Susana R Neves

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. doi request reprint Obtaining and estimating kinetic parameters from the literature
    Susana R Neves
    Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci Signal 4:tr8. 2011
  2. doi request reprint Developing models in virtual cell
    Susana R Neves
    Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci Signal 4:tr12. 2011
  3. doi request reprint Modeling of spatially-restricted intracellular signaling
    Susana R Neves
    Department of Pharmacology and System Therapeutics, Friedman Brain Institute, Systems Biology Center of New York, Mount Sinai School of Medicine, New York, NY, USA
    Wiley Interdiscip Rev Syst Biol Med 4:103-15. 2012
  4. pmc G Protein-regulated inducer of neurite outgrowth (GRIN) modulates Sprouty protein repression of mitogen-activated protein kinase (MAPK) activation by growth factor stimulation
    Tracy Anh Hwangpo
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 287:13674-85. 2012
  5. pmc Specification of spatial relationships in directed graphs of cell signaling networks
    Azi Lipshtat
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA
    Ann N Y Acad Sci 1158:44-56. 2009
  6. ncbi request reprint Role of the Go/i signaling network in the regulation of neurite outgrowth
    John Cijiang He
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Can J Physiol Pharmacol 84:687-94. 2006
  7. pmc ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion
    Roy S Song
    Departments of Pharmacology and Systems Therapeutics, Friedman Brain Institute, and System Biology Center NY, Icahn School of Medicine at Mount Sinai, New York, NY 10029
    Proc Natl Acad Sci U S A 110:15437-42. 2013
  8. pmc Decoding information in cell shape
    Padmini Rangamani
    Department of Pharmacology and Systems Therapeutics and Systems Biology Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    Cell 154:1356-69. 2013
  9. doi request reprint Modeling of spatial intracellular signaling events in neurons
    Wendy C Wenderski
    Department of Pharmacology and System Therapeutics, Friedman Brain Institute, Systems Biology Center of New York, Mount Sinai School of Medicine, New York, New York, USA
    Methods Enzymol 505:105-24. 2012
  10. pmc Models of spatially restricted biochemical reaction systems
    Susana R Neves
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 284:5445-9. 2009

Collaborators

Detail Information

Publications14

  1. doi request reprint Obtaining and estimating kinetic parameters from the literature
    Susana R Neves
    Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci Signal 4:tr8. 2011
    ....
  2. doi request reprint Developing models in virtual cell
    Susana R Neves
    Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci Signal 4:tr12. 2011
    ..Examples are provided of studies that have successfully exploited the Virtual Cell software to address the spatial contribution to signaling...
  3. doi request reprint Modeling of spatially-restricted intracellular signaling
    Susana R Neves
    Department of Pharmacology and System Therapeutics, Friedman Brain Institute, Systems Biology Center of New York, Mount Sinai School of Medicine, New York, NY, USA
    Wiley Interdiscip Rev Syst Biol Med 4:103-15. 2012
    ..Modeling-derived hypotheses have been experimentally tested and the integration of modeling and imaging approaches has led to non-intuitive mechanistic insights...
  4. pmc G Protein-regulated inducer of neurite outgrowth (GRIN) modulates Sprouty protein repression of mitogen-activated protein kinase (MAPK) activation by growth factor stimulation
    Tracy Anh Hwangpo
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 287:13674-85. 2012
    ..Free Sprouty then in turn inhibits growth factor signaling. Thus, here we present a novel mechanism of how G(o/i)-coupled receptors can inhibit growth factor signaling to MAPK...
  5. pmc Specification of spatial relationships in directed graphs of cell signaling networks
    Azi Lipshtat
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA
    Ann N Y Acad Sci 1158:44-56. 2009
    ..We suggest that such mixed graphs will provide more accurate descriptions of functional cellular networks and their regulatory capabilities and aid in the development of large-scale predictive models of cellular behavior...
  6. ncbi request reprint Role of the Go/i signaling network in the regulation of neurite outgrowth
    John Cijiang He
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Can J Physiol Pharmacol 84:687-94. 2006
    ..We also analyze the role neurotransmitters, which stimulate Go/i to activate a complex signaling network controlling neurite outgrowth, play in regeneration after neuronal injury...
  7. pmc ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion
    Roy S Song
    Departments of Pharmacology and Systems Therapeutics, Friedman Brain Institute, and System Biology Center NY, Icahn School of Medicine at Mount Sinai, New York, NY 10029
    Proc Natl Acad Sci U S A 110:15437-42. 2013
    ..The combination of dynamical models and experiments has helped us unravel the complex interactions between two protein kinase pathways in regulating a fundamental molecular process underlying synaptic plasticity. ..
  8. pmc Decoding information in cell shape
    Padmini Rangamani
    Department of Pharmacology and Systems Therapeutics and Systems Biology Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    Cell 154:1356-69. 2013
    ..These predictions were experimentally validated by changing cellular eccentricity, showing that shape is a locus of retrievable information storage in cells...
  9. doi request reprint Modeling of spatial intracellular signaling events in neurons
    Wendy C Wenderski
    Department of Pharmacology and System Therapeutics, Friedman Brain Institute, Systems Biology Center of New York, Mount Sinai School of Medicine, New York, New York, USA
    Methods Enzymol 505:105-24. 2012
    ..Computational modeling can provide mechanistic insight into the origins of these inhomogeneous distributions of signaling components and their role in the integrative capabilities of the neuron...
  10. pmc Models of spatially restricted biochemical reaction systems
    Susana R Neves
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 284:5445-9. 2009
    ..Thus, patterns of locally restricted signaling reaction systems can be considered an emergent property of the cell...
  11. doi request reprint Interconnected network motifs control podocyte morphology and kidney function
    Evren U Azeloglu
    1Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci Signal 7:ra12. 2014
    ..Thus, analysis of regulatory motifs using network dynamics can provide insights into pathophysiology that enable predictions for drug intervention strategies to treat kidney disease. ..
  12. pmc Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth
    Kenneth D Bromberg
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 320:903-9. 2008
    ....
  13. pmc Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways
    Mario Pagano
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, United States
    Cell Signal 20:1190-7. 2008
    ..These observations suggest that G(o/i)-coupled receptors, by stimulating the degradation of RGS20, can regulate how subsequent activation of the G(s) and G(i) pathways controls cellular cAMP levels, thus allowing for signal integration...
  14. ncbi request reprint G protein pathways
    Susana R Neves
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 296:1636-9. 2002
    ..These cellular processes in turn regulate systemic functions such as embryonic development, gonadal development, learning and memory, and organismal homeostasis...