J H Morrison

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi Life and death of neurons in the aging brain
    J H Morrison
    Neurobiology of Aging Laboratories, the Fishberg Research Center for Neurobiology, and the Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 278:412-9. 1997
  2. ncbi Amyotrophic lateral sclerosis associated with mutations in superoxide dismutase: a putative mechanism of degeneration
    B M Morrison
    Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res Brain Res Rev 29:121-35. 1999
  3. ncbi Differential synaptic localization of GluR2 and EAAC1 in the macaque monkey entorhinal cortex: a postembedding immunogold study
    Y He
    Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
    Neurosci Lett 311:161-4. 2001
  4. pmc Interactive effects of age and estrogen on cortical neurons: implications for cognitive aging
    M E Bailey
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 191:148-58. 2011
  5. ncbi AMPA GluR2 subunit is differentially distributed on GABAergic neurons and pyramidal cells in the macaque monkey visual cortex
    Y He
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res 921:60-7. 2001
  6. ncbi Immunohistochemical localization of the neuron-specific glutamate transporter EAAC1 (EAAT3) in rat brain and spinal cord revealed by a novel monoclonal antibody
    P Shashidharan
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res 773:139-48. 1997
  7. ncbi Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer's disease
    T Bussiere
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 117:577-92. 2003
  8. ncbi Neurofilament protein is differentially distributed in subpopulations of corticocortical projection neurons in the macaque monkey visual pathways
    P R Hof
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Comp Neurol 376:112-27. 1996
  9. ncbi Neuroendocrine aging in the female rat: the changing relationship of hypothalamic gonadotropin-releasing hormone neurons and N-methyl-D-aspartate receptors
    A C Gore
    Fishberg Research Center for Neurobiology, and Henry L Schwartz Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocrinology 141:4757-67. 2000
  10. ncbi Quantitative immunocytochemical analysis of the spinal cord in G86R superoxide dismutase transgenic mice: neurochemical correlates of selective vulnerability
    B M Morrison
    Laboratory for Neurobiology of Aging, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Comp Neurol 373:619-31. 1996

Collaborators

Detail Information

Publications36

  1. ncbi Life and death of neurons in the aging brain
    J H Morrison
    Neurobiology of Aging Laboratories, the Fishberg Research Center for Neurobiology, and the Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 278:412-9. 1997
    ..When these data are viewed comprehensively, it appears that the primary neurobiological substrates for functional impairment in aging differ in important ways from those in neurodegenerative disorders such as Alzheimer's disease...
  2. ncbi Amyotrophic lateral sclerosis associated with mutations in superoxide dismutase: a putative mechanism of degeneration
    B M Morrison
    Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res Brain Res Rev 29:121-35. 1999
    ..In this review, we will present the important findings from these model systems, provide a framework in which to evaluate these findings, and speculate on the mechanism of degeneration initiated by the mutations in SOD-1...
  3. ncbi Differential synaptic localization of GluR2 and EAAC1 in the macaque monkey entorhinal cortex: a postembedding immunogold study
    Y He
    Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
    Neurosci Lett 311:161-4. 2001
    ..The distribution of EAAC1 may also offer protection for these neurons against excessive glutamatergic stimuli that may occur under certain pathological conditions...
  4. pmc Interactive effects of age and estrogen on cortical neurons: implications for cognitive aging
    M E Bailey
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 191:148-58. 2011
    ..These findings have important implications for the design of hormone treatment strategies for both surgically and naturally menopausal women. This article is part of a Special Issue entitled: Neuroactive Steroids: Focus on Human Brain...
  5. ncbi AMPA GluR2 subunit is differentially distributed on GABAergic neurons and pyramidal cells in the macaque monkey visual cortex
    Y He
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res 921:60-7. 2001
    ....
  6. ncbi Immunohistochemical localization of the neuron-specific glutamate transporter EAAC1 (EAAT3) in rat brain and spinal cord revealed by a novel monoclonal antibody
    P Shashidharan
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res 773:139-48. 1997
    ....
  7. ncbi Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer's disease
    T Bussiere
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 117:577-92. 2003
    ....
  8. ncbi Neurofilament protein is differentially distributed in subpopulations of corticocortical projection neurons in the macaque monkey visual pathways
    P R Hof
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Comp Neurol 376:112-27. 1996
    ..It is possible that the preferential distribution of neurofilament protein within feedforward connections to area MT and all feedback projections is related to other distinctive properties of these corticocortical projection neurons...
  9. ncbi Neuroendocrine aging in the female rat: the changing relationship of hypothalamic gonadotropin-releasing hormone neurons and N-methyl-D-aspartate receptors
    A C Gore
    Fishberg Research Center for Neurobiology, and Henry L Schwartz Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocrinology 141:4757-67. 2000
    ..These molecular, physiological, and cellular neuroendocrine changes are proposed to be involved in the transition to acyclicity in aging female rats...
  10. ncbi Quantitative immunocytochemical analysis of the spinal cord in G86R superoxide dismutase transgenic mice: neurochemical correlates of selective vulnerability
    B M Morrison
    Laboratory for Neurobiology of Aging, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Comp Neurol 373:619-31. 1996
    ..Our findings suggest that NFP, which has been demonstrated previously to be involved mechanistically in motoneuron degeneration, may also be important in the mechanism of degeneration that is initiated by the SOD-1 mutation...
  11. ncbi Early and selective pathology of light chain neurofilament in the spinal cord and sciatic nerve of G86R mutant superoxide dismutase transgenic mice
    B M Morrison
    Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    Exp Neurol 165:207-20. 2000
    ..These results suggest that the mechanism of NF alteration in SOD-1 transgenic mice, and also perhaps in ALS patients, originates with the disruption of NF-L, only later involving the other subunits...
  12. ncbi Differential vulnerability of oculomotor, facial, and hypoglossal nuclei in G86R superoxide dismutase transgenic mice
    E A Nimchinsky
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Comp Neurol 416:112-25. 2000
    ..However, these patterns of cellular vulnerability may provide clues for understanding the differential susceptibility of neural structures in ALS and other neurodegenerative diseases...
  13. ncbi Numbers of meynert and layer IVB cells in area V1: a stereologic analysis in young and aged macaque monkeys
    P R Hof
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Comp Neurol 420:113-26. 2000
    ..Rather, it is possible that more subtle alterations in the neurochemical characteristics or synaptic organization of the functional pathways subserving the different visual modalities are responsible for these deficits...
  14. ncbi Bidirectional redistribution of AMPA but not NMDA receptors after perforant path simulation in the adult rat hippocampus in vivo
    D E Moga
    Fishberg Department of Neuroscience and Alfred B and Gudrun J Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Hippocampus 16:990-1003. 2006
    ..The results suggest a mechanism by which rapid adjustments in synaptic strength can occur through localized AMPA receptor mobility and that this process may be competitive across the dendritic tree...
  15. pmc Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery
    D S Goldwater
    Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Neuroscience 164:798-808. 2009
    ....
  16. ncbi Hippocampal dependent learning ability correlates with N-methyl-D-aspartate (NMDA) receptor levels in CA3 neurons of young and aged rats
    M M Adams
    Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, NY 10029-6574, USA
    J Comp Neurol 432:230-43. 2001
    ..These findings suggest that NMDA receptor abundance in CA3 bears a critical relationship to learning mediated by the hippocampus throughout the life span...
  17. pmc Different modes of hippocampal plasticity in response to estrogen in young and aged female rats
    M M Adams
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 98:8071-6. 2001
    ..These findings have important implications for estrogen replacement therapy in the context of aging...
  18. ncbi N-methyl-D-aspartate receptor mRNA levels change during reproductive senescence in the hippocampus of female rats
    M M Adams
    Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Neurol 170:171-9. 2001
    ..This shift in the NMDA receptor mRNA levels may be a possible molecular mechanism contributing to alterations in cognitive behavior during normal aging...
  19. ncbi Practical approaches to stereology in the setting of aging- and disease-related brain banks
    D P Perl
    Department of Pathology Neuropathology Division, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Chem Neuroanat 20:7-19. 2000
    ....
  20. ncbi Mitogen-activated protein kinase regulates early phosphorylation and delayed expression of Ca2+/calmodulin-dependent protein kinase II in long-term potentiation
    M G Giovannini
    Department of Pharmacology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 21:7053-62. 2001
    ..These results establish a novel bimodal regulation of CaMKII by MAPK, which may contribute to both post-translational modification and increased gene expression...
  21. ncbi Attenuated lesion-induced N-methyl-D-aspartate receptor (NMDAR) plasticity in the dentate gyrus of aged rats following perforant path lesions
    M M Adams
    Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, New York 10029-6574, USA
    Exp Neurol 172:244-9. 2001
    ....
  22. ncbi Atypical form of Alzheimer's disease with prominent posterior cortical atrophy: a review of lesion distribution and circuit disconnection in cortical visual pathways
    P R Hof
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Vision Res 37:3609-25. 1997
    ....
  23. ncbi Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex
    J J Radley
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 125:1-6. 2004
    ....
  24. pmc alpha-Isoform of calcium-calmodulin-dependent protein kinase II and postsynaptic density protein 95 differentially regulate synaptic expression of NR2A- and NR2B-containing N-methyl-d-aspartate receptors in hippocampus
    C S Park
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 151:43-55. 2008
    ..The contrasting phenotypes of the PSD-95 and alphaCaMKII mutant mice further establish the prospect of an independent and, possibly, competing mechanism for the regulation of NMDAR-dependent bidirectional synaptic plasticity...
  25. ncbi Activity-regulated cytoskeletal-associated protein is localized to recently activated excitatory synapses
    D E Moga
    Kastor Neurobiolgoy of Aging Labs, New York, NY, USA
    Neuroscience 125:7-11. 2004
    ..This upregulation did not occur with low frequency stimulation of the perforant path. Therefore Arc protein localization may be a powerful tool to isolate recently activated dendritic spines...
  26. pmc Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis
    M E Ripps
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029
    Proc Natl Acad Sci U S A 92:689-93. 1995
    ....
  27. ncbi Length of postovariectomy interval and age, but not estrogen replacement, regulate N-methyl-D-aspartate receptor mRNA levels in the hippocampus of female rats
    M M Adams
    Kastor Neurobiology of Aging Laboratory, Mount Sinai School of Medicine, New York, New York 10029, USA
    Exp Neurol 170:345-56. 2001
    ..These findings have important implications for postmenopausal or hysterectomy/oophorectomy estrogen depletion and replacement in humans...
  28. ncbi Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer's disease
    T Bussiere
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Box 1639, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 112:75-91. 2002
    ....
  29. ncbi Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala
    L R Johnson
    NIMH Conte Center for the Neuroscience of Fear and Anxiety Center for Neural Science, 4 Washington Place, New York University, New York, NY 10003, USA
    Neuroscience 136:289-99. 2005
    ....
  30. ncbi Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampus
    Y He
    Fishberg Research Center for Neurobiology and Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Comp Neurol 418:255-69. 2000
    ....
  31. ncbi Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain
    P Shashidharan
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029
    Brain Res 662:245-50. 1994
    ..Southern blot analysis revealed that the gene encoding this mRNA exists as a single copy in the human genome...
  32. ncbi Quantitative analysis of the dendritic morphology of corticocortical projection neurons in the macaque monkey association cortex
    H Duan
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Neuroscience 114:349-59. 2002
    ..The more complex dendritic arborization of such neurons is likely linked to their participation in cortical networks that require extensive convergence of multiple afferents at the cellular level...
  33. ncbi Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein
    M Migaud
    Centre for Genome Research, University of Edinburgh, UK
    Nature 396:433-9. 1998
    ..PSD-95 thus appears to be important in coupling the NMDA receptor to pathways that control bidirectional synaptic plasticity and learning...
  34. pmc Estrogen and aging affect synaptic distribution of phosphorylated LIM kinase (pLIMK) in CA1 region of female rat hippocampus
    M Yildirim
    Department of Pharmacology, Hacettepe University, Faculty of Medicine, Ankara, Turkey
    Neuroscience 152:360-70. 2008
    ....
  35. ncbi Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease
    P Giannakopoulos
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
    Neurology 60:1495-500. 2003
    ..To examine the relationship between stereologic estimates of AD-related pathology and severity of cognitive deficits in brain aging...
  36. ncbi The neurobiology of aging
    K M Kelly
    Department of Neurology, Drexel University College of Medicine, Allegheny General Hospital, 940 S Tower, 320 E North Ave, Pittsburgh, PA 15212, USA
    Epilepsy Res 68:S5-20. 2006
    ..Lastly, application of microarray gene chip technology to aging brain studies was presented and use of the hippocampal "zipper slice" preparation to study aged neurons was described...