M B Meyers
Affiliation: Mount Sinai School of Medicine
- Sorcin associates with the pore-forming subunit of voltage-dependent L-type Ca2+ channelsM B Meyers
Department of Medicine, Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 273:18930-5. 1998....
- Ultrastructural localization of sorcin, a 22 kDa calcium binding protein, in the rat caudate-putamen nucleus: association with ryanodine receptors and intracellular calcium releaseV M Pickel
Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York 10021, USA
J Comp Neurol 386:625-34. 1997..We conclude that in the rat CPN, sorcin may act independently or, in conjunction with RyR, to modulate cytoplasmic release of calcium, mainly from smooth endoplasmic reticulum and/or mitochondria in neurons...
- Association of sorcin with the cardiac ryanodine receptorM B Meyers
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Biol Chem 270:26411-8. 1995..These data demonstrate an interaction between sorcin and the ryanodine receptor and suggest a role for sorcin in modulation of calcium release channel activity, perhaps by stabilizing the channel protein...
- Calcium-dependent translocation of sorcin to membranes: functional relevance in contractile tissueM B Meyers
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461
FEBS Lett 357:230-4. 1995..This finding suggests that lipids are the target of sorcin on cellular membranes. The possible significance of the calcium-dependent translocation of sorcin in the specialized functions of sorcin-expressing cells is discussed...
- Genes amplified and overexpressed in human multidrug-resistant cell linesA M van der Bliek
Division of Molecular Biology, Netherlands Cancer Institute, Amsterdam
Cancer Res 48:5927-32. 1988..Our results confirm the central role of the mdr1 (pgp1) gene in MDR and suggest that different cross-resistance patterns are not due to differential expression of different P-glycoprotein genes...
- A minK-HERG complex regulates the cardiac potassium current I(Kr)T V McDonald
Section of Molecular Cardiology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Nature 388:289-92. 1997..MinK, through the formation of heteromeric channel complexes, is thus central to the control of the heart rate and rhythm...
- Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptorE Pack-Chung
Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Biol Chem 275:14440-5. 2000..Our findings reveal a molecular link between PS2 and intracellular Ca(2+) channels (i.e. ryanodine receptor) and substantiate normal and/or pathological roles of PS2 in intracellular Ca(2+) homeostasis...