Research Topics
Genomes and Genes
| Natalia NietoSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
A systems biology approach for understanding the collagen regulatory network in alcoholic liver diseaseNatalia Nieto
Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
Liver Int 32:189-98. 2012..Thus, this review article provides a snapshot on current efforts for identifying pathological protein regulatory networks in the liver using systems biology tools. These approaches hold great promise for future research in liver disease...
Repeated whiskey binges promote liver injury in rats fed a choline-deficient dietNatalia Nieto
Mount Sinai School of Medicine, Department of Medicine, Division of Liver Diseases, New York, NY, USA
J Hepatol 46:330-9. 2007..We investigated the relationship between alcohol intake (whiskey binge drinking) and a choline-deficient diet (CD) and assessed whether stellate cells could contribute to liver injury in this model...
Oxidative-stress and IL-6 mediate the fibrogenic effects of [corrected] Kupffer cells on stellate cellsNatalia Nieto
Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
Hepatology 44:1487-501. 2006..In conclusion, these results unveil a novel dual mechanism mediated by H2O2 and IL-6 by which KCs may modulate the fibrogenic response in HSCs...- S-adenosylmethionine blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoterNatalia Nieto
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 280:30963-74. 2005..These observations unveil a novel mechanism by which AdoMet could ameliorate liver fibrosis... - Ethanol and fish oil induce NFkappaB transactivation of the collagen alpha2(I) promoter through lipid peroxidation-driven activation of the PKC-PI3K-Akt pathwayNatalia Nieto
Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
Hepatology 45:1433-45. 2007.... - Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in miceElisabetta Mormone
Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Gastroenterology 142:612-621.e5. 2012..We propose that fibromodulin contributes to the pathogenesis of fibrosis by regulating the fibrogenic phenotype of hepatic stellate cells (HSCs)... - Ethanol and arachidonic acid synergize to activate Kupffer cells and modulate the fibrogenic response via tumor necrosis factor alpha, reduced glutathione, and transforming growth factor beta-dependent mechanismsFrancisco Javier Cubero
Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY, USA
Hepatology 48:2027-39. 2008.... - A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese ratsMichal Carmiel-Haggai
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
FASEB J 19:136-8. 2005..A role for oxidative stress is suggested via increased NADPH oxidase activity, lipid peroxidation, protein carbonyl formation, and low antioxidant defense... - Reactive nitrogen species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalphaRaquel Urtasun
Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
Gastroenterology 136:1410-22, e1-4. 2009..Liver injury leads to generation of reactive oxygen and nitrogen species, which can react to produce peroxynitrite (ONOO-). We investigated whether ONOO- and its metabolites modulate extracellular matrix remodeling... - Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathwayPengfei Gong
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 278:29693-700. 2003..This induction may serve as an adaptive mechanism to protect the E47 cells against the CYP2E1-dependent oxidative stress... - Argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in miceTung Ming Leung
Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Hepatology 55:1596-609. 2012..CONCLUSION: Partial Ass ablation protects only in acute ethanol-induced liver injury by decreasing nitrosative stress but not in a more chronic scenario where oxidative stress and impaired fatty acid β-oxidation are key events... - Cytochrome P450 2E1 responsiveness in the promoter of glutamate-cysteine ligase catalytic subunitNatalia Nieto
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
Hepatology 37:96-106. 2003.... - Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen speciesNatalia Nieto
Department of Biochemistry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
Hepatology 35:62-73. 2002..Thus, besides perturbing the homeostasis of hepatocytes, CYP2E1-derived diffusible oxidants may also interact with stellate cells and contribute to hepatic fibrosis... - Heme oxygenase-1 protects HepG2 cells against cytochrome P450 2E1-dependent toxicityPengfei Gong
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
Free Radic Biol Med 36:307-18. 2004..These results suggest that induction of HO-1 protects against CYP2E1-dependent toxicity and this protection may be mediated in part via production of CO and CO inhibition of CYP2E1 activity... - Cytochrome P450 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cellsNatalia Nieto
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 277:9853-64. 2002..These co-culture models may be useful for understanding the impact of CYP2E1-derived ROS on stellate cell function and activation... - Arachidonic acid stimulates TNFα production in Kupffer cells via a reactive oxygen species-pERK1/2-Egr1-dependent mechanismFrancisco Javier Cubero
Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Am J Physiol Gastrointest Liver Physiol 303:G228-39. 2012..This study unveils the mechanism whereby arachidonic acid and ethanol increase TNFα production in Kupffer cells, thus contributing to alcoholic liver disease... - Cannabinoids provoke alcoholic steatosis through a conspiracy of neighborsScott L Friedman
Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
Cell Metab 7:187-8. 2008.... - Increased Sp1-dependent transactivation of the LAMgamma 1 promoter in hepatic stellate cells co-cultured with HepG2 cells overexpressing cytochrome P450 2E1Natalia Nieto
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 278:15360-72. 2003..These results show that diffusable CYP2E1-derived oxidative-stress mediators induce synthesis of laminins by a transcriptional mechanism in HSC. Such interactions between hepatocytes and HSC may be important during liver fibrosis... - Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signalingRaquel Urtasun
Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Hepatology 55:594-608. 2012..CONCLUSION: OPN emerges as a key cytokine within the ECM protein network driving the increase in Collagen-I protein contributing to scarring and liver fibrosis... - The liver-selective nitric oxide donor O2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO) protects HepG2 cells against cytochrome P450 2E1-dependent toxicityPengfei Gong
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029
Mol Pharmacol 65:130-8. 2004.... - Binge ethanol exposure increases liver injury in obese ratsMichal Carmiel-Haggai
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, and Division of Livers Diseases, Mount Sinai Medical Center, New York, New York 10029, USA
Gastroenterology 125:1818-33. 2003..The objective of this study was to address the hepatic effects of acute alcohol consumption in obesity by simulating an alcohol binge in genetically obese fa/fa rats compared with lean Fa/? rats... - Partial deletion of argininosuccinate synthase protects from pyrazole plus lipopolysaccharide-induced liver injury by decreasing nitrosative stressYongke Lu
Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Am J Physiol Gastrointest Liver Physiol 302:G287-95. 2012..Partial Ass ablation prevents pyrazole plus LPS-mediated liver injury by reducing nitrosative stress, TNFα, apoptosis, and neutrophil infiltration... - Alcohol and liver fibrosisFrancisco Javier Cubero
Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
Semin Liver Dis 29:211-21. 2009.... - Alcohol disrupts endoplasmic reticulum function and protein secretion in hepatocytesDeanna L Howarth
Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
Alcohol Clin Exp Res 36:14-23. 2012..We investigated whether alcohol affects ER structure, function, and UPR activation in hepatocytes in vitro and in vivo... - Oxidative stress modulates KLF6Full and its splice variantsRaquel Urtasun
Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
Alcohol Clin Exp Res 36:1851-62. 2012.... - Molecular pathogenesis of hepatic fibrosis and current therapeutic approachesElisabetta Mormone
Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, NY 10029, USA
Chem Biol Interact 193:225-31. 2011..In this review, we discuss some aspects on the etiology of liver fibrosis, the cells involved, the molecular pathogenesis, and the current therapeutic approaches... - AT1R-CB₁R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin IIRaphael Rozenfeld
Department of Pharmacology and Systems Therapeutics, New York Mount Sinai School of Medicine, New York, NY, USA
EMBO J 30:2350-63. 2011..These results provide a molecular basis for the pivotal role of heteromer-dependent signal integration in pathology... - Contribution of polyunsaturated fatty acids to intestinal repair in protein-energy malnutritionNatalia Nieto
Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Granada, Campus Universitario de Cartuja s n, Granada, Spain
Dig Dis Sci 52:1485-96. 2007..These results suggest that dietary polyunsaturated fatty acids, particularly those in the n-3 series, may play an important role in intestinal repair in chronic diarrhea due to protein-energy malnutrition... - Dietary polyunsaturated fatty acids improve histological and biochemical alterations in rats with experimental ulcerative colitisNatalia Nieto
Department of Biochemistry and Molecular Biology, University of Granada, 18071 Granada, Spain
J Nutr 132:11-9. 2002..These results suggest that the use of balanced diets containing (n-3) LC-PUFA could ameliorate the inflammation and mucosal damage in UC...
Research Grants
- Communication between Kupffer cells and stellate cellsNatalia Nieto; Fiscal Year: 2009..We hope that this co-culture model will help us to define the effects of Kupffer cells on the stellate cell fibrogenic response and to dissect potential therapeutic targets for preventing liver disease. ..
- ASS, NOS2, AND ALCOHOLIC LIVER DISEASENatalia Nieto; Fiscal Year: 2009..Such information could lead to positive pharmacological targeting to ameliorate alcohol hepatotoxicity. ..
- ASS, NOS2, AND ALCOHOLIC LIVER DISEASENatalia Nieto; Fiscal Year: 2009..Such information could lead to positive pharmacological targeting to ameliorate alcohol hepatotoxicity. ..
- ASS, NOS2, AND ALCOHOLIC LIVER DISEASENatalia Nieto; Fiscal Year: 2010..Such information could lead to positive pharmacological targeting to ameliorate alcohol hepatotoxicity. ..