Research Topics
Genomes and GenesSpecies | Giulio PasinettiSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
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Publications
Novel role of red wine-derived polyphenols in the prevention of Alzheimer's disease dementia and brain pathology: experimental approaches and clinical implicationsGiulio Maria Pasinetti
Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA
Planta Med 78:1614-9. 2012....
Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's diseaseLap Ho
Department of Neurology, Mt Sinai School of Medicine, New York, NY 10029, USA
FASEB J 27:769-81. 2013....- Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathologySteve Pedrini
Farber Institute for the Neurosciences, Jefferson Medical College, Philadelphia PA USA
Mol Neurodegener 4:40. 2009..abstract:.. - Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivoPiali Mukherjee
Department of Psychiatry, Mount Sinai School of Medicine, 1 Gustav L, Levy Place, New York, NY 10029, USA
J Neuroinflammation 5:5. 2008..In this study we explored potential upstream mechanisms involved in C5a mediated neuroprotection in vivo and in vitro... - A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosisZhong Zhao
Neuroinflammation Research Laboratories, Department of Psychiatry, USA
BMC Neurosci 7:29. 2006..The cause of neuronal death in amyotrophic lateral sclerosis (ALS) is uncertain but mitochondrial dysfunction may play an important role. Ketones promote mitochondrial energy production and membrane stabilization... - Personalized medicine in traumatic brain injuryGiulio Maria Pasinetti
Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1137, New York, NY 10029, USA
Psychiatr Clin North Am 33:905-13. 2010..It is possible that the availability of TBI biomarkers may provide potential elements with clinical relevance to prevention, prognosis, and treatment of postconcussive disorders... - Metabolic syndrome and the role of dietary lifestyles in Alzheimer's diseaseGiulio Maria Pasinetti
Center of Excellence for Research in Complementary and Alternative Medicine in Alzheimer s Disease, Department of Psychiatry, The Mount Sinai School of Medicine, New York, New York, USA
J Neurochem 106:1503-14. 2008..to avoid foods and beverages with added sugars; to eat whole, unrefined foods with natural fats, especially fish, nuts and seeds, olives and olive oil; and to minimize foods that disrupt insulin and blood sugar balance... - Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathiesGiulio Maria Pasinetti
Center of Excellence for Novel Approaches to Neurodiagnostics and Neurotherapeutics, Brain Institute, Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
J Neurochem 114:1557-68. 2010..In this mini-review article, we discuss the biochemical characterization of GSPE in our laboratory and its potential preventative and therapeutic role in model systems of abnormal tau processing pertinent to PSP and related tauopathies... - Preclinical study of dimebon on β-amyloid-mediated neuropathology in Alzheimer's diseaseJun Wang
Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029 USA
Mol Neurodegener 6:7. 2011..Proper interpretations of these clinical observations, as well as future development of dimebon in AD treatment are complicated by the lack of concrete information on the mechanisms by which dimebon might benefit AD... - Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosisWei Zhao
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
Mol Neurodegener 6:51. 2011..abstract:.. - Neuroprotective and metabolic effects of resveratrol: therapeutic implications for Huntington's disease and other neurodegenerative disordersGiulio Maria Pasinetti
Center of Excellence for Research in Complementary and Alternative Medicine in Alzheimer s Disease, Department of Neurology, Mount Sinai School of Medicine, 1498 Madison Avenue, New York, NY 10029, USA
Exp Neurol 232:1-6. 2011..study and discusses the further prospects of resveratrol and other polyphenols, including novel grape-derived polyphenols, in the treatment of HD and other neurodegenerative disorders... 
Identification of potential CSF biomarkers in ALSG M Pasinetti
Geriatric Research, Education, and Clinical Center, Bronx Veterans Affairs Medical Center, Bronx, NY, USA
Neurology 66:1218-22. 2006..The clinical diagnosis of ALS is based entirely on clinical features. Identification of biomarkers for ALS would be important for diagnosis and might also provide clues to pathogenesis...- Cyclo-oxygenase inhibitors and Alzheimer's: are we well ADAPTed?Giulio Maria Pasinetti
Neuroinflammation Research Laboratories, Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029, USA
Lancet Neurol 1:403-4. 2002 - Cyclooxygenase as a target for the antiamyloidogenic activities of nonsteroidal anti-inflammatory drugs in Alzheimer's diseaseGiulio Maria Pasinetti
Neuroinflammation Research Laboratories, Department of Psychiatry, School of Medicine, Mount Sinai Medical Center, One Gustave L Levy Place, New York, N Y 10029, USA
Neurosignals 11:293-7. 2002.... - Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's diseaseJun Wang
Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Pl, New York, NY 10029, USA
FASEB J 20:2313-20. 2006.... - Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer diseaseJun Wang
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
J Clin Invest 117:3393-402. 2007..These preclinical studies suggest that certain antihypertensive drugs may have AD-modifying activity and may protect against progressive Abeta-related memory deficits in subjects with AD or in those at high risk of developing AD... - Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's diseaseLap Ho
Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
FASEB J 18:902-4. 2004.... - Amyloid immunization in Alzheimer's disease: do we promote amyloid scavenging at the cost of inflammatory degeneration?Giulio Maria Pasinetti
Department of Psychiatry, Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, NY 10089, USA
Neurobiol Aging 23:665-6. 2002 - Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathologyZhong Zhao
Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
FASEB J 19:2081-2. 2005.... - Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deteriorationLap Ho
Department of Psychiatry, Mount Sinai School of Medicine, NY, USA
J Alzheimers Dis 16:59-72. 2009..Results from these studies suggest the possibility of developing a "combination" of dietary polyphenolic compounds for AD prevention and/or therapy by modulating multiple Abeta-related mechanisms... - Caloric intake and Alzheimer's disease. Experimental approaches and therapeutic implicationsGiulio Maria Pasinetti
Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
Interdiscip Top Gerontol 35:159-75. 2007.... - Grape seed polyphenolic extract as a potential novel therapeutic agent in tauopathiesLap Ho
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
J Alzheimers Dis 16:433-9. 2009.... - Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's diseaseJun Wang
Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
FASEB J 19:659-61. 2005.... - Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathologyZhongmin Xiang
Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
Neurobiol Aging 23:327-34. 2002.... - Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathologyZhongmin Xiang
Neuroinflammation Research Laboratories, Department of Psychiatry, and Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Gene Expr 10:271-8. 2002..Collectively these data suggest that COX-2 influences APP processing and promotes amyloidosis in the brain... - From epidemiology to therapeutic trials with anti-inflammatory drugs in Alzheimer's disease: the role of NSAIDs and cyclooxygenase in beta-amyloidosis and clinical dementiaGiulio Maria Pasinetti
Mount Sinai School of Medicine, Department of Psychiatry, New York, USA
J Alzheimers Dis 4:435-45. 2002..These discussions may provide important criterion for the design of clinical trials of anti-inflammatory drugs in AD... - Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate-mediated excitotoxicityMana Mirjany
Neuroinflammation Research Laboratories of the Department of Psychiatry, The Mount Sinai School of Medicine, New York, New York 10029, USA
J Pharmacol Exp Ther 301:494-500. 2002..These data indicate that hCOX-2 overexpression causes neuronal cell cycle deregulation in the brain and provides further rationale for targeting neuronal COX-2 in neuroprotective therapeutic research... - Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer's disease-type amyloid neuropathology and spatial memory deteriorationWeiping Qin
Department of Psychiatry, Mount Sinnai School of Medicine, New York, NY 10029, USA
Ann N Y Acad Sci 1147:335-47. 2008..This study provides a novel metabolic pathway for prevention and/or treatment of AD... - Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus)Weiping Qin
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
J Alzheimers Dis 10:417-22. 2006..Collectively, the study suggests that investigation of the role of CR in non-human primates may provide a valuable approach for further clarifying the role of CR in AD... - Microglia activation in the brain as inflammatory biomarker of Alzheimer's disease neuropathology and clinical dementiaZhongmin Xiang
Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, 10029-6574, USA
Dis Markers 22:95-102. 2006..These results suggest that microglia activation increases with the progression of AD, with the increase varying depending on the involved brain region... - Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activityWeiping Qin
Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 278:50970-7. 2003.... - Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2Lauren Spielman
Neuroinflammation Research Laboratories, Department of Psychiatry, Box 1229, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
Acta Neuropathol 103:157-62. 2002..Because there is extensive evidence that C1q and other complement components are involved in Alzheimer's disease (AD) neurodegeneration, this study advances our understanding of the apparent benefits of COX-2 inhibition in AD... - Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's diseaseZhong Zhao
Neuroinflammation Research Laboratories, The Mount Sinai School of Medicine, New York, NY 10029, United States
Neurobiol Aging 28:824-30. 2007.... - Caspase gene expression in the brain as a function of the clinical progression of Alzheimer diseasePatrick N Pompl
Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
Arch Neurol 60:369-76. 2003..These data have relevance to potential therapeutic interventions for AD using selective caspase inhibitors... - Expression of tau reduces secretion of Abeta without altering the amyloid precursor protein content in CHOsw cellsZhong Zhao
Neuroinflammation Research Laboratories, Department of Psychiatry of the Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
FEBS Lett 579:2119-24. 2005..This was accompanied by a reduction in the gamma-secretase and an increase in the insulin degrading enzyme activities. Our results suggest that tau may play an inhibitory role in the amyloidogenic activity of APP... - Carvedilol reestablishes long-term potentiation in a mouse model of Alzheimer's diseaseIsabel Arrieta-Cruz
Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
J Alzheimers Dis 21:649-54. 2010..These results suggest that carvedilol reestablishes basal synaptic transmission, enhances neuronal plasticity and suppresses neuronal hyperexcitability in TgCRND8 mice... - Polyphenolic compounds for treating neurodegenerative disorders involving protein misfoldingLap Ho
Center of Excellence for Novel Approaches to Neurodiagnostics and Neurotherapeutics, Brain Institute, Center of Excellence for Research in Complementary and Alternative Medicine in Alzheimer s Disease, Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
Expert Rev Proteomics 7:579-89. 2010..Collectively, available information supports continued development of the GSPE for treating a variety of neurodegenerative disorders involving misfolded protein-mediated neuropathologic mechanisms... - The role of Sirt1: at the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathologyJun Wang
Center of Excellence for Novel Approaches to Neurodiagnostics and Neurotherapeutics, Brain Institute, Center of Excellence for Research in Complementary and Alternative Medicine in Alzheimer s Disease, Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
Biochim Biophys Acta 1804:1690-4. 2010..We will discuss Sirt1 as a potential novel target, in addition to the development of Sirt1 activators for the prevention and treatment of Alzheimer's disease... - Immunomodulation with glatiramer acetate prevents long-term inflammatory painNaresh Sharma
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
Int J Neurosci 118:433-53. 2008..This study is consistent with the hypothesis that a novel mechanism through which GA immunization therapy may beneficially influence long-term allodynia and hyperalgesia is through central regulation of fractalkine-mediated responses... - Alzheimer's disease biomarker discovery in symptomatic and asymptomatic patients: experimental approaches and future clinical applicationsLap Ho
Center of Excellence for Novel Approaches to Neurodiagnostics and Neurotherapeutics, Brain Institute, and Center of Excellence in Complementary and Alternative Medicine in Alzheimer s Disease, Department of Neurology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Box 1137, New York, NY 10029, USA
Exp Gerontol 45:15-22. 2010..The availability of biomarkers that promote early disease diagnosis, particularly among asymptomatic patients, will lead to the application of personalized medicine in AD... - Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesisZhong Zhao
James J Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA
Int J Med Sci 5:92-9. 2008.... - From proteomics to biomarker discovery in Alzheimer's diseaseLap Ho
Neuroinflammation Research Laboratories of the Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Brain Res Brain Res Rev 48:360-9. 2005.... - S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10Weiping Qin
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
PLoS ONE 4:e4183. 2009.... - Amyloid beta-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain existsD Allan Butterfield
Department of Chemistry, Center of Membrane Sciences, University of Kentucky, Lexington, KY 40506 0055, USA
J Alzheimers Dis 4:193-201. 2002..This review briefly examines each of these sources of oxidative stress and inflammation in AD brain and discusses their potential roles in the clinical progression of AD dementia...
Research Grants
- A modified dietary regiment as a potential novel therapeutic intervention in ALS.Giulio Pasinetti; Fiscal Year: 2007....
- Protective roles of grape-derived polyphenols in Alzheimer's diseaseGiulio Pasinetti; Fiscal Year: 2007..We are confident that the information that will come from this work will have a major impact on protective roles of grapederived polyphenols in Alzheimer's disease. ..
- COMPLEMENT AND NEUROPROTECTION: ALZHEIMER'S DISEASEGiulio Pasinetti; Fiscal Year: 2002..Further characterization of the complex role of complement proteins in neurodegeneration is essential especially in view of the possibility that the complement system represents a target for therapeutic interventions in AD. ..
- Cell Cycle and COX-2 in a Mouse Model of Alzheimer'sGiulio Pasinetti; Fiscal Year: 2004....
- Pinitol a Natural Extract from Pine Cones and Alzheimer's DiseaseGiulio Pasinetti; Fiscal Year: 2006..abstract_text> ..
- Anti-hypertensive drugs that prevent Alzheimer's disease beta-amyloid pathology aGiulio Pasinetti; Fiscal Year: 2007....
- CYCLOOXYGENASE AND ANTI-INFLAMMATORY DRUGS IN ADGiulio Pasinetti; Fiscal Year: 2001..The outcome of the proposed studies will be immediately relevant to the design of human trials. ..
- CYCLOOXYGENASE IN NEURODEGENERATIONGiulio Pasinetti; Fiscal Year: 2000..Aim 4. To study the role of COX-2 overexpression in bigenic NHC X APPsw (Hsiao mice) which are hypothesized to have accelerated neurodegeneration and cognitive impairment. ..