Catherine Mytilineou

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi Glutathione depletion and oxidative stress
    Catherine Mytilineou
    Department of Neurology, Mount Sinai School of Medicine, Box 1137, New York, NY 10029, USA
    Parkinsonism Relat Disord 8:385-7. 2002
  2. ncbi Toxicity of glutathione depletion in mesencephalic cultures: a role for arachidonic acid and its lipoxygenase metabolites
    Brian C Kramer
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Eur J Neurosci 19:280-6. 2004
  3. ncbi Alterations in the cellular distribution of bcl-2, bcl-x and bax in the adult rat substantia nigra following striatal 6-hydroxydopamine lesions
    Brian C Kramer
    Fishberg Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neurocytol 33:213-23. 2004
  4. ncbi Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures
    Kevin St P McNaught
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurochem 81:301-6. 2002
  5. ncbi Levodopa in the treatment of Parkinson's disease: current controversies
    C Warren Olanow
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mov Disord 19:997-1005. 2004
  6. ncbi Levodopa is toxic to dopamine neurons in an in vitro but not an in vivo model of oxidative stress
    Catherine Mytilineou
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Pharmacol Exp Ther 304:792-800. 2003

Detail Information

Publications6

  1. ncbi Glutathione depletion and oxidative stress
    Catherine Mytilineou
    Department of Neurology, Mount Sinai School of Medicine, Box 1137, New York, NY 10029, USA
    Parkinsonism Relat Disord 8:385-7. 2002
    ..The generation of superoxide radicals during the metabolism of arachidonic acid is likely to play an important role in the toxic events that follow GSH depletion...
  2. ncbi Toxicity of glutathione depletion in mesencephalic cultures: a role for arachidonic acid and its lipoxygenase metabolites
    Brian C Kramer
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Eur J Neurosci 19:280-6. 2004
    ..Our study suggests that limiting AA release and metabolism may provide benefit in conditions with an existing depletion of GSH, such as Parkinson's disease...
  3. ncbi Alterations in the cellular distribution of bcl-2, bcl-x and bax in the adult rat substantia nigra following striatal 6-hydroxydopamine lesions
    Brian C Kramer
    Fishberg Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neurocytol 33:213-23. 2004
    ..These data suggest that striatal 6-OHDA lesions do not result in classical apoptosis in the SN of the adult rat, even though there are changes in the content and distribution of members of the bcl-2 family of proteins...
  4. ncbi Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures
    Kevin St P McNaught
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurochem 81:301-6. 2002
    ..This study supports the concept that defects in the UPS may underlie nigral pathology in familial and sporadic forms of PD...
  5. ncbi Levodopa in the treatment of Parkinson's disease: current controversies
    C Warren Olanow
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mov Disord 19:997-1005. 2004
    ..Clinical trials to test this hypothesis are underway. We review current evidence relating to these areas of controversy...
  6. ncbi Levodopa is toxic to dopamine neurons in an in vitro but not an in vivo model of oxidative stress
    Catherine Mytilineou
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Pharmacol Exp Ther 304:792-800. 2003
    ..This study provides further evidence to support the notion that although levodopa can be toxic to dopamine neurons in vitro, it is not likely to be toxic to dopamine neurons in vivo and specifically in conditions such as PD...