Genomes and Genes
Affiliation: Mount Sinai School of Medicine
- In vivo gene transfer to kidney by lentiviral vectorG Luca Gusella
Divisions of Nephrology and Infectious Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
Kidney Int 61:S32-6. 2002..To date, the potential of lentiviral vectors to transfer genes in kidney has not been investigated. The scope of this work was to analyze the efficiencies of in vivo transduction of kidney by a lentiviral vector...
- Lentiviral gene transduction of kidneyG Luca Gusella
Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA
Hum Gene Ther 13:407-14. 2002..These results provide the first evidence that lentiviral vectors can stably transduce renal cells in vivo and may be effective vehicles for gene delivery to the kidney...
- Replication and compartmentalization of HIV-1 in kidney epithelium of patients with HIV-associated nephropathyDaniele Marras
Division of Nephrology, Department of Medicien, Mount Sinai School of Medicine, New York, New York, USA
Nat Med 8:522-6. 2002..These data, along with the detection of HIV-1-specific proviral DNA and mRNA in tubular epithelium cells, argue strongly for localized replication of HIV-1 in the kidney and the existence of a renal viral reservoir...
- Lentiviral gene delivery to CNS by spinal intrathecal administration to neonatal miceElena Fedorova
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
J Gene Med 8:414-24. 2006..Herein, we analyze the distribution and expression of LacZ and SEAP transgenes following the intrathecal delivery of lentivectors into the spinal canal...
- Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathyMichael D Ross
Department of Medicine, Divisions of Nephrology and Infectious Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 278:33248-55. 2003..Thus, podocan defines a new class within the SLR protein family and is a previously unrecognized component of the sclerotic glomerular lesion that develops in the course of experimental HIVAN...
- Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathyBouchra Zerhouni-Layachi
Division of Infectious Diseases, Department of Medicine, Mt Sinai School of Medicine, New York, NY, USA
AIDS 20:621-4. 2006..HIV-1 variants derived from renal epithelium were dual tropic whereas simultaneously derived viruses from PBMC were R5-tropic. Utilization of alternative co-receptors CCR3, BONZO and BOB, also differed...
- Genetic analysis of HIV by in situ PCR-directed laser capture microscopy of infected cellsDaniele Marras
Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
Methods Mol Biol 293:271-83. 2005..This chapter describes laser capture microdissection and in situ PCR and its role in the analysis of the genetic nature of HIV-1 variants and quasispecies...