Marek Mlodzik

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation?
    Marek Mlodzik
    Mount Sinai School of Medicine, Brookdale Department of Molecular, Cell and Developmental Biology, New York, NY 10029, USA
    Trends Genet 18:564-71. 2002
  2. doi request reprint Ubiquitin connects with planar cell polarity
    Marek Mlodzik
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell 137:209-11. 2009
  3. ncbi request reprint Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding
    Andreas Jenny
    Mount Sinai School of Medicine, Brookdale Department of Molecular, Cellular and Developmental Biology, 1 Gustave L Levy Place, New York, NY 10029, USA
    Nat Cell Biol 7:691-7. 2005
  4. pmc Combinatorial signaling by the Frizzled/PCP and Egfr pathways during planar cell polarity establishment in the Drosophila eye
    Ursula Weber
    Department of Developmental and Regenerative Biology, Mt Sinai School of Medicine, Annenberg Bldg 18 92, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Biol 316:110-23. 2008
  5. pmc Self-modulation of Notch signaling during ommatidial development via the Roughened eye transcriptional repressor
    David del Alamo
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Development 135:2895-904. 2008
  6. pmc The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors
    Jean Remy Courbard
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, Annenberg Bldg 18 92, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Biol 333:67-77. 2009
  7. pmc Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin
    Ivana Mirkovic
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York, USA
    Nat Struct Mol Biol 18:665-72. 2011
  8. ncbi request reprint Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes
    Gishnu Das
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Development 131:4467-76. 2004
  9. pmc Functional dissection of phosphorylation of Disheveled in Drosophila
    Wang A Yanfeng
    Dept of Developmental and Regenerative Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Biol 360:132-42. 2011
  10. pmc Frizzled-Dishevelled signaling specificity outcome can be modulated by Diego in Drosophila
    Jun Wu
    Developmental and Regenerative Biology, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mech Dev 125:30-42. 2008

Research Grants

Collaborators

Detail Information

Publications61

  1. ncbi request reprint Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation?
    Marek Mlodzik
    Mount Sinai School of Medicine, Brookdale Department of Molecular, Cell and Developmental Biology, New York, NY 10029, USA
    Trends Genet 18:564-71. 2002
    ..Here I discuss new developments in our molecular understanding of PCP in Drosophila and compare them towhat is known about the regulation of convergent extension in vertebrates...
  2. doi request reprint Ubiquitin connects with planar cell polarity
    Marek Mlodzik
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell 137:209-11. 2009
    ..In this issue, Narimatsu et al. (2009) report that the Smurf E3 ubiquitin ligases are required for localized protein degradation of a core PCP factor to generate cellular asymmetry...
  3. ncbi request reprint Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding
    Andreas Jenny
    Mount Sinai School of Medicine, Brookdale Department of Molecular, Cellular and Developmental Biology, 1 Gustave L Levy Place, New York, NY 10029, USA
    Nat Cell Biol 7:691-7. 2005
    ..Strikingly, Diego and Prickle compete with one another for Dishevelled binding, thereby modulating Frizzled/Dishevelled activity and ensuring tight control over Frizzled PCP signalling...
  4. pmc Combinatorial signaling by the Frizzled/PCP and Egfr pathways during planar cell polarity establishment in the Drosophila eye
    Ursula Weber
    Department of Developmental and Regenerative Biology, Mt Sinai School of Medicine, Annenberg Bldg 18 92, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Biol 316:110-23. 2008
    ..Taken together with previous work establishing a Notch-dependent Su(H) function in R4, we conclude that Fos, Yan, Pnt, and Su(H) integrate Egfr, Fz, and Notch signaling input in R3 or R4 to establish cell fate and ommatidial polarity...
  5. pmc Self-modulation of Notch signaling during ommatidial development via the Roughened eye transcriptional repressor
    David del Alamo
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Development 135:2895-904. 2008
    ..Thus, our data suggest that Roe acts as a transcriptional repressor in a negative-feedback loop of the N pathway...
  6. pmc The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors
    Jean Remy Courbard
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, Annenberg Bldg 18 92, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Biol 333:67-77. 2009
    ..We define a scribble allele that is largely PCP specific. Our data show that Scribble is part of the Stbm/Vang PCP complex and further suggest that it might act as an effector of Stbm/Vang during PCP establishment...
  7. pmc Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin
    Ivana Mirkovic
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York, USA
    Nat Struct Mol Biol 18:665-72. 2011
    ..Our data suggest that Nemo serves as a conserved molecular link between core PCP factors and E-cadherin-β-catenin complexes, promoting cell motility...
  8. ncbi request reprint Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes
    Gishnu Das
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Development 131:4467-76. 2004
    ..These interactions suggest a positive feedback loop initiated by Fz that results in the apical maintenance of other PCP factors through Fmi...
  9. pmc Functional dissection of phosphorylation of Disheveled in Drosophila
    Wang A Yanfeng
    Dept of Developmental and Regenerative Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Biol 360:132-42. 2011
    ..In summary, our combined data indicate that while many Ser/Thr and Tyr residues are indeed phosphorylated in vivo, strikingly most of these phosphorylation events are not critical for Dsh function with the exception of DshY473...
  10. pmc Frizzled-Dishevelled signaling specificity outcome can be modulated by Diego in Drosophila
    Jun Wu
    Developmental and Regenerative Biology, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mech Dev 125:30-42. 2008
    ..Our data suggest that Dgo sequesters Dsh to a functionally distinct Fz/PCP signaling compartment within the cell...
  11. ncbi request reprint Cooperative activities of drosophila DE-cadherin and DN-cadherin regulate the cell motility process of ommatidial rotation
    Ivana Mirkovic
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY, USA
    Development 133:3283-93. 2006
    ..A similar input into mammalian E- and N-cadherins might function in the progression of diseases such as metastatic ovarian cancer...
  12. ncbi request reprint Frizzled/PCP-dependent asymmetric neuralized expression determines R3/R4 fates in the Drosophila eye
    David del Alamo
    Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Dev Cell 11:887-94. 2006
    ..We demonstrate that Neur asymmetry is instructive in correct R3/R4 specification. Our data indicate that Fz/PCP-dependent Neur expression in R3 ensures the proper directionality of Dl-N signaling during R3/R4 specification...
  13. ncbi request reprint CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila
    Thomas J Klein
    Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, New York 10029, USA
    Curr Biol 16:1337-43. 2006
    ..Furthermore, we have identified the primary kinase target residue of CKIepsilon on Dsh. Thus, our data suggest that CKIepsilon modulates Wnt/beta-catenin and Fz/PCP signaling pathways via kinase-dependent and -independent mechanisms...
  14. pmc Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization
    Matias Simons
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Nat Cell Biol 11:286-94. 2009
    ..This stabilization is particularly important for the PCP signalling branch and, thus, promotes specific pathway selection in Wnt signalling...
  15. ncbi request reprint The apical determinants aPKC and dPatj regulate Frizzled-dependent planar cell polarity in the Drosophila eye
    Alexandre Djiane
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell 121:621-31. 2005
    ..We propose a model whereby the dPatj/aPKC complex regulates PCP by inhibiting Fz1 in cells where it should not be active...
  16. pmc Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation
    Jaskirat Singh
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Genes Dev 24:2157-68. 2010
    ..Taken together, our results argue for a conserved role of Abl family members in the positive regulation of Dsh activity toward Fz-Dsh/PCP signaling by Dsh phosphorylation...
  17. pmc Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling
    Andreas Jenny
    Mount Sinai School of Medicine, Brookdale Department of Molecular, Cellular and Developmental Biology, 1 Gustave L Levy Place, New York, NY 10029, USA
    EMBO J 22:4409-20. 2003
    ..Thus our data suggest that the Stbm/Pk complex modulates Fz/Dsh activity, resulting in a symmetry-breaking step during polarity signaling...
  18. pmc Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity
    Jun Wu
    Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, New York, USA
    PLoS Biol 2:E158. 2004
    ..Based on these data, we propose that subcellular Fz localization, through the association with other membrane proteins, is a critical aspect in regulating the signaling specificity within the Wnt/Fz signaling pathways...
  19. ncbi request reprint Notch signaling controls proliferation through cell-autonomous and non-autonomous mechanisms in the Drosophila eye
    Jessica Reynolds-Kenneally
    Brookdale Department of Molecular, Cell and Developmental Biology, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Biol 285:38-48. 2005
    ..However, cell-autonomous effects of Notch within and posterior to the furrow are independent of Upd. Here, Notch autonomously maintains cells in a proliferative state and blocks photoreceptor differentiation...
  20. ncbi request reprint Regulation of Lethal giant larvae by Dishevelled
    Gretchen L Dollar
    Department of Molecular, Cell and Developmental Biology, Box 1020, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    Nature 437:1376-80. 2005
    ..These findings suggest a molecular basis for the regulation of cell polarity by Frizzled and Dishevelled...
  21. pmc Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development
    Kimihiko Oishi
    Department of Pediatrics and the Center for Molecular Cardiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Hum Mol Genet 18:193-201. 2009
    ....
  22. pmc Centrosomal localization of Diversin and its relevance to Wnt signaling
    Keiji Itoh
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Sci 122:3791-8. 2009
    ..These observations suggest that the centrosomal localization of Diversin is crucial for its function in Wnt signaling...
  23. pmc Spalt transcription factors are required for R3/R4 specification and establishment of planar cell polarity in the Drosophila eye
    Pedro M Domingos
    Howard Hughes Medical Institute, Strang Laboratory of Cancer Research, The Rockefeller University, Box 252, 1230 York Avenue, New York, NY 10021, USA
    Development 131:5695-702. 2004
    ..Finally, we show that, posterior to row seven, seven-up represses spalt in R3/R4 in order to maintain the R3/R4 identity and to inhibit the transformation of these cells to the R7 cell fate...
  24. pmc The frizzled extracellular domain is a ligand for Van Gogh/Stbm during nonautonomous planar cell polarity signaling
    Jun Wu
    Mount Sinai School of Medicine, Department of Developmental and Regenerative Biology, 1 Gustav L Levy Place, New York, NY 10029, USA
    Dev Cell 15:462-9. 2008
    ..Thus, direct Fz-Vang/Stbm interactions represent an intriguing mechanism that may account for the global orientation of cells within the plane of their epithelial field...
  25. pmc distal antenna and distal antenna-related function in the retinal determination network during eye development in Drosophila
    Jennifer Curtiss
    Mount Sinai School of Medicine, Brookdale Department of Molecular, Cell and Developmental Biology, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Biol 306:685-702. 2007
    ..These data demonstrate a role for Dan and Danr in eye development and provide a link between eye specification and differentiation...
  26. pmc Hibris, a Drosophila nephrin homolog, is required for presenilin-mediated Notch and APP-like cleavages
    Jaskirat Singh
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine and Graduate School of Biological Sciences, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Cell 23:82-96. 2012
    ..Thus, Hbs/Nephrin appear to share a general requirement in Psn/γ-secretase regulation and associated processes...
  27. pmc Novel regulators of planar cell polarity: a genetic analysis in Drosophila
    Ursula Weber
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Genetics 191:145-62. 2012
    ..Interestingly, one of them is a member of the Meckel-Gruber syndrome factors, associated with human ciliopathies, suggesting an important role for cell polarity in nonciliated cells...
  28. pmc Drosophila CK1-γ, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking
    William J Gault
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Biol 196:605-21. 2012
    ..Our findings suggest that polarized Rab11-mediated vesicle trafficking regulated by CK1-γ is required for PCP-directed processes...
  29. ncbi request reprint Planar cell polarity signaling: a common mechanism for cellular polarization
    Andreas Jenny
    Brookdale Department of Molecular, Cell and Developmental Biology, Box 1020, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mt Sinai J Med 73:738-50. 2006
    ..This review presents recent results and new insights into the molecular mechanisms underlying the establishment of PCP, and compares and contrasts the intriguing similarities between PCP signaling in Drosophila and vertebrates...
  30. doi request reprint Microscopic analysis of the adult Drosophila retina using semithin plastic sections
    Konstantin Gaengel
    Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Biol 420:277-87. 2008
    ..This chapter described an essential technique in the analysis of different genotypes in the adult fly eye, and allows detailed analyses with single cell resolution...
  31. pmc Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling
    Ekatherina Serysheva
    Department of Developmental and Regenerative Biology, New York, New York 10029, USA
    EMBO Rep 14:718-25. 2013
    ..Importantly, knockdown of human WNK1 and WNK2 also results in decreased Wnt signalling in mammalian cell culture, suggesting that Wnk kinases have a conserved function in ensuring peak levels of canonical Wnt signalling. ..
  32. pmc Wg and Wnt4 provide long-range directional input to planar cell polarity orientation in Drosophila
    Jun Wu
    Department of Developmental and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, New York 10029, USA
    Nat Cell Biol 15:1045-55. 2013
    ..They affect PCP by modulating the intercellular interaction between Fz and Vang, which is thought to be a key step in setting up initial polarity, thus providing directionality to the PCP process. ..
  33. doi request reprint The Drosophila selectin furrowed mediates intercellular planar cell polarity interactions via frizzled stabilization
    Mei Ling Chin
    Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Cell 26:455-68. 2013
    ..Importantly, the carbohydrate function is dispensable for PCP establishment. In vivo studies suggest that Furrowed functions partially redundantly with Fmi, mediating intercellular Frizzled-Vang interactions between neighboring cells...
  34. pmc Intertissue mechanical stress affects Frizzled-mediated planar cell polarity in the Drosophila notum epidermis
    Patricio Olguin
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Curr Biol 21:236-42. 2011
    ....
  35. ncbi request reprint Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development
    Ursula Weber
    Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dev Cell 5:559-70. 2003
    ..A further link between PC/PI content, endocytosis, and signaling is supported by genetic interactions of dCCT1 with Egfr, Notch, and genes affecting endosomal traffic...
  36. ncbi request reprint Selector and signalling molecules cooperate in organ patterning
    Jennifer Curtiss
    Department of Molecular, Cell and Developmental Biology, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    Nat Cell Biol 4:E48-51. 2002
    ..Such enhancers include autoregulatory enhancers of the selector genes themselves, which drive the refinement of expression patterns of selector genes...
  37. pmc A quest for the mechanism regulating global planar cell polarity of tissues
    Jun Wu
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, Annenberg Building A18 92, New York, NY 10029, USA
    Trends Cell Biol 19:295-305. 2009
    ..This review focuses on these exciting features and attempts to provide an integrated picture of these recent and novel insights...
  38. pmc Cooperative control of Drosophila immune responses by the JNK and NF-kappaB signaling pathways
    Joseph R Delaney
    Brookdale Department of Developmental, Cell and Molecular Biology, The Mount Sinai School of Medicine, New York, NY, USA
    EMBO J 25:3068-77. 2006
    ..Our data indicate that dTAK1 is not required for Relish activation, but instead is required in JNK signaling for antimicrobial peptide gene expression...
  39. ncbi request reprint Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility
    Jessica R K Seifert
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Nat Rev Genet 8:126-38. 2007
    ..Whereas several mechanistic aspects of PCP have been uncovered, the global coordination of this polarization remains debated...
  40. pmc Planar cell polarity signaling: coordination of cellular orientation across tissues
    Jaskirat Singh
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY, USA
    Wiley Interdiscip Rev Dev Biol 1:479-99. 2012
    ..This review focuses mostly on several recent advances made in the Drosophila and vertebrate PCP field and integrates these within the existing PCP-signaling framework...
  41. pmc Planar cell polarity signaling: from fly development to human disease
    Matias Simons
    Mount Sinai School of Medicine, Department of Developmental and Regenerative Biology, New York, NY 10029, USA
    Annu Rev Genet 42:517-40. 2008
    ..This review discusses new developments in the molecular understanding of PCP establishment in Drosophila and vertebrates; these developments are integrated with new evidence that links PCP signaling to human disease...
  42. ncbi request reprint Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations
    Kimihiko Oishi
    Departments of Pediatrics and Human Genetics, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1498, New York, NY 10029, USA
    Hum Mol Genet 15:543-53. 2006
    ..In addition, these fly models can be used for sensitized screens to identify novel interacting genes as well as for high-throughput screening of therapeutic compounds for NS and PTPN11-related cancers...
  43. pmc The planar polarity gene strabismus regulates convergent extension movements in Xenopus
    Rachel S Darken
    Department of Cell Biology, Weill Medical College, New York, NY 10021, USA
    EMBO J 21:976-85. 2002
    ..Thus our results strongly support the emerging hypothesis that a vertebrate analog of the planar polarity pathway governs convergent extension movements...
  44. ncbi request reprint Planar cell polarization: an emerging model points in the right direction
    Thomas J Klein
    Mount Sinai School of Medicine, Brookdale Department of Molecular, Cell and Developmental Biology, New York, NY 10029, USA
    Annu Rev Cell Dev Biol 21:155-76. 2005
    ....
  45. ncbi request reprint A GAP in convergent extension scores PAR
    Marek Mlodzik
    Brookdale Department of Molecular, Cell and Developmental Biology, Mt Sinai School of Medicine, Annenberg Building 18 92, One Gustave L Levy Place, New York, New York 10029, USA
    Dev Cell 11:2-4. 2006
    ..An ArfGAP-PAR protein complex is required for the associated cellular polarization. Potential interactions between this complex and relevant planar cell polarity factors in this context are discussed...
  46. pmc A conserved signaling cassette regulates hair patterning from Drosophila to man
    Thomas J Klein
    Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
    Proc Natl Acad Sci U S A 101:9173-4. 2004
  47. ncbi request reprint Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6
    Konstantin Gaengel
    Mount Sinai School of Medicine, Brookdale Department of Molecular, Cell and Developmental Biology, 1 Gustave L Levy Place, New York, NY 10029, USA
    Development 130:5413-23. 2003
    ..In particular, the involvement of the cadherin Flamingo, a PCP gene, downstream of Egfr signaling provides the first link between PCP establishment and the Egfr pathway...
  48. pmc Planar cell polarity signalling couples cell division and morphogenesis during neurulation
    Brian Ciruna
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Nature 439:220-4. 2006
    ..These results reveal a function for PCP signalling in coupling cell division and morphogenesis at neurulation and indicate a previously unrecognized mechanism that might underlie NTDs...
  49. pmc Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium
    Andrea L Blitzer
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 108:2819-24. 2011
    ..Our results indicate an active role of cilia in orchestrating coordinated morphogenesis of CECs during development and repair and define the murine CE as a powerful in vivo system to study ciliary-based cellular dynamics...
  50. pmc Rescue of tropomyosin deficiency in Drosophila and human cancer cells by synaptopodin reveals a role of tropomyosin α in RhoA stabilization
    Jenny S Wong
    Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    EMBO J 31:1028-40. 2012
    ..Our findings elucidate RhoA stabilization by structurally unrelated actin-binding proteins as a conserved mechanism for regulation of stress fibre dynamics and cell motility in a cell type-specific fashion...
  51. ncbi request reprint A new piece to the unsolved planar cell polarity puzzle
    Luca Grumolato
    Department of Oncological Sciences, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Cell 20:146-7. 2011
    ..Many aspects of PCP-signaling regulation remain, however, poorly understood. A new paper establishes a potential link from Wnt5a to asymmetric PCP-factor localization via their phosphorylation...
  52. ncbi request reprint TGF-beta activated kinase-1: new insights into the diverse roles of TAK1 in development and immunity
    Joseph R Delaney
    Brookdale Department of Developmental, Cell and Molecular Biology, The Mount Sinai School of Medicine, New York, New York 10029, USA
    Cell Cycle 5:2852-5. 2006
    ..Here we provide an overview of the data concerning TAK1 from its discovery to more recent findings and provide a synthesis of the conclusions that have arisen from the multiple model systems and experimental approaches...
  53. pmc β-Catenin-independent activation of TCF1/LEF1 in human hematopoietic tumor cells through interaction with ATF2 transcription factors
    Luca Grumolato
    Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
    PLoS Genet 9:e1003603. 2013
    ....
  54. ncbi request reprint The atypical cadherin Flamingo links Frizzled and Notch signaling in planar polarity establishment in the Drosophila eye
    Gishnu Das
    Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Cell 2:655-66. 2002
    ..This in turn amplifies and enforces the initial Fz-signaling bias in the R3/R4 pair. Our results reveal differences in the planar cell polarity genetic circuitry between the eye and the wing...
  55. ncbi request reprint Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled
    Hing C Wong
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mol Cell 12:1251-60. 2003
    ..Together, our results identify a missing molecular connection within the Wnt pathway. Differences in the binding affinity of the Dvl PDZ domain and its binding partners may be important in regulating signal transduction by Dvl...
  56. ncbi request reprint Analysis of the role of the Rac/Cdc42 GTPases during planar cell polarity generation in Drosophila
    Silvia Muñoz-Descalzo
    Department of Genetics, Faculty of Biological Sciences, Valencia University, Spain
    Int J Dev Biol 51:379-87. 2007
    ..However, since not all of them function upstream of a JNK cassette, we propose that they may act in at least two parallel pathways...
  57. ncbi request reprint A new allele uncovers the role of echinus in the control of ommatidial rotation in the Drosophila eye
    Silvia Montrasio
    Dulbecco Telethon Institute, DIBIT, San Raffaele Scientific Institute, Milan, Italy
    Dev Dyn 236:2936-42. 2007
    ....
  58. ncbi request reprint Coordinating proliferation and tissue specification to promote regional identity in the Drosophila head
    Kristy L Kenyon
    Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA, 02114, USA
    Dev Cell 5:403-14. 2003
    ..We propose that field size modulates the interaction between the Decapentaplegic and Wingless pathways, thereby linking proliferation and patterning in eye primordium development...
  59. ncbi request reprint Distal antenna and distal antenna related encode nuclear proteins containing pipsqueak motifs involved in antenna development in Drosophila
    B Starling Emerald
    Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 130:1171-80. 2003
    ..We propose that dan and danr are effector genes that act downstream of these genes to control differentiation of distal antennal structures...
  60. ncbi request reprint The Drosophila formin DAAM regulates the tracheal cuticle pattern through organizing the actin cytoskeleton
    Tamás Matusek
    Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, H 6726 Szeged, Temesvari krt 62, Hungary
    Development 133:957-66. 2006
    ....
  61. ncbi request reprint Identification of the Drosophila progenitor of mammalian Krüppel-like factors 6 and 7 and a determinant of fly development
    Fabienne De Graeve
    INSERM UMR 384, Faculte de Medecine, 28 Place Henri Dunant BP38, Cedex 63001, Clermont Ferrand, France
    Gene 314:55-62. 2003
    ..We therefore propose that Luna is a novel transcriptional determinant of Drosophila development...

Research Grants33

  1. Establishment of epithelial planar cell polarity
    Marek Mlodzik; Fiscal Year: 2010
    ..g. several polarity determinants are tumor suppressors or proto-oncogenes). This application addresses the molecular regulation of PCP establishment;the information acquired here is of high significance for many medical disorders. ..
  2. Cell adhesion and photoreceptor morphogenesis in the retina
    Marek Mlodzik; Fiscal Year: 2010
    ..The information acquired here will be of importance for several eye diseases and other medical disorders. ..
  3. OMMATIDIAL PATTERNING DURING EYE DEVELOPMENT
    Marek Mlodzik; Fiscal Year: 2007
    ..Thus the information acquired in this application will advance our understanding of photoreceptor specification and eye diseases, and will also be of medical relevance in other areas, including stem cell biology. ..
  4. Ommatidial rotation and cell motility in the eye
    Marek Mlodzik; Fiscal Year: 2007
    ..Thus, the information acquired in this application will both advance our understanding of retinal cell motility and patterning, and will also be of importance for the study of carcinogenesis. ..
  5. TRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGY
    Marek Mlodzik; Fiscal Year: 2007
    ..The trainees will work closely with faculty drawn from throughout Mount Sinai and ensuring that the trainees' research is both comprehensive in scope and broad to cover all relevant areas of the CMB training program. ..
  6. Establishment of epithelial planar cell polarity
    Marek Mlodzik; Fiscal Year: 2009
    ..Thus the information acquired in this application will both advance our understanding of cellular polarization and patterning, and will be of medical relevance, particularly for the study of carcinogenesis. ..
  7. OMMATIDIAL PATTERNING DURING EYE DEVELOPMENT
    Marek Mlodzik; Fiscal Year: 2010
    ..Thus the information acquired in this application will advance our understanding of photoreceptor specification and eye diseases, and will also be of medical relevance in other areas, including stem cell biology. ..
  8. Establishment of epithelial planar cell polarity
    Marek Mlodzik; Fiscal Year: 2007
    ..Thus the information acquired in this application will both advance our understanding of cellular polarization and patterning, and will be of medical relevance, particularly for the study of carcinogenesis. ..
  9. OMMATIDIAL PATTERNING DURING EYE DEVELOPMENT
    Marek Mlodzik; Fiscal Year: 2005
    ..Thus the information acquired in this application will both advance our understanding of retinal patterning in the eye, and will also be of importance for the study of carcinogenesis. ..
  10. Establishment of epithelial planar cell polarity
    Marek Mlodzik; Fiscal Year: 2005
    ..Thus the information acquired in this application will both advance our understanding of cellular polarization and patterning, and will also be of medical relevance, particularly for the study of carcinogenesis ..
  11. Establishment of epithelial planar cell polarity
    Marek Mlodzik; Fiscal Year: 2011
    ..g. several polarity determinants are tumor suppressors or proto-oncogenes). This application addresses the molecular regulation of PCP establishment;the information acquired here is of high significance for many medical disorders. ..