Research Topics
Species | Thomas MoranSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Alpha-defensins 1-3 release by dendritic cells is reduced by estrogenMaria M Escribese
Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
Reprod Biol Endocrinol 9:118. 2011....- The virion host shutoff protein of herpes simplex virus 1 blocks the replication-independent activation of NF-κB in dendritic cells in the absence of type I interferon signalingChristopher R Cotter
Department of Microbiology and Immunology Institute, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
J Virol 85:12662-72. 2011.... - The NS1 protein of a human influenza virus inhibits type I interferon production and the induction of antiviral responses in primary human dendritic and respiratory epithelial cellsKester Haye
Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
J Virol 83:6849-62. 2009..Lastly, C-terminal truncations in the NS1 protein of human influenza virus are sufficient to make the virus attenuated and more immunogenic, supporting its use as a live attenuated influenza vaccine in humans... - A monoclonal thyroid-stimulating antibodyTakao Ando
Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
J Clin Invest 110:1667-74. 2002..The isolation and characterization of MS-1 provides a novel explanation for the prolonged thyroid stimulation in this disease which may be secondary to the lack of receptor cleavage in addition to the prolonged half-life of IgG itself... 
A novel model of demyelinating encephalomyelitis induced by monocytes and dendritic cellsGlaucia C Furtado
Immunobiology Center, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
J Immunol 177:6871-9. 2006..We propose that alterations in the numbers or function of monocytes and DC coupled to dysregulated expression of chemokines in the neural tissues, favors development of CNS autoimmune disease...- Optimization of human immunodeficiency virus gag expression by newcastle disease virus vectors for the induction of potent immune responsesElena Carnero
Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
J Virol 83:584-97. 2009..These results indicate that strategies directed toward increasing antigen expression by NDV result in enhanced immunogenicity and vaccine efficacy... - Cellular and synaptic distribution of NR2A and NR2B in macaque monkey and rat hippocampus as visualized with subunit-specific monoclonal antibodiesWilliam G M Janssen
Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
Exp Neurol 191:S28-44. 2005.... - Autocrine type I IFN and contact with endothelium promote the presentation of influenza A virus by monocyte-derived APCChunfeng Qu
Carl C. Icahn Institute for Gene Therapy and Molecular Medicine, Mt. Sinai School of Medicine, New York, NY 10029, USA
J Immunol 170:1010-8. 2003..However, when infected with live influenza virus, the role of type I IFN in mediating differentiation and Ag-presenting capacity is expendable, apparently due to other mechanisms of virus-mediated activation... - Type I interferon induction pathway, but not released interferon, participates in the maturation of dendritic cells induced by negative-strand RNA virusesCAROLINA B LOPEZ
Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
J Infect Dis 187:1126-36. 2003..It was demonstrated that these pathways have different sensitivities to the presence of viral stimulus... 
A comprehensive evaluation of human plasmacytoid dendritic cells using small volumes of human bloodHannah Phipps-Yonas
Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
J Interferon Cytokine Res 28:501-7. 2008..In addition, we have used multiplex enzyme-linked immunosorbent assays to measure secreted proteins. We demonstrate the validity of this technique and document its potential for use with blood from human study populations...- MDA5 participates in the detection of paramyxovirus infection and is essential for the early activation of dendritic cells in response to Sendai Virus defective interfering particlesJacob S Yount
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
J Immunol 180:4910-8. 2008..The unique mechanism by which DI particles trigger the maturation of DCs represents a novel strategy that could be further exploited for the development of potent adjuvant molecules... - Chromosome-specific and noisy IFNB1 transcription in individual virus-infected human primary dendritic cellsJianzhong Hu
Department of Microbiology, Mount Sinai School of Medicine, New York 10029, USA
Nucleic Acids Res 35:5232-41. 2007.... - Cytokine-independent upregulation of MDA5 in viral infectionJacob S Yount
Department of Microbiology, The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1124, New York, NY 10029, USA
J Virol 81:7316-9. 2007..This MDA5 upregulation is largely lost in IRF3 knockout DCs and is achieved in type I IFN-deficient cells expressing constitutively active IRF3... - In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccinationLaura C Bonifaz
Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
J Exp Med 199:815-24. 2004.... - A novel role for viral-defective interfering particles in enhancing dendritic cell maturationJacob S Yount
Department of Microbiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
J Immunol 177:4503-13. 2006.... - Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, normally nonimmunogenic proteinMarie K Brimnes
Department of Microbiology, Mount Sinai School of Medicine, New York, 10029 NY, USA
J Exp Med 198:133-44. 2003..Therefore respiratory infection can induce DC maturation and simultaneously B and T cell immunity to an innocuous antigen inhaled concurrently... - Toll-like receptor-independent triggering of dendritic cell maturation by virusesCAROLINA B LOPEZ
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
J Virol 80:3128-34. 2006 - Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccineChristine Trumpfheller
Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
J Exp Med 203:607-17. 2006..We suggest that a DEC-targeted vaccine, in part because of an unusually strong and protective CD4+ T cell response, will improve vaccine efficacy as a stand-alone approach or with other modalities... - Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin/CD209 is abundant on macrophages in the normal human lymph node and is not required for dendritic cell stimulation of the mixed leukocyte reactionAngela Granelli-Piperno
Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, Rockefeller University, New York, NY 10021, USA
J Immunol 175:4265-73. 2005..These results indicate that DC-SIGN has the potential to contribute to macrophage function in normal human lymph node, and that DCs do not require DC-SIGN to transmit HIV or to initiate T cell responses... - Reepithelialized orthotopic tracheal allografts expand memory cytotoxic T lymphocytes but show no evidence of chronic rejectionHeidi A Cleven
Mount Sinai School of Medicine, Department of Microbiology, New York, New York 10029, USA
Transplantation 79:861-8. 2005.... - TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA virusesCAROLINA B LOPEZ
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
J Immunol 173:6882-9. 2004..The revelation of this pathway should stimulate invigorating research into the mechanism for virus-induced DC maturation and immunity... - Influenza virus evades innate and adaptive immunity via the NS1 proteinAna Fernandez-Sesma
Department of Microbiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
J Virol 80:6295-304. 2006..Our observations also support the potential use of NS1 mutant influenza viruses as live attenuated influenza virus vaccines...
Research Grants
- Inflammatory Dendritic Cells in Influenza Virus InfectionThomas Moran; Fiscal Year: 2007....
- TH1 AND TH2 RESPONSES IN VIRAL IMMUNITYThomas Moran; Fiscal Year: 2007..Thus, having examined only a limited array of viruses, we are aware that different viruses exhibit different effects on DC maturation and result in different types of immune responses. ..
- Center for Investigating Viral Immunity and AntagonismThomas Moran; Fiscal Year: 2004..In addition, the developed technology will facilitate the analysis of human/pathogen interactions that modulate the innate and adaptive immune response. ..
- R21 Planning Grant for the CCTRHIB ProgramThomas Moran; Fiscal Year: 2003....
- TH1 AND TH2 RESPONSES IN VIRAL IMMUNITYThomas Moran; Fiscal Year: 2002..They will also try to produce monoclonal antibodies to the IL-12B2 chain and to the gamma-interferon beta component. These may be extremely valuable reagents for analyzing or manipulating TH1 and TH2 immunity. ..
- TH1 AND TH2 RESPONSES IN VIRAL IMMUNITYThomas M Moran; Fiscal Year: 2010..This will allow us to observe both the interferon dependent and independent activation that occurs in the bone marrow during virus infection. ..