Research Topics
Species | Venkatesh ManiSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
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Detail Information
Publications
Quantification of human atherosclerotic plaques using spatially enhanced cluster analysis of multicontrast-weighted magnetic resonance imagesVitalii V Itskovich
Imaging Science Laboratories, Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029-6574, USA
Magn Reson Med 52:515-23. 2004..MRI combined with SECA provides an objective method for atherosclerotic plaque component characterization and quantification...
Evaluation of neovessels in atherosclerotic plaques of rabbits using an albumin-binding intravascular contrast agent and MRIJean Christophe Cornily
Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
J Magn Reson Imaging 27:1406-11. 2008..To test whether B-22956/1, a novel intravascular contrast agent with a high affinity to serum albumin (Bracco Imaging SpA.), allowed quantifying neovessel and macrophage density in atherosclerotic plaques of rabbits using MRI...- Comparison of 3D-diffusion-prepared segmented steady-state free precession and 2D fast spin echo imaging of femoral artery atherosclerosisKatsumi Hayashi
Imaging Science Laboratories, Room BM24, Department of Radiology, Box 1234, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Int J Cardiovasc Imaging 26:309-21. 2010..Inter-observer reproducibility for the 3D plaque burden measures was excellent. 3D-DP-SSFP may be a useful and reproducible technique for evaluating atherosclerosis in peripheral arteries... - Dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) of atherosclerotic plaque angiogenesisClaudia Calcagno
Imaging Science Laboratories, Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
Angiogenesis 13:87-99. 2010..Finally, we will examine the current limitations and challenges faced by DCE-MRI and briefly discuss its future applications in the context of atherosclerosis... 
Cardiovascular magnetic resonance parameters of atherosclerotic plaque burden improve discrimination of prior major adverse cardiovascular eventsVenkatesh Mani
Imaging Science Laboratories Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Medicine, New York, NY, USA
J Cardiovasc Magn Reson 11:10. 2009..The purpose of this study was to determine if patients with traditional risk factors and prior MACE had increased cardiovascular magnetic resonance (CMR) plaque burden measures compared to patients with risk factors but no prior events...- Impact of noninsulin-dependent type 2 diabetes on carotid wall 18F-fluorodeoxyglucose positron emission tomography uptakeJan Bucerius
Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
J Am Coll Cardiol 59:2080-8. 2012..In this study, the impact of noninsulin-dependent type 2 diabetes mellitus on carotid wall (18)F-fluorodeoxyglucose (FDG) uptake in patients with documented or suspected cardiovascular disease was evaluated... - Macrophage-specific lipid-based nanoparticles improve cardiac magnetic resonance detection and characterization of human atherosclerosisMichael J Lipinski
Translational and Molecular Imaging Institute, Mount Sinai Medical Center, New York, New York, USA
JACC Cardiovasc Imaging 2:637-47. 2009..We sought to determine whether gadolinium (Gd)-containing lipid-based nanoparticles (NPs) targeting the macrophage scavenger receptor-B (CD36) improve cardiac magnetic resonance (CMR) detection and characterization of human atherosclerosis... - Reproducibility of black blood dynamic contrast-enhanced magnetic resonance imaging in aortic plaques of atherosclerotic rabbitsClaudia Calcagno
Translational and Molecular Imaging Institute, Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
J Magn Reson Imaging 32:191-8. 2010.... - Detection of neovessels in atherosclerotic plaques of rabbits using dynamic contrast enhanced MRI and 18F-FDG PETClaudia Calcagno
FAHA, FACC, Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
Arterioscler Thromb Vasc Biol 28:1311-7. 2008..Our aim was to test 2 techniques, black blood dynamic contrast enhanced MRI (DCE-MRI) and 18-fluorine-fluorodeoxyglucose (18F-FDG) PET, to quantify inflammation expressed as plaque neovessels content in a rabbit model of atherosclerosis... - Prevalence and risk factors of carotid vessel wall inflammation in coronary artery disease patients: FDG-PET and CT imaging studyJan Bucerius
Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
JACC Cardiovasc Imaging 4:1195-205. 2011..We investigated the prevalence and clinical risk factors of carotid vessel wall inflammation by means of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in a population consisting of coronary artery disease (CAD) patients... - Magnetic resonance imaging of vulnerable atherosclerotic plaques: current imaging strategies and molecular imaging probesKaren C Briley Saebo
Imaging Science Laboratories, Department of Radiology, Mount Sinai School of Medicine, New York, New York, USA
J Magn Reson Imaging 26:460-79. 2007..We also discuss molecular imaging strategies that are currently being used to design specific imaging probes targeted to biochemical and cellular markers of atherosclerotic plaque vulnerability... - Comparison of gated and non-gated fast multislice black-blood carotid imaging using rapid extended coverage and inflow/outflow saturation techniquesVenkatesh Mani
Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029-6574, USA
J Magn Reson Imaging 22:628-33. 2005..CONCLUSION: Non-gated sequences may be used instead of gated sequences in atherosclerotic vessel wall imaging without compromising image quality. This may shorten examination time and improve patient comfort... - Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRIVardan Amirbekian
Imaging Science Laboratories, Department of Radiology, The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
Proc Natl Acad Sci U S A 104:961-6. 2007..The enhancement seen is related to the macrophage content of the atherosclerotic vessel areas imaged. Immunomicelles may aid in the detection of high macrophage content associated with plaques vulnerable to rupture... - Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trialZahi A Fayad
Translational and Molecular Imaging Institute and Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA
Lancet 378:1547-59. 2011..dal-PLAQUE is the first multicentre study using novel non-invasive multimodality imaging to assess structural and inflammatory indices of atherosclerosis as primary endpoints... - Variations in atherosclerosis and remodeling patterns in aorta and carotidsKatsumi Hayashi
Imaging Science Laboratories, Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Med, New York, NY, USA
J Cardiovasc Magn Reson 12:10. 2010..The purpose of this study was to examine arterial remodeling and progression/regression of atherosclerosis in aorta and carotid arteries of individuals at risk for atherosclerosis normalized over a 1-year period... - Fractionated Feridex and positive contrast: in vivo MR imaging of atherosclerosisKaren C Briley-Saebo
Department of Radiology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
Magn Reson Med 59:721-30. 2008..No signal attenuation or iron deposition was observed in the vessel wall of rabbits administered Feridex. Results of this study suggest that it may be possible to optimize USPIOs for intraplaque macrophage detection... - Multimodality imaging of atherosclerotic plaque activity and composition using FDG-PET/CT and MRI in carotid and femoral arteriesStephane S Silvera
Sinai Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Atherosclerosis 207:139-43. 2009.... - MRI to detect atherosclerosis with gadolinium-containing immunomicelles targeting the macrophage scavenger receptorMichael J Lipinski
Zena and Michael A. Wiener Cardiovascular Institute, , Imaging Science Laboratories, Department of Radiology, Mount Sinai School of Medicine, New York, New York 10029, USA
Magn Reson Med 56:601-10. 2006..Immunomicelles and micelles improve in vitro and ex vivo MR detection of macrophages, and may prove useful in the detection of macrophage-rich plaques... - Gadolinium mixed-micelles: effect of the amphiphile on in vitro and in vivo efficacy in apolipoprotein E knockout mouse models of atherosclerosisKaren C Briley-Saebo
Imaging Science Laboratories, Department of Radiology, Mount Sinai School of Medicine, New York, New York 10029-6574, USA
Magn Reson Med 56:1336-46. 2006..was not influenced by the choice of amphiphile. The results of this study strongly suggest that liver uptake and wall enhancement may be regulated by the surface properties of the micelle and not by other factors, such as micelle size... - In vivo detection of embryonic stem cell-derived cardiovascular progenitor cells using Cy3-labeled Gadofluorine M in murine myocardiumEric D Adler
Cardiovascular Institute and Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
JACC Cardiovasc Imaging 2:1114-22. 2009.... - Cross-sectional, prospective study of MRI reproducibility in the assessment of plaque burden of the carotid arteries and aortaHamza El Aidi
Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
Nat Clin Pract Cardiovasc Med 6:219-28. 2009..We did a cross-sectional, prospective study to test reproducibility of MRI when imaging arteries, to assess risk of cardiovascular disease and correlations with age and sex... - Multimodal clinical imaging to longitudinally assess a nanomedical anti-inflammatory treatment in experimental atherosclerosisMark E Lobatto
Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, United States
Mol Pharm 7:2020-9. 2010..Importantly, we demonstrate unprecedented rapid anti-inflammatory effects in atherosclerotic lesions after the nanomedical therapy... - Rapid extended coverage simultaneous multisection black-blood vessel wall MR imagingVenkatesh Mani
Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, NY 10029-6574, USA
Radiology 232:281-8. 2004..Use of the REX method significantly shortened aortic imaging acquisition times without degrading image quality... - Carotid black blood MRI burden of atherosclerotic disease assessment correlates with ultrasound intima-media thicknessVenkatesh Mani
Imaging Science Laboratories, Mount Sinai School of Medicine, New York, NY 10029-6574, USA
J Cardiovasc Magn Reson 8:529-34. 2006..2 mm. Vessel wall measurements assessed by black-blood MRI may be potentially used clinically to evaluate plaque progression and regression... - Rationale and design of dal-PLAQUE: a study assessing efficacy and safety of dalcetrapib on progression or regression of atherosclerosis using magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography/computed tomographyZahi A Fayad
Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
Am Heart J 162:214-221.e2. 2011..Results are expected in 2011... - Feasibility of in vivo identification of endogenous ferritin with positive contrast MRI in rabbit carotid crush injury using GRASPVenkatesh Mani
Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029-6574, USA
Magn Reson Med 56:1096-106. 2006..GRASP sequences in combination with conventional GRE sequences may be used to detect the presence of ferritin deposition in in vitro thrombi and in vivo crush-injured rabbit carotid arteries... - Feasibility of [18F]-2-Fluoro-A85380-PET imaging of human vascular nicotinic acetylcholine receptors in vivoJan Bucerius
Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
JACC Cardiovasc Imaging 5:528-36. 2012..Furthermore, potentially different vascular uptake patterns of this new tracer were evaluated in healthy volunteers and in patients with neurodegenerative disorders... - Serial studies of mouse atherosclerosis by in vivo magnetic resonance imaging detect lesion regression after correction of dyslipidemiaEugene Trogan
Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, USA
Arterioscler Thromb Vasc Biol 24:1714-9. 2004..Serial in vivo MRI will enhance studies of plaque regression in animal models in response to therapeutic interventions... - Targeted iron oxide particles for in vivo magnetic resonance detection of atherosclerotic lesions with antibodies directed to oxidation-specific epitopesKaren C Briley-Saebo
Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Medicine, New York, New York, USA
J Am Coll Cardiol 57:337-47. 2011..The aim of this study was to determine whether iron oxide particles targeted to oxidation-specific epitopes image atherosclerotic lesions... - Lipid-rich atherosclerotic plaques detected by gadofluorine-enhanced in vivo magnetic resonance imagingMarc Sirol
, Mount Sinai School of Medicine, New York, NY 10029-6574, USA
Circulation 109:2890-6. 2004..CONCLUSIONS: Gadofluorine-enhanced MRI improves atherosclerotic plaque detection. The IR-DIFF-TFL method allows early detection of atherosclerotic plaque within 1 hour after gadofluorine injection... - Multislice dark-blood carotid artery wall imaging: a 1.5 T and 3.0 T comparisonIoannis Koktzoglou
Department of Radiology, Northwestern University, Chicago, Illinois 60611, USA
J Magn Reson Imaging 23:699-705. 2006..To compare two multislice turbo spin-echo (TSE) carotid artery wall imaging techniques at 1.5 T and 3.0 T, and to investigate the feasibility of higher spatial resolution carotid artery wall imaging at 3.0 T... - Serial in vivo positive contrast MRI of iron oxide-labeled embryonic stem cell-derived cardiac precursor cells in a mouse model of myocardial infarctionVenkatesh Mani
Imaging Science Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
Magn Reson Med 60:73-81. 2008..Good correlation was observed between signal loss seen on conventional T(2)* images, bright areas on GRASP, and the presence of iron on histology. This demonstrated the feasibility of in vivo stem cell imaging with positive contrast MRI... - Noninvasive cardiovascular imaging in rheumatoid arthritis: current modalities and the emerging role of magnetic resonance and positron emission tomography imagingVictoria Furer
Division of Rheumatology, New York University Hospital for Joint Diseases, New York, New York 10003, USA
Semin Arthritis Rheum 41:676-88. 2012.... - Gradient echo acquisition for superparamagnetic particles with positive contrast (GRASP): sequence characterization in membrane and glass superparamagnetic iron oxide phantoms at 1.5T and 3TVenkatesh Mani
Imaging Science Laboratories, Mount Sinai School of Medicine, New York, NY 10029-6574, USA
Magn Reson Med 55:126-35. 2006..5T(R = 0.84). Additionally, correlation between field change across the volume and CNR was observed. In conclusion, GRASP sequences may be used to generate positive signal enhancement in the presence of iron using MRI... - Multifunctional nanoemulsion platform for imaging guided therapy evaluated in experimental cancerAnita Gianella
Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Medicine, New York, New York 10029, United States
ACS Nano 5:4422-33. 2011..This study demonstrated that our nanoemulsions, when loaded with PAV, iron oxide nanocrystals, and Cy7, represent a flexible and unique theranostic nanoparticle platform that can be applied for imaging guided therapy of cancer... - The cardiomyocyte lineage is critical for optimization of stem cell therapy in a mouse model of myocardial infarctionEric D Adler
Mount Sinai Hospital, New York, New York, USA
FASEB J 24:1073-81. 2010..Giovannone, S., Briley-Saebo, K., Young, W., Kattman, S., Mani, V., Laflamme, M., Zhu, W.-Z., Fayad, Z., Keller, G. The cardiomyocyte lineage is critical for optimization of stem cell therapy in a mouse model of myocardial infarction... - Parallel and nonparallel simultaneous multislice black-blood double inversion recovery techniques for vessel wall imagingVitalii V Itskovich
Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029-6574, USA
J Magn Reson Imaging 19:459-67. 2004..The DIR-RARE-GRAPPA multislice sequence showed 8.35-fold time improvement vs. single-slice DIR-2RARE sequence. CONCLUSION: Future MRI atherosclerotic plaque studies can be performed in substantially shorter times using these methods... - Longitudinal tracking of human dendritic cells in murine models using magnetic resonance imagingKaren C Briley-Saebo
Department of Radiology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
Magn Reson Med 64:1510-9. 2010..This study suggests that magnetic resonance imaging may be used to longitudinally track Feridex-labeled human dendritic cells for up to 2 weeks after injection...