Natalia Nieto

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. doi request reprint A systems biology approach for understanding the collagen regulatory network in alcoholic liver disease
    Natalia Nieto
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    Liver Int 32:189-98. 2012
  2. ncbi request reprint Ethanol and fish oil induce NFkappaB transactivation of the collagen alpha2(I) promoter through lipid peroxidation-driven activation of the PKC-PI3K-Akt pathway
    Natalia Nieto
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Hepatology 45:1433-45. 2007
  3. pmc Repeated whiskey binges promote liver injury in rats fed a choline-deficient diet
    Natalia Nieto
    Mount Sinai School of Medicine, Department of Medicine, Division of Liver Diseases, New York, NY, USA
    J Hepatol 46:330-9. 2007
  4. ncbi request reprint Oxidative-stress and IL-6 mediate the fibrogenic effects of [corrected] Kupffer cells on stellate cells
    Natalia Nieto
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 44:1487-501. 2006
  5. ncbi request reprint S-adenosylmethionine blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoter
    Natalia Nieto
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 280:30963-74. 2005
  6. pmc Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice
    Elisabetta Mormone
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 142:612-621.e5. 2012
  7. ncbi request reprint A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats
    Michal Carmiel-Haggai
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    FASEB J 19:136-8. 2005
  8. doi request reprint Ethanol and arachidonic acid synergize to activate Kupffer cells and modulate the fibrogenic response via tumor necrosis factor alpha, reduced glutathione, and transforming growth factor beta-dependent mechanisms
    Francisco Javier Cubero
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY, USA
    Hepatology 48:2027-39. 2008
  9. doi request reprint Reactive nitrogen species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha
    Raquel Urtasun
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 136:1410-22, e1-4. 2009
  10. ncbi request reprint Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway
    Pengfei Gong
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:29693-700. 2003

Research Grants

  1. Communication between Kupffer cells and stellate cells
    Natalia Nieto; Fiscal Year: 2009
  2. ASS, NOS2, AND ALCOHOLIC LIVER DISEASE
    Natalia Nieto; Fiscal Year: 2009
  3. ASS, NOS2, AND ALCOHOLIC LIVER DISEASE
    Natalia Nieto; Fiscal Year: 2009
  4. ASS, NOS2, AND ALCOHOLIC LIVER DISEASE
    Natalia Nieto; Fiscal Year: 2010
  5. Communication between Kupffer cells and stellate cells
    Natalia Nieto; Fiscal Year: 2005
  6. Communication between Kupffer cells and stellate cells
    Natalia Nieto; Fiscal Year: 2006
  7. Communication between Kupffer cells and stellate cells
    Natalia Nieto; Fiscal Year: 2007

Collaborators

Detail Information

Publications35

  1. doi request reprint A systems biology approach for understanding the collagen regulatory network in alcoholic liver disease
    Natalia Nieto
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    Liver Int 32:189-98. 2012
    ..Thus, this review article provides a snapshot on current efforts for identifying pathological protein regulatory networks in the liver using systems biology tools. These approaches hold great promise for future research in liver disease...
  2. ncbi request reprint Ethanol and fish oil induce NFkappaB transactivation of the collagen alpha2(I) promoter through lipid peroxidation-driven activation of the PKC-PI3K-Akt pathway
    Natalia Nieto
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Hepatology 45:1433-45. 2007
    ..Furthermore, inhibitors of all 3 kinases blocked the increase in collagen I and NFkappaB binding to the COL1A2 promoter; the latter was also prevented by vitamin E...
  3. pmc Repeated whiskey binges promote liver injury in rats fed a choline-deficient diet
    Natalia Nieto
    Mount Sinai School of Medicine, Department of Medicine, Division of Liver Diseases, New York, NY, USA
    J Hepatol 46:330-9. 2007
    ..We investigated the relationship between alcohol intake (whiskey binge drinking) and a choline-deficient diet (CD) and assessed whether stellate cells could contribute to liver injury in this model...
  4. ncbi request reprint Oxidative-stress and IL-6 mediate the fibrogenic effects of [corrected] Kupffer cells on stellate cells
    Natalia Nieto
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 44:1487-501. 2006
    ..In conclusion, these results unveil a novel dual mechanism mediated by H2O2 and IL-6 by which KCs may modulate the fibrogenic response in HSCs...
  5. ncbi request reprint S-adenosylmethionine blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoter
    Natalia Nieto
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 280:30963-74. 2005
    ..These observations unveil a novel mechanism by which AdoMet could ameliorate liver fibrosis...
  6. pmc Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice
    Elisabetta Mormone
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 142:612-621.e5. 2012
    ..We propose that fibromodulin contributes to the pathogenesis of fibrosis by regulating the fibrogenic phenotype of hepatic stellate cells (HSCs)...
  7. ncbi request reprint A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats
    Michal Carmiel-Haggai
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    FASEB J 19:136-8. 2005
    ..A role for oxidative stress is suggested via increased NADPH oxidase activity, lipid peroxidation, protein carbonyl formation, and low antioxidant defense...
  8. doi request reprint Ethanol and arachidonic acid synergize to activate Kupffer cells and modulate the fibrogenic response via tumor necrosis factor alpha, reduced glutathione, and transforming growth factor beta-dependent mechanisms
    Francisco Javier Cubero
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY, USA
    Hepatology 48:2027-39. 2008
    ....
  9. doi request reprint Reactive nitrogen species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha
    Raquel Urtasun
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 136:1410-22, e1-4. 2009
    ..Liver injury leads to generation of reactive oxygen and nitrogen species, which can react to produce peroxynitrite (ONOO-). We investigated whether ONOO- and its metabolites modulate extracellular matrix remodeling...
  10. ncbi request reprint Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway
    Pengfei Gong
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:29693-700. 2003
    ..This induction may serve as an adaptive mechanism to protect the E47 cells against the CYP2E1-dependent oxidative stress...
  11. ncbi request reprint Osteopontin binding to lipopolysaccharide lowers tumor necrosis factor-α and prevents early alcohol-induced liver injury in mice
    Xiaodong Ge
    Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    Hepatology 59:1600-16. 2014
    ..Conclusion: Natural induction plus forced overexpression of OPN in the liver or treatment with m-OPN protect from early alcohol-induced liver injury by blocking the gut-derived LPS and TNFα effects in the liver...
  12. doi request reprint Argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in mice
    Tung Ming Leung
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 55:1596-609. 2012
    ....
  13. ncbi request reprint Cytochrome P450 2E1 responsiveness in the promoter of glutamate-cysteine ligase catalytic subunit
    Natalia Nieto
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Hepatology 37:96-106. 2003
    ....
  14. ncbi request reprint Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species
    Natalia Nieto
    Department of Biochemistry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Hepatology 35:62-73. 2002
    ..Thus, besides perturbing the homeostasis of hepatocytes, CYP2E1-derived diffusible oxidants may also interact with stellate cells and contribute to hepatic fibrosis...
  15. ncbi request reprint Heme oxygenase-1 protects HepG2 cells against cytochrome P450 2E1-dependent toxicity
    Pengfei Gong
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 36:307-18. 2004
    ..These results suggest that induction of HO-1 protects against CYP2E1-dependent toxicity and this protection may be mediated in part via production of CO and CO inhibition of CYP2E1 activity...
  16. doi request reprint Osteopontin delays resolution of liver fibrosis
    Tung Ming Leung
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Lab Invest 93:1082-9. 2013
    ..In conclusion, these results suggest that OPN delays liver fibrosis resolution due to sustained fibrillar collagen-I deposition; hence, inhibiting OPN could be an effective therapeutic strategy for resolving liver fibrosis. ..
  17. ncbi request reprint Cytochrome P450 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells
    Natalia Nieto
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 277:9853-64. 2002
    ..These co-culture models may be useful for understanding the impact of CYP2E1-derived ROS on stellate cell function and activation...
  18. pmc Arachidonic acid stimulates TNFα production in Kupffer cells via a reactive oxygen species-pERK1/2-Egr1-dependent mechanism
    Francisco Javier Cubero
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Physiol Gastrointest Liver Physiol 303:G228-39. 2012
    ..This study unveils the mechanism whereby arachidonic acid and ethanol increase TNFα production in Kupffer cells, thus contributing to alcoholic liver disease...
  19. doi request reprint Cannabinoids provoke alcoholic steatosis through a conspiracy of neighbors
    Scott L Friedman
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Metab 7:187-8. 2008
    ....
  20. ncbi request reprint Increased Sp1-dependent transactivation of the LAMgamma 1 promoter in hepatic stellate cells co-cultured with HepG2 cells overexpressing cytochrome P450 2E1
    Natalia Nieto
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:15360-72. 2003
    ..These results show that diffusable CYP2E1-derived oxidative-stress mediators induce synthesis of laminins by a transcriptional mechanism in HSC. Such interactions between hepatocytes and HSC may be important during liver fibrosis...
  21. pmc Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy
    Virginia Hernandez-Gea
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Hepatol 59:98-104. 2013
    ..The aim of our study was to determine the impact of oxidant and ER stress on stellate cell activation...
  22. pmc Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signaling
    Raquel Urtasun
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 55:594-608. 2012
    ..Last, chronic CCl(4) injection and TAA treatment caused more liver fibrosis to WT than to Opn(-/-) mice and the reverse occurred in Opn(HEP) Tg mice...
  23. ncbi request reprint The liver-selective nitric oxide donor O2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO) protects HepG2 cells against cytochrome P450 2E1-dependent toxicity
    Pengfei Gong
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029
    Mol Pharmacol 65:130-8. 2004
    ....
  24. pmc Milk osteopontin, a nutritional approach to prevent alcohol-induced liver injury
    Xiaodong Ge
    Div of Liver Diseases, Dept of Medicine, Mount Sinai School of Medicine, Box 11 23, 1425 Madison Ave, Rm 11 70, New York, NY 10029, USA
    Am J Physiol Gastrointest Liver Physiol 304:G929-39. 2013
    ..Milk osteopontin could be a simple effective nutritional therapeutic strategy to prevent alcohol hepatotoxicity due, among others, to gut protective, anti-inflammatory, and anti-steatotic actions...
  25. ncbi request reprint Binge ethanol exposure increases liver injury in obese rats
    Michal Carmiel-Haggai
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, and Division of Livers Diseases, Mount Sinai Medical Center, New York, New York 10029, USA
    Gastroenterology 125:1818-33. 2003
    ..The objective of this study was to address the hepatic effects of acute alcohol consumption in obesity by simulating an alcohol binge in genetically obese fa/fa rats compared with lean Fa/? rats...
  26. pmc Oxidative stress modulates KLF6Full and its splice variants
    Raquel Urtasun
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    Alcohol Clin Exp Res 36:1851-62. 2012
    ....
  27. doi request reprint CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease
    Tung Ming Leung
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Hepatol 58:395-8. 2013
    ..Cytochrome P450 2E1 (CYP2E1) plays a critical role in ROS generation and CYP2E1 is also induced by alcohol itself. This review summarizes the role of CYP2E1 in ALD and NAFLD...
  28. pmc Partial deletion of argininosuccinate synthase protects from pyrazole plus lipopolysaccharide-induced liver injury by decreasing nitrosative stress
    Yongke Lu
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Physiol Gastrointest Liver Physiol 302:G287-95. 2012
    ..Partial Ass ablation prevents pyrazole plus LPS-mediated liver injury by reducing nitrosative stress, TNFα, apoptosis, and neutrophil infiltration...
  29. doi request reprint Alcohol and liver fibrosis
    Francisco Javier Cubero
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
    Semin Liver Dis 29:211-21. 2009
    ....
  30. pmc Alcohol disrupts endoplasmic reticulum function and protein secretion in hepatocytes
    Deanna L Howarth
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Alcohol Clin Exp Res 36:14-23. 2012
    ..We investigated whether alcohol affects ER structure, function, and UPR activation in hepatocytes in vitro and in vivo...
  31. doi request reprint Ethanol plus the Jo2 Fas agonistic antibody-induced liver injury is attenuated in mice with partial ablation of argininosuccinate synthase
    Yongke Lu
    Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York
    Alcohol Clin Exp Res 38:649-56. 2014
    ..Thus, ASS conditions NO· synthesis by NOS2. Because of the relevance of NOS2 activation for liver injury, we examined the contribution of ASS to NO· generation and how it impacts liver injury...
  32. pmc Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches
    Elisabetta Mormone
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, NY 10029, USA
    Chem Biol Interact 193:225-31. 2011
    ..In this review, we discuss some aspects on the etiology of liver fibrosis, the cells involved, the molecular pathogenesis, and the current therapeutic approaches...
  33. pmc AT1R-CB₁R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II
    Raphael Rozenfeld
    Department of Pharmacology and Systems Therapeutics, New York Mount Sinai School of Medicine, New York, NY, USA
    EMBO J 30:2350-63. 2011
    ..These results provide a molecular basis for the pivotal role of heteromer-dependent signal integration in pathology...
  34. ncbi request reprint Contribution of polyunsaturated fatty acids to intestinal repair in protein-energy malnutrition
    Natalia Nieto
    Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Granada, Campus Universitario de Cartuja s n, Granada, Spain
    Dig Dis Sci 52:1485-96. 2007
    ..These results suggest that dietary polyunsaturated fatty acids, particularly those in the n-3 series, may play an important role in intestinal repair in chronic diarrhea due to protein-energy malnutrition...
  35. ncbi request reprint Dietary polyunsaturated fatty acids improve histological and biochemical alterations in rats with experimental ulcerative colitis
    Natalia Nieto
    Department of Biochemistry and Molecular Biology, University of Granada, 18071 Granada, Spain
    J Nutr 132:11-9. 2002
    ..These results suggest that the use of balanced diets containing (n-3) LC-PUFA could ameliorate the inflammation and mucosal damage in UC...

Research Grants9

  1. Communication between Kupffer cells and stellate cells
    Natalia Nieto; Fiscal Year: 2009
    ..We hope that this co-culture model will help us to define the effects of Kupffer cells on the stellate cell fibrogenic response and to dissect potential therapeutic targets for preventing liver disease. ..
  2. ASS, NOS2, AND ALCOHOLIC LIVER DISEASE
    Natalia Nieto; Fiscal Year: 2009
    ..Such information could lead to positive pharmacological targeting to ameliorate alcohol hepatotoxicity. ..
  3. ASS, NOS2, AND ALCOHOLIC LIVER DISEASE
    Natalia Nieto; Fiscal Year: 2009
    ..Such information could lead to positive pharmacological targeting to ameliorate alcohol hepatotoxicity. ..
  4. ASS, NOS2, AND ALCOHOLIC LIVER DISEASE
    Natalia Nieto; Fiscal Year: 2010
    ..Such information could lead to positive pharmacological targeting to ameliorate alcohol hepatotoxicity. ..
  5. Communication between Kupffer cells and stellate cells
    Natalia Nieto; Fiscal Year: 2005
    ..We hope that this co-culture model will help us to define the effects of Kupffer cells on the stellate cell fibrogenic response and to dissect potential therapeutic targets for preventing liver disease. ..
  6. Communication between Kupffer cells and stellate cells
    Natalia Nieto; Fiscal Year: 2006
    ..We hope that this co-culture model will help us to define the effects of Kupffer cells on the stellate cell fibrogenic response and to dissect potential therapeutic targets for preventing liver disease. ..
  7. Communication between Kupffer cells and stellate cells
    Natalia Nieto; Fiscal Year: 2007
    ..We hope that this co-culture model will help us to define the effects of Kupffer cells on the stellate cell fibrogenic response and to dissect potential therapeutic targets for preventing liver disease. ..