Research Topics
| S J MathewSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Recent advances in the neurobiology of anxiety disorders: implications for novel therapeuticsSanjay J Mathew
Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place Box 1217, New York, NY 10029
Am J Med Genet C Semin Med Genet 148:89-98. 2008..Each of these active areas of research holds promise for expanding and improving evidence-based treatment options for individuals suffering with clinical anxiety...- Novel drugs and therapeutic targets for severe mood disordersSanjay J Mathew
Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Neuropsychopharmacology 33:2080-92. 2008.... 
Hippocampal N-acetylaspartate concentration and response to riluzole in generalized anxiety disorderSanjay J Mathew
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
Biol Psychiatry 63:891-8. 2008....- Short-term tolerability of a nonazapirone selective serotonin 1A agonist in adults with generalized anxiety disorder: a 28-day, open-label studySanjay J Mathew
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
Clin Ther 30:1658-66. 2008..The serotonin 1A (5-hydroxytryptamine 1A [5-HT1A]) receptor likely plays a critical role in anxiety pathophysiology... 
Etiology and neurobiology of social anxiety disorderSanjay J Mathew
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
J Clin Psychiatry 67:9-13. 2006..In the future, novel uses of imaging genomics integrated with rational, biologically informed treatments will offer a more refined understanding of this complex and disabling disorder...- A pilot study of the effects of chronic paroxetine administration on hippocampal N-acetylaspartate in generalized anxiety disorderS J Mathew
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
J Psychopharmacol 24:1175-81. 2010..This pilot study failed to support an association between a hippocampal neuronal marker and anxiolytic response to paroxetine, and suggests further investigation of potential trait-like hippocampal abnormalities in GAD... - Open-label trial of riluzole in generalized anxiety disorderSanjay J Mathew
Department of Biological Psychiatry, New York State Psychiatric Institute, USA
Am J Psychiatry 162:2379-81. 2005..There is a need to identify novel pharmacotherapies for anxiety disorders. The authors examined the safety and efficacy of riluzole, an antiglutamatergic agent, in adult outpatients with generalized anxiety disorder... - Glutamate modulators as novel interventions for mood disordersSanjay J Mathew
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Rev Bras Psiquiatr 27:243-8. 2005..CONCLUSIONS: Pharmacological approaches that modulate components of the glutamate system offer novel targets for severe, recurrent mood disorders. Controlled studies are necessary... - Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trialSanjay J Mathew
Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Int J Neuropsychopharmacol 13:71-82. 2010..Riluzole did not prevent relapse in the first month following ketamine. Further investigation of relapse prevention strategies post-ketamine is necessary... - Neurobiological mechanisms of social anxiety disorderS J Mathew
New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Am J Psychiatry 158:1558-67. 2001..The authors critically surveyed several preclinical and clinical neurobiological models of social anxiety disorder... - Neurostimulatory therapeutics in management of treatment-resistant depression with focus on deep brain stimulationDani Dumitriu
Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
Mt Sinai J Med 75:263-75. 2008.... - Dorsolateral prefrontal cortical pathology in generalized anxiety disorder: a proton magnetic resonance spectroscopic imaging studySanjay J Mathew
Department of Biological Psychiatry, New York State Psychiatric Institute, Columbia Unversity, New York, NY 10032, USA
Am J Psychiatry 161:1119-21. 2004..The present study used proton magnetic resonance spectroscopy to assess concentrations of N-acetylaspartate, often considered a marker of neuronal viability, in generalized anxiety disorder patients... - Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depressionMarije aan het Rot
Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York
Biol Psychiatry 67:139-45. 2010.... - Amino acid neurotransmitters assessed by proton magnetic resonance spectroscopy: relationship to treatment resistance in major depressive disorderRebecca B Price
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
Biol Psychiatry 65:792-800. 2009.... - Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depressionRebecca B Price
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
Biol Psychiatry 66:522-6. 2009..The Implicit Association Test (IAT), a performance-based measure of association between concepts, may have utility in suicide assessment... - A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressorsSanjay J Mathew
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
Biol Psychiatry 54:727-35. 2003..Long-term behavioral, immunologic, and neurochemical alterations have been found in primates exposed to adverse early rearing... - Management of treatment-refractory panic disorderS J Mathew
Columbia University, College of Physicians and Surgeons, Department of Clinical Psychobiology, New York State Psychiatric Institute, Unit 84, 1051 Riverside Drive, New York, NY 10032, USA
Psychopharmacol Bull 35:97-110. 2001..The role of CBT in the medication refractory patient has been explored, with preliminary suggestions of efficacy... - Potential psychiatric applications of metabotropic glutamate receptor agonists and antagonistsJohn H Krystal
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
CNS Drugs 24:669-93. 2010..This review also links growing insights into the role of glutamate in the pathophysiology of these disorders to hypothesized mGluR-related treatment mechanisms... - Neuroendocrine predictors of response to intravenous clomipramine therapy for refractory obsessive-compulsive disorderS J Mathew
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Depress Anxiety 14:199-208. 2001..The limitations of IV CMI as a specific probe of serotonin function are discussed... - Glutamate and anxiety disordersJonathan M Amiel
Columbia University Department of Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
Curr Psychiatry Rep 9:278-83. 2007.... - Molecular targets in the treatment of anxietyJustine M Kent
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
Biol Psychiatry 52:1008-30. 2002.... - Cerebrospinal fluid concentrations of biogenic amines and corticotropin-releasing factor in adolescent non-human primates as a function of the timing of adverse early rearingSanjay J Mathew
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
Stress 5:185-93. 2002..Thus, the timing of exposure to VFD conditions early in life evidently determines whether CSF CRF was found to be elevated or decreased, within the context of increased serotonin metabolism, during the course of primate maturation... - Differentiating depressed adolescent 24 h cortisol secretion in light of their adult clinical outcomeSanjay J Mathew
Department of Psychiatry, Columbia University, College of Physicians and Surgeons, USA
Neuropsychopharmacology 28:1336-43. 2003..Dysregulation of the HPA axis, combined with dysfunction of sleep-onset mechanisms previously reported in this same cohort, might serve as premorbid biological substrates that predict suicide attempts during follow-up... - Decreased choline and creatine concentrations in centrum semiovale in patients with generalized anxiety disorder: relationship to IQ and early traumaJeremy D Coplan
Department of Psychiatry, Division of Neuropsychopharmacology, State University of New York, Downstate Medical Center, Brooklyn, 11023, USA
Psychiatry Res 147:27-39. 2006..These conclusions are deemed preliminary due to small sample size, with further study of cerebral WM in anxiety disorders suggested... - Neurobiology of anxiety disorders and implications for treatmentAmir Garakani
Mount Sinai School of Medicine, New York, NY, USA
Mt Sinai J Med 73:941-9. 2006..Combining these medication approaches with psychotherapies that promote extinction, such as cognitive behavioral therapy (CBT), may offer patients with anxiety disorders a rapid and robust treatment with good durability of effect... - Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorderJames W Murrough
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
NMR Biomed 23:643-50. 2010..Future (1)H MRS studies with larger sample sizes and well-characterized populations will be necessary to further clarify the sensitivity and specificity of neurometabolic abnormalities in CFS and MDD... - Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demandJeremy D Coplan
Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
CNS Spectr 10:530-6. 2005..Environmental contribution to the neurobiology of psychopathology is perhaps most relevant during infancy, where vulnerability to early-life stressors is particularly evident... - Ventricular cerebrospinal fluid lactate is increased in chronic fatigue syndrome compared with generalized anxiety disorder: an in vivo 3.0 T (1)H MRS imaging studySanjay J Mathew
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
NMR Biomed 22:251-8. 2009.... - Anxiety disorders: a comprehensive review of pharmacotherapiesEllen J Hoffman
Department of Psychiatry, Division of Child and Adolescent Psychiatry, Mount Sinai School of Medicine, New York, NY 10 019, USA
Mt Sinai J Med 75:248-62. 2008.... - Maternal-infant response to variable foraging demand in nonhuman primates: effects of timing of stressor on cerebrospinal fluid corticotropin-releasing factor and circulating glucocorticoid concentrationsJeremy D Coplan
State University of New York SUNY, Downstate Medical Center Box 120, 450 Clarkson Ave, Brooklyn, NY 11203, USA
Ann N Y Acad Sci 1071:525-33. 2006..However, absolute cortisol change was greater in early versus late VFD. Timing of the VFD stressor differentially affects maternal neuroendocrine response, with potential implications for the offspring's developmental trajectory...
Research Grants
- PROTON MRS STUDIES IN GENERALIZED ANXIETY DISORDERSanjay Mathew; Fiscal Year: 2007..A specific long-term goal is for the candidate to develop sufficient expertise in MRS to sustain valid and creative application to problems of GAD and related conditions. ..