PETER M PALESE

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Transmission of influenza B viruses in the guinea pig
    Natalie Pica
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
    J Virol 86:4279-87. 2012
  2. pmc H5N1 influenza viruses: facts, not fear
    Peter Palese
    Department of Microbiology and Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 109:2211-3. 2012
  3. ncbi request reprint Influenza: old and new threats
    Peter Palese
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Med 10:S82-7. 2004
  4. ncbi request reprint Effective replication of human influenza viruses in mice lacking a major alpha2,6 sialyltransferase
    Laurel Glaser
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Virus Res 126:9-18. 2007
  5. ncbi request reprint What can we learn from reconstructing the extinct 1918 pandemic influenza virus?
    Peter Palese
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Immunity 24:121-4. 2006
  6. pmc Making better influenza virus vaccines?
    Peter Palese
    Mount Sinai School of Medicine, New York, New York 10029, USA
    Emerg Infect Dis 12:61-5. 2006
  7. pmc Influenza vaccines: present and future
    Peter Palese
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    J Clin Invest 110:9-13. 2002
  8. pmc New directions in vaccine research
    Peter Palese
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 109:1517-8. 2002
  9. pmc Nipah virus V and W proteins have a common STAT1-binding domain yet inhibit STAT1 activation from the cytoplasmic and nuclear compartments, respectively
    Megan L Shaw
    Department of Microbiology, Box 1124, Mount Sinai School of Medicine, One Gustave L Levy Pl, New York, NY 10029, USA
    J Virol 78:5633-41. 2004
  10. pmc Newcastle disease virus V protein is a determinant of host range restriction
    Man Seong Park
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 77:9522-32. 2003

Collaborators

Detail Information

Publications66

  1. pmc Transmission of influenza B viruses in the guinea pig
    Natalie Pica
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
    J Virol 86:4279-87. 2012
    ..We therefore present, for the first time, a small animal model with which to study the underlying mechanisms of influenza B virus transmission...
  2. pmc H5N1 influenza viruses: facts, not fear
    Peter Palese
    Department of Microbiology and Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 109:2211-3. 2012
    ..In addition, there are calls in the media to destroy the viruses, curtail future research in this area, and protect the public from such "frightening" research efforts. Fear needs to be put to rest with solid science and not speculation...
  3. ncbi request reprint Influenza: old and new threats
    Peter Palese
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Med 10:S82-7. 2004
    ....
  4. ncbi request reprint Effective replication of human influenza viruses in mice lacking a major alpha2,6 sialyltransferase
    Laurel Glaser
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Virus Res 126:9-18. 2007
    ..This work demonstrates that the presence of a major alpha2,6 sialic acid on N-linked glycoproteins is not essential for human influenza virus infection in mice...
  5. ncbi request reprint What can we learn from reconstructing the extinct 1918 pandemic influenza virus?
    Peter Palese
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Immunity 24:121-4. 2006
  6. pmc Making better influenza virus vaccines?
    Peter Palese
    Mount Sinai School of Medicine, New York, New York 10029, USA
    Emerg Infect Dis 12:61-5. 2006
    ..These new strategies will be successful if they are supported by regulatory agencies and if a robust market for influenza virus vaccines against inter-pandemic and pandemic threats is made and sustained...
  7. pmc Influenza vaccines: present and future
    Peter Palese
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    J Clin Invest 110:9-13. 2002
  8. pmc New directions in vaccine research
    Peter Palese
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 109:1517-8. 2002
  9. pmc Nipah virus V and W proteins have a common STAT1-binding domain yet inhibit STAT1 activation from the cytoplasmic and nuclear compartments, respectively
    Megan L Shaw
    Department of Microbiology, Box 1124, Mount Sinai School of Medicine, One Gustave L Levy Pl, New York, NY 10029, USA
    J Virol 78:5633-41. 2004
    ..We also show that the IFN antagonist activity of the P protein is not as strong as that of V or W, perhaps explaining why Nipah virus has evolved to express these two edited products...
  10. pmc Newcastle disease virus V protein is a determinant of host range restriction
    Man Seong Park
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 77:9522-32. 2003
    ..Taken together, these data suggest that the host range of NDV is limited by the ability of its V protein to efficiently prevent innate host defenses, such as the IFN response and apoptosis...
  11. pmc Influenza A virus PB1-F2 protein contributes to viral pathogenesis in mice
    Dmitriy Zamarin
    Department of Microbiology, Box 1124, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, NY 10029, USA
    J Virol 80:7976-83. 2006
    ....
  12. pmc Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza
    John Steel
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Virol 83:1742-53. 2009
    ....
  13. ncbi request reprint An unconventional NLS is critical for the nuclear import of the influenza A virus nucleoprotein and ribonucleoprotein
    Jerome F Cros
    Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Traffic 6:205-13. 2005
    ..Finally, viral replication could be specifically inhibited by a membrane-permeable peptide containing the unconventional NLS, confirming the crucial role of this signal during the replicative cycle of the virus...
  14. pmc Induction of cellular immune responses to simian immunodeficiency virus gag by two recombinant negative-strand RNA virus vectors
    Yurie Nakaya
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 78:9366-75. 2004
    ..These results suggest that rNDV and influenza virus vectors are suitable candidate vaccines against AIDS as well as against other infectious diseases...
  15. pmc Effects of influenza A virus NS1 protein on protein expression: the NS1 protein enhances translation and is not required for shutoff of host protein synthesis
    Mirella Salvatore
    Department of Microbiology Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 76:1206-12. 2002
    ..In contrast to the earlier proposal suggesting that the NS1 protein regulates the levels of spliced M2 mRNA, no effects on M2 protein accumulation were seen in Vero cells infected with delNS1 virus...
  16. pmc Functional replacement of the carboxy-terminal two-thirds of the influenza A virus NS1 protein with short heterologous dimerization domains
    Xiuyan Wang
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Virol 76:12951-62. 2002
    ..These results suggest that the main biological function of the carboxy-terminal region of the NS1 protein of influenza A virus is the enhancement of its IFN antagonist properties by stabilizing the NS1 dimeric structure...
  17. pmc A nine-segment influenza a virus carrying subtype H1 and H3 hemagglutinins
    Qinshan Gao
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 84:8062-71. 2010
    ..Using the described methodology, we show that a ninth segment can also be incorporated by manipulation of the PB2 or PA segment-specific packaging signals. This approach offers a means of generating a bivalent influenza virus vaccine...
  18. pmc Influenza B virus NS1-truncated mutants: live-attenuated vaccine approach
    Rong Hai
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Virol 82:10580-90. 2008
    ..We also provide evidence that influenza B virus NS1 mutants induce a self-adjuvanted immune response and confer effective protection against challenge with both homologous and heterologous B virus strains in mice...
  19. pmc Blocking interhost transmission of influenza virus by vaccination in the guinea pig model
    Anice C Lowen
    Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave Levy Pl, New York, NY 10029 6574, USA
    J Virol 83:2803-18. 2009
    ..In conclusion, we have shown that the guinea pig model can be used to test influenza virus vaccines and that the efficiency of transmission is a valuable readout when vaccine efficacy is evaluated...
  20. pmc A novel paramyxovirus?
    Christopher F Basler
    Department of Microbiology, Mount Sinai School of Medicine, Box 1124, New York, NY 10029, USA
    Emerg Infect Dis 11:108-12. 2005
    ..These genes are sufficiently unique to suggest the existence of a novel paramyxovirus genus...
  21. pmc Cellular proteins in influenza virus particles
    Megan L Shaw
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Pathog 4:e1000085. 2008
    ..While not all of the host proteins are necessarily incorporated specifically, those that are and are found to have an essential role represent novel targets for antiviral drugs and for attenuation of viruses for vaccine purposes...
  22. pmc Enhancement of oncolytic properties of recombinant newcastle disease virus through antagonism of cellular innate immune responses
    Dmitriy Zamarin
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Ther 17:697-706. 2009
    ..These findings demonstrate that modulation of innate immune responses by NDV results in enhancement of its oncolytic properties and warrant further investigation of this strategy in design of oncolytic NDV vectors against human tumors...
  23. pmc Newcastle disease virus expressing a dendritic cell-targeted HIV gag protein induces a potent gag-specific immune response in mice
    Jad Maamary
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Virol 85:2235-46. 2011
    ..Here we demonstrate that the targeting of the HIV Gag antigen to DCs via the DEC205 receptor enhances the ability of an rNDV vector to induce a potent antigen-specific immune response...
  24. pmc Budding capability of the influenza virus neuraminidase can be modulated by tetherin
    Mark A Yondola
    Mount Sinai School of Medicine, 1 Gustave L Levy Place, Department of Microbiology, Annenberg Bldg 16 20, New York, NY 10128, USA
    J Virol 85:2480-91. 2011
    ....
  25. pmc Influenza virus transmission is dependent on relative humidity and temperature
    Anice C Lowen
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
    PLoS Pathog 3:1470-6. 2007
    ..We provide direct, experimental evidence to support the role of weather conditions in the dynamics of influenza and thereby address a long-standing question fundamental to the understanding of influenza epidemiology and evolution...
  26. pmc Newcastle disease virus (NDV)-based assay demonstrates interferon-antagonist activity for the NDV V protein and the Nipah virus V, W, and C proteins
    Man Seong Park
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 77:1501-11. 2003
    ....
  27. pmc Nuclear localization of the Nipah virus W protein allows for inhibition of both virus- and toll-like receptor 3-triggered signaling pathways
    Megan L Shaw
    Department of Microbiology, Box 1124, Mount Sinai School of Medicine, One Gustave L Levy Pl, New York, NY 10029, USA
    J Virol 79:6078-88. 2005
    ....
  28. pmc Induction of protective immunity against malaria by priming-boosting immunization with recombinant cold-adapted influenza and modified vaccinia Ankara viruses expressing a CD8+-T-cell epitope derived from the circumsporozoite protein of Plasmodium yoelii
    Gloria Gonzalez-Aseguinolaza
    Department of Medical and Molecular Parasitology, NYU School of Medicine Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 77:11859-66. 2003
    ..This vaccination regimen elicited high levels of protection against malaria. This is the first time that the vaccine efficacy of a recombinant cold-adapted influenza virus vector expressing a foreign antigen has been evaluated...
  29. pmc The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3
    Christopher F Basler
    Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    J Virol 77:7945-56. 2003
    ..These data suggest that in Ebola virus-infected cells, VP35 inhibits the induction of antiviral genes, including the IFN-beta gene, by blocking IRF-3 activation...
  30. doi request reprint Recombinant vectors as influenza vaccines
    Sarah A Kopecky-Bromberg
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Curr Top Microbiol Immunol 333:243-67. 2009
    ..This review explores the advantages and limitations of several different vectors that are currently being tested, and highlights some of the newer viruses being used as recombinant vectors...
  31. pmc Modulation of influenza virus replication by alteration of sodium ion transport and protein kinase C activity
    H Heinrich Hoffmann
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Antiviral Res 80:124-34. 2008
    ..Furthermore, we raise the possibility that compounds that result in increased viral titers may be beneficial for boosting the production of tissue culture-grown influenza vaccines...
  32. pmc High temperature (30 degrees C) blocks aerosol but not contact transmission of influenza virus
    Anice C Lowen
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 82:5650-2. 2008
    ..Our data imply that contact or short-range spread predominates in the tropics and offer an explanation for the lack of a well-defined, recurrent influenza season affecting tropical and subtropical regions of the world...
  33. pmc Alpha-C-galactosylceramide as an adjuvant for a live attenuated influenza virus vaccine
    Sarah A Kopecky-Bromberg
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029 6574, United States
    Vaccine 27:3766-74. 2009
    ..Thus, our data indicate that stimulators of NKT cells represent a new avenue of adjuvants to pursue for live attenuated virus vaccines...
  34. pmc PB1-F2 expression by the 2009 pandemic H1N1 influenza virus has minimal impact on virulence in animal models
    Rong Hai
    Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, NY 10029 6574, USA
    J Virol 84:4442-50. 2010
    ..In summary, our study demonstrates that PB1-F2 expression by the Cal/09 virus modulates the immune response to infection while having a minimal effect on virus virulence in two mammalian models...
  35. pmc The guinea pig as a transmission model for human influenza viruses
    Anice C Lowen
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1124, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 103:9988-92. 2006
    ..Our results demonstrate that influenza virus can pass between guinea pigs by means of droplet spread and thereby establish the suitability of the guinea pig as a model host for influenza virus transmission studies...
  36. ncbi request reprint Transmission of influenza virus via aerosols and fomites in the guinea pig model
    Samira Mubareka
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Infect Dis 199:858-65. 2009
    ..The data provide new and much-needed insights into the modes of influenza virus spread and strain-specific differences in the efficiency of transmission...
  37. pmc A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence
    Gina M Conenello
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
    PLoS Pathog 3:1414-21. 2007
    ..Together, these data show that a single amino acid substitution in PB1-F2 can result in increased viral pathogenicity and could be one of the factors contributing to the high lethality seen with the 1918 pandemic virus...
  38. pmc 7a protein of severe acute respiratory syndrome coronavirus inhibits cellular protein synthesis and activates p38 mitogen-activated protein kinase
    Sarah A Kopecky-Bromberg
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Virol 80:785-93. 2006
    ..Taken together, these data indicate that the induction of apoptosis by the 7a protein may be related to its ability to inhibit cellular translation and activate p38 MAPK...
  39. pmc Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza
    Gary K Geiss
    Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 99:10736-41. 2002
    ....
  40. pmc Rewiring the RNAs of influenza virus to prevent reassortment
    Qinshan Gao
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 106:15891-6. 2009
    ..A similar approach can be applied to the other influenza A virus segments to diminish their ability to form reassortant viruses...
  41. pmc Apical budding of a recombinant influenza A virus expressing a hemagglutinin protein with a basolateral localization signal
    Rosalia Mora
    Dyson Vision Research Institute, Departments of Ophthalmology and Cell Biology, Joan and Sanford Weill Medical College of Cornell University, New York, New York 10021, USA
    J Virol 76:3544-53. 2002
    ..These results are consistent with a model in which apical viral budding is a shared function of various viral components rather than a role of the major viral envelope glycoprotein HA...
  42. pmc Transmission of pandemic H1N1 influenza virus and impact of prior exposure to seasonal strains or interferon treatment
    John Steel
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Virol 84:21-6. 2010
    ..In addition, the use of interferon as an antiviral prophylaxis may be an effective way to limit spread in at-risk populations...
  43. pmc Detection of free peritoneal cancer cells in gastric cancer using cancer-specific Newcastle disease virus
    Joyce Wong
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Gastrointest Surg 14:7-14. 2010
    ..We evaluated a novel detection technique using Newcastle disease virus expressing the enhanced green fluorescent protein (NDV-GFP) gene...
  44. pmc Oseltamivir-resistant variants of the 2009 pandemic H1N1 influenza A virus are not attenuated in the guinea pig and ferret transmission models
    Christopher W Seibert
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029 6574, USA
    J Virol 84:11219-26. 2010
    ..Our data suggest that the currently circulating pandemic 2009 H1N1 virus has a high potential to acquire drug resistance without losing fitness...
  45. pmc Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes
    Taia T Wang
    Department of Microbiology and Medicine, Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 107:18979-84. 2010
    ..These results provide proof of concept for an HA2-based influenza vaccine that could diminish the threat of pandemic influenza disease and generally reduce the significance of influenza viruses as human pathogens...
  46. pmc Nipah virus edits its P gene at high frequency to express the V and W proteins
    Sachin Kulkarni
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Virol 83:3982-7. 2009
    ..Eighty-two percent of transcripts are edited, with up to 11 G insertions observed. This exceptionally high editing frequency ensures expression of the V and W proteins...
  47. pmc Oseltamivir-resistant influenza A viruses are transmitted efficiently among guinea pigs by direct contact but not by aerosol
    Nicole M Bouvier
    Department of Microbiology, Box 1124, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Virol 82:10052-8. 2008
    ..The present results suggest that oseltamivir resistance mutations reduce aerosol transmission of influenza virus, which could have implications for public health measures taken in the event of an influenza pandemic...
  48. ncbi request reprint Influenza virus transmission: basic science and implications for the use of antiviral drugs during a pandemic
    Anice C Lowen
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1124, New York, NY 10029, USA
    Infect Disord Drug Targets 7:318-28. 2007
    ..Anti-influenza drugs in development which show efficacy in terms of mitigating disease or viral growth should also be tested for their potential to block transmission...
  49. ncbi request reprint Sequence analysis and receptor specificity of the hemagglutinin of a recent influenza H2N2 virus isolated from chicken in North America
    Laurel Glaser
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Glycoconj J 23:93-9. 2006
    ..Sequence analysis revealed that this HA is a member of the Eurasian clade, and receptor binding studies show that it maintains its specificity for the avian influenza virus alpha2-3 linked sialic acid receptor...
  50. pmc Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists
    Sarah A Kopecky-Bromberg
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Virol 81:548-57. 2007
    ..ORF 6 protein, but not ORF 3b or N protein, inhibited nuclear translocation but not phosphorylation of STAT1. Thus, it appears that these three interferon antagonists of SARS-CoV inhibit the interferon response by different mechanisms...
  51. pmc A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity
    Laurel Glaser
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Virol 79:11533-6. 2005
    ..Mutation of this single amino acid back to the avian consensus resulted in a preference for the avian receptor...
  52. ncbi request reprint Influenza A virus PB1-F2: a small protein with a big punch
    Gina M Conenello
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Host Microbe 2:207-9. 2007
    ..This work sheds light on the mechanisms of pathogenicity during influenza A virus infections...
  53. pmc A combination in-ovo vaccine for avian influenza virus and Newcastle disease virus
    John Steel
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Vaccine 26:522-31. 2008
    ..We propose that this virus has potential as a safe in-ovo live, attenuated, bivalent avian influenza and Newcastle disease virus vaccine...
  54. pmc Attenuation of equine influenza viruses through truncations of the NS1 protein
    Michelle Quinlivan
    Department of Microbiology, Box 1124, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, New York 10029, USA
    J Virol 79:8431-9. 2005
    ..Therefore, these attenuated mutant NS1 viruses may have potential as candidates for a live equine influenza vaccine...
  55. pmc Expression of transgenes from newcastle disease virus with a segmented genome
    Qinshan Gao
    Department of Microbiology, Mount Sinai School of Medicine, Box 1124, One Gustave L Levy Place, New York, NY 10029, USA
    J Virol 82:2692-8. 2008
    ..The chimeric virus extends the coding capacity of NDV by 30%, suggesting that the two-segmented NDV can be used for development of vaccines or gene therapy vectors carrying long and multiple transgenes...
  56. pmc Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N
    John Steel
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
    PLoS Pathog 5:e1000252. 2009
    ..Thus, our data show that PB2 amino acids 627 and 701 are determinants of mammalian inter-host transmission in diverse virus backgrounds...
  57. pmc A seven-segmented influenza A virus expressing the influenza C virus glycoprotein HEF
    Qinshan Gao
    Department of Microbiology, Mount Sinai School of Medicine, Box 1124, One Gustave L Levy Place, New York, NY 10029, USA
    J Virol 82:6419-26. 2008
    ..These results support a selective mechanism of viral RNA recruitment to the budding site...
  58. pmc Hemagglutinin-pseudotyped green fluorescent protein-expressing influenza viruses for the detection of influenza virus neutralizing antibodies
    Luis Martinez-Sobrido
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Virol 84:2157-63. 2010
    ..These GFP-expressing influenza viruses replicate to high titers in HA-expressing cell lines, but in non-HA-expressing cells, their replication is restricted to a single cycle...
  59. pmc Chimeric influenza A viruses with a functional influenza B virus neuraminidase or hemagglutinin
    Astrid Flandorfer
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 77:9116-23. 2003
    ..Taken together, we show here that the absence of reassortment between influenza viruses belonging to different A and B types is not due to spike glycoprotein incompatibility at the level of the full-length NA or of the HA ectodomain...
  60. pmc Protection of mice against lethal challenge with 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 based vaccines
    Balaji Manicassamy
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Pathog 6:e1000745. 2010
    ..Our results also support the notion that pigs can act as an animal reservoir where influenza virus HAs become antigenically frozen for long periods of time, facilitating the generation of human pandemic viruses...
  61. ncbi request reprint Trafficking of viral genomic RNA into and out of the nucleus: influenza, Thogoto and Borna disease viruses
    Jerome F Cros
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Virus Res 95:3-12. 2003
    ..Various mechanisms, ranging from simple post-translational modification to complex, sequential masking-and-exposure of localization signals, are used to insure the proper movement of the vRNPs...
  62. pmc Engineered viral vaccine constructs with dual specificity: avian influenza and Newcastle disease
    Man Seong Park
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 103:8203-8. 2006
    ..We propose that chimeric constructs should be developed for convenient, affordable, and effective vaccination against avian influenza and Newcastle disease in chickens and other poultry...
  63. pmc A reassortment-incompetent live attenuated influenza virus vaccine for protection against pandemic virus strains
    Rong Hai
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029 6574, USA
    J Virol 85:6832-43. 2011
    ..Overall, our data indicate that the chimeric live-attenuated influenza B viruses expressing the modified influenza A hemagglutinin are effective LAIVs...
  64. pmc A single N66S mutation in the PB1-F2 protein of influenza A virus increases virulence by inhibiting the early interferon response in vivo
    Gina M Conenello
    Mount Sinai School of Medicine, Department of Microbiology, One Gustave L Levy Place, Box 1124, New York, NY 10029, USA
    J Virol 85:652-62. 2011
    ..These data suggest that PB1-F2 N66S may contribute to the delay of innate immune responses, allowing for unchecked viral growth and ultimately severe immunopathology observed in the lungs...
  65. pmc Highly conserved regions of influenza a virus polymerase gene segments are critical for efficient viral RNA packaging
    Glenn A Marsh
    Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    J Virol 82:2295-304. 2008
    ..This work provides further evidence for a selective packaging mechanism for influenza A viruses, demonstrating that these highly conserved regions are important for efficient packaging...
  66. pmc The biology of influenza viruses
    Nicole M Bouvier
    Department of Microbiology, Mount Sinai School of Medicine, New York 10029, USA
    Vaccine 26:D49-53. 2008
    ..The particular structure ofthe influenza virus genome and function of its viral proteins enable antigenic drift and antigenic shift. These processes result in viruses able to evade the long-term adaptive immune responses in many hosts...

Research Grants22

  1. INFLUENZA VIRUS RIBONUCLEOPROTEINS (RNP)
    Peter Palese; Fiscal Year: 2006
    ..abstract_text> ..
  2. Development of Guinea Pig as Mamalian for Influenza Virus Transmission
    Peter Palese; Fiscal Year: 2007
    ....
  3. TRAINING PROGRAM: MECHANISMS OF VIRUS-HOST INTERACTIONS
    Peter Palese; Fiscal Year: 2007
    ....
  4. NOVEL CELLULAR AND VIRAL TARGETS FOR ANTI-INFLUENZA VIRUS DRUGS
    Peter Palese; Fiscal Year: 2007
    ....
  5. GENETIC ANALYSIS OF INFLUENZA A, B AND C VIRUSES
    Peter Palese; Fiscal Year: 2001
    ..These studies should allow us to compare a fundamental genetic property among different virus classes and to correlate error rate of viral polymerases with variability of viruses in nature. ..