S J Mathew

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint Recent advances in the neurobiology of anxiety disorders: implications for novel therapeutics
    Sanjay J Mathew
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place Box 1217, New York, NY 10029
    Am J Med Genet C Semin Med Genet 148:89-98. 2008
  2. doi request reprint Novel drugs and therapeutic targets for severe mood disorders
    Sanjay J Mathew
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychopharmacology 33:2080-92. 2008
  3. pmc Hippocampal N-acetylaspartate concentration and response to riluzole in generalized anxiety disorder
    Sanjay J Mathew
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 63:891-8. 2008
  4. doi request reprint Short-term tolerability of a nonazapirone selective serotonin 1A agonist in adults with generalized anxiety disorder: a 28-day, open-label study
    Sanjay J Mathew
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Clin Ther 30:1658-66. 2008
  5. ncbi request reprint Etiology and neurobiology of social anxiety disorder
    Sanjay J Mathew
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Clin Psychiatry 67:9-13. 2006
  6. ncbi request reprint A pilot study of the effects of chronic paroxetine administration on hippocampal N-acetylaspartate in generalized anxiety disorder
    S J Mathew
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Psychopharmacol 24:1175-81. 2010
  7. ncbi request reprint Open-label trial of riluzole in generalized anxiety disorder
    Sanjay J Mathew
    Department of Biological Psychiatry, New York State Psychiatric Institute, USA
    Am J Psychiatry 162:2379-81. 2005
  8. ncbi request reprint Glutamate modulators as novel interventions for mood disorders
    Sanjay J Mathew
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Rev Bras Psiquiatr 27:243-8. 2005
  9. pmc Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trial
    Sanjay J Mathew
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Neuropsychopharmacol 13:71-82. 2010
  10. ncbi request reprint Neurobiological mechanisms of social anxiety disorder
    S J Mathew
    New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Am J Psychiatry 158:1558-67. 2001

Research Grants

Detail Information

Publications30

  1. ncbi request reprint Recent advances in the neurobiology of anxiety disorders: implications for novel therapeutics
    Sanjay J Mathew
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place Box 1217, New York, NY 10029
    Am J Med Genet C Semin Med Genet 148:89-98. 2008
    ..Each of these active areas of research holds promise for expanding and improving evidence-based treatment options for individuals suffering with clinical anxiety...
  2. doi request reprint Novel drugs and therapeutic targets for severe mood disorders
    Sanjay J Mathew
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychopharmacology 33:2080-92. 2008
    ....
  3. pmc Hippocampal N-acetylaspartate concentration and response to riluzole in generalized anxiety disorder
    Sanjay J Mathew
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 63:891-8. 2008
    ....
  4. doi request reprint Short-term tolerability of a nonazapirone selective serotonin 1A agonist in adults with generalized anxiety disorder: a 28-day, open-label study
    Sanjay J Mathew
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Clin Ther 30:1658-66. 2008
    ..The serotonin 1A (5-hydroxytryptamine 1A [5-HT1A]) receptor likely plays a critical role in anxiety pathophysiology...
  5. ncbi request reprint Etiology and neurobiology of social anxiety disorder
    Sanjay J Mathew
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Clin Psychiatry 67:9-13. 2006
    ..In the future, novel uses of imaging genomics integrated with rational, biologically informed treatments will offer a more refined understanding of this complex and disabling disorder...
  6. ncbi request reprint A pilot study of the effects of chronic paroxetine administration on hippocampal N-acetylaspartate in generalized anxiety disorder
    S J Mathew
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Psychopharmacol 24:1175-81. 2010
    ..This pilot study failed to support an association between a hippocampal neuronal marker and anxiolytic response to paroxetine, and suggests further investigation of potential trait-like hippocampal abnormalities in GAD...
  7. ncbi request reprint Open-label trial of riluzole in generalized anxiety disorder
    Sanjay J Mathew
    Department of Biological Psychiatry, New York State Psychiatric Institute, USA
    Am J Psychiatry 162:2379-81. 2005
    ..There is a need to identify novel pharmacotherapies for anxiety disorders. The authors examined the safety and efficacy of riluzole, an antiglutamatergic agent, in adult outpatients with generalized anxiety disorder...
  8. ncbi request reprint Glutamate modulators as novel interventions for mood disorders
    Sanjay J Mathew
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Rev Bras Psiquiatr 27:243-8. 2005
    ..Open-label trials in treatment-resistant depression have yielded promising results. Likewise, AMPA receptor potentiators favorably impact neurotrophic factors as well as enhance cognition...
  9. pmc Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trial
    Sanjay J Mathew
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Neuropsychopharmacol 13:71-82. 2010
    ..Riluzole did not prevent relapse in the first month following ketamine. Further investigation of relapse prevention strategies post-ketamine is necessary...
  10. ncbi request reprint Neurobiological mechanisms of social anxiety disorder
    S J Mathew
    New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Am J Psychiatry 158:1558-67. 2001
    ..The authors critically surveyed several preclinical and clinical neurobiological models of social anxiety disorder...
  11. ncbi request reprint Neurostimulatory therapeutics in management of treatment-resistant depression with focus on deep brain stimulation
    Dani Dumitriu
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 75:263-75. 2008
    ....
  12. ncbi request reprint Dorsolateral prefrontal cortical pathology in generalized anxiety disorder: a proton magnetic resonance spectroscopic imaging study
    Sanjay J Mathew
    Department of Biological Psychiatry, New York State Psychiatric Institute, Columbia Unversity, New York, NY 10032, USA
    Am J Psychiatry 161:1119-21. 2004
    ..The present study used proton magnetic resonance spectroscopy to assess concentrations of N-acetylaspartate, often considered a marker of neuronal viability, in generalized anxiety disorder patients...
  13. doi request reprint Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression
    Marije aan het Rot
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York
    Biol Psychiatry 67:139-45. 2010
    ....
  14. pmc Amino acid neurotransmitters assessed by proton magnetic resonance spectroscopy: relationship to treatment resistance in major depressive disorder
    Rebecca B Price
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Biol Psychiatry 65:792-800. 2009
    ....
  15. pmc Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression
    Rebecca B Price
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Biol Psychiatry 66:522-6. 2009
    ..The Implicit Association Test (IAT), a performance-based measure of association between concepts, may have utility in suicide assessment...
  16. ncbi request reprint A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors
    Sanjay J Mathew
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 54:727-35. 2003
    ..Long-term behavioral, immunologic, and neurochemical alterations have been found in primates exposed to adverse early rearing...
  17. ncbi request reprint Management of treatment-refractory panic disorder
    S J Mathew
    Columbia University, College of Physicians and Surgeons, Department of Clinical Psychobiology, New York State Psychiatric Institute, Unit 84, 1051 Riverside Drive, New York, NY 10032, USA
    Psychopharmacol Bull 35:97-110. 2001
    ..The role of CBT in the medication refractory patient has been explored, with preliminary suggestions of efficacy...
  18. ncbi request reprint Potential psychiatric applications of metabotropic glutamate receptor agonists and antagonists
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    CNS Drugs 24:669-93. 2010
    ..This review also links growing insights into the role of glutamate in the pathophysiology of these disorders to hypothesized mGluR-related treatment mechanisms...
  19. ncbi request reprint Neuroendocrine predictors of response to intravenous clomipramine therapy for refractory obsessive-compulsive disorder
    S J Mathew
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Depress Anxiety 14:199-208. 2001
    ..The limitations of IV CMI as a specific probe of serotonin function are discussed...
  20. ncbi request reprint Glutamate and anxiety disorders
    Jonathan M Amiel
    Columbia University Department of Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
    Curr Psychiatry Rep 9:278-83. 2007
    ....
  21. ncbi request reprint Molecular targets in the treatment of anxiety
    Justine M Kent
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 52:1008-30. 2002
    ....
  22. ncbi request reprint Cerebrospinal fluid concentrations of biogenic amines and corticotropin-releasing factor in adolescent non-human primates as a function of the timing of adverse early rearing
    Sanjay J Mathew
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Stress 5:185-93. 2002
    ..Thus, the timing of exposure to VFD conditions early in life evidently determines whether CSF CRF was found to be elevated or decreased, within the context of increased serotonin metabolism, during the course of primate maturation...
  23. ncbi request reprint Differentiating depressed adolescent 24 h cortisol secretion in light of their adult clinical outcome
    Sanjay J Mathew
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, USA
    Neuropsychopharmacology 28:1336-43. 2003
    ..Dysregulation of the HPA axis, combined with dysfunction of sleep-onset mechanisms previously reported in this same cohort, might serve as premorbid biological substrates that predict suicide attempts during follow-up...
  24. ncbi request reprint Decreased choline and creatine concentrations in centrum semiovale in patients with generalized anxiety disorder: relationship to IQ and early trauma
    Jeremy D Coplan
    Department of Psychiatry, Division of Neuropsychopharmacology, State University of New York, Downstate Medical Center, Brooklyn, 11023, USA
    Psychiatry Res 147:27-39. 2006
    ..These conclusions are deemed preliminary due to small sample size, with further study of cerebral WM in anxiety disorders suggested...
  25. ncbi request reprint Neurobiology of anxiety disorders and implications for treatment
    Amir Garakani
    Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 73:941-9. 2006
    ..Combining these medication approaches with psychotherapies that promote extinction, such as cognitive behavioral therapy (CBT), may offer patients with anxiety disorders a rapid and robust treatment with good durability of effect...
  26. ncbi request reprint Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder
    James W Murrough
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    NMR Biomed 23:643-50. 2010
    ..Future (1)H MRS studies with larger sample sizes and well-characterized populations will be necessary to further clarify the sensitivity and specificity of neurometabolic abnormalities in CFS and MDD...
  27. ncbi request reprint Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand
    Jeremy D Coplan
    Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    CNS Spectr 10:530-6. 2005
    ..Environmental contribution to the neurobiology of psychopathology is perhaps most relevant during infancy, where vulnerability to early-life stressors is particularly evident...
  28. doi request reprint Ventricular cerebrospinal fluid lactate is increased in chronic fatigue syndrome compared with generalized anxiety disorder: an in vivo 3.0 T (1)H MRS imaging study
    Sanjay J Mathew
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    NMR Biomed 22:251-8. 2009
    ....
  29. ncbi request reprint Anxiety disorders: a comprehensive review of pharmacotherapies
    Ellen J Hoffman
    Department of Psychiatry, Division of Child and Adolescent Psychiatry, Mount Sinai School of Medicine, New York, NY 10 019, USA
    Mt Sinai J Med 75:248-62. 2008
    ....
  30. ncbi request reprint Maternal-infant response to variable foraging demand in nonhuman primates: effects of timing of stressor on cerebrospinal fluid corticotropin-releasing factor and circulating glucocorticoid concentrations
    Jeremy D Coplan
    State University of New York SUNY, Downstate Medical Center Box 120, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Ann N Y Acad Sci 1071:525-33. 2006
    ..However, absolute cortisol change was greater in early versus late VFD. Timing of the VFD stressor differentially affects maternal neuroendocrine response, with potential implications for the offspring's developmental trajectory...

Research Grants2

  1. PROTON MRS STUDIES IN GENERALIZED ANXIETY DISORDER
    Sanjay Mathew; Fiscal Year: 2007
    ..A specific long-term goal is for the candidate to develop sufficient expertise in MRS to sustain valid and creative application to problems of GAD and related conditions. ..
  2. PROTON MRS STUDIES IN GENERALIZED ANXIETY DISORDER
    Sanjay Mathew; Fiscal Year: 2008
    ..A specific long-term goal is for the candidate to develop sufficient expertise in MRS to sustain valid and creative application to problems of GAD and related conditions. ..