S Morgello

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer's disease
    Andrew J Levine
    Department of Neurology, National Neurological AIDS Bank, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA
    BMC Med Genomics 6:4. 2013
  2. pmc Plasma metabolomics identifies lipid abnormalities linked to markers of inflammation, microbial translocation, and hepatic function in HIV patients receiving protease inhibitors
    Edana Cassol
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02215, USA
    BMC Infect Dis 13:203. 2013
  3. ncbi request reprint Effects of hepatic function and hepatitis C virus on the nervous system assessment of advanced-stage HIV-infected individuals
    Susan Morgello
    Department of Pathology, Mount Sinai Medical Center, New York, NY 10029, USA
    AIDS 19:S116-22. 2005
  4. ncbi request reprint HIV-associated distal sensory polyneuropathy in the era of highly active antiretroviral therapy: the Manhattan HIV Brain Bank
    Susan Morgello
    Department of Pathology, The Mount Sinai Medical Center, New York, NY 10029, USA
    Arch Neurol 61:546-51. 2004
  5. ncbi request reprint The nervous system and hepatitis C virus
    Susan Morgello
    Department of Pathology Neuropathology Mount Sinai Medical Center, Box 1134, 1 Gustave L Levy Place, New York, NY 10029, USA
    Semin Liver Dis 25:118-21. 2005
  6. ncbi request reprint Interrater reliability of the Psychiatric Research Interview for Substance and Mental Disorders in an HIV-infected cohort: experience of the National NeuroAIDS Tissue Consortium
    S Morgello
    Mount Sinai School of Medicine, New York, NY10029, USA
    Int J Methods Psychiatr Res 15:131-8. 2006
  7. ncbi request reprint Autopsy findings in a human immunodeficiency virus-infected population over 2 decades: influences of gender, ethnicity, risk factors, and time
    Susan Morgello
    Manhattan HIV Brain Bank, Department of Pathology, Division of Neuropathology, The Mount Sinai Medical Center, 1 Gustave L Levy Pl, New York, NY 10029, USA
    Arch Pathol Lab Med 126:182-90. 2002
  8. ncbi request reprint The interstitial nuclei of the human anterior hypothalamus: an investigation of sexual variation in volume and cell size, number and density
    W Byne
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Brain Res 856:254-8. 2000
  9. pmc Neuropsychiatric impact of hepatitis C on advanced HIV
    E L Ryan
    Departments of Psychiatry, The Mount Sinai Medical Center, New York, NY, USA
    Neurology 62:957-62. 2004
  10. pmc Clinicopathologic correlates of hepatitis C virus in brain: a pilot study
    Jacinta Murray
    Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurovirol 14:17-27. 2008

Research Grants

  1. The Manahattan HIV Brain Bank
    Susan Morgello; Fiscal Year: 2007
  2. The Mount Sinai Institute for NeuroAIDS Disparities
    Susan Morgello; Fiscal Year: 2007

Collaborators

Detail Information

Publications47

  1. pmc Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer's disease
    Andrew J Levine
    Department of Neurology, National Neurological AIDS Bank, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA
    BMC Med Genomics 6:4. 2013
    ..Additionally, we compare these data to those derived from brains of individuals with Alzheimer's disease (AD) in order to identify common pathways of neuropathogenesis...
  2. pmc Plasma metabolomics identifies lipid abnormalities linked to markers of inflammation, microbial translocation, and hepatic function in HIV patients receiving protease inhibitors
    Edana Cassol
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02215, USA
    BMC Infect Dis 13:203. 2013
    ..Metabolic abnormalities are common in HIV-infected individuals on antiretroviral therapy (ART), but the biochemical details and underlying mechanisms of these disorders have not been defined...
  3. ncbi request reprint Effects of hepatic function and hepatitis C virus on the nervous system assessment of advanced-stage HIV-infected individuals
    Susan Morgello
    Department of Pathology, Mount Sinai Medical Center, New York, NY 10029, USA
    AIDS 19:S116-22. 2005
    ..To examine the effects of liver function and hepatitis C virus (HCV) serostatus on neurological, neuropsychological, and psychiatric abnormalities in an advanced-stage HIV-infected cohort...
  4. ncbi request reprint HIV-associated distal sensory polyneuropathy in the era of highly active antiretroviral therapy: the Manhattan HIV Brain Bank
    Susan Morgello
    Department of Pathology, The Mount Sinai Medical Center, New York, NY 10029, USA
    Arch Neurol 61:546-51. 2004
    ....
  5. ncbi request reprint The nervous system and hepatitis C virus
    Susan Morgello
    Department of Pathology Neuropathology Mount Sinai Medical Center, Box 1134, 1 Gustave L Levy Place, New York, NY 10029, USA
    Semin Liver Dis 25:118-21. 2005
    ..HCV has been localized to the central nervous system; much of its basic neurobiology remains to be described and awaits further correlation with clinical abnormalities...
  6. ncbi request reprint Interrater reliability of the Psychiatric Research Interview for Substance and Mental Disorders in an HIV-infected cohort: experience of the National NeuroAIDS Tissue Consortium
    S Morgello
    Mount Sinai School of Medicine, New York, NY10029, USA
    Int J Methods Psychiatr Res 15:131-8. 2006
    ..We conclude that the PRISM yields reliable diagnoses in a multicentre study of substance-experienced, HIV-infected individuals...
  7. ncbi request reprint Autopsy findings in a human immunodeficiency virus-infected population over 2 decades: influences of gender, ethnicity, risk factors, and time
    Susan Morgello
    Manhattan HIV Brain Bank, Department of Pathology, Division of Neuropathology, The Mount Sinai Medical Center, 1 Gustave L Levy Pl, New York, NY 10029, USA
    Arch Pathol Lab Med 126:182-90. 2002
    ..To examine autopsy pathology in an urban population infected with the human immunodeficiency virus (HIV) and to determine if age at death and disease frequencies are associated with gender, HIV risk factors, ethnicity, and therapeutic era...
  8. ncbi request reprint The interstitial nuclei of the human anterior hypothalamus: an investigation of sexual variation in volume and cell size, number and density
    W Byne
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Brain Res 856:254-8. 2000
    ..The present data corroborate two previous reports of sexual dimorphism of INAH3 but provide no support for previous reports of sexual variation in other INAH...
  9. pmc Neuropsychiatric impact of hepatitis C on advanced HIV
    E L Ryan
    Departments of Psychiatry, The Mount Sinai Medical Center, New York, NY, USA
    Neurology 62:957-62. 2004
    ..To determine whether hepatitis C (HCV) contributes to CNS dysfunction among HIV-infected individuals...
  10. pmc Clinicopathologic correlates of hepatitis C virus in brain: a pilot study
    Jacinta Murray
    Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurovirol 14:17-27. 2008
    ..Differences in abstraction/executive function of HCV/HIV coinfected patients compared to HIV monoinfected warrant further studies to determine if neuropsychiatric effects are predicated upon brain infection...
  11. pmc Cannabinoid receptor expression in HIV encephalitis and HIV-associated neuropathologic comorbidities
    M A Cosenza-Nashat
    Department of Pathology, Albert Einstein College of Medicine, Bronx Department of Pathology, Mt Sinai School of Medicine, New York, NY, USA
    Neuropathol Appl Neurobiol 37:464-83. 2011
    ....
  12. pmc Association of self-reported painful symptoms with clinical and neurophysiologic signs in HIV-associated sensory neuropathy
    J Robinson-Papp
    Department of Neurology, Mount Sinai, School of Medicine, New York, NY 10029, USA
    Pain 151:732-6. 2010
    ..This finding holds true regardless of demographic factors, depression or substance use history...
  13. pmc Motor function and human immunodeficiency virus-associated cognitive impairment in a highly active antiretroviral therapy-era cohort
    Jessica Robinson-Papp
    Departments of Pathology, Mount Sinai Medical Center, Box 1052, One Gustave L Levy Place, New York, NY 10029, USA
    Arch Neurol 65:1096-101. 2008
    ..Cognitive impairment has long been recognized as a manifestation of human immunodeficiency virus (HIV) infection. However, highly active antiretroviral therapy (HAART) has altered the neurologic manifestations of HIV...
  14. pmc The spectrum of kidney disease in patients with AIDS in the era of antiretroviral therapy
    Christina M Wyatt
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Kidney Int 75:428-34. 2009
    ....
  15. pmc Vulnerabilities and caregiving in an ethnically diverse HIV-infected population
    Anissa L Moody
    Department of Pathology, Mt Sinai School of Medicine, New York, NY, USA
    AIDS Behav 13:337-47. 2009
    ....
  16. pmc Characterization and sociocultural predictors of neuropsychological test performance in HIV+ Hispanic individuals
    Monica Rivera Mindt
    Fordham University Department of Psychology, New York, NY 10023, USA
    Cultur Divers Ethnic Minor Psychol 14:315-25. 2008
    ....
  17. pmc The roles of ethnicity and antiretrovirals in HIV-associated polyneuropathy: a pilot study
    Jessica Robinson-Papp
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Acquir Immune Defic Syndr 51:569-73. 2009
    ..As HAART became widespread, and the AIDS epidemic shifted into minority populations, the risk factors for DSP became less clear. We explore the roles of ethnicity and ARV in the development of DSP in an HAART era cohort...
  18. pmc Understanding the neuropsychological profile of HIV+ participants with low literacy: role of the General Ability Measure for Adults (GAMA)
    Elizabeth L Ryan
    Department of Psychiatry, Fordham University, New York, NY, USA
    Clin Neuropsychol 22:1018-34. 2008
    ..The GAMA may be a useful test when disparities in educational quality render reading-based measures of IQ a poor surrogate of premorbid function...
  19. ncbi request reprint Polyomaviruses and primary central nervous system lymphomas
    Jacinta M Murray
    Department of Pathology, Box 1143, Mount Sinai School of Medicine, New York, NY 11377, USA
    Neurology 63:1299-301. 2004
    ..The authors conclude that polyomaviruses are unlikely to be related to the pathogenesis of most PCNSL...
  20. pmc Molecular and bioinformatic evidence of hepatitis C virus evolution in brain
    Sarah L Fishman
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    J Infect Dis 197:597-607. 2008
    ..Neurocognitive deficits in patients with hepatitis C virus (HCV) infection prompted a search for HCV in brain...
  21. ncbi request reprint The National NeuroAIDS Tissue Consortium: a new paradigm in brain banking with an emphasis on infectious disease
    S Morgello
    Department of Pathology, The Mount Sinai Medical Center, New York, NY 10029, USA
    Neuropathol Appl Neurobiol 27:326-35. 2001
    ..We describe the neuropathology protocol that was adopted and successfully implemented at the four participating banks of the Consortium...
  22. pmc Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain
    M Cosenza-Nashat
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuropathol Appl Neurobiol 35:306-28. 2009
    ..TSPO is presumably present in activated microglia, but may be present in other neural cells...
  23. ncbi request reprint Epstein-Barr virus-associated dural leiomyosarcoma in a man infected with human immunodeficiency virus. Case report
    S Morgello
    Department of Pathology, The Mount Sinai Medical Center, New York, New York 10029, USA
    J Neurosurg 86:883-7. 1997
    ..With increasing numbers of individuals being afflicted with long-term immunosuppression, EBV-associated dural leiomyoma and leiomyosarcoma may be encountered more frequently in the future...
  24. ncbi request reprint The interstitial nuclei of the human anterior hypothalamus: an investigation of variation with sex, sexual orientation, and HIV status
    W Byne
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Horm Behav 40:86-92. 2001
    ..Although there was a trend for INAH3 to occupy a smaller volume in homosexual men than in heterosexual men, there was no difference in the number of neurons within the nucleus based on sexual orientation...
  25. pmc A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain
    Vadim Yuferov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Neuropsychopharmacology 34:1185-97. 2009
    ....
  26. ncbi request reprint Peripheral neuropathies associated with HIV and hepatitis C co-infection: a review
    Lydia B Estanislao
    Department of Neurology NeuroAIDS Research Program, Mount Sinai Medical Center, New York, NY 10029, USA
    AIDS 19:S135-9. 2005
    ..It is not known whether there are additive or synergistic effects on the peripheral nerve by these two viruses. There is a need for studies to further elucidate the mechanisms involved...
  27. pmc Human immunodeficiency virus (HIV) infects human arterial smooth muscle cells in vivo and in vitro: implications for the pathogenesis of HIV-mediated vascular disease
    Eliseo A Eugenin
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Am J Pathol 172:1100-11. 2008
    ..Our data suggest that direct infection of human arterial SMCs by HIV represents a potential mechanism in a multifactorial paradigm to explain the exacerbated atherosclerosis and vasculopathy reported in individuals infected with HIV...
  28. ncbi request reprint Abnormal cobalamin-dependent transmethylation in AIDS-associated myelopathy
    A Di Rocco
    Department of Neurology, Albert Einstein College of Medicine and Beth Israel Medical Center, New York, NY 10003, USA
    Neurology 58:730-5. 2002
    ....
  29. ncbi request reprint Detection of HIV-1 DNA in microglia/macrophages, astrocytes and neurons isolated from brain tissue with HIV-1 encephalitis by laser capture microdissection
    G Trillo-Pazos
    Division of Molecular Virology, St Luke s Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York, NY 10019, USA
    Brain Pathol 13:144-54. 2003
    ..These findings suggest that in addition to microglia, the infection of astrocytes and neurons by HIV-1 may contribute to the development of HIV-1 disease in the brain...
  30. ncbi request reprint Primary dural mucosa-associated lymphoid tissue-type lymphoma: case report and review of the literature
    M Rottnek
    Department of Pathology Division of Neuropathology, The Mount Sinai Medical Center, New York City, NY 10029, USA
    J Neurooncol 68:19-23. 2004
    ....
  31. pmc Mechanisms of HIV-tat-induced phosphorylation of N-methyl-D-aspartate receptor subunit 2A in human primary neurons: implications for neuroAIDS pathogenesis
    Jessie E King
    Department of Pathology, The Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Am J Pathol 176:2819-30. 2010
    ..These findings suggest new avenues of treatment for HIV-associated cognitive impairment...
  32. ncbi request reprint Effects of human immunodeficiency virus type 1 on astrocyte gene expression and function: potential role in neuropathogenesis
    Zhuying Wang
    Molecular Virology Division, St Luke s Roosevelt Hospital Center and College of Physicians and Surgeons, Columbia University, New York, New York 10019, USA
    J Neurovirol 10:25-32. 2004
    ..These findings define new pathways through which HIV-1 may contribute to neuropathogenesis under conditions of limited virus replication in the brain...
  33. pmc Urinary NGAL marks cystic disease in HIV-associated nephropathy
    Neal Paragas
    College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Am Soc Nephrol 20:1687-92. 2009
    ..These data show that marked upregulation of NGAL accompanies HIVAN and support further study of uNGAL levels in large cohorts to aid in the noninvasive diagnosis of HIVAN and screen for HIVAN-related tubular damage...
  34. ncbi request reprint Axonal damage is a late component of vacuolar myelopathy
    Matthew Rottnek
    Department of Pathology, Division of Neuropathology, The Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Neurology 58:479-81. 2002
    ..The authors conclude that axonal damage is not present in early disease; it is present in moderate to severe vacuolar myelopathy and may contribute to clinical deficits in late stages of this disorder...
  35. pmc Psychiatric management of HIV/HCV-coinfected patients beginning treatment for hepatitis C virus infection: survey of provider practices
    Jeffrey J Weiss
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1228, New York, NY 10029, USA
    Gen Hosp Psychiatry 31:531-7. 2009
    ..To determine expert clinical practice in the management of psychiatric status of HIV/hepatitis C virus (HCV)-coinfected patients initiating pegylated interferon/ribavirin for the treatment of hepatitis C...
  36. ncbi request reprint Human immunodeficiency virus infection inhibits granulocyte-macrophage colony-stimulating factor-induced microglial proliferation
    Melissa Cosenza-Nashat
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurovirol 13:536-48. 2007
    ..These data suggest that there might be a viral gain in the suppressed host cell proliferation...
  37. ncbi request reprint Movement disorders and AIDS: a review
    Winona Tse
    Department of Neurology, Mount Sinai Medical Center, One Gustave L Levy Place, Box 1052, New York, NY 10029, USA
    Parkinsonism Relat Disord 10:323-34. 2004
    ..This review will also summarize current concepts regarding the pathophysiology of parkinsonism in HIV infection...
  38. pmc Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients
    Petronela Ancuta
    Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 3:e2516. 2008
    ....
  39. pmc Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system
    Scott Letendre
    University of California, San Diego, 150 W Washington St, San Diego, CA 92103, USA
    Arch Neurol 65:65-70. 2008
    ..To evaluate whether penetration of a combination regimen into the central nervous system (CNS), as estimated by the CNS Penetration-Effectiveness (CPE) rank, is associated with lower cerebrospinal fluid (CSF) viral load...
  40. ncbi request reprint Interrater reliability of clinical ratings and neurocognitive diagnoses in HIV
    Steven Paul Woods
    University of California, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 26:759-78. 2004
    ..Not surprisingly, most diagnostic disagreements concerned the etiology of impairments in persons with medical and neuropsychiatric risk factors in addition to HIV...
  41. ncbi request reprint JC virus granule cell neuronopathy: A novel clinical syndrome distinct from progressive multifocal leukoencephalopathy
    Igor J Koralnik
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Ann Neurol 57:576-80. 2005
    ..We propose to call this novel syndrome JCV granule cell neuronopathy (JCV GCN)...
  42. ncbi request reprint Env gp120 sequence analysis of HIV type 1 strains from diverse areas of the brain shows preponderance of CCR5 usage
    Meet Shah
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Darcy Road, Westmead NSW 2145, Australia
    AIDS Res Hum Retroviruses 22:177-81. 2006
    ....
  43. pmc Independent evolution of human immunodeficiency virus (HIV) drug resistance mutations in diverse areas of the brain in HIV-infected patients, with and without dementia, on antiretroviral treatment
    Theresa K Smit
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Darcy Rd, Westmead NSW 2145, Sydney, Australia
    J Virol 78:10133-48. 2004
    ..The emergence of resistant virus in the CNS may have considerable influence on the outcome of neurologic disease and also the reseeding of HIV in the systemic circulation upon failure of therapy...
  44. ncbi request reprint The role of cohort studies in drug development: clinical evidence of antiviral activity of serotonin reuptake inhibitors and HMG-CoA reductase inhibitors in the central nervous system
    Scott L Letendre
    University of California, 150 W Washington St, San Diego, CA 92103, USA
    J Neuroimmune Pharmacol 2:120-7. 2007
    ..Some of these drugs, such as serotonin reuptake inhibitors (SRIs) and HMG-CoA reductase inhibitors (statins), may do so by reducing HIV replication in the CNS and are already widely used by HIV-infected individuals...
  45. ncbi request reprint Neuronal injury regulates fractalkine: relevance for HIV-1 associated dementia
    David Erichsen
    Laboratory of Neurotoxicology, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neuroimmunol 138:144-55. 2003
    ..0345). These results demonstrate a possible role of FKN in HAD pathogenesis...
  46. pmc Differential effects of HIV infected macrophages on dorsal root ganglia neurons and axons
    Katrin Hahn
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Exp Neurol 210:30-40. 2008
    ..These observations suggest a differential effect on the axon and cell body. Different mechanisms of injury may be operative in these two structures...
  47. pmc Macrophage/microglial accumulation and proliferating cell nuclear antigen expression in the central nervous system in human immunodeficiency virus encephalopathy
    Tracy Fischer-Smith
    Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Am J Pathol 164:2089-99. 2004
    ..PCNA positivity was also observed in some endothelial cells and ependymal cells in HIVE CNS. Our results would support a role for HIV-1-induced alterations in MP trafficking and homeostasis in the pathogenesis of HIVE...

Research Grants4

  1. The Manahattan HIV Brain Bank
    Susan Morgello; Fiscal Year: 2007
    ....
  2. The Mount Sinai Institute for NeuroAIDS Disparities
    Susan Morgello; Fiscal Year: 2007
    ..By combining the strengths of these two programs, the MSINAD will help create high quality, REM researchers whose long term careers will make a lasting contribution to the area of neuroAIDS disparities. ..