involve both Purkinje cells and specialized astrocytes...
  11. ncbi request reprint Dissociation of neuropathology from severity of dementia in late-onset Alzheimer disease
    I Prohovnik
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Neurology 66:49-55. 2006
    ..Little is known about Alzheimer disease at advanced ages, although its incidence continues to increase at least through the ninth decade of life...
  12. ncbi request reprint TorsinA accumulation in Lewy bodies in sporadic Parkinson's disease
    P Shashidharan
    Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Brain Res 877:379-81. 2000
    ..The significance of this finding is unknown, but may implicate torsinA in neuronal dysfunction that occurs in PD as well as in primary dystonia...
  13. ncbi request reprint Distribution of neurofibrillary tangles and senile plaques in the cerebral cortex in postencephalitic parkinsonism
    P R Hof
    Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY 10029
    Neurosci Lett 139:10-4. 1992
    ....
  14. ncbi request reprint Increased neurofibrillary tangles in patients with Alzheimer disease with comorbid depression
    Michael A Rapp
    Department of Psychiatry, Mount Sinai School of Medicine, New York, USA
    Am J Geriatr Psychiatry 16:168-74. 2008
    ..The authors tested the hypothesis that neuritic plaques and neurofibrillary tangles are more pronounced in the brains of patients with AD with comorbid depression as compared with patients with AD without depression...
  15. pmc Type 2 diabetes is negatively associated with Alzheimer's disease neuropathology
    Michal Schnaider Beeri
    Department of Psychiatry, Mount Sinai School of Medicine, New York, USA
    J Gerontol A Biol Sci Med Sci 60:471-5. 2005
    ..The present descriptive study compared diabetic and nondiabetic subjects on the severity of neuritic plaques and neurofibrillary tangles (NFTs) in the cerebral cortex and in the hippocampus...
  16. ncbi request reprint Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer's disease
    T Bussiere
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Box 1639, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 112:75-91. 2002
    ....
  17. pmc Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers
    M S Beeri
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Neurology 66:1399-404. 2006
    ..To examine the associations between postmortem Alzheimer disease (AD) neuropathology and autopsy-verified cardiovascular disease...
  18. ncbi request reprint Contribution of Lewy body inclusions to dementia in patients with and without Alzheimer disease neuropathological conditions
    V Haroutunian
    Psychiatry Research, Room 3F 02, Bronx VA Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468, USA
    Arch Neurol 57:1145-50. 2000
    ..However, the degree to which the density of LBs in the brain contributes to the severity of dementia has not been clear...
  19. pmc Clinical dementia rating performed several years prior to death predicts regional Alzheimer's neuropathology
    Michal Schnaider Beeri
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dement Geriatr Cogn Disord 25:392-8. 2008
    ..To assess the relationships between early and late antemortem measures of dementia severity and Alzheimer disease (AD) neuropathology severity...
  20. ncbi request reprint Brainstem pathology in DYT1 primary torsion dystonia
    Kevin St P McNaught
    Department of Neurology, Neuropathology Division, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann Neurol 56:540-7. 2004
    ..and cuneiform nuclei, and related brainstem brainstem structures, in mediating motor activity and controlling muscle tone suggests that alterations in these structures could underlie the pathophysiology of DYT1 dystonia [corrected]..
  21. pmc Number of children is associated with neuropathology of Alzheimer's disease in women
    Michal Schnaider Beeri
    The Mount Sinai School of Medicine, Department of Psychiatry, New York, NY 10029, USA
    Neurobiol Aging 30:1184-91. 2009
    ..To examine the association between number of born children and neuropathology of Alzheimer's disease (AD)...
  22. pmc Role of the neuropathology of Alzheimer disease in dementia in the oldest-old
    Vahram Haroutunian
    James J Peters VA Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468, USA
    Arch Neurol 65:1211-7. 2008
    ..However, this association has not been extensively studied in the rapidly growing population of the very old...
  23. ncbi request reprint Stereologic evidence for persistence of viable neurons in layer II of the entorhinal cortex and the CA1 field in Alzheimer disease
    Patrick R Hof
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, and Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neuropathol Exp Neurol 62:55-67. 2003
    ....
  24. ncbi request reprint A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease
    C Warren Olanow
    Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Ann Neurol 54:403-14. 2003
    ..Fetal nigral transplantation currently cannot be recommended as a therapy for PD based on these results...
  25. ncbi request reprint Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression
    Michael A Rapp
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arch Gen Psychiatry 63:161-7. 2006
    ..Although there is increasing evidence that major depression may interact with neuropathological processes in AD, there have been no studies of neuropathological changes in AD as a function of history of major depression...
  26. ncbi request reprint Neurofibrillary tangles in the primary motor cortex in Guamanian amyotrophic lateral sclerosis/parkinsonism-dementia complex
    Patrick R Hof
    Kastor Neurobiology of Aging Laboratories, Box 1639, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Neurosci Lett 328:294-8. 2002
    ....
  27. ncbi request reprint Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease
    Kevin St P McNaught
    Department of Neurology, Neuropathology Division, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann Neurol 56:149-62. 2004
    ..This animal model induced by proteasome inhibitors closely recapitulates key features of PD and may be valuable in studying etiopathogenic mechanisms and putative neuroprotective therapies for the illness...
  28. ncbi request reprint Aggresome-related biogenesis of Lewy bodies
    Kevin St P McNaught
    Department of Neurology, Mount Sinai School of Medicine, Annenberg 14 73, One Gustave L Levy Place, New York, NY 10029, USA
    Eur J Neurosci 16:2136-48. 2002
    ..This phenomenon is consistent with growing evidence that altered protein handling underlies the etiopathogenesis of PD and related disorders...
  29. ncbi request reprint Lewy-body formation is an aggresome-related process: a hypothesis
    C Warren Olanow
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Lancet Neurol 3:496-503. 2004
    ..The concept of Lewy bodies as aggresome-related inclusions fits well with ongoing discoveries suggesting that altered protein handling might contribute to the neurodegenerative process in familial and sporadic forms of PD...
  30. ncbi request reprint An unusual population of pyramidal neurons in the anterior cingulate cortex of hominids contains the calcium-binding protein calretinin
    P R Hof
    Kastor Neurobiology of Aging Laboratories, Box 1639, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Neurosci Lett 307:139-42. 2001
    ....
  31. pmc Parkinson's disease dementia: a diminished role for the Lewy body
    Leslie S Libow
    The Jewish Home and Hospital Lifecare System, New York, NY 10025, USA
    Parkinsonism Relat Disord 15:572-5. 2009
    ..More research with a larger sample size is needed to determine whether the LB may be a secondary phenomenon and/or an "innocent-bystander". The entire role of the LB in PD dementia is again brought into question...
  32. pmc Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease
    Afia Akram
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurobiol Aging 29:1296-307. 2008
    ..6% of MMSE and 25.6% of the Clinical Dementia Rating scores variability. Our data suggest that neocortical dendritic spine loss is an independent parameter to consider in AD clinicopathologic correlations...
  33. ncbi request reprint Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: stereologic analysis of prefrontal cortex area 9
    Thierry Bussiere
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029
    J Comp Neurol 463:281-302. 2003
    ..Their preferential involvement suggests that neurons providing specific corticocortical connections between association areas are at high risk for degeneration in AD...
  34. ncbi request reprint Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Neurology 65:768-9. 2005
    ..In contrast to others, they detected no free BMAA in any of these samples...
  35. pmc Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy
    Wan Yang
    Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, Seattle, WA 98104, USA
    Am J Pathol 171:993-1002. 2007
    ..These results show that frontal and temporal cortex in PDC is distinguished from AD and PSP by its accumulation of abnormal SNCA and suggest that PDC be considered a synucleinopathy as well as a tauopathy...
  36. ncbi request reprint The sweet thing about Type 1 diabetes: a cryoprotective evolutionary adaptation
    S Moalem
    Department of Pathology, Mount Sinai School of Medicine, Box 1134, New York, NY 10029, USA
    Med Hypotheses 65:8-16. 2005
    ..In so doing we propose that factors resulting in Type 1 diabetes be considered a result of environmental pathogenic selection (EnPS)...
  37. pmc A novel approach to non-biased systematic random sampling: a stereologic estimate of Purkinje cells in the human cerebellum
    Rajiv M Agashiwala
    Department of Pathology, Neuropathology Division, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1134, New York, NY 10029 6574, USA
    Brain Res 1236:73-8. 2008
    ..Our novel approach, which offers an improvement over previous methodologies, is of value for quantitative work of this nature. This approach could be applied to morphometric studies of other similarly complex tissues as well...
  38. ncbi request reprint Aluminum and Alzheimer's disease, a personal perspective after 25 years
    Daniel P Perl
    Mount Sinai School of Medicine, Department of Pathology, Neuropathology Division, USA
    J Alzheimers Dis 9:291-300. 2006
    ....
  39. ncbi request reprint Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia
    Patrick R Hof
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology and Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 53:1075-85. 2003
    ..Brain imaging, molecular genetic, and ultrastructural evidence indicate the existence of pathologic alterations in the cortical and subcortical white matter of schizophrenic patients...
  40. ncbi request reprint Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam
    Felix Geser
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Alzheimer s Disease Core Center, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104 4283, USA
    Acta Neuropathol 115:133-45. 2008
    ..Finally, we conclude that the spectrum of TDP-43 proteinopathies should be expanded to include neurodegenerative cognitive and motor diseases, affecting the Chamorro population of Guam...
  41. pmc Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam
    Mark S Forman
    Center for Neurodegenerative Disease Research and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 160:1725-31. 2002
    ..Furthermore, in PDC, tau and alpha-synuclein pathology occurs independent of beta-amyloid deposition in amygdala thereby implicating the aggregation of these molecules in the severe neurodegeneration frequently observed in this location...
  42. ncbi request reprint Characterization of tau pathologies in gray and white matter of Guam parkinsonism-dementia complex
    Matthew J Winton
    The Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 111:401-12. 2006
    ....