Charles Mobbs

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint Impaired glucose signaling as a cause of obesity and the metabolic syndrome: the glucoadipostatic hypothesis
    Charles V Mobbs
    Fishberg Center for Neuroscience Neurobiology of Aging Laboratories, P O Box 1639 and Department of Geriatrics, Mt Sinai School of Medicine, 1 Gustave Levy Pl, New York, NY 10029 6574, United States
    Physiol Behav 85:3-23. 2005
  2. ncbi request reprint VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity
    Elizabeth Watson
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocrinology 146:5151-63. 2005
  3. ncbi request reprint The "domino theory" of hunger: the hypothalamus is hot
    Charles V Mobbs
    Department of Neuroscience and Department of Geriatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Metab 5:1-2. 2007
  4. pmc FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity
    Alex Lublin
    Fishberg Center for Neurobiology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 6:e27762. 2011
  5. pmc Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling
    Minhua Zhang
    Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Biol 7:e1000245. 2009
  6. pmc Naloxone, but not valsartan, preserves responses to hypoglycemia after antecedent hypoglycemia: role of metabolic reprogramming in counterregulatory failure
    Michal M Poplawski
    Fishberg Center for Neurobiology, Mount Sinai School of Medicine, New York, New York, USA
    Diabetes 60:39-46. 2011
  7. pmc Reversal of diabetic nephropathy by a ketogenic diet
    Michal M Poplawski
    Fishberg Center for Neurobiology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 6:e18604. 2011
  8. doi request reprint Treatment of diabetes and diabetic complications with a ketogenic diet
    Charles V Mobbs
    The Graduate School of the Icahn School of Medicine at Mount Sinai, New York, NY 10028, USA
    J Child Neurol 28:1009-14. 2013
  9. doi request reprint Metabolic mystery: aging, obesity, diabetes, and the ventromedial hypothalamus
    Charles V Mobbs
    Departments of Neuroscience, Endocrinology, and Geriatrics, and the Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA Electronic address
    Trends Endocrinol Metab 24:488-94. 2013
  10. doi request reprint Glucose-induced metabolic memory in Schwann cells: prevention by PPAR agonists
    Esther S Kim
    Department of Neuroscience, Icahn School of Medicine at Mt Sinai School, New York, New York 10029, USA
    Endocrinology 154:3054-66. 2013

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Impaired glucose signaling as a cause of obesity and the metabolic syndrome: the glucoadipostatic hypothesis
    Charles V Mobbs
    Fishberg Center for Neuroscience Neurobiology of Aging Laboratories, P O Box 1639 and Department of Geriatrics, Mt Sinai School of Medicine, 1 Gustave Levy Pl, New York, NY 10029 6574, United States
    Physiol Behav 85:3-23. 2005
    ..In support of this glucoadipostatic hypothesis, the 5 present review examines evidence that obesity and the metabolic syndrome may be due to reduction in neuroendocrine sensitivity to glucose leading to increased metabolic efficiency...
  2. ncbi request reprint VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity
    Elizabeth Watson
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocrinology 146:5151-63. 2005
    ..Modulation of VGF levels and/or VGF signaling may consequently represent an alternative means to regulate circulating glucose levels and insulin sensitivity...
  3. ncbi request reprint The "domino theory" of hunger: the hypothalamus is hot
    Charles V Mobbs
    Department of Neuroscience and Department of Geriatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Metab 5:1-2. 2007
    ..Now, report that hypothalamic neurons sense nutritional deficit through a cascade of events involving leptin, corticosterone, and glial production of thyroid hormone, leading to neuronal induction of uncoupling protein...
  4. pmc FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity
    Alex Lublin
    Fishberg Center for Neurobiology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 6:e27762. 2011
    ..These results also provide novel lead compounds with known safety profiles in human for treatment of age-related diseases, including Alzheimer's disease and diabetic complications...
  5. pmc Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling
    Minhua Zhang
    Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Biol 7:e1000245. 2009
    ..Other factors implicated in lifespan extension are also CBP-binding partners, suggesting that CBP constitutes a common factor in the modulation of lifespan and disease burden by DR and the insulin/IGF1 signaling pathway...
  6. pmc Naloxone, but not valsartan, preserves responses to hypoglycemia after antecedent hypoglycemia: role of metabolic reprogramming in counterregulatory failure
    Michal M Poplawski
    Fishberg Center for Neurobiology, Mount Sinai School of Medicine, New York, New York, USA
    Diabetes 60:39-46. 2011
    ..The goal of this study was to generate novel hypothalamic markers of hypoglycemia and use them to assess mechanisms mediating HAAF and its reversal...
  7. pmc Reversal of diabetic nephropathy by a ketogenic diet
    Michal M Poplawski
    Fishberg Center for Neurobiology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 6:e18604. 2011
    ..These studies demonstrate that diabetic nephropathy can be reversed by a relatively simple dietary intervention. Whether reduced glucose metabolism mediates the protective effects of the ketogenic diet remains to be determined...
  8. doi request reprint Treatment of diabetes and diabetic complications with a ketogenic diet
    Charles V Mobbs
    The Graduate School of the Icahn School of Medicine at Mount Sinai, New York, NY 10028, USA
    J Child Neurol 28:1009-14. 2013
    ..Future studies should assess if ketogenic diets would be effective to reverse diabetic complications in humans. ..
  9. doi request reprint Metabolic mystery: aging, obesity, diabetes, and the ventromedial hypothalamus
    Charles V Mobbs
    Departments of Neuroscience, Endocrinology, and Geriatrics, and the Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA Electronic address
    Trends Endocrinol Metab 24:488-94. 2013
    ..Here we discuss recent studies demonstrating the key role of hypothalamic neurons in driving aging and age-related diseases. ..
  10. doi request reprint Glucose-induced metabolic memory in Schwann cells: prevention by PPAR agonists
    Esther S Kim
    Department of Neuroscience, Icahn School of Medicine at Mt Sinai School, New York, New York 10029, USA
    Endocrinology 154:3054-66. 2013
    ..Furthermore, targeting PPAR may prevent metabolic memory and the development of diabetic complications. ..
  11. pmc Hypothalamic Fkbp51 is induced by fasting, and elevated hypothalamic expression promotes obese phenotypes
    Linda Yang
    Fishberg Dept of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Physiol Endocrinol Metab 302:E987-91. 2012
    ..Body weight remained elevated for more than 8 wk and was associated with elevated corticosterone and impaired glucose tolerance. These studies suggest that elevated hypothalamic Fkbp51 promotes obese phenotypes...
  12. pmc Adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet-induced obesity
    Hideo Makimura
    Fishberg Center for Neurobiology, Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, One Gustave L, Levy Place, New York, New York 10029, USA
    BMC Physiol 3:4. 2003
    ..We hypothesized that adrenalectomy would increase hypothalamic POMC mRNA and reverse obese phenotypes in obesity due to a high-fat diet as it does in obesity due to leptin deficiency...
  13. pmc Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression
    Hideo Makimura
    Fishberg Center for Neurobiology, Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, One Gustave L, Levy Place, New York, New York 10029, USA
    BMC Physiol 3:5. 2003
    ..To assess if elevated corticosterone is sufficient for the hypothalamic responses to fasting and diabetes, we assessed the effect of corticosterone pellets implanted for 48 hours on hypothalamic gene expression...
  14. pmc Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake
    Hideo Makimura
    Fishberg Center for Neurobiology, Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, One Gustave L, Levy Place, Box 1639, New York, New York 10029, USA
    BMC Neurosci 3:18. 2002
    ....
  15. pmc Secrets of the lac operon. Glucose hysteresis as a mechanism in dietary restriction, aging and disease
    Charles V Mobbs
    Departments of Neuroscience and Geriatrics, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Interdiscip Top Gerontol 35:39-68. 2007
    ..According to this mechanism, dietary restriction increases life span and reduces pathology by reducing exposure to glucose and therefore delaying the development of glucose-induced glycolytic capacity...
  16. ncbi request reprint Not wisely but too well: aging as a cost of neuroendocrine activity
    Charles V Mobbs
    Department of Neuroscience, Mt Sinai School of Medicine, One Gustav Levy Place, Box 1065, New York, NY 10129, USA
    Sci Aging Knowledge Environ 2004:pe33. 2004
    ....
  17. pmc Low-carbohydrate diets cause obesity, low-carbohydrate diets reverse obesity: a metabolic mechanism resolving the paradox
    Charles V Mobbs
    Mt Sinai School of Medicine, Department of Neuroscience and Geriatrics, Mt Sinai School of Medicine, New York, NY 10029, USA
    Appetite 48:135-8. 2007
    ....
  18. ncbi request reprint Fathead: the gain in brain falls mainly with leptin wane
    Charles V Mobbs
    Mount Sinai School of Medicine, Neurobiology of Aging Laboratories, New York, New York 10029, USA
    Endocrinology 147:645-6. 2006
  19. ncbi request reprint Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression
    Charles V Mobbs
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Neurochem Res 29:1093-103. 2004
    ....
  20. ncbi request reprint Adiponectin is stimulated by adrenalectomy in ob/ob mice and is highly correlated with resistin mRNA
    Hideo Makimura
    Neurobiology of Aging Laboratories, Fishberg Center for Neurobiology and Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Physiol Endocrinol Metab 283:E1266-71. 2002
    ..In addition, adiponectin and resistin expression were also highly correlated in diet-induced obese mice. The data support a role for adiponectin in mediating some effects of adrenalectomy on insulin sensitivity...
  21. ncbi request reprint VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting
    Seung Hahm
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 22:6929-38. 2002
    ....
  22. ncbi request reprint Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathology
    Zhong Zhao
    Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
    FASEB J 19:2081-2. 2005
    ....
  23. ncbi request reprint Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice
    Tooru M Mizuno
    Fishberg Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Diabetes 52:2675-83. 2003
    ....
  24. ncbi request reprint The physiological function of the agouti-related peptide gene: the control of weight and metabolic rate
    Tooru M Mizuno
    Fishberg Center for Neurobiology, Neurobiology of Aging Laboratories, Department of Geriatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann Med 35:425-33. 2003
    ....
  25. ncbi request reprint Obesity over the life course
    Tooru Mizuno
    Fishberg Center for Neurobiology, Neurobiology of Aging Laboratories, Department of Geriatrics, Mt Sinai School of Medicine, New York, NY 10029, USA
    Sci Aging Knowledge Environ 2004:re4. 2004
    ..Indeed, these trends suggest that for the first time in modern history, the life expectancy of people in developed societies will begin to decrease, unless the rapid increase in the prevalence of obesity can be reversed...
  26. ncbi request reprint Inhibition of agouti-related peptide expression by glucose in a clonal hypothalamic neuronal cell line is mediated by glycolysis, not oxidative phosphorylation
    Hui Cheng
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Endocrinology 149:703-10. 2008
    ..These studies support that cytoplasmic or nuclear NADH, uniquely produced by glucose metabolism, mediates effects of glucose on AgRP expression...
  27. pmc Hypothalamic responses to fasting indicate metabolic reprogramming away from glycolysis toward lipid oxidation
    Michal M Poplawski
    Fishberg Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocrinology 151:5206-17. 2010
    ..The present studies also provide a large panel of novel glucose-regulated genes that can be used as markers of glucose action to address mechanisms mediating hypothalamic responses to nutritional state...
  28. ncbi request reprint Glucokinase regulates reproductive function, glucocorticoid secretion, food intake, and hypothalamic gene expression
    Xue jun Yang
    Fishberg Center for Neuroscience and Department of Geriatrics, Mt Sinai School of Medicine, 1 Gustave Levy Place, New York, New York 10029 6574, USA
    Endocrinology 148:1928-32. 2007
    ..These data support the hypothesis that glucokinase plays a key role in the neuroendocrine regulation of metabolic economy...
  29. ncbi request reprint The fatty acid synthase inhibitor cerulenin and feeding, like leptin, activate hypothalamic pro-opiomelanocortin (POMC) neurons
    I Wei Shu
    Fishberg Research Center for Neurobiology, New York, NY, USA
    Brain Res 985:1-12. 2003
    ..These results suggest that activation of hypothalamic POMC neurons may help to mediate some of the catabolic effects associated with feeding, cerulenin and leptin...
  30. doi request reprint SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold
    Kelvin Yen
    Mount Sinai School of Medicine, One Gustave Levy Place, Box 1065, New York, NY 10029, USA
    Mech Ageing Dev 130:173-8. 2009
    ..Furthermore, CHIL paradoxically increases lifespan while reducing resistance to oxidative stress, further disassociating oxidative stress resistance and lifespan...
  31. ncbi request reprint Specific preservation of biosynthetic responses to insulin in adipose tissue may contribute to hyperleptinemia in insulin-resistant obese mice
    Tooru M Mizuno
    Fishberg Center for Neurobiology, Neurobiology of Aging Laboratories and Department of Geriatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Nutr 134:1045-50. 2004
    ..These studies demonstrate the utility of immediate-early gene expression in the analysis of biosynthetic mechanisms of insulin resistance...
  32. pmc Estradiol impairs hypothalamic molecular responses to hypoglycemia
    Hui Cheng
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res 1280:77-83. 2009
    ..Taken together, these findings suggest hypothalamic mechanisms mediating attenuation of hypoglycemia-induced neuroendocrine responses...
  33. ncbi request reprint Acute induction of gene expression in brain and liver by insulin-induced hypoglycemia
    Jason W Mastaitis
    Fishberg Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Diabetes 54:952-8. 2005
    ....
  34. ncbi request reprint D-chiro-Inositol enhances effects of hypothalamic toxin gold-thioglucose
    Fumiko Isoda
    Neurobiology of Aging Laboratories, Fishberg Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res 993:172-6. 2003
    ..In contrast, when given to mice exposed to DCI, this dose of GTG produced significant increase in body weight and evidence of an enhanced medial arcuate hypothalamic lesion...
  35. doi request reprint Chemosensory and caloric mechanisms influence distinct components of mortality rate
    Kelvin Yen
    Department of Neuroscience, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1065, New York, NY 10029, USA
    Exp Gerontol 43:1058-60. 2008
    ..Based on this analysis, life-extending effects of dietary restriction are mediated primarily by caloric mechanisms in rats and nematodes and by both mechanisms in mice and flies...
  36. ncbi request reprint Validated genomic approach to study differentially expressed genes in complex tissues
    Elisa Wurmbach
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurochem Res 27:1027-33. 2002
    ....
  37. ncbi request reprint Lifespan is not determined by metabolic rate: evidence from fishes and C. elegans
    Kelvin Yen
    Fishberg Center for Neurobiology, Neurobiology of Aging Laboratories, Department of Geriatrics, Mount Sinai School of Medicine, Box 1639, One Gustave L Levy Place, New York, NY 10029, USA
    Exp Gerontol 39:947-9. 2004
  38. ncbi request reprint Metabolic pathways that mediate inhibition of hypothalamic neurons by glucose
    Xue jun Yang
    Fishberg Center for Neurobiology, Neurobiology of Aging Laboratories, and Department of Geriatrics Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Diabetes 53:67-73. 2004
    ..Thus, counterregulatory failure could be due to relatively enhanced glycolysis in glucose-stimulated neurons during hypoglycemia and attenuation of glycolysis in glucose-inhibited neurons might reverse counterregulatory failure...
  39. ncbi request reprint Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
    Lap Ho
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    FASEB J 18:902-4. 2004
    ....
  40. pmc Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome
    Sergei Musatov
    Neurologix, Inc, Fort Lee, NJ 07024, USA
    Proc Natl Acad Sci U S A 104:2501-6. 2007
    ..Together, these findings indicate that ERalpha in the ventromedial nucleus of the hypothalamus neurons plays an essential role in the control of energy balance and the maintenance of normal body weight...
  41. ncbi request reprint Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats
    Gang Li
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida, USA
    Diabetes 52:1951-7. 2003
    ..The mechanisms may involve the sustained hypophagia and the augmentation of thermogenesis in BAT...
  42. ncbi request reprint Block the FAS, lose the fat
    Charles V Mobbs
    Nat Med 8:335-6. 2002

Research Grants21

  1. AUTONOMIC DIABETIC NEUROPATHY IN MICE
    Charles Mobbs; Fiscal Year: 2000
    ..The present study should clarify the mechanisms and significance of glucose-sensitive hypothalamic and brainstem neurons in autonomic diabetic neuropathy. ..
  2. Genes mediating glucopenia-induced obesity in nematodes
    Charles Mobbs; Fiscal Year: 2006
    ..Of particular interest will be genes whose ablation does not produce an obvious phenotype in standard conditions, but whose ablation blocks glucopenia-induced obesity. These studies will suggest potential targets for anti-obesity drugs ..
  3. Adenosine receptors and hypoglycemic responses
    Charles Mobbs; Fiscal Year: 2006
    ..These studies could lead to the development of A2a receptor antagonists to improve outcome of hypoglycemia in patients with diabetes. ..
  4. Genes mediating glucopenia-induced obesity in nematodes
    Charles Mobbs; Fiscal Year: 2007
    ..Of particular interest will be genes whose ablation does not produce an obvious phenotype in standard conditions, but whose ablation blocks glucopenia-induced obesity. These studies will suggest potential targets for anti-obesity drugs ..
  5. Adenosine receptors and hypoglycemic responses
    Charles Mobbs; Fiscal Year: 2007
    ..These studies could lead to the development of A2a receptor antagonists to improve outcome of hypoglycemia in patients with diabetes. ..
  6. Protective role of creb-binding protein in maturation and aging
    Charles Mobbs; Fiscal Year: 2009
    ..If successful human trials may ensue. ..
  7. Protective role of creb-binding protein in maturation and aging
    Charles V Mobbs; Fiscal Year: 2010
    ..If successful human trials may ensue. ..
  8. Protective role of creb-binding protein in maturation and aging
    Charles Mobbs; Fiscal Year: 2009
    ..If successful human trials may ensue. ..
  9. Adenosine receptors and hypoglycemic responses
    Charles Mobbs; Fiscal Year: 2005
    ..These studies could lead to the development of A2a receptor antagonists to improve outcome of hypoglycemia in patients with diabetes. ..
  10. Hypothalamic mechanisms in caloric restriction and aging
    Charles Mobbs; Fiscal Year: 2005
    ..These studies should clarify mechanisms mediating effects of caloric restriction on age- related pathologies and longevity. ..
  11. Adenosine receptors and hypoglycemic responses
    Charles Mobbs; Fiscal Year: 2004
    ..These studies could lead to the development of A2a receptor antagonists to improve outcome of hypoglycemia in patients with diabetes. ..
  12. AUTONOMIC DIABETIC NEUROPATHY IN MICE
    Charles Mobbs; Fiscal Year: 2001
    ..The present study should clarify the mechanisms and significance of glucose-sensitive hypothalamic and brainstem neurons in autonomic diabetic neuropathy. ..
  13. Hypothalamic mechanisms in caloric restriction and aging
    Charles Mobbs; Fiscal Year: 2001
    ..These studies should clarify mechanisms mediating effects of caloric restriction on age- related pathologies and longevity. ..
  14. AUTONOMIC DIABETIC NEUROPATHY IN MICE
    Charles Mobbs; Fiscal Year: 2002
    ..The present study should clarify the mechanisms and significance of glucose-sensitive hypothalamic and brainstem neurons in autonomic diabetic neuropathy. ..
  15. Hypothalamic mechanisms in caloric restriction and aging
    Charles Mobbs; Fiscal Year: 2002
    ..These studies should clarify mechanisms mediating effects of caloric restriction on age- related pathologies and longevity. ..
  16. Hypothalamic mechanisms in caloric restriction and aging
    Charles Mobbs; Fiscal Year: 2003
    ..These studies should clarify mechanisms mediating effects of caloric restriction on age- related pathologies and longevity. ..
  17. AUTONOMIC DIABETIC NEUROPATHY IN MICE
    Charles Mobbs; Fiscal Year: 2003
    ..The present study should clarify the mechanisms and significance of glucose-sensitive hypothalamic and brainstem neurons in autonomic diabetic neuropathy. ..
  18. Hypothalamic mechanisms in caloric restriction and aging
    Charles Mobbs; Fiscal Year: 2004
    ..These studies should clarify mechanisms mediating effects of caloric restriction on age- related pathologies and longevity. ..
  19. AUTONOMIC DIABETIC NEUROPATHY IN MICE
    Charles Mobbs; Fiscal Year: 2004
    ..The present study should clarify the mechanisms and significance of glucose-sensitive hypothalamic and brainstem neurons in autonomic diabetic neuropathy. ..
  20. Protective role of creb-binding protein in maturation and aging
    Charles V Mobbs; Fiscal Year: 2011
    ..If successful human trials may ensue. ..