P R Moreno

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi Increased macrophage infiltration and neovascularization in congenital bicuspid aortic valve stenosis
    Pedro R Moreno
    Zena and Michael A Weiner Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Thorac Cardiovasc Surg 142:895-901. 2011
  2. ncbi Vulnerable plaque: definition, diagnosis, and treatment
    Pedro R Moreno
    Zena and Michael A Wiener Cardiovascular Institute and The Marie Josee and Henry R Kravis Cardiovascular Health Center, The Mount Sinai School of Medicine, Box 1030, New York, NY 10029, USA
    Cardiol Clin 28:1-30. 2010
  3. ncbi Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: implications for plaque vulnerability
    Pedro R Moreno
    Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1030, New York, NY 10029, USA
    Circulation 110:2032-8. 2004
  4. ncbi Neovascularization in human atherosclerosis
    P R Moreno
    The Zena and Michael A Wiener Cardiovascular Institute, and the Marie Josee and Henry R Kravis Cardiovascular Health Center, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Mol Med 6:457-77. 2006
  5. ncbi New aspects in the pathogenesis of diabetic atherothrombosis
    Pedro R Moreno
    Zena and Michael Wiener Cardiovascular Institute, Mount Sinai School of Medicine, PO Box 1030, One Gustave L Levy Place, New York, NY 10029, USA
    J Am Coll Cardiol 44:2293-300. 2004
  6. ncbi Neovascularization in human atherosclerosis
    Pedro R Moreno
    Zena and Michael A. Wiener Cardiovascular Institute, Marie-Josee and Henry R. Kravis Cardiovascular Health Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circulation 113:2245-52. 2006
  7. ncbi Inflammation and neovascularization in diabetic atherosclerosis
    K R Purushothaman
    Zena and Michael A Wiener Cardiovascular Institute and The Marie Jose and Henry R Kravis Cardiovascular Health Center, The Mount Sinai School of Medicine, Box 1030, New York, NY, USA
    Indian J Exp Biol 45:93-102. 2007
  8. ncbi Atherosclerosis neovascularization and imaging
    K R Purushothaman
    The Zena and Michael A. Wiener Cardiovascular Institute, and The Marie-Josee and Henry R. Kravis Cardiovascular Health Center, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Mol Med 6:549-56. 2006
  9. ncbi Atherothrombosis: role of tissue factor; link between diabetes, obesity and inflammation
    P Meerarani
    Zena and Michael A Wiener Cardiovascular Institute and The Marie Jose and Henry R Kravis Cardiovascular Health Center, The Mount Sinai School of Medicine, New York, 10029 NY, USA
    Indian J Exp Biol 45:103-10. 2007
  10. ncbi Metabolic syndrome and diabetic atherothrombosis: implications in vascular complications
    P Meerarani
    The Zena and Michael Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Mol Med 6:501-14. 2006

Collaborators

  • Javier Sanz
  • P Meerarani
  • K R Purushothaman
  • V Fuster
  • Samin K Sharma
  • J J Badimon
  • Zahi Fayad
  • David A Vorchheimer
  • Orit Lache
  • J F Toussaint
  • Annapoorna S Kini
  • Michael C Kim
  • Prakash Krishnan
  • Andrew P Levy
  • Juan F Granada
  • Sanjay Rajdev
  • Prabhakar B Kunamneni
  • Mohammad Urooj Zafar
  • Nina S Levy
  • Javed Suleman
  • Marc Sirol
  • Albert E Raizner
  • Victor H T Chen
  • Angelica Mares
  • Adil Irani
  • Paul Lee
  • Oana C Ivan
  • Mauricio Velez
  • Chingwen Yang
  • Osher Cohen
  • Soren K Moestrup
  • Merav Strauss
  • Satoshi Kunitada
  • Rabea Asleh
  • Rachel Miller-Lotan
  • Shiri Kalet-Litman
  • Daniel Benhayon
  • Juan Pagan
  • Juan Gaztanaga
  • Joanne E Levy
  • Julia Guetta
  • Meerarani Purushothaman
  • Roy Asaf
  • Holger J Moller
  • Elias A Zias
  • Daniel Yadegar
  • Stuart Marsh
  • Madhu Prattipati
  • John T Fallon
  • Allen P Burke
  • Daryl G Schulz
  • Greg L Kaluza
  • Angelica M Steinheimer
  • Grzegorz L Kaluza

Detail Information

Publications32

  1. ncbi Increased macrophage infiltration and neovascularization in congenital bicuspid aortic valve stenosis
    Pedro R Moreno
    Zena and Michael A Weiner Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Thorac Cardiovasc Surg 142:895-901. 2011
    ..We hypothesize that aortic valve stenosis evolves from a more aggressive inflammatory process, with increased macrophage/T-cell and neovessel content in congenital bicuspid aortic valveswhen compared with that seen in tricuspid valves...
  2. ncbi Vulnerable plaque: definition, diagnosis, and treatment
    Pedro R Moreno
    Zena and Michael A Wiener Cardiovascular Institute and The Marie Josee and Henry R Kravis Cardiovascular Health Center, The Mount Sinai School of Medicine, Box 1030, New York, NY 10029, USA
    Cardiol Clin 28:1-30. 2010
    ..The third section relates to invasive plaque imaging. The fourth section is devoted to therapy, from conservative pharmacologic options to aggressive percutaneous coronary intervention alternatives...
  3. ncbi Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: implications for plaque vulnerability
    Pedro R Moreno
    Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1030, New York, NY 10029, USA
    Circulation 110:2032-8. 2004
    ..Accordingly, we tested this hypothesis by investigating whether microvessels in the tunica media, the base of the plaque, and the fibrous cap are increased in ruptured atherosclerotic plaques in human aorta...
  4. ncbi Neovascularization in human atherosclerosis
    P R Moreno
    The Zena and Michael A Wiener Cardiovascular Institute, and the Marie Josee and Henry R Kravis Cardiovascular Health Center, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Mol Med 6:457-77. 2006
    ....
  5. ncbi New aspects in the pathogenesis of diabetic atherothrombosis
    Pedro R Moreno
    Zena and Michael Wiener Cardiovascular Institute, Mount Sinai School of Medicine, PO Box 1030, One Gustave L Levy Place, New York, NY 10029, USA
    J Am Coll Cardiol 44:2293-300. 2004
    ..Multiple experimental studies have documented plaque stabilization with PPAR-gamma agonists, a group of medications holding great promise in the treatment of diabetes atherosclerosis...
  6. ncbi Neovascularization in human atherosclerosis
    Pedro R Moreno
    Zena and Michael A. Wiener Cardiovascular Institute, Marie-Josee and Henry R. Kravis Cardiovascular Health Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circulation 113:2245-52. 2006
  7. ncbi Inflammation and neovascularization in diabetic atherosclerosis
    K R Purushothaman
    Zena and Michael A Wiener Cardiovascular Institute and The Marie Jose and Henry R Kravis Cardiovascular Health Center, The Mount Sinai School of Medicine, Box 1030, New York, NY, USA
    Indian J Exp Biol 45:93-102. 2007
    ..We conclude that inflammation and neovascularization of the plaque may act as major mechanism augmenting plaque instability in diabetes mellitus...
  8. ncbi Atherosclerosis neovascularization and imaging
    K R Purushothaman
    The Zena and Michael A. Wiener Cardiovascular Institute, and The Marie-Josee and Henry R. Kravis Cardiovascular Health Center, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Mol Med 6:549-56. 2006
    ..In this manuscript we will review current evidence on the potential application of the various modalities, with a particular emphasis in molecular imaging...
  9. ncbi Atherothrombosis: role of tissue factor; link between diabetes, obesity and inflammation
    P Meerarani
    Zena and Michael A Wiener Cardiovascular Institute and The Marie Jose and Henry R Kravis Cardiovascular Health Center, The Mount Sinai School of Medicine, New York, 10029 NY, USA
    Indian J Exp Biol 45:103-10. 2007
    ..Therapeutic strategies have been developed to specifically interfere with TF activity in the treatment of cardiovascular disease...
  10. ncbi Metabolic syndrome and diabetic atherothrombosis: implications in vascular complications
    P Meerarani
    The Zena and Michael Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Mol Med 6:501-14. 2006
    ....
  11. ncbi The year in atherothrombosis
    Pedro R Moreno
    Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA
    J Am Coll Cardiol 44:2099-110. 2004
  12. ncbi Atherothrombosis and high-risk plaque: part I: evolving concepts
    Valentin Fuster
    Zena and Michael A. Wiener Cardiovascular Institute and the Marie-Josee and Henry R. Kravis Cardiovascular Health Center, The Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Coll Cardiol 46:937-54. 2005
    ..In the final thrombosis section, focal and circulating tissue factor associated with apoptotic macrophages and circulatory monocytes is examined, closing the link between inflammation, plaque rupture, and blood thrombogenicity...
  13. ncbi Comparison of coronary flow reserve and fractional flow reserve in patients with versus without diabetes mellitus and having elective percutaneous coronary intervention and abciximab therapy (from the PREDICT Trial)
    Annapoorna S Kini
    Cardiac Catheterization Laboratory of the Cardiovascular Institute, Mount Sinai Hospital, New York, NY, USA
    Am J Cardiol 101:796-800. 2008
    ..In conclusion, patients with DM have significantly lower CFR after stenting despite equivalent FFR and myonecrosis compared with patients without DM, indicating greater microvascular obstruction after PCI despite abciximab...
  14. ncbi The year in atherothrombosis
    Javier Sanz
    The Zena and Michael A. Wiener Cardiovascular Institute/Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, New York, USA
    J Am Coll Cardiol 49:1740-9. 2007
  15. ncbi Outcome of intracoronary stenting after failed maximal medical therapy in patients with symptomatic myocardial bridge
    Prabhakar B Kunamneni
    Cardiac Catheterization Laboratory of the Cardiovascular Institute, Mount Sinai Hospital, New York, New York 10029 6754, USA
    Catheter Cardiovasc Interv 71:185-90. 2008
    ..The aim of the present study was to study the outcome of coronary stenting in patients with symptomatic myocardial bridging refractory to standard medical therapy...
  16. ncbi Antithrombotic effects of factor Xa inhibition with DU-176b: Phase-I study of an oral, direct factor Xa inhibitor using an ex-vivo flow chamber
    Mohammad Urooj Zafar
    Cardiovascular Biology Research Lab, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1030, New York, NY 10029, USA
    Thromb Haemost 98:883-8. 2007
    ..The effects mirrored changes in clotting parameters, suggesting their potential usefulness for monitoring in a clinical setting...
  17. ncbi Bolus-only versus bolus + infusion of glycoprotein IIb/IIIa inhibitors during percutaneous coronary intervention
    Annapoorna S Kini
    Cardiac Catheterization Laboratory, Cardiovascular Institute, Mount Sinai Medical Center, New York, NY 10029 6574, USA
    Am Heart J 156:513-9. 2008
    ..However, GPI bolus + infusion may increase vascular/bleeding complications and may not reduce MACE when compared with GPI bolus-only...
  18. ncbi Update on advances in atherothrombosis
    Javier Sanz
    Department of Medicine Cardiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 4:78-89. 2007
    ..Awareness of these recent advances and new lines of active research is fundamental for health professionals involved in the care of patients with atherothrombosis. In this Review we present an overview of data in these areas...
  19. ncbi Promoting mechanisms of vascular health: circulating progenitor cells, angiogenesis, and reverse cholesterol transport
    Pedro R Moreno
    Zena and Michael A Wiener Cardiovascular Institute, Marie Josee and Henry R Kravis Cardiovascular Health Center, The Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Coll Cardiol 53:2315-23. 2009
    ....
  20. ncbi Effectiveness of the stent pull-back technique for nonaorto ostial coronary narrowings
    Annapoorna S Kini
    Cardiac Catheterization Laboratory of the Cardiovascular Institute, Mount Sinai Hospital, New York, New York, USA
    Am J Cardiol 96:1123-8. 2005
    ..The technique is associated with a lower use of additional stents and improved clinical outcome, reducing TVR at 8 months of follow-up...
  21. ncbi Atherothrombosis and high-risk plaque: Part II: approaches by noninvasive computed tomographic/magnetic resonance imaging
    Valentin Fuster
    Zena and Michael A. Wiener Cardiovascular Institute and the Marie-Josee and Henry R. Kravis Cardiovascular Health Center, The Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Coll Cardiol 46:1209-18. 2005
    ..In addition, such technology facilitates the understanding of the processes involved in the development and progression of atherothrombosis responsible for coronary, cerebral, and peripheral ischemic events...
  22. ncbi The year in atherothrombosis
    Javier Sanz
    The Zena and Michael A. Wiener Cardiovascular Institute/Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, New York, USA
    J Am Coll Cardiol 51:944-55. 2008
  23. ncbi Haptoglobin genotype is a determinant of iron, lipid peroxidation, and macrophage accumulation in the atherosclerotic plaque
    Andrew P Levy
    Technion Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Arterioscler Thromb Vasc Biol 27:134-40. 2007
    ..We tested the hypothesis that the Hp 2-2 genotype is associated with increased oxidative and macrophage accumulation in atherosclerotic plaques...
  24. ncbi Endovascular needle injection of cholesteryl linoleate into the arterial wall produces complex vascular lesions identifiable by intravascular ultrasound: early development in a porcine model of vulnerable plaque
    Juan F Granada
    Cardiovascular Intervention Core, Methodist Hospital Research Institute, Houston, Texas 77030, USA
    Coron Artery Dis 16:217-24. 2005
    ..These lesions are already identifiable by IVUS at 2 weeks and colocalize with histologic findings. Further development of this model may allow the validation of technologies designed to detect and treat high-risk atherosclerotic lesions...
  25. ncbi Intimomedial interface damage and adventitial inflammation is increased beneath disrupted atherosclerosis in the aorta: implications for plaque vulnerability
    Pedro R Moreno
    Linda and Jack Gill Heart Institute, University of Kentucky, Lexington 40511, USA
    Circulation 105:2504-11. 2002
    ....
  26. ncbi Clinical application of prophylactic percutaneous left ventricular assist device (TandemHeart) in high-risk percutaneous coronary intervention using an arterial preclosure technique: single-center experience
    Sanjay Rajdev
    Mount Sinai Hospital, Box 1030, Cardiac Cath Lab and Intervention, One Gustave L Levy Place, New York, NY 10029 6754, USA
    J Invasive Cardiol 20:67-72. 2008
    ....
  27. ncbi Downregulation of the hemoglobin scavenger receptor in individuals with diabetes and the Hp 2-2 genotype: implications for the response to intraplaque hemorrhage and plaque vulnerability
    Andrew P Levy
    Technion Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Circ Res 101:106-10. 2007
    ..04). Taken together, these results demonstrate an impaired hemoglobin clearance capacity in Hp 2-2 DM individuals and may provide the key insight explaining the increased incidence of myocardial infarction in this population...
  28. ncbi Chronic thrombus detection with in vivo magnetic resonance imaging and a fibrin-targeted contrast agent
    Marc Sirol
    Department of Cardiology, , Paris, France
    Circulation 112:1594-600. 2005
    ....
  29. ncbi Detection of high-risk atherosclerotic coronary plaques by intravascular spectroscopy
    Pedro R Moreno
    Linda and Jack Gill Heart Institute, University of Kentucky, Lexington, KY, USA
    J Interv Cardiol 16:243-52. 2003
    ..Potential benefits and challenges are addressed. Finally, diffuse reflectance near-infrared spectroscopy is discussed in more detail as a promising technique to characterize plaque vulnerability in humans...
  30. ncbi Vulnerable plaque paradigm: prediction of future clinical events based on a morphological definition
    Juan F Granada
    Methodist DeBakey Heart Center, Baylor College of Medicine, Houston, Texas, USA
    Catheter Cardiovasc Interv 62:364-74. 2004
  31. ncbi Atherothrombosis as a systemic, often silent, disease
    Valentin Fuster
    Nat Clin Pract Cardiovasc Med 2:431. 2005
  32. ncbi Detection of lipid pool, thin fibrous cap, and inflammatory cells in human aortic atherosclerotic plaques by near-infrared spectroscopy
    Pedro R Moreno
    Linda and Jack Gill Heart Institute, University of Kentucky, Lexington, USA
    Circulation 105:923-7. 2002
    ..We tested the hypothesis that NIR spectroscopy can identify plaque composition and features associated with plaque vulnerability in human aortic atherosclerotic plaques obtained at the time of autopsy...