Miriam Merad

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men
    Milena Bogunovic
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 203:2627-38. 2006
  2. pmc Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 204:3133-46. 2007
  3. pmc The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting
    Miriam Merad
    Department of Oncological Sciences, Mount Sinai Medical School, New York, NY 10029, USA
    Annu Rev Immunol 31:563-604. 2013
  4. ncbi request reprint Dendritic cell homeostasis and trafficking in transplantation
    Miriam Merad
    Department of Gene and Cell Medicine, Mount Sinai Medical School, 1425 Madison Avenue, New York, NY 10029, USA
    Trends Immunol 28:353-9. 2007
  5. ncbi request reprint Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease
    Miriam Merad
    Department of Pathology, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Nat Med 10:510-7. 2004
  6. doi request reprint Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
    Miriam Merad
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Rev Immunol 8:935-47. 2008
  7. pmc Dendritic cell homeostasis
    Miriam Merad
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Blood 113:3418-27. 2009
  8. doi request reprint Langerhans cells at the interface of medicine, science, and industry
    Miriam Merad
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Invest Dermatol 128:251-5. 2008
  9. pmc The origin and development of nonlymphoid tissue CD103+ DCs
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 206:3115-30. 2009
  10. pmc Origin of the lamina propria dendritic cell network
    Milena Bogunovic
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Immunity 31:513-25. 2009

Detail Information

Publications66

  1. pmc Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men
    Milena Bogunovic
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 203:2627-38. 2006
    ..Given the role of residual host tissue DCs in transplant immune reactions, these results suggest that dermal DC homeostasis may contribute to the development of cutaneous graft-versus-host disease in clinical transplantation...
  2. pmc Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 204:3133-46. 2007
    ..We propose that this is an important and previously unappreciated element of immunosurveillance that needs to be taken into account in the design of novel vaccine strategies...
  3. pmc The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting
    Miriam Merad
    Department of Oncological Sciences, Mount Sinai Medical School, New York, NY 10029, USA
    Annu Rev Immunol 31:563-604. 2013
    ..This review discusses major advances in our understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ...
  4. ncbi request reprint Dendritic cell homeostasis and trafficking in transplantation
    Miriam Merad
    Department of Gene and Cell Medicine, Mount Sinai Medical School, 1425 Madison Avenue, New York, NY 10029, USA
    Trends Immunol 28:353-9. 2007
    ..Here, we review studies on DC homeostasis and trafficking after transplantation, and examine the role of the host and graft DC in post-transplant immune responses. We also discuss the therapeutic implications of these studies...
  5. ncbi request reprint Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease
    Miriam Merad
    Department of Pathology, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Nat Med 10:510-7. 2004
    ....
  6. doi request reprint Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
    Miriam Merad
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Rev Immunol 8:935-47. 2008
    ..In this Review we describe new developments in the understanding of the biology of LCs and other langerin(+) DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity...
  7. pmc Dendritic cell homeostasis
    Miriam Merad
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Blood 113:3418-27. 2009
    ..We furthermore highlight how knowledge of these maintenance mechanisms might impact on understanding of DC malignancies as well as posttransplant immune reactions and their respective therapies...
  8. doi request reprint Langerhans cells at the interface of medicine, science, and industry
    Miriam Merad
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Invest Dermatol 128:251-5. 2008
  9. pmc The origin and development of nonlymphoid tissue CD103+ DCs
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 206:3115-30. 2009
    ..Our results reveal that nonlymphoid tissue CD103(+) DCs and lymphoid organ CD8(+) DCs derive from the same precursor and follow a related differentiation program...
  10. pmc Origin of the lamina propria dendritic cell network
    Milena Bogunovic
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Immunity 31:513-25. 2009
    ..Altogether, these results underline the diverse origin of the lamina propria DC network and identify mucosal DCs that arise from pre-DCs as key sentinels of the gut immune system...
  11. pmc GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells
    Melanie Greter
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunity 36:1031-46. 2012
    ..Thus, Csf-2 is important in vaccine-induced CD8(+) T cell immunity through the regulation of nonlymphoid tissue DC homeostasis rather than control of inflammatory DCs in vivo...
  12. pmc Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
    Emmanuel L Gautier
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York, USA
    Nat Immunol 13:1118-28. 2012
    ..We further identified how these transcripts and the proteins they encode facilitated distinguishing macrophages from dendritic cells...
  13. pmc Adrenergic nerves govern circadian leukocyte recruitment to tissues
    Christoph Scheiermann
    Ruth L and David S Gottesman Institute for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, New York, NY 10461, USA
    Immunity 37:290-301. 2012
    ..These data provide unique insights in the leukocyte adhesion cascade and the potential for time-based therapeutics for transplantation and inflammatory diseases...
  14. pmc Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils
    Jingjing Jiao
    Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029
    J Immunol 192:3374-82. 2014
    ..These data underscore the role of the DC pool in regulating the neutrophil compartment in nonlymphoid organs. ..
  15. pmc Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery
    Frank Tacke
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 203:583-97. 2006
    ..These data reveal that immature monocytes unexpectedly sample antigen from the bone marrow environment and that they can present these antigens after they leave the bone marrow...
  16. ncbi request reprint In vivo manipulation of dendritic cells overcomes tolerance to unmodified tumor-associated self antigens and induces potent antitumor immunity
    Fumiyoshi Okano
    Department of Pathology, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    J Immunol 174:2645-52. 2005
    ..These findings demonstrate that unmodified tumor-associated self Ags can be targeted to DCs in vivo to induce potent systemic antitumor immunity...
  17. pmc Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    Florent Ginhoux
    Department of Gene and Cell Medicine and the Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Science 330:841-5. 2010
    ..These results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders...
  18. ncbi request reprint Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations
    Claudia Jakubzick
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 180:3019-27. 2008
    ..Overall, these data demonstrate that the two circulating subsets of monocytes give rise to distinct tissue DC populations...
  19. pmc Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes
    Daigo Hashimoto
    Department of Oncological Sciences and Tisch Cancer Institute, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunity 38:792-804. 2013
    ..Collectively, these results indicate that tissue-resident macrophages and circulating monocytes should be classified as mononuclear phagocyte lineages that are independently maintained in the steady state...
  20. pmc Flk2+ myeloid progenitors are the main source of Langerhans cells
    Ines Mende
    Stanford Blood Center, 3373 Hillview Ave, Palo Alto, CA 94304, USA
    Blood 107:1383-90. 2006
    ..These results indicate that LCs are derived mainly from myeloid progenitors and are dependent on Flt3-ligand for their development...
  21. pmc Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes
    Claudia Jakubzick
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 205:2839-50. 2008
    ..Instead, our analysis suggests that nonlymphoid organ DCs comprise a major population of DCs within lymph nodes only after introduction of an inflammatory stimulus...
  22. pmc Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
    Andrew Chow
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 208:261-71. 2011
    ..Thus, strategies that target BM MΦ hold the potential to augment stem cell yields in patients that mobilize HSCs/progenitors poorly...
  23. pmc Systemic analysis of PPARγ in mouse macrophage populations reveals marked diversity in expression with critical roles in resolution of inflammation and airway immunity
    Emmanuel L Gautier
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 189:2614-24. 2012
    ..In addition, this work identifies specific macrophage populations as potential targets for the anti-inflammatory actions of PPARγ agonists...
  24. ncbi request reprint Langerhans cells renew in the skin throughout life under steady-state conditions
    Miriam Merad
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94304, USA
    Nat Immunol 3:1135-41. 2002
    ..These data indicate that under steady-state conditions, LCs are maintained locally, but inflammatory changes in the skin result in their replacement by blood-borne LC progenitors...
  25. pmc Induction of potent antitumor immunity by in situ targeting of intratumoral DCs
    Katsuyoshi Furumoto
    Department of Pathology, Stanford University School of Medicine, Palo Alto, California, USA
    J Clin Invest 113:774-83. 2004
    ....
  26. ncbi request reprint B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization
    Veronique Angeli
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Immunity 24:203-15. 2006
    ..Knowledge that DC migration from the periphery is augmented by B cell-dependent signals reveals new potential strategies to increase DC migration during vaccination...
  27. pmc Cross-presenting CD103+ dendritic cells are protected from influenza virus infection
    Julie Helft
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 122:4037-47. 2012
    ..These results show that efficient cross-priming by migratory lung DCs is coupled to the acquisition of an anti-viral status, which is dependent on the type I IFN signaling pathway...
  28. pmc Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling
    Taheri Sathaliyawala
    Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA
    Immunity 33:597-606. 2010
    ..Thus, PI3K-mTOR signaling downstream of Flt3L controls DC development, and its restriction by Pten ensures optimal DC pool size and subset composition...
  29. ncbi request reprint Langerhans cells arise from monocytes in vivo
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Immunol 7:265-73. 2006
    ..These results identify Gr-1(hi) monocytes as the direct precursors for LCs in vivo and establish the importance of the CSF-1 receptor in this process...
  30. pmc BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups
    Marie Luise Berres
    Department of Oncological Sciences, 2 Tisch Cancer Institute, and 3 Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029
    J Exp Med 211:669-83. 2014
    ....
  31. ncbi request reprint The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics
    Levi G Ledgerwood
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Immunol 9:42-53. 2008
    ..Thus, the increased sphingosine 1-phosphate present in inflamed peripheral tissues may induce T cell retention and suppress T cell egress...
  32. doi request reprint Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice
    Julie Helft
    Department of Gene and Cell Medicine and Mount Sinai School of Medicine, New York, NY, USA
    Immunol Rev 234:55-75. 2010
    ..We also review recent results underlining the functional specialization of tissue DCs and discuss the potential implications of these findings in tissue immunity and in the development of novel vaccine strategies...
  33. pmc Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation
    Daigo Hashimoto
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 208:1069-82. 2011
    ..This study establishes the unexpected key role of host macrophages in inhibiting GVHD and identifies CSF-1 as a potential prophylactic therapy to limit acute GVHD after allo-HCT in the clinic...
  34. ncbi request reprint Developmental origin of interferon-alpha-producing dendritic cells from hematopoietic precursors
    Holger Karsunky
    Department of Pathology, Stanford University School of Medicine, Stanford, Calif, USA
    Exp Hematol 33:173-81. 2005
    ....
  35. pmc The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids
    Judith Agudo
    Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Immunol 15:54-62. 2014
    ..Our studies identify the miR-126-VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs. ..
  36. pmc CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress
    Andrew Chow
    Ruth L and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Med 19:429-36. 2013
    ..These results indicate that CD169(+) macrophages promote late erythroid maturation and that modulation of the macrophage compartment may be a new strategy to treat erythropoietic disorders...
  37. ncbi request reprint Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis
    Arthur Mortha
    Department of Oncological Sciences, 1470 Madison Avenue, New York, NY 10029, USA
    Science 343:1249288. 2014
    ..Our findings reveal that commensal microbes promote a crosstalk between innate myeloid and lymphoid cells that leads to immune homeostasis in the intestine...
  38. pmc Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection
    Pierre Guermonprez
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA
    Nat Med 19:730-8. 2013
    ..Our findings highlight a new mechanism that regulates dendritic cell homeostasis and T cell responses to infection...
  39. pmc Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine
    Kanako L Lewis
    Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA
    Immunity 35:780-91. 2011
    ..Thus, Notch2 is a common differentiation signal for T cell-priming CD11b(+) DC subsets in the spleen and intestine...
  40. pmc Deciphering the transcriptional network of the dendritic cell lineage
    Jennifer C Miller
    Immunology Institute, Mount Sinai School of Medicine, New York, New York, USA
    Nat Immunol 13:888-99. 2012
    ..We also identified a transcriptional program expressed specifically during the steady-state migration of tissue DCs to the draining lymph nodes that may control tolerance to self tissue antigens...
  41. pmc Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells
    William van der Touw
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 190:5921-5. 2013
    ....
  42. pmc Specialized role of migratory dendritic cells in peripheral tolerance induction
    Juliana Idoyaga
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York, USA
    J Clin Invest 123:844-54. 2013
    ..These results provide a rationale for the development of novel therapies targeting migratory DCs for the treatment of autoimmune diseases...
  43. doi request reprint Dendritic cell and macrophage heterogeneity in vivo
    Daigo Hashimoto
    Department of Oncological Sciences, 1425 Madison Avenue, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunity 35:323-35. 2011
    ..We also emphasize the need to further understand the functional heterogeneity of the tissue DC and macrophage lineages to better comprehend the complex role of these cells in tissue homeostasis and immunity...
  44. pmc Antigen-presenting cell-derived complement modulates graft-versus-host disease
    Wing Hong Kwan
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 122:2234-8. 2012
    ..Our data mechanistically link APC-derived complement to T cell-mediated GvHD and support complement inhibition as a therapeutic strategy for GvHD in humans...
  45. doi request reprint Harnessing dendritic cells to improve allogeneic hematopoietic cell transplantation outcome
    Daigo Hashimoto
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Semin Immunol 23:50-7. 2011
    ..In this review, we summarize recent progress and potential new therapeutic avenues using dendritic cell-based strategies to improve allogeneic HCT outcome...
  46. pmc The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues
    Claudia Waskow
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065, USA
    Nat Immunol 9:676-83. 2008
    ..In contrast, Flt3 was essential to the regulation of homeostatic DC development in the spleen, where it was needed to maintain normal numbers of DCs by controlling their division in the periphery...
  47. pmc Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression
    Jingjing Jiao
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Hepatology 55:244-55. 2012
    ..In contrast, transfer of DCs from MMP-9-deficient mice failed to improve fibrosis regression...
  48. ncbi request reprint Ontogeny of Lagerhans cells and graft versus host disease
    Miriam Merad
    Center for Gene Therapy, Department of Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Adv Exp Med Biol 560:115-23. 2005
  49. ncbi request reprint MHC class I/peptide transfer between dendritic cells overcomes poor cross-presentation by monocyte-derived APCs that engulf dying cells
    Chunfeng Qu
    Department of Gene and Cell Medicine and Institute for Immunology, Icahn Medical Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 182:3650-9. 2009
    ..These data reveal a way in which migratory monocyte-derived DCs and other DCs, like lymph node resident DCs, both mediate cross-presentation...
  50. pmc Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility
    Paul Andrew Muller
    Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA The Immunology Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA
    Cell 158:300-13. 2014
    ..Our findings identify a plastic, microbiota-driven crosstalk between muscularis macrophages and enteric neurons that controls gastrointestinal motility. PAPERFLICK: ..
  51. doi request reprint Studying the mononuclear phagocyte system in the molecular age
    Andrew Chow
    Department of Oncological Sciences and Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Rev Immunol 11:788-98. 2011
    ..The purpose of this manuscript is to review the tools that are currently available and those that are under development to study the origin and function of mononuclear phagocytes...
  52. pmc R-Ras is required for murine dendritic cell maturation and CD4+ T-cell priming
    Gobind Singh
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY, USA
    Blood 119:1693-701. 2012
    ..Altogether, these findings provide the first demonstration of a role for R-Ras in cell-mediated immunity and further expand on the complexity of small G-protein signaling in DCs...
  53. doi request reprint Isolation of cutaneous dendritic cells
    Julie Helft
    Department of Gene and Cell Medicine and the Immunology Institute, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Biol 595:231-3. 2010
    ..This protocol describes how to isolate cutaneous dendritic cells from mouse ears for flow cytometry analysis and functional assay studies...
  54. ncbi request reprint Dendritic cells in transplantation and immune-based therapies
    James W Young
    Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, New York, New York 10021, USA
    Biol Blood Marrow Transplant 13:23-32. 2007
    ..The use of defined DC subtypes to stimulate both innate and adaptive immunity, either in combination or in a prime-boost vaccine sequence, may prove most useful clinically by harnessing both effector cell compartments...
  55. doi request reprint Melanoma immunotherapy
    Shanthi Sivendran
    Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 77:620-42. 2010
    ..Novel strategies to induce the immune system to attack melanomas are reviewed. In the future, it is envisioned that immunotherapy will have further application in combination with cytotoxic and targeted therapies...
  56. doi request reprint Decoding dendritic cell function through module and network analysis
    Gaurav Pandey
    Institute for Genomics and Multiscale Biology and Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol Methods 387:71-80. 2013
    ..In addition to recapitulating genes known to regulate the functions of these subsets, these networks reveal several novel genes and interactions that might have important roles in DC biology...
  57. pmc Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice
    Gerold Bongers
    Mount Sinai, New York, NY 10029
    J Exp Med 211:457-72. 2014
    ....
  58. doi request reprint Mononuclear phagocyte diversity in the intestine
    Milena Bogunovic
    The Immunology Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Immunol Res 54:37-49. 2012
    ....
  59. pmc Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine
    Limin Shang
    Immunology Institute, Mount Sinai School of Medicine, New York, New York, USA
    Gastroenterology 137:1006-18, 1018.e1-3. 2009
    ..We analyzed the differential expression of chemokines in distinct segments of the intestine and investigated the importance of chemokines for the distribution of leukocytes in the intestine during homeostatic and inflammatory conditions...
  60. pmc Pathological consequence of misguided dendritic cell differentiation in histiocytic diseases
    Marie Luise Berres
    Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, USA Tisch Cancer Institute Immunology Institute
    Adv Immunol 120:127-61. 2013
    ..We propose reclassification of Langerhans cell histiocytosis, juvenile xanthogranuloma, and Erdheim-Chester disease as inflammatory myeloid neoplasias. ..
  61. pmc Longitudinal tracking of human dendritic cells in murine models using magnetic resonance imaging
    Karen C Briley-Saebo
    Department of Radiology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Magn Reson Med 64:1510-9. 2010
    ..This study suggests that magnetic resonance imaging may be used to longitudinally track Feridex-labeled human dendritic cells for up to 2 weeks after injection...
  62. ncbi request reprint In vivo manipulation of dendritic cells to induce therapeutic immunity
    Miriam Merad
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Blood 99:1676-82. 2002
    ..Natural killer cells also contributed to tumor protection. These results show that dendritic cells can be loaded with antigen and activated, in situ, and provide the basis for dendritic cell- targeted clinical strategies...
  63. doi request reprint Dendritic cells in alcoholic liver injury and fibrosis
    Costica Aloman
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Alcohol Clin Exp Res 35:776-81. 2011
    ..Understanding the mechanism by which DC modulate liver function after alcohol consumption may help uncover novel therapeutic strategies for the treatment of these conditions...
  64. ncbi request reprint Exosomes as potent cell-free peptide-based vaccine. II. Exosomes in CpG adjuvants efficiently prime naive Tc1 lymphocytes leading to tumor rejection
    Nathalie Chaput
    Unite d immunologie, ERM0208 Institut National de la Sante et de la Recherche Medicale, Department of Clinical Biology, Institut Gustave Roussy, Villejuif, France
    J Immunol 172:2137-46. 2004
    ..CpG adjuvants appear to be ideal adjuvants for exosome-based cancer vaccines...
  65. pmc Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo
    Holger Karsunky
    Institute for Research in Biomedicine IRB, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    J Exp Med 198:305-13. 2003
    ....
  66. ncbi request reprint Dendritic cell genealogy: a new stem or just another branch?
    Miriam Merad
    Nat Immunol 8:1199-201. 2007

Research Grants12

  1. Homeostasis of dendritic cells and GVHD
    Miriam Merad; Fiscal Year: 2006
    ..These studies should provide valuable insights into LC regulation of skin immune responses and may lead to improved prevention or treatment of skin GVHD, a major medical problem in transplantation therapy of patients with malignancies. ..
  2. Dissecting the origin and the function of the cutaneous dendritic cell network
    Miriam Merad; Fiscal Year: 2010
    ..Program Director/Principal Investigator (Last, First, Middle): Merad, Miriam 1R01 AI080884-01A1 DISSECTING THE ORIGIN AND THE FUNCTION OF THE CUTANEOUS DENDRTITIC CELL NETWORK ..
  3. Homeostasis of dendritic cells and GVHD
    Miriam Merad; Fiscal Year: 2010
    ....
  4. Ontogeny of Gut Dendritic Cells in Steady State and Inflamed Settings
    Miriam Merad; Fiscal Year: 2010
    ..Finally, our finding that induction of DC chimerism is critical to prevent GVHD leads us, in aim 3, to determine the nature of the circulating precursor that repopulates DCs in a clinically relevant model for allo-BMT. ..
  5. Dissecting the origin and the function of the cutaneous dendritic cell network
    Miriam Merad; Fiscal Year: 2009
    ..Program Director/Principal Investigator (Last, First, Middle): Merad, Miriam 1R01 AI080884-01A1 DISSECTING THE ORIGIN AND THE FUNCTION OF THE CUTANEOUS DENDRTITIC CELL NETWORK ..
  6. Homeostasis of dendritic cells and GVHD
    Miriam Merad; Fiscal Year: 2009
    ....
  7. Ontogeny of Gut Dendritic Cells in Steady State and Inflamed Settings
    Miriam Merad; Fiscal Year: 2009
    ..Finally, our finding that induction of DC chimerism is critical to prevent GVHD leads us, in aim 3, to determine the nature of the circulating precursor that repopulates DCs in a clinically relevant model for allo-BMT. ..
  8. Homeostasis of dendritic cells and GVHD
    Miriam Merad; Fiscal Year: 2007
    ..These studies should provide valuable insights into LC regulation of skin immune responses and may lead to improved prevention or treatment of skin GVHD, a major medical problem in transplantation therapy of patients with malignancies. ..
  9. Ontogeny of Gut Dendritic Cells in Steady State and Inflamed Settings
    Miriam Merad; Fiscal Year: 2007
    ..Finally, our finding that induction of DC chimerism is critical to prevent GVHD leads us, in aim 3, to determine the nature of the circulating precursor that repopulates DCs in a clinically relevant model for allo-BMT. ..
  10. Dissecting the origin and the function of the cutaneous dendritic cell network
    Miriam Merad; Fiscal Year: 2010
    ..Program Director/Principal Investigator (Last, First, Middle): Merad, Miriam 1R01 AI080884-01A1 DISSECTING THE ORIGIN AND THE FUNCTION OF THE CUTANEOUS DENDRTITIC CELL NETWORK ..