Research Topics
Species | KEVIN MCNAUGHTSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
The pattern of neuronal loss and survival may reflect differential expression of proteasome activators in Parkinson's diseaseKevin St P McNaught
Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Synapse 64:241-50. 2010..Thus, the differential distribution and activity of proteasome activations could play a significant role in the pathogenesis of PD...
Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic culturesKevin St P McNaught
Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
J Neurochem 81:301-6. 2002..This study supports the concept that defects in the UPS may underlie nigral pathology in familial and sporadic forms of PD...- Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's diseaseKevin St P McNaught
Department of Neurology, Mount Sinai School of Medicine, Annenberg 14 73, One Gustave L Levy Place, New York, NY 10029, USA
Neurosci Lett 326:155-8. 2002..Thus, structural and function defects in 26/20S proteasomes may underlie protein accumulation, formation of proteinaceous Lewy bodies and dopaminergic neuronal death in the SNc in sporadic PD... - Aggresome-related biogenesis of Lewy bodiesKevin St P McNaught
Department of Neurology, Mount Sinai School of Medicine, Annenberg 14 73, One Gustave L Levy Place, New York, NY 10029, USA
Eur J Neurosci 16:2136-48. 2002..This phenomenon is consistent with growing evidence that altered protein handling underlies the etiopathogenesis of PD and related disorders... - Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's diseaseKevin St P McNaught
Department of Neurology, Neuropathology Division, Mount Sinai School of Medicine, New York, NY 10029, USA
Ann Neurol 56:149-62. 2004..This animal model induced by proteasome inhibitors closely recapitulates key features of PD and may be valuable in studying etiopathogenic mechanisms and putative neuroprotective therapies for the illness... - Brainstem pathology in DYT1 primary torsion dystoniaKevin St P McNaught
Department of Neurology, Neuropathology Division, Mount Sinai School of Medicine, New York, NY 10029, USA
Ann Neurol 56:540-7. 2004..and cuneiform nuclei, and related brainstem brainstem structures, in mediating motor activity and controlling muscle tone suggests that alterations in these structures could underlie the pathophysiology of DYT1 dystonia [corrected].. - Protein aggregation in the pathogenesis of familial and sporadic Parkinson's diseaseKevin St P McNaught
Department of Neurology, Mount Sinai School of Medicine, Annenberg 14 73, One Gustave L Levy Place, New York, NY 10029, USA
Neurobiol Aging 27:530-45. 2006..This suggests that manipulation of proteolytic systems is a rational approach in the development of neuroprotective therapies that could modify the pathological course of PD... - Proteasomal dysfunction in sporadic Parkinson's diseaseKevin St P McNaught
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
Neurology 66:S37-49. 2006..It remains to be established if proteasomal dysfunction plays a primary or a secondary role in the initiation or progression of the neurodegenerative process in PD... - Proteasome inhibitor-induced model of Parkinson's diseaseKevin St P McNaught
Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA
Ann Neurol 60:243-7. 2006..We have begun to examine various factors that alone or in combination might explain these differences, and we present in this article preliminary results from these studies...
Research Grants
- ROLE OF PROTEASOMAL DYSFUNCTION IN PARKINSON'S DISEASEKEVIN MCNAUGHT; Fiscal Year: 2007..These studies will test our hypothesis that inadequate proteasomal function underlies both vulnerability and degeneration of the SNc in sporadic Parkinson's disease. ..