Marie Anne O'Donnell

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi NFκB and ubiquitination: partners in disarming RIPK1-mediated cell death
    Marie Anne O'Donnell
    Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunol Res 54:214-26. 2012
  2. ncbi NEMO inhibits programmed necrosis in an NFκB-independent manner by restraining RIP1
    Marie Anne O'Donnell
    Immunology Institute, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 7:e41238. 2012
  3. ncbi Chronicles of a death foretold: dual sequential cell death checkpoints in TNF signaling
    Marie Anne O'Donnell
    Immunology Institute, Mount Sinai School of Medicine, New York, NY, USA
    Cell Cycle 9:1065-71. 2010
  4. ncbi RIP1 comes back to life as a cell death regulator in TNFR1 signaling
    Marie Anne O'Donnell
    Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    FEBS J 278:877-87. 2011
  5. ncbi Caspase 8 inhibits programmed necrosis by processing CYLD
    Marie Anne O'Donnell
    Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Cell Biol 13:1437-42. 2011
  6. ncbi Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling
    Marie Anne O'Donnell
    Immunobiology Center, Mount Sinai School of Medicine, Box 1630, One Gustave L Levy Place, New York, NY 10029, USA
    Curr Biol 17:418-24. 2007
  7. ncbi Inquiry learning. Integrating content detail and critical reasoning by peer review
    Ravi Iyengar
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 319:1189-90. 2008
  8. ncbi Teaching resources. Using web-based discussion forums as a model of the peer-review process and a tool for assessment
    Sherry L Jenkins
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci Signal 1:tr2. 2008
  9. ncbi The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response
    Constantin S Friedman
    Immunology Institute, Mount Sinai School of Medicine, Box 1630, One Gustave L Levy Place, New York, New York 10029, USA
    EMBO Rep 9:930-6. 2008

Collaborators

  • Andrew Chan
  • Daniel C Weinstein
  • Ravi Iyengar
  • Ramin Massoumi
  • Adrian T Ting
  • Sherry L Jenkins
  • Constantin S Friedman
  • Washington B Cardenas
  • Thomas M Moran
  • Jacob S Yount
  • Lakshmi A Devi
  • Christopher F Basler
  • Eric A Sobie
  • Maria A Diverse-Pierluissi
  • Akihiko Komuro
  • Ramnik Xavier
  • Aylwin Ng
  • Curt M Horvath
  • Diana Legarda-Addison

Detail Information

Publications9

  1. ncbi NFκB and ubiquitination: partners in disarming RIPK1-mediated cell death
    Marie Anne O'Donnell
    Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunol Res 54:214-26. 2012
    ....
  2. ncbi NEMO inhibits programmed necrosis in an NFκB-independent manner by restraining RIP1
    Marie Anne O'Donnell
    Immunology Institute, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 7:e41238. 2012
    ..These results indicate that recruitment of NEMO to ubiquitinated RIP1 is a key step in the TNFR1 signaling pathway that determines whether RIP1 triggers a necrotic death response...
  3. ncbi Chronicles of a death foretold: dual sequential cell death checkpoints in TNF signaling
    Marie Anne O'Donnell
    Immunology Institute, Mount Sinai School of Medicine, New York, NY, USA
    Cell Cycle 9:1065-71. 2010
    ..If RIP1 is not decorated with ubiquitin chains it becomes an unstoppable harbinger of bad news: programmed cell death...
  4. ncbi RIP1 comes back to life as a cell death regulator in TNFR1 signaling
    Marie Anne O'Donnell
    Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    FEBS J 278:877-87. 2011
    ..In this minireview, we focus on two major cell-death checkpoints that determine whether receptor-interacting protein 1 functions as a pro-survival or pro-death molecule...
  5. ncbi Caspase 8 inhibits programmed necrosis by processing CYLD
    Marie Anne O'Donnell
    Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Cell Biol 13:1437-42. 2011
    ..In contrast, loss of caspase 8 prevented CYLD degradation, resulting in necrotic death. A CYLD substitution mutation at Asp 215 that cannot be cleaved by caspase 8 switches cell survival to necrotic cell death in response to TNF...
  6. ncbi Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling
    Marie Anne O'Donnell
    Immunobiology Center, Mount Sinai School of Medicine, Box 1630, One Gustave L Levy Place, New York, NY 10029, USA
    Curr Biol 17:418-24. 2007
    ..Because TRAF2 is the E3 ligase for RIP1 [13], these observations provide an explanation for the NF-kappaB-independent antiapoptotic function previously described for TRAF2 [14-16]...
  7. ncbi Inquiry learning. Integrating content detail and critical reasoning by peer review
    Ravi Iyengar
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 319:1189-90. 2008
  8. ncbi Teaching resources. Using web-based discussion forums as a model of the peer-review process and a tool for assessment
    Sherry L Jenkins
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci Signal 1:tr2. 2008
    ....
  9. ncbi The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response
    Constantin S Friedman
    Immunology Institute, Mount Sinai School of Medicine, Box 1630, One Gustave L Levy Place, New York, New York 10029, USA
    EMBO Rep 9:930-6. 2008
    ..These findings show that CYLD is a negative regulator of RIG-I-mediated innate antiviral response...