Thomas Moran

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, normally nonimmunogenic protein
    Marie K Brimnes
    Department of Microbiology, Mount Sinai School of Medicine, New York, 10029 NY, USA
    J Exp Med 198:133-44. 2003
  2. pmc Estrogen mediates innate and adaptive immune alterations to influenza infection in pregnant mice
    Michael A Pazos
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 7:e40502. 2012
  3. pmc Unique type I interferon responses determine the functional fate of migratory lung dendritic cells during influenza virus infection
    Bruno Moltedo
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Pathog 7:e1002345. 2011
  4. pmc Interferon-beta pretreatment of conventional and plasmacytoid human dendritic cells enhances their activation by influenza virus
    Hannah Phipps-Yonas
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
    PLoS Pathog 4:e1000193. 2008
  5. pmc The virion host shut-off (vhs) protein blocks a TLR-independent pathway of herpes simplex virus type 1 recognition in human and mouse dendritic cells
    Christopher R Cotter
    Department of Microbiology and Immunology Institute, Mount Sinai School of Medicine, New York, New York, USA
    PLoS ONE 5:e8684. 2010
  6. pmc Alpha-defensins 1-3 release by dendritic cells is reduced by estrogen
    Maria M Escribese
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
    Reprod Biol Endocrinol 9:118. 2011
  7. pmc The virion host shutoff protein of herpes simplex virus 1 blocks the replication-independent activation of NF-κB in dendritic cells in the absence of type I interferon signaling
    Christopher R Cotter
    Department of Microbiology and Immunology Institute, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    J Virol 85:12662-72. 2011
  8. pmc The NS1 protein of a human influenza virus inhibits type I interferon production and the induction of antiviral responses in primary human dendritic and respiratory epithelial cells
    Kester Haye
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Virol 83:6849-62. 2009
  9. ncbi request reprint Evaluation of yellow fever virus 17D strain as a new vector for HIV-1 vaccine development
    David Franco
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, 7th Floor, New York, NY 10016, USA
    Vaccine 28:5676-85. 2010
  10. pmc A monoclonal thyroid-stimulating antibody
    Takao Ando
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    J Clin Invest 110:1667-74. 2002

Research Grants

  1. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas M Moran; Fiscal Year: 2010
  2. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas Moran; Fiscal Year: 2009
  3. Inflammatory Dendritic Cells in Influenza Virus Infection
    Thomas Moran; Fiscal Year: 2007
  4. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas Moran; Fiscal Year: 2007
  5. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas Moran; Fiscal Year: 2006
  6. R21 Planning Grant for the CCTRHIB Program
    Thomas Moran; Fiscal Year: 2003
  7. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas Moran; Fiscal Year: 2002
  8. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas Moran; Fiscal Year: 2001
  9. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas Moran; Fiscal Year: 2000
  10. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas Moran; Fiscal Year: 2005

Collaborators

Detail Information

Publications28

  1. pmc Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, normally nonimmunogenic protein
    Marie K Brimnes
    Department of Microbiology, Mount Sinai School of Medicine, New York, 10029 NY, USA
    J Exp Med 198:133-44. 2003
    ..Therefore respiratory infection can induce DC maturation and simultaneously B and T cell immunity to an innocuous antigen inhaled concurrently...
  2. pmc Estrogen mediates innate and adaptive immune alterations to influenza infection in pregnant mice
    Michael A Pazos
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 7:e40502. 2012
    ..We conclude that elevated estrogen levels result in an attenuated anti-viral immune response, and that pregnancy-associated morbidities occur in the context of this anti-inflammatory phenotype...
  3. pmc Unique type I interferon responses determine the functional fate of migratory lung dendritic cells during influenza virus infection
    Bruno Moltedo
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Pathog 7:e1002345. 2011
    ..Conversely, this trait may be exploitable by viral pathogens as a mechanism for systemic dissemination...
  4. pmc Interferon-beta pretreatment of conventional and plasmacytoid human dendritic cells enhances their activation by influenza virus
    Hannah Phipps-Yonas
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
    PLoS Pathog 4:e1000193. 2008
    ..This strongly suggests that type I IFN functions not only to reduce viral replication in these immune cells, but also to promote greater DC activation during influenza virus infections...
  5. pmc The virion host shut-off (vhs) protein blocks a TLR-independent pathway of herpes simplex virus type 1 recognition in human and mouse dendritic cells
    Christopher R Cotter
    Department of Microbiology and Immunology Institute, Mount Sinai School of Medicine, New York, New York, USA
    PLoS ONE 5:e8684. 2010
    ..Our results demonstrate for the first time that a viral protein contained in the tegument of HSV-1 can block the induction of DC activation by TLR-independent pathways of viral recognition...
  6. pmc Alpha-defensins 1-3 release by dendritic cells is reduced by estrogen
    Maria M Escribese
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
    Reprod Biol Endocrinol 9:118. 2011
    ....
  7. pmc The virion host shutoff protein of herpes simplex virus 1 blocks the replication-independent activation of NF-κB in dendritic cells in the absence of type I interferon signaling
    Christopher R Cotter
    Department of Microbiology and Immunology Institute, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    J Virol 85:12662-72. 2011
    ....
  8. pmc The NS1 protein of a human influenza virus inhibits type I interferon production and the induction of antiviral responses in primary human dendritic and respiratory epithelial cells
    Kester Haye
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Virol 83:6849-62. 2009
    ..Lastly, C-terminal truncations in the NS1 protein of human influenza virus are sufficient to make the virus attenuated and more immunogenic, supporting its use as a live attenuated influenza vaccine in humans...
  9. ncbi request reprint Evaluation of yellow fever virus 17D strain as a new vector for HIV-1 vaccine development
    David Franco
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, 7th Floor, New York, NY 10016, USA
    Vaccine 28:5676-85. 2010
    ..These results suggest that YF17D warrants serious consideration as a live-attenuated vector for HIV-1 vaccine development...
  10. pmc A monoclonal thyroid-stimulating antibody
    Takao Ando
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    J Clin Invest 110:1667-74. 2002
    ..The isolation and characterization of MS-1 provides a novel explanation for the prolonged thyroid stimulation in this disease which may be secondary to the lack of receptor cleavage in addition to the prolonged half-life of IgG itself...
  11. ncbi request reprint A novel model of demyelinating encephalomyelitis induced by monocytes and dendritic cells
    Glaucia C Furtado
    Immunobiology Center, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Immunol 177:6871-9. 2006
    ..We propose that alterations in the numbers or function of monocytes and DC coupled to dysregulated expression of chemokines in the neural tissues, favors development of CNS autoimmune disease...
  12. pmc Optimization of human immunodeficiency virus gag expression by newcastle disease virus vectors for the induction of potent immune responses
    Elena Carnero
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 83:584-97. 2009
    ..These results indicate that strategies directed toward increasing antigen expression by NDV result in enhanced immunogenicity and vaccine efficacy...
  13. pmc Development of a high-throughput assay to measure the neutralization capability of anti-cytomegalovirus antibodies
    Thomas J Gardner
    Mount Sinai School of Medicine, Department of Microbiology, New York, NY, USA
    Clin Vaccine Immunol 20:540-50. 2013
    ..Collectively, we have demonstrated that a robust high-throughput infection assay can analyze the early steps of the CMV life cycle and quantify the potency of biological reagents to attenuate a virus infection...
  14. ncbi request reprint Cellular and synaptic distribution of NR2A and NR2B in macaque monkey and rat hippocampus as visualized with subunit-specific monoclonal antibodies
    William G M Janssen
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Neurol 191:S28-44. 2005
    ....
  15. ncbi request reprint A novel role for viral-defective interfering particles in enhancing dendritic cell maturation
    Jacob S Yount
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Immunol 177:4503-13. 2006
    ....
  16. ncbi request reprint Autocrine type I IFN and contact with endothelium promote the presentation of influenza A virus by monocyte-derived APC
    Chunfeng Qu
    Carl C Icahn Institute for Gene Therapy and Molecular Medicine, Mt Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 170:1010-8. 2003
    ..However, when infected with live influenza virus, the role of type I IFN in mediating differentiation and Ag-presenting capacity is expendable, apparently due to other mechanisms of virus-mediated activation...
  17. ncbi request reprint Type I interferon induction pathway, but not released interferon, participates in the maturation of dendritic cells induced by negative-strand RNA viruses
    CAROLINA B LOPEZ
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Infect Dis 187:1126-36. 2003
    ..It was demonstrated that these pathways have different sensitivities to the presence of viral stimulus...
  18. pmc In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination
    Laura C Bonifaz
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 199:815-24. 2004
    ....
  19. ncbi request reprint TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA viruses
    CAROLINA B LOPEZ
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 173:6882-9. 2004
    ..The revelation of this pathway should stimulate invigorating research into the mechanism for virus-induced DC maturation and immunity...
  20. ncbi request reprint Reepithelialized orthotopic tracheal allografts expand memory cytotoxic T lymphocytes but show no evidence of chronic rejection
    Heidi A Cleven
    Mount Sinai School of Medicine, Department of Microbiology, New York, New York 10029, USA
    Transplantation 79:861-8. 2005
    ..We hypothesize that reepithelialization will also prevent chronic rejection of the trachea after withdrawal of immunosuppression...
  21. pmc Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin/CD209 is abundant on macrophages in the normal human lymph node and is not required for dendritic cell stimulation of the mixed leukocyte reaction
    Angela Granelli-Piperno
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, Rockefeller University, New York, NY 10021, USA
    J Immunol 175:4265-73. 2005
    ..These results indicate that DC-SIGN has the potential to contribute to macrophage function in normal human lymph node, and that DCs do not require DC-SIGN to transmit HIV or to initiate T cell responses...
  22. pmc Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine
    Christine Trumpfheller
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 203:607-17. 2006
    ..We suggest that a DEC-targeted vaccine, in part because of an unusually strong and protective CD4+ T cell response, will improve vaccine efficacy as a stand-alone approach or with other modalities...
  23. pmc Toll-like receptor-independent triggering of dendritic cell maturation by viruses
    CAROLINA B LOPEZ
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Virol 80:3128-34. 2006
  24. ncbi request reprint A comprehensive evaluation of human plasmacytoid dendritic cells using small volumes of human blood
    Hannah Phipps-Yonas
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
    J Interferon Cytokine Res 28:501-7. 2008
    ..In addition, we have used multiplex enzyme-linked immunosorbent assays to measure secreted proteins. We demonstrate the validity of this technique and document its potential for use with blood from human study populations...
  25. ncbi request reprint MDA5 participates in the detection of paramyxovirus infection and is essential for the early activation of dendritic cells in response to Sendai Virus defective interfering particles
    Jacob S Yount
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 180:4910-8. 2008
    ..The unique mechanism by which DI particles trigger the maturation of DCs represents a novel strategy that could be further exploited for the development of potent adjuvant molecules...
  26. pmc Chromosome-specific and noisy IFNB1 transcription in individual virus-infected human primary dendritic cells
    Jianzhong Hu
    Department of Microbiology, Mount Sinai School of Medicine, New York 10029, USA
    Nucleic Acids Res 35:5232-41. 2007
    ....
  27. pmc Influenza virus evades innate and adaptive immunity via the NS1 protein
    Ana Fernandez-Sesma
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Virol 80:6295-304. 2006
    ..Our observations also support the potential use of NS1 mutant influenza viruses as live attenuated influenza virus vaccines...
  28. pmc Cytokine-independent upregulation of MDA5 in viral infection
    Jacob S Yount
    Department of Microbiology, The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1124, New York, NY 10029, USA
    J Virol 81:7316-9. 2007
    ..This MDA5 upregulation is largely lost in IRF3 knockout DCs and is achieved in type I IFN-deficient cells expressing constitutively active IRF3...

Research Grants16

  1. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas M Moran; Fiscal Year: 2010
    ..This will allow us to observe both the interferon dependent and independent activation that occurs in the bone marrow during virus infection. ..
  2. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas Moran; Fiscal Year: 2009
    ..This will allow us to observe both the interferon dependent and independent activation that occurs in the bone marrow during virus infection. ..
  3. Inflammatory Dendritic Cells in Influenza Virus Infection
    Thomas Moran; Fiscal Year: 2007
    ....
  4. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas Moran; Fiscal Year: 2007
    ..Thus, having examined only a limited array of viruses, we are aware that different viruses exhibit different effects on DC maturation and result in different types of immune responses. ..
  5. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas Moran; Fiscal Year: 2006
    ..Thus, having examined only a limited array of viruses, we are aware that different viruses exhibit different effects on DC maturation and result in different types of immune responses. ..
  6. R21 Planning Grant for the CCTRHIB Program
    Thomas Moran; Fiscal Year: 2003
    ....
  7. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas Moran; Fiscal Year: 2002
    ..They will also try to produce monoclonal antibodies to the IL-12B2 chain and to the gamma-interferon beta component. These may be extremely valuable reagents for analyzing or manipulating TH1 and TH2 immunity. ..
  8. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas Moran; Fiscal Year: 2001
    ..They will also try to produce monoclonal antibodies to the IL-12B2 chain and to the gamma-interferon beta component. These may be extremely valuable reagents for analyzing or manipulating TH1 and TH2 immunity. ..
  9. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas Moran; Fiscal Year: 2000
    ..They will also try to produce monoclonal antibodies to the IL-12B2 chain and to the gamma-interferon beta component. These may be extremely valuable reagents for analyzing or manipulating TH1 and TH2 immunity. ..
  10. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas Moran; Fiscal Year: 2005
    ..Thus, having examined only a limited array of viruses, we are aware that different viruses exhibit different effects on DC maturation and result in different types of immune responses. ..
  11. Center for Investigating Viral Immunity and Antagonism
    Thomas Moran; Fiscal Year: 2004
    ..In addition, the developed technology will facilitate the analysis of human/pathogen interactions that modulate the innate and adaptive immune response. ..
  12. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas Moran; Fiscal Year: 2004
    ..Thus, having examined only a limited array of viruses, we are aware that different viruses exhibit different effects on DC maturation and result in different types of immune responses. ..
  13. TH1 AND TH2 RESPONSES IN VIRAL IMMUNITY
    Thomas Moran; Fiscal Year: 1999
    ..They will also try to produce monoclonal antibodies to the IL-12B2 chain and to the gamma-interferon beta component. These may be extremely valuable reagents for analyzing or manipulating TH1 and TH2 immunity. ..