Eric Nestler

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
    Quincey LaPlant
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 13:1137-43. 2010
  2. pmc Self-administration of ethanol, cocaine, or nicotine does not decrease the soma size of ventral tegmental area dopamine neurons
    Michelle S Mazei-Robison
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America Department of Physiology and Neuroscience Program, Michigan State University, East Lansing, Michigan, United States of America
    PLoS ONE 9:e95962. 2014
  3. pmc The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons
    Mary Kay Lobo
    Fishberg Department of Neuroscience, Friedman Brain Institute, Mount Sinai School of Medicine New York, NY, USA
    Front Neuroanat 5:41. 2011
  4. pmc Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons
    David M Dietz
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA
    Nat Neurosci 15:891-6. 2012
  5. pmc Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation
    Pamela J Kennedy
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Neurosci 16:434-40. 2013
  6. pmc Transcriptional mechanisms of drug addiction
    Eric J Nestler
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, USA
    Clin Psychopharmacol Neurosci 10:136-43. 2012
  7. pmc Cellular basis of memory for addiction
    Eric J Nestler
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA
    Dialogues Clin Neurosci 15:431-43. 2013
  8. pmc Epigenetic mechanisms of drug addiction
    Eric J Nestler
    Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1065, New York, NY 10029, USA Electronic address
    Neuropharmacology 76:259-68. 2014
  9. pmc Treating the brain deep down: Brain surgery for anorexia nervosa?
    Eric J Nestler
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Med 19:678-9. 2013
  10. pmc Epigenetic mechanisms of depression and antidepressant action
    Vincent Vialou
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Annu Rev Pharmacol Toxicol 53:59-87. 2013

Research Grants

Collaborators

Detail Information

Publications87

  1. pmc Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
    Quincey LaPlant
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 13:1137-43. 2010
    ..These data establish the importance of Dnmt3a in the NAc in regulating cellular and behavioral plasticity to emotional stimuli...
  2. pmc Self-administration of ethanol, cocaine, or nicotine does not decrease the soma size of ventral tegmental area dopamine neurons
    Michelle S Mazei-Robison
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America Department of Physiology and Neuroscience Program, Michigan State University, East Lansing, Michigan, United States of America
    PLoS ONE 9:e95962. 2014
    ..These data suggest that VTA morphological changes are induced in a drug-specific manner and reinforce recent findings that some changes in mesolimbic signaling and neuroplasticity are drug-class dependent. ..
  3. pmc The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons
    Mary Kay Lobo
    Fishberg Department of Neuroscience, Friedman Brain Institute, Mount Sinai School of Medicine New York, NY, USA
    Front Neuroanat 5:41. 2011
    ..Here we review progress in defining the distinct molecular and functional contributions of the two MSN subtypes in mediating addiction...
  4. pmc Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons
    David M Dietz
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA
    Nat Neurosci 15:891-6. 2012
    ..These findings establish that Rac1 signaling mediates structural and behavioral plasticity in response to cocaine exposure...
  5. pmc Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation
    Pamela J Kennedy
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Neurosci 16:434-40. 2013
    ..Our findings suggest a new mechanism by which prolonged and selective HDAC inhibition can alter behavioral and molecular adaptations to cocaine and inform the development of therapeutics for cocaine addiction...
  6. pmc Transcriptional mechanisms of drug addiction
    Eric J Nestler
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, USA
    Clin Psychopharmacol Neurosci 10:136-43. 2012
    ..This work promises to reveal fundamentally new insight into the molecular basis of addiction, which will contribute to improved diagnostic tests and therapeutics for addictive disorders...
  7. pmc Cellular basis of memory for addiction
    Eric J Nestler
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA
    Dialogues Clin Neurosci 15:431-43. 2013
    ..The goal of these studies which aim to explicate the molecular and cellular basis of drug addiction is to eventually develop biologically based diagnostic tests, as well as more effective treatments for addiction disorders. ..
  8. pmc Epigenetic mechanisms of drug addiction
    Eric J Nestler
    Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1065, New York, NY 10029, USA Electronic address
    Neuropharmacology 76:259-68. 2014
    ..This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  9. pmc Treating the brain deep down: Brain surgery for anorexia nervosa?
    Eric J Nestler
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Med 19:678-9. 2013
    ..In "Bedside to Bench", Eric Nestler discusses two trials of individuals with anorexia nervosa in which deep brain stimulation of different brain ..
  10. pmc Epigenetic mechanisms of depression and antidepressant action
    Vincent Vialou
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Annu Rev Pharmacol Toxicol 53:59-87. 2013
    ....
  11. pmc Animal models of neuropsychiatric disorders
    Eric J Nestler
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 13:1161-9. 2010
    ..We argue for areas of focus that might increase the likelihood of creating more useful models, at least for some disorders, and for explicit guidelines when animal models are reported...
  12. pmc Review. Transcriptional mechanisms of addiction: role of DeltaFosB
    Eric J Nestler
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Philos Trans R Soc Lond B Biol Sci 363:3245-55. 2008
    ....
  13. pmc Essential role of the histone methyltransferase G9a in cocaine-induced plasticity
    Ian Maze
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
    Science 327:213-6. 2010
    ....
  14. pmc DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses
    Vincent Vialou
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 13:745-52. 2010
    ..Together, these findings establish a previously unknown molecular pathway underlying both resilience and antidepressant action...
  15. pmc The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens
    Scott J Russo
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Trends Neurosci 33:267-76. 2010
    ..We define areas where future investigation can provide a more detailed picture of drug-induced synaptic reorganization, including ultrastructural, electrophysiological and behavioral studies...
  16. pmc Psychobiology and molecular genetics of resilience
    Adriana Feder
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Rev Neurosci 10:446-57. 2009
    ..These changes shape the functioning of the neural circuits that regulate reward, fear, emotion reactivity and social behaviour, which together are thought to mediate successful coping with stress...
  17. pmc Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward
    Scott J Russo
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 29:3529-37. 2009
    ..Together, these studies establish a direct role for NFkappaB pathways in the NAc to regulate structural and behavioral plasticity to cocaine...
  18. pmc Neurotrophic factors and structural plasticity in addiction
    Scott J Russo
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Neuropharmacology 56:73-82. 2009
    ..This review discusses recent advances in our understanding of how BDNF and its signaling pathways regulate structural and behavioral plasticity in the context of drug addiction...
  19. pmc Serum response factor promotes resilience to chronic social stress through the induction of DeltaFosB
    Vincent Vialou
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 30:14585-92. 2010
    ....
  20. pmc Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward
    Mary Kay Lobo
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 330:385-90. 2010
    ..These results provide insight into the molecular control of D1+ and D2+ neuronal activity as well as the circuit-level contribution of these cell types to cocaine reward...
  21. pmc Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling
    Hong Wang
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10065, USA
    Science 326:1554-7. 2009
    ....
  22. pmc Role of nuclear factor kappaB in ovarian hormone-mediated stress hypersensitivity in female mice
    Quincey LaPlant
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Biol Psychiatry 65:874-80. 2009
    ..The molecular mechanisms of stress-induced depressive behaviors have been characterized extensively in male rodents; however, much less is known about female subjects, despite the fact that human depression is far more prevalent in women...
  23. pmc Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models
    Matthew B Wilkinson
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Neurosci 29:7820-32. 2009
    ..They also raise the novel idea that certain individuals resistant to stress may naturally mount antidepressant-like adaptations in response to chronic stress...
  24. pmc Antidepressant actions of histone deacetylase inhibitors
    Herbert E Covington
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 29:11451-60. 2009
    ....
  25. pmc Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors
    Helen S Bateup
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:14845-50. 2010
    ..These findings provide insight into the selective contributions of the direct and indirect pathways to striatal motor behaviors...
  26. pmc From synapse to nucleus: novel targets for treating depression
    Herbert E Covington
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, NY 10029, USA
    Neuropharmacology 58:683-93. 2010
    ..Although some of these targets for depression already appear promising, new waves of more selective compounds for any molecular system should promote a better understanding of this complex disease and perhaps improved treatments...
  27. ncbi request reprint Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
    Olivier Berton
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Science 311:864-8. 2006
    ..These results establish an essential role for BDNF in mediating long-term neural and behavioral plasticity in response to aversive social experiences...
  28. pmc The neurobiology of cocaine addiction
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Sci Pract Perspect 3:4-10. 2005
    ..Further pursuit of this and similar leads are first steps toward a complete understanding of the transition from cocaine abuse to addiction -- and, ultimately, more effective treatments for those who are addicted...
  29. ncbi request reprint Neural mechanisms of addiction: the role of reward-related learning and memory
    Steven E Hyman
    Office of the Provost, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Neurosci 29:565-98. 2006
    ..Here we review progress in identifying candidate mechanisms of addiction...
  30. ncbi request reprint Delta FosB regulates wheel running
    Martin Werme
    Department of Neuroscience, Karolinska Institutet, Stockholm, S 171 77 Sweden
    J Neurosci 22:8133-8. 2002
    ....
  31. pmc Epigenetic mechanisms in drug addiction
    William Renthal
    Departments of Psychiatry and Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Trends Mol Med 14:341-50. 2008
    ..This novel mechanistic insight might open new avenues for improved treatments of drug addiction...
  32. pmc Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure
    William Renthal
    Department of Psychiatry and Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:7344-9. 2008
    ..This study reveals a novel epigenetic pathway through which DeltaFosB mediates distinct transcriptional programs that may ultimately alter behavioral plasticity to chronic amphetamine exposure...
  33. ncbi request reprint Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli
    William Renthal
    Department of Psychiatry and Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Neuron 56:517-29. 2007
    ....
  34. ncbi request reprint Induction of deltaFosB in the periaqueductal gray by stress promotes active coping responses
    Olivier Berton
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuron 55:289-300. 2007
    ..These results indicate that IS-induced accumulation of DeltaFosB in the vlPAG desensitizes substance P neurons enriched in this area and opposes behavioral despair by promoting active defense responses...
  35. ncbi request reprint Pathological gambling: focusing on the addiction, not the activity
    Carol A Tamminga
    Am J Psychiatry 163:180-1. 2006
  36. ncbi request reprint An essential role for DeltaFosB in the nucleus accumbens in morphine action
    Venetia Zachariou
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 9:205-11. 2006
    ..Together, these experiments demonstrated that DeltaFosB in the NAc, partly through the repression of dynorphin expression, mediates several major features of opiate addiction...
  37. ncbi request reprint Induction of deltaFosB in reward-related brain structures after chronic stress
    Linda I Perrotti
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 24:10594-602. 2004
    ..These findings establish that chronic stress induces DeltaFosB in several discrete regions of the brain. Such induction could contribute to the long-term effects of stress on the brain...
  38. ncbi request reprint The addicted brain
    Eric J Nestler
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, USA
    Sci Am 290:78-85. 2004
  39. ncbi request reprint Regulation of gene expression and cocaine reward by CREB and DeltaFosB
    Colleen A McClung
    The University of Texas Southwestern Medical Center, Department of Psychiatry and Center for Basic Neuroscience, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 6:1208-15. 2003
    ..These findings help define the molecular functions of CREB and DeltaFosB and identify clusters of genes that contribute to cocaine addiction...
  40. pmc The influence of DeltaFosB in the nucleus accumbens on natural reward-related behavior
    Deanna L Wallace
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:10272-7. 2008
    ..Additionally, our findings show that chronic exposure to stimuli that induce DeltaFosB in the NAc can increase consumption of other natural rewards...
  41. ncbi request reprint Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum
    Arvind Kumar
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Neuron 48:303-14. 2005
    ..Furthermore, modulating histone deacetylase activity alters locomotor and rewarding responses to cocaine. Thus, chromatin remodeling is an important regulatory mechanism underlying cocaine-induced neural and behavioral plasticity...
  42. ncbi request reprint Epigenetic mechanisms and gene networks in the nervous system
    Christine M Colvis
    Division of Basic Neurosciences and Behavioral Research, National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    J Neurosci 25:10379-89. 2005
  43. ncbi request reprint Is there a common molecular pathway for addiction?
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9070, USA
    Nat Neurosci 8:1445-9. 2005
    ..A major goal for future research is to determine whether such common underpinnings of addiction can be exploited for the development of more effective treatments for a wide range of addictive disorders...
  44. ncbi request reprint Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions
    Vaishnav Krishnan
    Department of Psychiatry, The University of Texas Southwestern Medical Center UTSWMC, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Cell 131:391-404. 2007
    ....
  45. pmc Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studies
    Venetia Zachariou
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, Texas, USA
    Biol Psychiatry 63:1013-21. 2008
    ..Earlier work revealed the selective induction of two calmodulin-dependent AC isoforms, AC1 and AC8, after chronic morphine, but their role in opiate dependence has remained unknown...
  46. doi request reprint Induction of activating transcription factors (ATFs) ATF2, ATF3, and ATF4 in the nucleus accumbens and their regulation of emotional behavior
    Thomas A Green
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:2025-32. 2008
    ....
  47. pmc Cocaine regulates MEF2 to control synaptic and behavioral plasticity
    Suprabha Pulipparacharuvil
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9127, USA
    Neuron 59:621-33. 2008
    ....
  48. ncbi request reprint Lateral hypothalamic neuropeptides in reward and drug addiction
    Ralph J DiLeone
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas 75390 9070, USA
    Life Sci 73:759-68. 2003
    ..Regulation of LH intracellular signaling pathways in response to drugs of abuse supports a role for the LH neuropeptides in addiction...
  49. pmc The molecular neurobiology of depression
    Vaishnav Krishnan
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 455:894-902. 2008
    ..They also show that understanding the mechanisms of resilience to stress offers a crucial new dimension for the development of fundamentally novel antidepressant treatments...
  50. ncbi request reprint DeltaFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction
    Catharine A Winstanley
    Department of Psychiatry and Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 27:10497-507. 2007
    ..Identification of deltaFosB in the OFC as a mediator of tolerance to the effects of cocaine on cognition provides fundamentally new insight into the transcriptional modifications associated with addiction...
  51. ncbi request reprint Neuroplasticity mediated by altered gene expression
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuropsychopharmacology 33:3-17. 2008
    ..This review summarizes some of the major transcriptional mechanisms that are thought to underlie neuronal and behavioral plasticity...
  52. ncbi request reprint Molecular mechanisms of drug addiction
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Neuropharmacology 47:24-32. 2004
    ....
  53. ncbi request reprint Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures
    Nadia M Tsankova
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 24:5603-10. 2004
    ....
  54. ncbi request reprint Neurotrophic mechanisms in drug addiction
    Carlos A Bolanos
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuromolecular Med 5:69-83. 2004
    ..Here the evidence for the role of neurotrophins and other neurotrophic factors-and the signaling pathways they activate-in mediating long-term molecular, cellular, and behavioral adaptations associated with drug addiction is reviewed...
  55. ncbi request reprint Molecular neurobiology of drug addiction
    Jennifer Chao
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas, Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Annu Rev Med 55:113-32. 2004
    ..Knowledge of these mechanisms could lead to more effective treatments for addictive disorders...
  56. ncbi request reprint Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression
    Amelia J Eisch
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Texas, Dallas 75390 9070, USA
    Biol Psychiatry 54:994-1005. 2003
    ..Here we show that BDNF in the ventral tegmental area-nucleus accumbens (VTA-NAc) pathway is also involved in the development of a depression-like phenotype...
  57. ncbi request reprint Downregulation of the CCAAT-enhancer binding protein beta in deltaFosB transgenic mice and by electroconvulsive seizures
    Jingshan Chen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Neuropsychopharmacology 29:23-31. 2004
    ....
  58. ncbi request reprint Phospholipase Cgamma in distinct regions of the ventral tegmental area differentially modulates mood-related behaviors
    Carlos A Bolanos
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 23:7569-76. 2003
    ..Moreover, these data also support a role for drug-induced elevations in PLCgamma1 expression in the VTA in mediating long-term adaptations to drugs of abuse and aversive stimuli...
  59. ncbi request reprint RGS9 modulates dopamine signaling in the basal ganglia
    Zia Rahman
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 38:941-52. 2003
    ....
  60. ncbi request reprint Morphine acutely regulates opioid receptor trafficking selectively in dendrites of nucleus accumbens neurons
    Helena Haberstock-Debic
    Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 2140, USA
    J Neurosci 23:4324-32. 2003
    ....
  61. ncbi request reprint Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal
    Dan Georgescu
    Department of Psychiatry, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 23:3106-11. 2003
    ..Together, these studies support a role for the orexin system in molecular adaptations to morphine, and demonstrate dramatic differences in molecular responses among different populations of LH neurons...
  62. ncbi request reprint Common molecular and cellular substrates of addiction and memory
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas 75390 9070, USA
    Neurobiol Learn Mem 78:637-47. 2002
    ..A better understanding of the molecular and cellular adaptations that occur in these neural circuits may lead to novel interventions to improve memory and combat addiction in humans...
  63. ncbi request reprint Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse?
    William A Carlezon
    Dept of Psychiatry, Harvard Medical School, and McLean Hospital, MRC 217, 115 Mill Street, Belmont MA 02478, USA
    Trends Neurosci 25:610-5. 2002
    ..However, there is ongoing debate over whether elevated levels of GluR1 in the VTA are a primary cause, or secondary effect, of the neurobiological underpinnings of sensitization...
  64. ncbi request reprint From neurobiology to treatment: progress against addiction
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9070, USA
    Nat Neurosci 5:1076-9. 2002
    ..The latter approach is the most speculative, but also the most promising in terms of translating basic knowledge of addiction into clinical progress...
  65. pmc CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli
    Michel Barrot
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 99:11435-40. 2002
    ..This control appears to be independent of the intrinsic appetitive or aversive value of the stimulus. The potential relevance of these data to addiction and mood disorders is discussed...
  66. ncbi request reprint Stimulation of protein kinase a activity in the rat amygdala enhances reward-related learning
    J David Jentsch
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 52:111-8. 2002
    ....
  67. ncbi request reprint Inducible and brain region-specific CREB transgenic mice
    Norio Sakai
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    Mol Pharmacol 61:1453-64. 2002
    ..Finally, there was a significant reduction in cocaine-induced locomotor activity in the CREB bitransgenic mice. These results are consistent with a role for CREB in mediating adaptive changes that occur in response to drugs of abuse...
  68. ncbi request reprint DeltaFosB: a molecular switch for long-term adaptation in the brain
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Brain Res Mol Brain Res 132:146-54. 2004
    ....
  69. ncbi request reprint The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance
    Dan Georgescu
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9070, USA
    J Neurosci 25:2933-40. 2005
    ..This work identifies a novel hypothalamic-AcSh circuit that influences appetitive behavior and mediates the antidepressant activity of MCH1R antagonists...
  70. pmc Blockade of melanocortin transmission inhibits cocaine reward
    Richard Hsu
    Laboratory of Molecular Psychiatry, Center for Genes and Behaviour, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Eur J Neurosci 21:2233-42. 2005
    ..Modulation of cocaine reward is a novel action of the melanocortin-MC4-R system and could be targeted for the development of new medications for cocaine addiction...
  71. ncbi request reprint Proteasome-dependent and -independent mechanisms for FosB destabilization: identification of FosB degron domains and implications for DeltaFosB stability
    Tiffany L Carle
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, 75390 9070, USA
    Eur J Neurosci 25:3009-19. 2007
    ..These data indicate that alternative splicing specifically removes two destabilizing elements from FosB in order to generate a longer-lived transcription factor, DeltaFosB, in response to chronic perturbations to the brain...
  72. ncbi request reprint Epigenetic regulation in psychiatric disorders
    Nadia Tsankova
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Rev Neurosci 8:355-67. 2007
    ....
  73. pmc Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine
    Jane R Taylor
    Department of Psychiatry, Division of Molecular Psychiatry and Center for Genes and Behavior, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06508, USA
    Proc Natl Acad Sci U S A 104:4147-52. 2007
    ....
  74. pmc Regulation of fosB and DeltafosB mRNA expression: in vivo and in vitro studies
    Imran N Alibhai
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Brain Res 1143:22-33. 2007
    ....
  75. ncbi request reprint Regulation of DeltaFosB transcriptional activity by Ser27 phosphorylation
    Paula G Ulery
    Department of Psychiatry, Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas Texas, USA
    Eur J Neurosci 25:224-30. 2007
    ..In contrast, Ser27 does not seem to play a role in the transactivation potential of full-length FosB. These findings constitute the first evidence of a role for phosphorylation in DeltaFosB's transcriptional activity...
  76. ncbi request reprint Regulation of morphine reward and feeding by CREB in the lateral hypothalamus
    Valerie G Olson
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Synapse 61:110-3. 2007
  77. ncbi request reprint DeltaFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation
    Peter Olausson
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 26:9196-204. 2006
    ....
  78. ncbi request reprint Induction of inducible cAMP early repressor expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli
    Thomas A Green
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 26:8235-42. 2006
    ..These results suggest that ICER is an important mechanism for modulating CRE-mediated transcription in the nucleus accumbens...
  79. ncbi request reprint The mesolimbic dopamine reward circuit in depression
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Biol Psychiatry 59:1151-9. 2006
    ....
  80. ncbi request reprint CREB modulates excitability of nucleus accumbens neurons
    Yan Dong
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California 94304, USA
    Nat Neurosci 9:475-7. 2006
    ....
  81. ncbi request reprint Phosphorylation of DARPP-32 at Threonine-34 is required for cocaine action
    Venetia Zachariou
    Department of Psychiatry, Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuropsychopharmacology 31:555-62. 2006
    ..These findings highlight distinct roles of the Thr-34 and Thr-75 phosphorylation sites of DARPP-32 in mediating short- and long-term behavioral and biochemical actions of cocaine...
  82. ncbi request reprint The many faces of CREB
    William A Carlezon
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont MA 02478, USA
    Trends Neurosci 28:436-45. 2005
    ....
  83. pmc Regulation of dopaminergic transmission and cocaine reward by the Clock gene
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 102:9377-81. 2005
    ..These findings demonstrate the involvement of a circadian-associated gene, Clock, in regulating dopamine function and cocaine reward...
  84. ncbi request reprint Regulation of drug reward by cAMP response element-binding protein: evidence for two functionally distinct subregions of the ventral tegmental area
    Valerie G Olson
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 25:5553-62. 2005
    ..These results suggest a novel role for CREB in mediating drug-induced plasticity in the VTA and establish two functionally distinct subregions of the VTA in which CREB differentially regulates drug reward...
  85. ncbi request reprint DeltaFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment
    Linda I Perrotti
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Eur J Neurosci 21:2817-24. 2005
    ..These results provide the first evidence of deltaFosB induction in a discrete population of GABA cells in the VTA, which may regulate the functioning of the brain's reward mechanisms...
  86. pmc Regulation of anxiety and initiation of sexual behavior by CREB in the nucleus accumbens
    Michel Barrot
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 102:8357-62. 2005
    ..The results also provide insight into the molecular mechanisms by which social interactions affect brain plasticity and behavior...
  87. ncbi request reprint Regional and cellular mapping of cAMP response element-mediated transcription during naltrexone-precipitated morphine withdrawal
    Tamara Z Shaw-Lutchman
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 22:3663-72. 2002
    ..CRE-mediated transcription may itself contribute to re-establishing homeostasis in the organism through target gene regulation in these regions...

Research Grants32

  1. NEUROTROPHIC FACTORS AND DRUGS OF ABUSE
    Eric Nestler; Fiscal Year: 2007
    ..Moreover, in a more general sense, the proposed studies will utilize models of addiction to better understand the potent influence of BDNF on mesolimbic dopamine function in the fully differentiated, adult brain. ..
  2. Pharmacological Actions of Stress and Antidepressants
    Eric Nestler; Fiscal Year: 2006
    ..Together, the proposed research will improve our understanding of the ways in which the brain adapts to chronic stress and antidepressant treatments. ..
  3. Pharmacological Actions of Stress and Antidepressants
    Eric Nestler; Fiscal Year: 2005
    ..Together, the proposed research will improve our understanding of the ways in which the brain adapts to chronic stress and antidepressant treatments. ..
  4. PHARMACOLOGICAL ACTIONS OF ANTIDEPRESSANT TREATMENTS
    Eric Nestler; Fiscal Year: 2001
    ..More fundamentally, however, the proposed studies will improve our general understanding of the precise molecular mechanisms that control the expression of glutamate receptors, key mediators of synaptic transmission, in the brain. ..
  5. Pharmacological Actions of Antidepressants Treatments
    Eric J Nestler; Fiscal Year: 2010
    ....
  6. MOLECULAR STUDIES OF COCAINE ACTION IN BRAIN
    Eric J Nestler; Fiscal Year: 2010
    ..This work will contribute to our growing knowledge of drug-induced neuroadaptations in the brain at the molecular level. ..
  7. MOLECULAR STUDIES OF COCAINE ACTION IN BRAIN
    Eric Nestler; Fiscal Year: 2009
    ..This work will contribute to our growing knowledge of drug-induced neuroadaptations in the brain at the molecular level. ..
  8. Pharmacological Actions of Antidepressants Treatments
    Eric Nestler; Fiscal Year: 2009
    ....
  9. NEUROTROPHIC FACTORS AND DRUGS OF ABUSE
    Eric Nestler; Fiscal Year: 2009
    ..Moreover, in a more general sense, the proposed studies will utilize models of addiction to better understand the potent influence of BDNF on mesolimbic dopamine function in the fully differentiated, adult brain. ..
  10. PHARMACOLOGICAL ACTIONS OF ANTIDEPRESSANT TREATMENTS
    Eric Nestler; Fiscal Year: 2000
    ..More fundamentally, however, the proposed studies will improve our general understanding of the precise molecular mechanisms that control the expression of glutamate receptors, key mediators of synaptic transmission, in the brain. ..
  11. NEUROTROPHIC FACTORS AND DRUGS OF ABUSE
    Eric Nestler; Fiscal Year: 2002
    ..Moreover, in a general sense, the studies will utilize models of addiction to better understand the continued influence of neurotrophic factors in controlling mesolimbic dopamine function in the fully differentiated, adult brain. ..
  12. PHARMACOLOGICAL ACTIONS OF ANTIDEPRESSANT TREATMENTS
    Eric Nestler; Fiscal Year: 2002
    ..More fundamentally, however, the proposed studies will improve our general understanding of the precise molecular mechanisms that control the expression of glutamate receptors, key mediators of synaptic transmission, in the brain. ..
  13. NEUROTROPHIC FACTORS AND DRUGS OF ABUSE
    Eric Nestler; Fiscal Year: 2003
    ..Moreover, in a general sense, the studies will utilize models of addiction to better understand the continued influence of neurotrophic factors in controlling mesolimbic dopamine function in the fully differentiated, adult brain. ..
  14. Neurotrophic Mechanisms in Opiate and Cocaine Action
    Eric J Nestler; Fiscal Year: 2010
    ....
  15. Pharmacological Actions of Stress and Antidepressants
    Eric Nestler; Fiscal Year: 2004
    ..Together, the proposed research will improve our understanding of the ways in which the brain adapts to chronic stress and antidepressant treatments. ..
  16. NEUROTROPHIC FACTORS AND DRUGS OF ABUSE
    Eric Nestler; Fiscal Year: 2005
    ..Moreover, in a more general sense, the proposed studies will utilize models of addiction to better understand the potent influence of BDNF on mesolimbic dopamine function in the fully differentiated, adult brain. ..
  17. MOLECULAR STUDIES OF COCAINE ACTION IN BRAIN
    Eric Nestler; Fiscal Year: 2006
    ..This work will contribute to our growing knowledge of drug-induced neuroadaptations in the brain at the molecular level. ..
  18. NEUROTROPHIC FACTORS AND DRUGS OF ABUSE
    Eric Nestler; Fiscal Year: 2006
    ..Moreover, in a more general sense, the proposed studies will utilize models of addiction to better understand the potent influence of BDNF on mesolimbic dopamine function in the fully differentiated, adult brain. ..
  19. Pharmacological Actions of Stress and Antidepressants
    Eric Nestler; Fiscal Year: 2007
    ..Together, the proposed research will improve our understanding of the ways in which the brain adapts to chronic stress and antidepressant treatments. ..
  20. NEUROTROPHIC FACTORS AND DRUGS OF ABUSE
    Eric Nestler; Fiscal Year: 2001
    ..Moreover, in a general sense, the studies will utilize models of addiction to better understand the continued influence of neurotrophic factors in controlling mesolimbic dopamine function in the fully differentiated, adult brain. ..
  21. PHARMACOLOGICAL ACTIONS OF ANTIDEPRESSANT TREATMENTS
    Eric Nestler; Fiscal Year: 2003
    ..More fundamentally, however, the proposed studies will improve our general understanding of the precise molecular mechanisms that control the expression of glutamate receptors, key mediators of synaptic transmission, in the brain. ..
  22. NEUROTROPHIC FACTORS AND DRUGS OF ABUSE
    Eric Nestler; Fiscal Year: 2004
    ..Moreover, in a general sense, the studies will utilize models of addiction to better understand the continued influence of neurotrophic factors in controlling mesolimbic dopamine function in the fully differentiated, adult brain. ..