Antonia New

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Laboratory induced aggression: a positron emission tomography study of aggressive individuals with borderline personality disorder
    Antonia S New
    James J Peters Veterans Affairs Medical Center, Bronx, New York 10468, USA
    Biol Psychiatry 66:1107-14. 2009
  2. pmc Developmental differences in diffusion tensor imaging parameters in borderline personality disorder
    Antonia S New
    The Mental Illness Research Education and Clinical Center, James J Peters Veterans Affairs Medical Center, NY 10029, USA
    J Psychiatr Res 47:1101-9. 2013
  3. ncbi request reprint Empathy and alexithymia in borderline personality disorder: clinical and laboratory measures
    Antonia S New
    James J Peters Veterans Affairs Medical Center, New York, USA
    J Pers Disord 26:660-75. 2012
  4. ncbi request reprint Fluoxetine increases relative metabolic rate in prefrontal cortex in impulsive aggression
    Antonia S New
    Psychiatry Service Mount Sinai School of Medicine and the Bronx VA Medical Center, 130 West Kingsbridge Road, PO Box 1168, Bronx, NY 10468, USA
    Psychopharmacology (Berl) 176:451-8. 2004
  5. ncbi request reprint Amygdala-prefrontal disconnection in borderline personality disorder
    Antonia S New
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychopharmacology 32:1629-40. 2007
  6. doi request reprint The case for shifting borderline personality disorder to Axis I
    Antonia S New
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 64:653-9. 2008
  7. doi request reprint Recent advances in the biological study of personality disorders
    Antonia S New
    The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1217, New York, NY 10029, USA
    Psychiatr Clin North Am 31:441-61, vii. 2008
  8. doi request reprint A functional magnetic resonance imaging study of deliberate emotion regulation in resilience and posttraumatic stress disorder
    Antonia S New
    Mental Health Care Center, James J Peters Veterans Affairs Medical Center, Bronx, New York, New York 10468, USA
    Biol Psychiatry 66:656-64. 2009
  9. pmc Neural correlates of using distancing to regulate emotional responses to social situations
    Harold W Koenigsberg
    James J Peters VA Medical Center, Bronx, NY 10468, USA
    Neuropsychologia 48:1813-22. 2010
  10. ncbi request reprint Cingulate gyrus volume and metabolism in the schizophrenia spectrum
    M Mehmet Haznedar
    Department of Psychiatry, Mount Sinai School of Medicine, Neuroscience PET Laboratory, One Gustave L Levy Place, P O Box 1505, New York, NY 10029 6574, USA
    Schizophr Res 71:249-62. 2004

Research Grants

Detail Information

Publications50

  1. pmc Laboratory induced aggression: a positron emission tomography study of aggressive individuals with borderline personality disorder
    Antonia S New
    James J Peters Veterans Affairs Medical Center, Bronx, New York 10468, USA
    Biol Psychiatry 66:1107-14. 2009
    ..Preclinical studies show that orbital frontal cortex (OFC) plays a role in regulating impulsive aggression. Prior work has found OFC dysfunction in BPD...
  2. pmc Developmental differences in diffusion tensor imaging parameters in borderline personality disorder
    Antonia S New
    The Mental Illness Research Education and Clinical Center, James J Peters Veterans Affairs Medical Center, NY 10029, USA
    J Psychiatr Res 47:1101-9. 2013
    ..However, diffusion tensor imaging (DTI) studies in adult BPD have been inconclusive, and, as yet, there are no published DTI studies in borderline adolescents...
  3. ncbi request reprint Empathy and alexithymia in borderline personality disorder: clinical and laboratory measures
    Antonia S New
    James J Peters Veterans Affairs Medical Center, New York, USA
    J Pers Disord 26:660-75. 2012
    ..BPD patients are highly responsive to the feelings of others, but they are impaired in identifying/describing feelings and in taking the perspective of others...
  4. ncbi request reprint Fluoxetine increases relative metabolic rate in prefrontal cortex in impulsive aggression
    Antonia S New
    Psychiatry Service Mount Sinai School of Medicine and the Bronx VA Medical Center, 130 West Kingsbridge Road, PO Box 1168, Bronx, NY 10468, USA
    Psychopharmacology (Berl) 176:451-8. 2004
    ..In addition, patients with impulsive aggression have an attenuation of symptoms with selective serotonin reuptake inhibitor (SSRI) treatment...
  5. ncbi request reprint Amygdala-prefrontal disconnection in borderline personality disorder
    Antonia S New
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychopharmacology 32:1629-40. 2007
    ..We demonstrated no significant differences in amygdala volumes or metabolism between BPD patients and controls...
  6. doi request reprint The case for shifting borderline personality disorder to Axis I
    Antonia S New
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 64:653-9. 2008
    ..Finally, we suggest future directions for research that might permit the identification of core features of this disorder, with a focus on the importance of naturalistic assessments and of assessments through the course of development...
  7. doi request reprint Recent advances in the biological study of personality disorders
    Antonia S New
    The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1217, New York, NY 10029, USA
    Psychiatr Clin North Am 31:441-61, vii. 2008
    ..Clearly SPD falls within the schizophrenia spectrum, but precisely the nature of what predicts full-blown schizophrenia as opposed to the milder symptoms of SPD is not yet clear...
  8. doi request reprint A functional magnetic resonance imaging study of deliberate emotion regulation in resilience and posttraumatic stress disorder
    Antonia S New
    Mental Health Care Center, James J Peters Veterans Affairs Medical Center, Bronx, New York, New York 10468, USA
    Biol Psychiatry 66:656-64. 2009
    ..g., trauma-exposed non-PTSD). In this project, we examined the neural mechanisms underlying differences in response to sexual violence, focusing specifically on the deliberate modification of emotional responses to negative stimuli...
  9. pmc Neural correlates of using distancing to regulate emotional responses to social situations
    Harold W Koenigsberg
    James J Peters VA Medical Center, Bronx, NY 10468, USA
    Neuropsychologia 48:1813-22. 2010
    ..These findings demonstrate that distancing from aversive social cues modulates amygdala activity via engagement of networks implicated in social perception, perspective-taking, and attentional allocation...
  10. ncbi request reprint Cingulate gyrus volume and metabolism in the schizophrenia spectrum
    M Mehmet Haznedar
    Department of Psychiatry, Mount Sinai School of Medicine, Neuroscience PET Laboratory, One Gustave L Levy Place, P O Box 1505, New York, NY 10029 6574, USA
    Schizophr Res 71:249-62. 2004
    ....
  11. doi request reprint Parental burden associated with borderline personality disorder in female offspring
    Marianne Goodman
    James J Peters Veterans Affairs Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468, USA
    J Pers Disord 25:59-74. 2011
    ..Increasing awareness of co-morbid conditions in the BPD proband that significantly increase parental burden may be indicators for the provision of increased family support...
  12. ncbi request reprint Efficacy of open-label venlafaxine in subjects with major depressive disorder: associations with neuroendocrine response to serotonergic and noradrenergic probes
    Robert Grossman
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1230, New York, NY 10029 6574, USA
    Psychiatry Res 128:203-6. 2004
    ..low-dose responders. Evaluation of models of "serotonergic-responsive" and norepinephrine-responsive" depression requires larger numbers of patients...
  13. pmc Pergolide treatment of cognitive deficits associated with schizotypal personality disorder: continued evidence of the importance of the dopamine system in the schizophrenia spectrum
    Margaret M McClure
    VA VISN 3 Mental Illness Research, Education, and Clinical Center, Bronx, NY, USA
    Neuropsychopharmacology 35:1356-62. 2010
    ..These results suggest that dopamine agonists may provide benefit for the cognitive abnormalities of schizophrenia spectrum disorders...
  14. ncbi request reprint Functional MRI of visuospatial working memory in schizotypal personality disorder: a region-of-interest analysis
    Harold W Koenigsberg
    Bronx Veterans Affairs Medical Center, Bronx 1046, NY, USA
    Psychol Med 35:1019-30. 2005
    ..The study of schizotypal personality disorder (SPD) provides regional analysis in unmedicated patients in the schizophrenia spectrum...
  15. doi request reprint Neural correlates of emotion processing in borderline personality disorder
    Harold W Koenigsberg
    Mount Sinai School of Medicine, New York, NY, United States
    Psychiatry Res 172:192-9. 2009
    ..The patients activate neural networks in emotion processing that are phylogeneticall older and more reflexive than those activated by HC subjects...
  16. ncbi request reprint Blunted prefrontal cortical 18fluorodeoxyglucose positron emission tomography response to meta-chlorophenylpiperazine in impulsive aggression
    Antonia S New
    Psychiatry Service, Bronx Veterans Affairs Medical Center, NY 10468, USA
    Arch Gen Psychiatry 59:621-9. 2002
    ..Preclinical and human studies suggest that the orbital frontal cortex and anterior cingulate cortex play an inhibitory role in the regulation of aggression...
  17. doi request reprint Parental viewpoints of trajectories to borderline personality disorder in female offspring
    Marianne Goodman
    Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, New York 10468, USA
    J Pers Disord 24:204-16. 2010
    ..By adolescence, difficulties with impulsivity, aggression, acting out, and self-destructive behaviors dominate the profile...
  18. pmc Neural correlates of the use of psychological distancing to regulate responses to negative social cues: a study of patients with borderline personality disorder
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10468, USA
    Biol Psychiatry 66:854-63. 2009
    ..One possible contributing factor to emotional instability is a failure to adequately employ adaptive cognitive regulatory strategies such as psychological distancing...
  19. pmc Smaller superior temporal gyrus volume specificity in schizotypal personality disorder
    Kim E Goldstein
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 112:14-23. 2009
    ..This is the first morphometric study to directly compare SPD and BPD patients in temporal lobe volume...
  20. ncbi request reprint Irritable assault and variation in the COMT gene
    Janine D Flory
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Psychiatr Genet 17:344-6. 2007
    ..These findings provide limited support for a role of COMT in modulating aggressive behavior, and are extended to people with personality disorders...
  21. ncbi request reprint Deficient attentional modulation of the startle response in patients with schizotypal personality disorder
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1505, New York, NY 10029, USA
    Am J Psychiatry 160:1621-6. 2003
    ..The purpose of this study was to examine automatic sensorimotor gating and controlled attentional modulation of the startle eye blink response in unmedicated subjects with schizotypal personality disorder...
  22. pmc Frontolimbic structural changes in borderline personality disorder
    Michael J Minzenberg
    Mount Sinai School of Medicine and Bronx VA Medical Center, Bronx, NY, USA
    J Psychiatr Res 42:727-33. 2008
    ..We tested the hypothesis that BPD patients exhibit gross structural changes that parallel the respective increases in amygdala activation and impairment of rostral/subgenual ACC activation...
  23. ncbi request reprint Trauma, genes, and the neurobiology of personality disorders
    Marianne Goodman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Ann N Y Acad Sci 1032:104-16. 2004
    ..Gene-environment interactions involving childhood maltreatment are demonstrated in recent studies on antisocial behaviors and aggressive rhesus monkeys and highlight the need for further research in this important area...
  24. ncbi request reprint Reduced anterior and posterior cingulate gray matter in borderline personality disorder
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1505, New York, NY 10029, USA
    Biol Psychiatry 58:614-23. 2005
    ..We extended this investigation by examining gray and white matter volume of frontal and cingulate gyrus Brodmann areas (BAs) in a large group of patients and healthy controls...
  25. pmc Frontal-striatal-thalamic mediodorsal nucleus dysfunction in schizophrenia-spectrum patients during sensorimotor gating
    Erin A Hazlett
    Department of Psychiatry, Box 1505, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroimage 42:1164-77. 2008
    ..Dysfunctional FST activation, particularly in the caudate may underlie PPI abnormalities in schizophrenia-spectrum patients...
  26. ncbi request reprint Effects of acute metabolic stress on the dopaminergic and pituitary-adrenal axis activity in patients with schizotypal personality disorder
    Vivian Mitropoulou
    Department of Psychiatry, Mt Sinai School of Medicine Clinical Reseach Center, New York, NY 10029, USA
    Schizophr Res 70:27-31. 2004
    ..We hypothesized that SPD patients would demonstrate comparable or lower DA and HPA responses after 2-DG to HV...
  27. ncbi request reprint Neurobiologic function and temperament in subjects with personality disorders
    Vivian Mitropoulou
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:725-30. 2003
    ....
  28. ncbi request reprint The relationship of borderline personality disorder to posttraumatic stress disorder and traumatic events
    Julia A Golier
    Department of Psychiatry, Veterans Affairs Medical Center 116 A, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Am J Psychiatry 160:2018-24. 2003
    ..The authors examined the relationship of borderline personality disorder to posttraumatic stress disorder (PTSD) with respect to the role of trauma and its timing...
  29. ncbi request reprint Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups
    Michael J Minzenberg
    Bronx Veterans Affairs Medical Center, Bronx, New York, 14068, USA
    Psychiatr Genet 16:117-24. 2006
    ..We evaluated the relationship of the COMT genotype with diagnostic status and cognitive performance in schizotypal personality disorder...
  30. ncbi request reprint Risperidone in the treatment of schizotypal personality disorder
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10468, USA
    J Clin Psychiatry 64:628-34. 2003
    ..In addition, if SPD patients respond to an antipsychotic medication, this will provide support for the notion of a commonality in treatment response between SPD and schizophrenia...
  31. pmc Increased serotonin 2A receptor availability in the orbitofrontal cortex of physically aggressive personality disordered patients
    Daniel R Rosell
    James J Peters Veterans Affairs Medical Center, Bronx, New York, NY, USA
    Biol Psychiatry 67:1154-62. 2010
    ..We have previously hypothesized that increased 5-HT(2A)R function in the OFC is a state phenomenon that promotes impulsive aggression...
  32. pmc Cortical gray and white matter volume in unmedicated schizotypal and schizophrenia patients
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Schizophr Res 101:111-23. 2008
    ..Overall, our findings suggest that increased prefrontal volume in BA10 and sparing of volume loss in temporal cortex (BAs 22 and 20) may be a protective factor in SPD which reduces vulnerability to psychosis...
  33. ncbi request reprint Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, 1051 Riverside Dr, Box 31, New York, NY 10032, USA
    Am J Psychiatry 162:915-23. 2005
    ..This study evaluated regional serotonin transporter distribution in the brain of individuals with impulsive aggression by using positron emission tomography (PET) with the serotonin transporter PET radiotracer [(11)C]McN 5652...
  34. ncbi request reprint Blunted hormone responses to Ipsapirone are associated with trait impulsivity in personality disorder patients
    Michael J Minzenberg
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Neuropsychopharmacology 31:197-203. 2006
    ..In addition, D(2) receptor dysfunction may play a role in impulsivity, whereas 5-HT(1A) cell-body autoreceptor function may be spared in these disorders...
  35. ncbi request reprint Neuropsychological performance in schizotypal personality disorder: importance of working memory
    Vivian Mitropoulou
    Clinical Research Center, Box 1027, Mt Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Am J Psychiatry 162:1896-903. 2005
    ....
  36. ncbi request reprint Dispositional impulsivity in normal and abnormal samples
    Janine D Flory
    Department of Psychiatry, Box 1230, One Gustave Levy Place, Mount Sinai School of Medicine, New York, NY 10029, United States
    J Psychiatr Res 40:438-47. 2006
    ..Results from these analyses also lend support to a large body of work that demonstrates that normal and abnormal personality features are related...
  37. ncbi request reprint Exaggerated affect-modulated startle during unpleasant stimuli in borderline personality disorder
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 62:250-5. 2007
    ..The affect-modulated startle response is a reliable indicator of emotional processing of stimuli. The aim of this study was to examine emotional processing in BPD patients (n = 27) and healthy control subjects (n = 21)...
  38. ncbi request reprint Deficient attentional modulation of startle eyeblink is associated with symptom severity in the schizophrenia spectrum
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, United States
    Schizophr Res 93:288-95. 2007
    ..Among the schizophrenia-spectrum sample, more deficient PPI during the attended prepulses was associated with greater symptom severity as measured by the total 18-item Brief Psychiatric Rating Scale score...
  39. pmc Fronto-limbic dysfunction in response to facial emotion in borderline personality disorder: an event-related fMRI study
    Michael J Minzenberg
    Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Psychiatry Res 155:231-43. 2007
    ..The neural substrates underlying processing of anger may also be altered. These changes may represent an expression of the volumetric and serotonergic deficits observed in these brain areas in BPD...
  40. ncbi request reprint Neuropsychological performance in schizotypal personality disorder: evidence regarding diagnostic specificity
    Vivian Mitropoulou
    Mt Sinai School of Medicine, Department of Psychiatry, The Bronx Veterans Affairs Medical Center, New York, New York, USA
    Biol Psychiatry 52:1175-82. 2002
    ..We investigated the neuropsychological profile in SPD patients compared with two comparison groups: healthy volunteers (HV) and patients who met criteria for another non-schizophrenia spectrum personality disorder (NSS)...
  41. ncbi request reprint Characterizing affective instability in borderline personality disorder
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Am J Psychiatry 159:784-8. 2002
    ..The authors also examined the subjective intensity with which moods are experienced and the association between instability and intensity of affect...
  42. ncbi request reprint Dexamethasone suppression test findings in subjects with personality disorders: associations with posttraumatic stress disorder and major depression
    Robert Grossman
    Department of Psychatry Bronx VeteransAffairs medical Center, Bronx, NY, USA
    Am J Psychiatry 160:1291-8. 2003
    ..To investigate the effect of PTSD, the authors conducted a 0.5-mg DST, which is more sensitive than the 1.0-mg DST for detection of increased cortisol suppression, in a group of subjects with personality disorders...
  43. ncbi request reprint 24-h Monitoring of plasma norepinephrine, MHPG, cortisol, growth hormone and prolactin in depression
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    J Psychiatr Res 38:503-11. 2004
    ..The present study takes advantage of frequent plasma sampling over the 24-h period and a multioscillator cosinor model to fit the 24-h rhythms...
  44. ncbi request reprint Low prolactin response to fenfluramine in impulsive aggression
    Antonia S New
    Psychiatry Service 116 A, Bronx VA Medical Center, Bronx, NY 10468, USA
    J Psychiatr Res 38:223-30. 2004
    ..This study represents a replication of previous studies, in a much larger sample, showing a blunted PRL response to fenfluramine of male patients with personality disorder in relation to impulsive aggression and to suicide attempts...
  45. ncbi request reprint Biochemical endophenotypes in personality disorders
    Antonia S New
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Med 77:199-213. 2003
  46. ncbi request reprint Abuse and neglect in childhood: relationship to personality disorder diagnoses
    Linda M Bierer
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:737-54. 2003
    ..Most of these findings have been generated from inpatient clinical samples...
  47. doi request reprint Phenotype, endophenotype, and genotype comparisons between borderline personality disorder and major depressive disorder
    Marianne Goodman
    James J Peters VA Medical Center, Bronx, NY 10468, USA
    J Pers Disord 24:38-59. 2010
    ..Definitive clarification of what MDD and BPD have in common and in what ways they are distinct will only be derived from studies that examine both illnesses using the same study design and methodology...
  48. pmc Preclinical assessment for selectively disrupting a traumatic memory via postretrieval inhibition of glucocorticoid receptors
    Stephen M Taubenfeld
    Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA
    Biol Psychiatry 65:249-57. 2009
    ..Here we tested parameters important for designing novel clinical protocols targeting the reconsolidation of a traumatic memory with RU38486...
  49. ncbi request reprint The role of childhood trauma in differences in affective instability in those with personality disorders
    Marianne Goodman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:763-70. 2003
    ..This study examined the relationship of self-reported histories of childhood trauma to measures of affective instability in a sample of unmedicated outpatients with various personality disorders (n=174)...
  50. ncbi request reprint Context-processing deficits in schizotypal personality disorder
    Deanna M Barch
    Department of Psychology, Washington University, Campus Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    J Abnorm Psychol 113:556-68. 2004
    ..Context processing was strongly associated with working memory and selective attention performance in the SPD individuals...

Research Grants4

  1. FDG PET Study of Laboratory Induced Aggression
    Antonia New; Fiscal Year: 2007
    ..abstract_text> ..